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Volumn 6, Issue 2, 2015, Pages 61-79

Novel agents for the treatment of childhood acute leukemia

Author keywords

ALL; AML; blinatumomab; CAR T cells; carfilzomib; EPZ 5676; FLT3; moxetumomab

Indexed keywords


EID: 84993813859     PISSN: 20406207     EISSN: 20406215     Source Type: Journal    
DOI: 10.1177/2040620714565963     Document Type: Review
Times cited : (50)

References (144)
  • 1
    • 77951648118 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study
    • Advani A. Coiffier B. Czuczman M. Dreyling M. Foran J. Gine E. et al. (2010) Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. J Clin Oncol 28: 2085–2093.
    • (2010) J Clin Oncol , vol.28 , pp. 2085-2093
    • Advani, A.1    Coiffier, B.2    Czuczman, M.3    Dreyling, M.4    Foran, J.5    Gine, E.6
  • 2
    • 84901003824 scopus 로고    scopus 로고
    • Gemtuzumab Ozogamicin (GO) in children with de Novo Acute Myeloid Leukemia (AML) improves Event-Free Survival (EFS) by reducing relapse risk – results from the randomized Phase III Children's Oncology Group (COG) trial, AAML0531
    • Aplenc R. Alonzo T. Sung L. Meshinchi S. Gerbing R. Raimondi S. et al. (2013) Gemtuzumab Ozogamicin (GO) in children with de Novo Acute Myeloid Leukemia (AML) improves Event-Free Survival (EFS) by reducing relapse risk – results from the randomized Phase III Children's Oncology Group (COG) trial, AAML0531. Blood 122: 355–356.
    • (2013) Blood , vol.122 , pp. 355-356
    • Aplenc, R.1    Alonzo, T.2    Sung, L.3    Meshinchi, S.4    Gerbing, R.5    Raimondi, S.6
  • 3
    • 79955498420 scopus 로고    scopus 로고
    • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events
    • Arastu-Kapur S. Anderl J. Kraus M. Parlati F. Shenk K. Lee S. et al. (2011) Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res 17: 2734–2743.
    • (2011) Clin Cancer Res , vol.17 , pp. 2734-2743
    • Arastu-Kapur, S.1    Anderl, J.2    Kraus, M.3    Parlati, F.4    Shenk, K.5    Lee, S.6
  • 4
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong S. Staunton J. Silverman L. Pieters R. den Boer M. Minden M. et al. (2002) MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Gen 30: 41–47.
    • (2002) Nat Gen , vol.30 , pp. 41-47
    • Armstrong, S.1    Staunton, J.2    Silverman, L.3    Pieters, R.4    den Boer, M.5    Minden, M.6
  • 5
    • 40949128188 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of bortezomib in combination with idarubicin and cytarabine in patients with acute myelogenous leukemia
    • Attar E. de Angelo D. Supko J. D'Amato F. Zahrieh D. Sirulnik A. et al. (2008) Phase I and pharmacokinetic study of bortezomib in combination with idarubicin and cytarabine in patients with acute myelogenous leukemia. Clin Cancer Res 14: 1446–1454.
    • (2008) Clin Cancer Res , vol.14 , pp. 1446-1454
    • Attar, E.1    de Angelo, D.2    Supko, J.3    D'Amato, F.4    Zahrieh, D.5    Sirulnik, A.6
  • 6
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton P. Cleary M. (2001) Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 20: 5695–5707.
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.1    Cleary, M.2
  • 7
    • 77958196417 scopus 로고    scopus 로고
    • Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
    • Bachmann P. Piazza R. Janes M. Wong N. Davies C. Mogavero A. et al. (2010) Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. Blood 116: 3013–3022.
    • (2010) Blood , vol.116 , pp. 3013-3022
    • Bachmann, P.1    Piazza, R.2    Janes, M.3    Wong, N.4    Davies, C.5    Mogavero, A.6
  • 8
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R. Leo E. Zugmaier G. Klinger M. Goebeler M. Knop S. et al. (2008) Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321: 974–977.
