-
3
-
-
65449181143
-
Down syndrome: A cardiovascular perspective
-
Vis JC, Duffels MG, Winter MM, Weijerman ME, Cobben JM, Huisman SA et al. Down syndrome: a cardiovascular perspective. J Intellect Disabil Res 2009; 53: 419-425
-
(2009)
J Intellect Disabil Res
, vol.53
, pp. 419-425
-
-
Vis, J.C.1
Duffels, M.G.2
Winter, M.M.3
Weijerman, M.E.4
Cobben, J.M.5
Huisman, S.A.6
-
4
-
-
84919933374
-
Refractive error, binocular vision and accommodation of children with Down syndrome
-
Watt T, Robertson K, Jacobs RJ. Refractive error, binocular vision and accommodation of children with Down syndrome. Clin Exp Optom 2015; 98: 3-11
-
(2015)
Clin Exp Optom
, vol.98
, pp. 3-11
-
-
Watt, T.1
Robertson, K.2
Jacobs, R.J.3
-
5
-
-
84941900265
-
Motor, linguistic, personal and social aspects of children with Down syndrome
-
Ferreira-Vasques AT, Lamônica DA. Motor, linguistic, personal and social aspects of children with Down syndrome. J Appl Oral Sci 2015; 23: 424-430
-
(2015)
J Appl Oral Sci
, vol.23
, pp. 424-430
-
-
Ferreira-Vasques, A.T.1
Lamônica, D.A.2
-
6
-
-
0033780541
-
The management of neoplastic disorders of haematopoiesis in children with Down's syndrome
-
Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol 2000; 110: 512-524
-
(2000)
Br J Haematol
, vol.110
, pp. 512-524
-
-
Lange, B.1
-
7
-
-
0342905433
-
Risks of leukaemia and solid tumours in individuals with Down's syndrome
-
Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 2000; 355: 165-169
-
(2000)
Lancet
, vol.355
, pp. 165-169
-
-
Hasle, H.1
Clemmensen, I.H.2
Mikkelsen, M.3
-
8
-
-
0037160991
-
Mortality associated with Down's syndrome in the USA from 1983 to 1997: A population-based study
-
Yang Q, Rasmussen SA, Friedman JM. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 2002; 359: 1019-1025
-
(2002)
Lancet
, vol.359
, pp. 1019-1025
-
-
Yang, Q.1
Rasmussen, S.A.2
Friedman, J.M.3
-
9
-
-
18944363334
-
Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts
-
Langebrake C, Creutzig U, Reinhardt D. Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts. Klin Padiatr 2005; 217: 126-134
-
(2005)
Klin Padiatr
, vol.217
, pp. 126-134
-
-
Langebrake, C.1
Creutzig, U.2
Reinhardt, D.3
-
10
-
-
0036727413
-
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down qsyndrome
-
Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down qsyndrome. Nat Genet 2002; 32: 148-152
-
(2002)
Nat Genet
, vol.32
, pp. 148-152
-
-
Wechsler, J.1
Greene, M.2
McDevitt, M.A.3
Anastasi, J.4
Karp, J.E.5
Le Beau, M.M.6
-
11
-
-
84911446376
-
Prognosis and management of acute myeloid leukemia in patients with Down syndrome
-
Caldwell JT, Ge Y, Taub JW. Prognosis and management of acute myeloid leukemia in patients with Down syndrome. Expert Rev Hematol 2014; 7: 831-840
-
(2014)
Expert Rev Hematol
, vol.7
, pp. 831-840
-
-
Caldwell, J.T.1
Ge, Y.2
Taub, J.W.3
-
12
-
-
84868129082
-
Diagnosis and management of acute myeloid leukemia in children and adolescents: Recommendations from an international expert panel
-
Creutzig U, Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E et al. Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel. Blood 2012; 120: 3187-3205
-
(2012)
Blood
, vol.120
, pp. 3187-3205
-
-
Creutzig, U.1
Heuvel-Eibrink, M.M.2
Gibson, B.3
Dworzak, M.N.4
Adachi, S.5
De Bont, E.6
-
13
-
-
85006320195
-