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3    Klinger, M.4    Goebeler, M.5    Knop, S.6
  • 10
    • 79960044951 scopus 로고    scopus 로고
    • MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
    • Bernt K. Zhu N. Sinha A. Vempati S. Faber J. Krivtsov A. et al. (2011) MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 20: 66–78.
    • (2011) Cancer Cell , vol.20 , pp. 66-78
    • Bernt, K.1    Zhu, N.2    Sinha, A.3    Vempati, S.4    Faber, J.5    Krivtsov, A.6
  • 11
    • 84861904198 scopus 로고    scopus 로고
    • Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia
    • Bhatla T. Wang J. Morrison D. Raetz E. Burke M. Brown P. et al. (2012) Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia. Blood 119: 5201–5210.
    • (2012) Blood , vol.119 , pp. 5201-5210
    • Bhatla, T.1    Wang, J.2    Morrison, D.3    Raetz, E.4    Burke, M.5    Brown, P.6
  • 12
    • 0345166113 scopus 로고    scopus 로고
    • Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
    • Brown V. Fang J. Alcorn K. Barr R. Kim J. Wasserman R. et al. (2003) Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proc Natl Acad Sci USA 100: 15113–15118.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15113-15118
    • Brown, V.1    Fang, J.2    Alcorn, K.3    Barr, R.4    Kim, J.5    Wasserman, R.6
  • 13
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML 15 trial
    • Burnett A. Hills R. Milligan D. Kjeldsen L. Kell J. Russell N. et al. (2011) Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML 15 trial. J Clin Oncol 29: 369–377.
    • (2011) J Clin Oncol , vol.29 , pp. 369-377
    • Burnett, A.1    Hills, R.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.6
  • 14
    • 77951079020 scopus 로고    scopus 로고
    • Af9/Mllt3 interferes with Tbr 1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex
    • Buttner N. Johnsen S. Kugler S. Vogel T. (2010) Af9/Mllt3 interferes with Tbr 1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex. Proc Natl Acad Sci USA 107: 7042–7047.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7042-7047
    • Buttner, N.1    Johnsen, S.2    Kugler, S.3    Vogel, T.4
  • 15
    • 12444270688 scopus 로고    scopus 로고
    • Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties
    • Carnahan J. Wang P. Kendall R. Chen C. Hu S. Boone T. et al. (2003) Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties. Clin Cancer Res 9: 3982S–3990S.
    • (2003) Clin Cancer Res , vol.9 , pp. 3982S-3990S
    • Carnahan, J.1    Wang, P.2    Kendall, R.3    Chen, C.4    Hu, S.5    Boone, T.6
  • 16
    • 13344282746 scopus 로고    scopus 로고
    • Expression of the hematopoietic growth factor receptor FLT 3 (STK-1/Flk2) in human leukemias
    • Carow C. Levenstein M. Kaufmann S. Chen J. Amin S. Rockwell P. et al. (1996) Expression of the hematopoietic growth factor receptor FLT 3 (STK-1/Flk2) in human leukemias. Blood 87: 1089–1096.
    • (1996) Blood , vol.87 , pp. 1089-1096
    • Carow, C.1    Levenstein, M.2    Kaufmann, S.3    Chen, J.4    Amin, S.5    Rockwell, P.6
  • 17
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study
    • Castaigne S. Pautas C. Terre C. Raffoux E. Bordessoule D. Bastie J. et al. (2012) Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet 379: 1508–1516.
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terre, C.3    Raffoux, E.4    Bordessoule, D.5    Bastie, J.6
  • 18
    • 84859970467 scopus 로고    scopus 로고
    • Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph+ ALL: a Children's Oncology Group (COG) study