Preserved high probability of overall survival with significant reduction of chemotherapy for myeloid leukemia in Down syndrome: A Nationwide Prospective Study in Japan
-
Taga T, Watanabe T, Tomizawa D, Kudo K, Terui K, Moritake H et al. Preserved high probability of overall survival with significant reduction of chemotherapy for myeloid leukemia in Down syndrome: A Nationwide Prospective Study in Japan. Pediatr Blood Cancer 2016; 63: 248-254
-
(2016)
Pediatr Blood Cancer
, vol.63
, pp. 248-254
-
-
Taga, T.1
Watanabe, T.2
Tomizawa, D.3
Kudo, K.4
Terui, K.5
Moritake, H.6
-
14
-
-
13744252262
-
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia
-
Ge Y, Stout ML, Tatman DA, Jensen TL, Buck S, Thomas RL et al. GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. J Natl Cancer Inst 2005; 97: 226-231
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 226-231
-
-
Ge, Y.1
Stout, M.L.2
Tatman, D.A.3
Jensen, T.L.4
Buck, S.5
Thomas, R.L.6
-
15
-
-
77954491626
-
Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: A report from the Children's Oncology Group
-
Maloney KW, Carroll WL, Carroll AJ, Devidas M, Borowitz MJ, Martin PL et al. Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group. Blood 2010; 116: 1045-1050
-
(2010)
Blood
, vol.116
, pp. 1045-1050
-
-
Maloney, K.W.1
Carroll, W.L.2
Carroll, A.J.3
Devidas, M.4
Borowitz, M.J.5
Martin, P.L.6
-
16
-
-
20144388603
-
Acute leukaemia in children with Down syndrome: A population-based Nordic study
-
Zeller B, Gustafsson G, Forestier E, Abrahamsson J, Clausen N, Heldrup J et al. Acute leukaemia in children with Down syndrome: a population-based Nordic study. Br J Haematol 2005; 128: 797-804
-
(2005)
Br J Haematol
, vol.128
, pp. 797-804
-
-
Zeller, B.1
Gustafsson, G.2
Forestier, E.3
Abrahamsson, J.4
Clausen, N.5
Heldrup, J.6
-
17
-
-
84891823402
-
Acute lymphoblastic leukemia in children with Down syndrome: A retrospective analysis from the Ponte di Legno study group
-
Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, Heuvel-Eibrink MM et al. Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group. Blood 2014; 123: 70-77
-
(2014)
Blood
, vol.123
, pp. 70-77
-
-
Buitenkamp, T.D.1
Izraeli, S.2
Zimmermann, M.3
Forestier, E.4
Heerema, N.A.5
Heuvel-Eibrink, M.M.6
-
18
-
-
49049105472
-
Acute lymphoblastic leukemia and Down syndrome: Presenting features and treatment outcome in the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP)
-
Arico M, Ziino O, Valsecchi MG, Cazzaniga G, Baronci C, Messina C et al. Acute lymphoblastic leukemia and Down syndrome: presenting features and treatment outcome in the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP). Cancer 2008; 113: 515-521
-
(2008)
Cancer
, vol.113
, pp. 515-521
-
-
Arico, M.1
Ziino, O.2
Valsecchi, M.G.3
Cazzaniga, G.4
Baronci, C.5
Messina, C.6
-
19
-
-
0036098159
-
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome
-
Zwaan CM, Kaspers GJ, Pieters R, Hahlen K, Janka-Schaub GE, van Zantwijk CH et al. Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. Blood 2002; 99: 245-251
-
(2002)
Blood
, vol.99
, pp. 245-251
-
-
Zwaan, C.M.1
Kaspers, G.J.2
Pieters, R.3
Hahlen, K.4
Janka-Schaub, G.E.5
Van Zantwijk, C.H.6
-
20
-
-
84876159587
-
Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia
-
Bohnstedt C, Levinsen M, Rosthoj S, Zeller B, Taskinen M, Hafsteinsdottir S et al. Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia. Leukemia 2013; 27: 866-870
-
(2013)
Leukemia
, vol.27
, pp. 866-870
-
-
Bohnstedt, C.1
Levinsen, M.2
Rosthoj, S.3
Zeller, B.4
Taskinen, M.5
Hafsteinsdottir, S.6
-
21
-
-
85028636933
-
Event free (EFS) and overall survival (OS) for children with Down syndrome (DS) and B-lymhoblastic leukemia in Children's Oncology Group (COG) trials AALL0232 and AALL0331
-
abstract no. 4009
-
Maloney KW, Wood B, Whitlock JA, Loh M, Raetz EA, Winick N et al. Event free (EFS) and overall survival (OS) for children with Down syndrome (DS) and B-lymhoblastic leukemia in Children's Oncology Group (COG) trials AALL0232 and AALL0331. Pediatr Blood Cancer 2014; 61: S4; abstract no. 4009
-
(2014)
Pediatr Blood Cancer
, vol.61
, pp. S4
-
-
Maloney, K.W.1
Wood, B.2
Whitlock, J.A.3
Loh, M.4
Raetz, E.A.5
Winick, N.6
-
22
-
-
77954519312
-
Methotrexateinduced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia
-
Buitenkamp TD, Mathot RA, de Haas V, Pieters R, Zwaan CM. Methotrexateinduced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia. Haematologica 2010; 95: 1106-1113
-
(2010)
Haematologica
, vol.95
, pp. 1106-1113
-
-
Buitenkamp, T.D.1
Mathot, R.A.2
De Haas, V.3
Pieters, R.4
Zwaan, C.M.5
-
23
-
-
84922803297
-
Hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia and Down syndrome
-
Goto H, Kaneko T, Shioda Y, Kajiwara M, Sakashita K, Kitoh T et al. Hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia and Down syndrome. Pediatr Blood Cancer 2015; 62: 148-152
-
(2015)
Pediatr Blood Cancer
, vol.62
, pp. 148-152
-
-
Goto, H.1
Kaneko, T.2
Shioda, Y.3
Kajiwara, M.4
Sakashita, K.5
Kitoh, T.6
-
24
-
-
84898801407
-
Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome
-
Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW et al. Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatr Blood Cancer 2014; 61: 1126-1128
-
(2014)
Pediatr Blood Cancer
, vol.61
, pp. 1126-1128
-
-
Hitzler, J.K.1
He, W.2
Doyle, J.3
Cairo, M.4
Camitta, B.M.5
Chan, K.W.6
-
25
-
-
84923019006
-
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
-
Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 2015; 385: 517-528
-
(2015)
Lancet
, vol.385
, pp. 517-528
-
-
Lee, D.W.1
Kochenderfer, J.N.2
Stetler-Stevenson, M.3
Cui, Y.K.4
Delbrook, C.5
Feldman, S.A.6
-
26
-
-
84933510694
-
CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
-
Maude SL, Teachey DT, Porter DL, Grupp SA. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood 2015; 125: 4017-4023
-
(2015)
Blood
, vol.125
, pp. 4017-4023
-
-
Maude, S.L.1
Teachey, D.T.2
Porter, D.L.3
Grupp, S.A.4
-
28
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014; 371: 1507-1517
-
(2014)
N Engl J Med
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
Aplenc, R.4
Barrett, D.M.5
Bunin, N.J.6
-
29
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 2014; 6, 224ra25
-
(2014)
Sci Transl Med
, vol.6
, pp. 224ra25
-
-
Davila, M.L.1
Riviere, I.2
Wang, X.3
Bartido, S.4
Park, J.5
Curran, K.6
-
30
-
-
84926099033
-
Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-arm, phase 2 study
-
Topp MS, Gökbuget N, Stein AS, Zugmaier G, O'Brien S, Bargou RC et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. Lancet Oncol 2015; 16: 57-66
-
(2015)
Lancet Oncol
, vol.16
, pp. 57-66
-
-
Topp, M.S.1
Gökbuget, N.2
Stein, A.S.3
Zugmaier, G.4
O'Brien, S.5
Bargou, R.C.6
-
31
-
-
84882782587
-
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
-
Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE et al. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood 2013; 121: 5154-5157
-
(2013)
Blood
, vol.121
, pp. 5154-5157
-
-
Teachey, D.T.1
Rheingold, S.R.2
Maude, S.L.3
Zugmaier, G.4
Barrett, D.M.5
Seif, A.E.6
-
32
-
-
84993813859
-
Novel agents for the treatment of childhood acute leukemia
-
Annesley CE, Brown P. Novel agents for the treatment of childhood acute leukemia. Ther Adv Hematol 2015; 6: 61-79
-
(2015)
Ther Adv Hematol
, vol.6
, pp. 61-79
-
-
Annesley, C.E.1
Brown, P.2
-
33
-
-
84868528389
-
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
-
Maude SL, Tasian SK, Vincent T, Hall JW, Sheen C, Roberts KG et al. Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 2012; 120: 3510-3518
-
(2012)
Blood
, vol.120
, pp. 3510-3518
-
-
Maude, S.L.1
Tasian, S.K.2
Vincent, T.3
Hall, J.W.4
Sheen, C.5
Roberts, K.G.6
-
34
-
-
84864440264
-
Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia
-
Tasian SK, Doral MY, Borowitz MJ, Wood BL, Chen IM, Harvey RC et al. Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. Blood 2012; 120: 833-842
-
(2012)
Blood
, vol.120
, pp. 833-842
-
-
Tasian, S.K.1
Doral, M.Y.2
Borowitz, M.J.3
Wood, B.L.4
Chen, I.M.5
Harvey, R.C.6
-
35
-
-
84901651797
-
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
-
Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat Genet 2014; 46: 618-623
-
(2014)
Nat Genet
, vol.46
, pp. 618-623
-
-
Lane, A.A.1
Chapuy, B.2
Lin, C.Y.3
Tivey, T.4
Li, H.5
Townsend, E.C.6
-
36
-
-
84973317381
-
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3
-
Thompson BJ, Bhansali R, Diebold L, Cook DE, Stolzenburg L, Casagrande AS et al. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med 2015; 212: 953-970
-
(2015)
J Exp Med
, vol.212
, pp. 953-970
-
-
Thompson, B.J.1
Bhansali, R.2
Diebold, L.3
Cook, D.E.4
Stolzenburg, L.5
Casagrande, A.S.6
-
38
-
-
84889772559
-
IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan
-
Asai D, Imamura T, Suenobu S, Saito A, Hasegawa D, Deguchi T et al. IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan. Cancer Med 2013; 2: 412-419
-
(2013)
Cancer Med
, vol.2
, pp. 412-419
-
-
Asai, D.1
Imamura, T.2
Suenobu, S.3
Saito, A.4
Hasegawa, D.5
Deguchi, T.6
-
39
-
-
84867403265
-
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: Role of IKZF1 deletions and CRLF2 aberrations
-
Buitenkamp TD, Pieters R, Gallimore NE, van der Veer A, Meijerink JP, Beverloo HB et al. Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations. Leukemia 2012; 26: 2204-2211
-
(2012)
Leukemia
, vol.26
, pp. 2204-2211
-
-
Buitenkamp, T.D.1
Pieters, R.2
Gallimore, N.E.3
Vander Veer, A.4
Meijerink, J.P.5
Beverloo, H.B.6
-
40
-
-
60249086789
-
Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
-
Kearney L, Gonzalez Castro D, Yeung J, Procter J, Horsley SW, Eguchi-Ishimae M et al. Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. Blood 2009; 113: 646-648
-
(2009)
Blood
, vol.113
, pp. 646-648
-
-
Kearney, L.1
Gonzalez Castro, D.2
Yeung, J.3
Procter, J.4
Horsley, S.W.5
Eguchi-Ishimae, M.6
-
41
-
-
84986221329
-
A case of B-cell acute lymphoblastic leukemia in a child with Down syndrome bearing a t (2;12)(p12;p13) involving ETV6 and biallelic IGH@ rearrangements
-
Tirado CA, Shabsovich D, Kim Y, Traum P, Pullarkat S, Kallen M et al. A case of B-cell acute lymphoblastic leukemia in a child with Down syndrome bearing a t (2;12)(p12;p13) involving ETV6 and biallelic IGH@ rearrangements. Biomarker Res 2015; 3: 11
-
(2015)
Biomarker Res
, vol.3
, pp. 11
-
-
Tirado, C.A.1
Shabsovich, D.2
Kim, Y.3
Traum, P.4
Pullarkat, S.5
Kallen, M.6
-
42
-
-
80054047151
-
Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles
-
Loudin MG, Wang J, Leung HC, Gurusiddappa S, Meyer J, Condos G et al. Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles. Leukemia 2011; 25: 1555-1563
-
(2011)
Leukemia
, vol.25
, pp. 1555-1563
-
-
Loudin, M.G.1
Wang, J.2
Leung, H.C.3
Gurusiddappa, S.4
Meyer, J.5
Condos, G.6
-
43
-
-
77649214639
-
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group
-
Hertzberg L, Vendramini E, Ganmore I, Cazzaniga G, Schmitz M, Chalker J et al. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood 2010; 115: 1006-1017
-
(2010)
Blood
, vol.115
, pp. 1006-1017
-
-
Hertzberg, L.1
Vendramini, E.2
Ganmore, I.3
Cazzaniga, G.4
Schmitz, M.5
Chalker, J.6
-
44
-
-
77956539403
-
Similar yet different
-
Izraeli S. Similar yet different. Blood 2010; 116: 1019-1020
-
(2010)
Blood
, vol.116
, pp. 1019-1020
-
-
Izraeli, S.1
-
45
-
-
70350680415
-
Rearrangement of CRLF2 in B-progenitor-and Down syndrome-associated acute lymphoblastic leukemia
-
Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin MG, Liu W, Zhang J et al. Rearrangement of CRLF2 in B-progenitor-and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet 2009; 41: 1243-1246
-
(2009)
Nat Genet
, vol.41
, pp. 1243-1246
-
-
Mullighan, C.G.1
Collins-Underwood, J.R.2
Phillips, L.A.3
Loudin, M.G.4
Liu, W.5
Zhang, J.6
-
46
-
-
70350519430
-
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
-
Russell LJ, Capasso M, Vater I, Akasaka T, Bernard OA, Calasanz MJ et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood 2009; 114: 2688-2698
-
(2009)
Blood
, vol.114
, pp. 2688-2698
-
-
Russell, L.J.1
Capasso, M.2
Vater, I.3
Akasaka, T.4
Bernard, O.A.5
Calasanz, M.J.6
-
47
-
-
76249096219
-
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
-
Yoda A, Yoda Y, Chiaretti S, Bar-Natan M, Mani K, Rodig SJ et al. Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2010; 107: 252-257
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 252-257
-
-
Yoda, A.1
Yoda, Y.2
Chiaretti, S.3
Bar-Natan, M.4
Mani, K.5
Rodig, S.J.6
-
48
-
-
77957342601
-
CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: A novel association in oncogenesis
-
Roll JD, Reuther GW. CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis. Cancer Res 2010; 70: 7347-7352
-
(2010)
Cancer Res
, vol.70
, pp. 7347-7352
-
-
Roll, J.D.1
Reuther, G.W.2
-
49
-
-
84907080295
-
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
-
Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014; 371: 1005-1015
-
(2014)
N Engl J Med
, vol.371
, pp. 1005-1015
-
-
Roberts, K.G.1
Li, Y.2
Payne-Turner, D.3
Harvey, R.C.4
Yang, Y.L.5
Pei, D.6
-
50
-
-
33847393317
-
Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
-
Malinge S, Ben-Abdelali R, Settegrana C, Radford-Weiss I, Debre M, Beldjord K et al. Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia. Blood 2007; 109: 2202-2204
-
(2007)
Blood
, vol.109
, pp. 2202-2204
-
-
Malinge, S.1
Ben-Abdelali, R.2
Settegrana, C.3
Radford-Weiss, I.4
Debre, M.5
Beldjord, K.6
-
51
-
-
54349086521
-
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
-
Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, Elimelech A et al. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet 2008; 372: 1484-1492
-
(2008)
Lancet
, vol.372
, pp. 1484-1492
-
-
Bercovich, D.1
Ganmore, I.2
Scott, L.M.3
Wainreb, G.4
Birger, Y.5
Elimelech, A.6
-
52
-
-
60649110931
-
Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia
-
Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S et al. Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. Br J Haematol 2009; 144: 930-932
-
(2009)
Br J Haematol
, vol.144
, pp. 930-932
-
-
Gaikwad, A.1
Rye, C.L.2
Devidas, M.3
Heerema, N.A.4
Carroll, A.J.5
Izraeli, S.6
-
53
-
-
84923242220
-
A primer on genomic and epigenomic alterations in the myeloproliferative neoplasms
-
Rampal R, Levine RL. A primer on genomic and epigenomic alterations in the myeloproliferative neoplasms. Bailliere's Best Pract Clin Haematol 2014; 27: 83-93
-
(2014)
Bailliere's Best Pract Clin Haematol
, vol.27
, pp. 83-93
-
-
Rampal, R.1
Levine, R.L.2
-
54
-
-
84904638434
-
The molecular regulation of Janus kinase (JAK) activation
-
Babon JJ, Lucet IS, Murphy JM, Nicola NA, Varghese LN. The molecular regulation of Janus kinase (JAK) activation. Biochem J 2014; 462: 1-13
-
(2014)
Biochem J
, vol.462
, pp. 1-13
-
-
Babon, J.J.1
Lucet, I.S.2
Murphy, J.M.3
Nicola, N.A.4
Varghese, L.N.5
-
55
-
-
77953482860
-
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
-
Haan C, Behrmann I, Haan S. Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases. J Cell Mol Med 2010; 14: 504-527
-
(2010)
J Cell Mol Med
, vol.14
, pp. 504-527
-
-
Haan, C.1
Behrmann, I.2
Haan, S.3
-
56
-
-
79956108320
-
Gain-offunction mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias
-
Shochat C, Tal N, Bandapalli OR, Palmi C, Ganmore I, te Kronnie G et al. Gain-offunction mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med 2011; 208: 901-908
-
(2011)
J Exp Med
, vol.208
, pp. 901-908
-
-
Shochat, C.1
Tal, N.2
Bandapalli, O.R.3
Palmi, C.4
Ganmore, I.5
Te Kronnie, G.6
-
57
-
-
84907341405
-
Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations
-
Nikolaev SI, Garieri M, Santoni F, Falconnet E, Ribaux P, Guipponi M et al. Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations. Nat Commun 2014; 5: 4654
-
(2014)
Nat Commun
, vol.5
, pp. 4654
-
-
Nikolaev, S.I.1
Garieri, M.2
Santoni, F.3
Falconnet, E.4
Ribaux, P.5
Guipponi, M.6
-
58
-
-
38349119730
-
Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
-
Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM et al. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 2008; 111: 767-775
-
(2008)
Blood
, vol.111
, pp. 767-775
-
-
Kirsammer, G.1
Jilani, S.2
Liu, H.3
Davis, E.4
Gurbuxani, S.5
Le Beau, M.M.6
-
59
-
-
84857814609
-
Increased dosage of the murine chromosome 21 orthog Dyrk1a promotes megakaryoblastic leukemia in Down syndrome
-
Malinge S, Bliss-Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S et al. Increased dosage of the murine chromosome 21 orthog Dyrk1a promotes megakaryoblastic leukemia in Down syndrome. J Clin Invest 2012; 122: 948-962
-
(2012)
J Clin Invest
, vol.122
, pp. 948-962
-
-
Malinge, S.1
Bliss-Moreau, M.2
Kirsammer, G.3
Diebold, L.4
Chlon, T.5
Gurbuxani, S.6
-
60
-
-
0025868702
-
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
-
Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med 1991; 173: 1213-1225
-
(1991)
J Exp Med
, vol.173
, pp. 1213-1225
-
-
Hardy, R.R.1
Carmack, C.E.2
Shinton, S.A.3
Kemp, J.D.4
Hayakawa, K.5
-
61
-
-
27144452299
-
Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3
-
Lim JH, West KL, Rubinstein Y, Bergel M, Postnikov YV, Bustin M. Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3. EMBO J 2005; 24: 3038-3048
-
(2005)
EMBO J
, vol.24
, pp. 3038-3048
-
-
Lim, J.H.1
West, K.L.2
Rubinstein, Y.3
Bergel, M.4
Postnikov, Y.V.5
Bustin, M.6
-
62
-
-
84867909526
-
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
-
Roy A, Cowan G, Mead AJ, Filippi S, Bohn G, Chaidos A et al. Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc Natl Acad Sci USA 2012; 109: 17579-17584
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 17579-17584
-
-
Roy, A.1
Cowan, G.2
Mead, A.J.3
Filippi, S.4
Bohn, G.5
Chaidos, A.6
-
63
-
-
84930087450
-
DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications
-
Abbassi R, Johns TG, Kassiou M, Munoz L. DYRK1A in neurodegeneration and cancer: molecular basis and clinical implications. Pharmacol Ther 2015; 151: 87-98
-
(2015)
Pharmacol Ther
, vol.151
, pp. 87-98
-
-
Abbassi, R.1
Johns, T.G.2
Kassiou, M.3
Munoz, L.4
-
64
-
-
79957648087
-
Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling
-
Hammerle B, Ulin E, Guimera J, Becker W, Guillemot F, Tejedor FJ. Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling. Development 2011; 138: 2543-2554
-
(2011)
Development
, vol.138
, pp. 2543-2554
-
-
Hammerle, B.1
Ulin, E.2
Guimera, J.3
Becker, W.4
Guillemot, F.5
Tejedor, F.J.6
-
65
-
-
84861190576
-
Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A
-
Ding S, Shi J, Qian W, Iqbal K, Grundke-Iqbal I, Gong CX et al. Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Neurobiol Aging 2012; 33: 1389-1399
-
(2012)
Neurobiol Aging
, vol.33
, pp. 1389-1399
-
-
Ding, S.1
Shi, J.2
Qian, W.3
Iqbal, K.4
Grundke-Iqbal, I.5
Gong, C.X.6
-
66
-
-
84903771640
-
DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease
-
Barallobre MJ, Perier C, Bove J, Laguna A, Delabar JM, Vila M et al. DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. Cell Death Dis 2014; 5: e1289
-
(2014)
Cell Death Dis
, vol.5
, pp. e1289
-
-
Barallobre, M.J.1
Perier, C.2
Bove, J.3
Laguna, A.4
Delabar, J.M.5
Vila, M.6
-
67
-
-
67649506317
-
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
-
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ et al. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009; 459: 1126-1130
-
(2009)
Nature
, vol.459
, pp. 1126-1130
-
-
Baek, K.H.1
Zaslavsky, A.2
Lynch, R.C.3
Britt, C.4
Okada, Y.5
Siarey, R.J.6
-
68
-
-
79955432610
-
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
-
Litovchick L, Florens LA, Swanson SK, Washburn MP, DeCaprio JA. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev 2011; 25: 801-813
-
(2011)
Genes Dev
, vol.25
, pp. 801-813
-
-
Litovchick, L.1
Florens, L.A.2
Swanson, S.K.3
Washburn, M.P.4
DeCaprio, J.A.5
-
69
-
-
84903760824
-
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and cyclin D1 and induces cell cycle exit and neuronal differentiation
-
Soppa U, Schumacher J, Florencio Ortiz V, Pasqualon T, Tejedor FJ, Becker W. The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and cyclin D1 and induces cell cycle exit and neuronal differentiation. Cell Cycle 2014; 13: 2084-2100
-
(2014)
Cell Cycle
, vol.13
, pp. 2084-2100
-
-
Soppa, U.1
Schumacher, J.2
Florencio Ortiz, V.3
Pasqualon, T.4
Tejedor, F.J.5
Becker, W.6
-
70
-
-
84885334501
-
Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle
-
Chen JY, Lin JR, Tsai FC, Meyer T. Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle. Mol Cell 2013; 52: 87-100
-
(2013)
Mol Cell
, vol.52
, pp. 87-100
-
-
Chen, J.Y.1
Lin, J.R.2
Tsai, F.C.3
Meyer, T.4
-
71
-
-
84937569595
-
The genomic landscape of acute lymphoblastic leukemia in children and young adults
-
Mullighan CG. The genomic landscape of acute lymphoblastic leukemia in children and young adults. Hematology 2014; 2014: 174-180
-
(2014)
Hematology
, vol.2014
, pp. 174-180
-
-
Mullighan, C.G.1
-
72
-
-
33947257508
-
Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
-
Moorman AV, Richards SM, Robinson HM, Strefford JC, Gibson BE, Kinsey SE et al. Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21). Blood 2007; 109: 2327-2330
-
(2007)
Blood
, vol.109
, pp. 2327-2330
-
-
Moorman, A.V.1
Richards, S.M.2
Robinson, H.M.3
Strefford, J.C.4
Gibson, B.E.5
Kinsey, S.E.6
-
73
-
-
84897528140
-
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
-
Li Y, Schwab C, Ryan SL, Papaemmanuil E, Robinson HM, Jacobs P et al. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia. Nature 2014; 508: 98-102
-
(2014)
Nature
, vol.508
, pp. 98-102
-
-
Li, Y.1
Schwab, C.2
Ryan, S.L.3
Papaemmanuil, E.4
Robinson, H.M.5
Jacobs, P.6
-
74
-
-
79959510774
-
Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
-
Rand V, Parker H, Russell LJ, Schwab C, Ensor H, Irving J et al. Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia. Blood 2011; 117: 6848-6855
-
(2011)
Blood
, vol.117
, pp. 6848-6855
-
-
Rand, V.1
Parker, H.2
Russell, L.J.3
Schwab, C.4
Ensor, H.5
Irving, J.6
-
75
-
-
84899488064
-
Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol
-
Patrick K, Wade R, Goulden N, Rowntree C, Hough R, Moorman AV et al. Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol. Br J Haematol 2014; 165: 552-555
-
(2014)
Br J Haematol
, vol.165
, pp. 552-555
-
-
Patrick, K.1
Wade, R.2
Goulden, N.3
Rowntree, C.4
Hough, R.5
Moorman, A.V.6
-
76
-
-
84899990860
-
Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries
-
Lundin C, Forestier E, Klarskov Andersen M, Autio K, Barbany G, Cavelier L et al. Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries. J Hematol Oncol 2014; 7: 32
-
(2014)
J Hematol Oncol
, vol.7
, pp. 32
-
-
Lundin, C.1
Forestier, E.2
Klarskov Andersen, M.3
Autio, K.4
Barbany, G.5
Cavelier, L.6
-
77
-
-
28844446288
-
Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: A Children's Cancer Group study
-
Whitlock JA, Sather HN, Gaynon P, Robison LL, Wells RJ, Trigg M et al. Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study. Blood 2005; 106: 4043-4049
-
(2005)
Blood
, vol.106
, pp. 4043-4049
-
-
Whitlock, J.A.1
Sather, H.N.2
Gaynon, P.3
Robison, L.L.4
Wells, R.J.5
Trigg, M.6
|