    • Chang B. Willis S. Stork L. Hunger S. Carroll W. Camitta B. et al. (2012) Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph+ ALL: a Children's Oncology Group (COG) study. Br J Haematol 157: 507–510.
    • (2012) Br J Haematol , vol.157 , pp. 507-510
    • Chang, B.1    Willis, S.2    Stork, L.3    Hunger, S.4    Carroll, W.5    Camitta, B.6
  • 19
    • 78650358037 scopus 로고    scopus 로고
    • Histone H 3 lysine 79 methyltransferase Dot 1 is required for immortalization by MLL oncogenes
    • Chang M. Wu H. Achille N. Reisenauer M. Chou C. Zeleznik-Le N. et al. (2010) Histone H 3 lysine 79 methyltransferase Dot 1 is required for immortalization by MLL oncogenes. Cancer Res 70: 10234–10242.
    • (2010) Cancer Res , vol.70 , pp. 10234-10242
    • Chang, M.1    Wu, H.2    Achille, N.3    Reisenauer, M.4    Chou, C.5    Zeleznik-Le, N.6
  • 20
    • 84876143288 scopus 로고    scopus 로고
    • Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
    • Chen L. Deshpande A. Banka D. Bernt K. Dias S. Buske C. et al. (2013) Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia 27: 813–822.
    • (2013) Leukemia , vol.27 , pp. 813-822
    • Chen, L.1    Deshpande, A.2    Banka, D.3    Bernt, K.4    Dias, S.5    Buske, C.6
  • 21
    • 80055064760 scopus 로고    scopus 로고
    • AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group
    • Cooper T. Franklin J. Gerbing R. Alonzo T. Hurwitz C. Raimondi S. et al. (2012) AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group. Cancer 118: 761–769.
    • (2012) Cancer , vol.118 , pp. 761-769
    • Cooper, T.1    Franklin, J.2    Gerbing, R.3    Alonzo, T.4    Hurwitz, C.5    Raimondi, S.6
  • 22
    • 84901030045 scopus 로고    scopus 로고
    • A phase I study of AC 220 (Quizartinib) in combination with cytarabine and etoposide in relapsed / refractory childhood ALL and AML: a therapeutic advances in childhood leukemia & lymphoma (TACL) study
    • Cooper, T., Malvar J. Cassar J. Eckroth E. Sposto R. Gaynon P. Dubois S. et al. (2013) A phase I study of AC 220 (Quizartinib) in combination with cytarabine and etoposide in relapsed / refractory childhood ALL and AML: a therapeutic advances in childhood leukemia & lymphoma (TACL) study. Blood 122: 624–626.
    • (2013) Blood , vol.122 , pp. 624-626
    • Cooper, T., Malvar, J.1    Cassar, J.2    Eckroth, E.3    Sposto, R.4    Gaynon, P.5    Dubois, S.6
  • 24
    • 0028845148 scopus 로고
    • Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87
    • Creutzig U. Harbott J. Sperling C. Ritter J. Zimmermann M. Loffler H. et al. (1995) Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87. Blood 86: 3097–3108.
    • (1995) Blood , vol.86 , pp. 3097-3108
    • Creutzig, U.1    Harbott, J.2    Sperling, C.3    Ritter, J.4    Zimmermann, M.5    Loffler, H.6
  • 25
    • 76349102339 scopus 로고    scopus 로고
    • A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study
    • Crump M. Hedley D. Kamel-Reid S. Leber B. Wells R. Brandwein J. et al. (2010) A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study. Leukemia Lymphoma 51: 252–260.
    • (2010) Leukemia Lymphoma , vol.51 , pp. 252-260
    • Crump, M.1    Hedley, D.2    Kamel-Reid, S.3    Leber, B.4    Wells, R.5    Brandwein, J.6
  • 26
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
    • Daigle S. Olhava E. Therkelsen C. Majer C. Sneeringer C. Song J. et al. (2011) Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 20 (1): 53–65.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 53-65
    • Daigle, S.1    Olhava, E.2    Therkelsen, C.3    Majer, C.4    Sneeringer, C.5    Song, J.6
  • 27
    • 84859768494 scopus 로고    scopus 로고
    • Molecular targeted therapy in acute myeloid leukemia
    • Daver N. Cortes J. (2012) Molecular targeted therapy in acute myeloid leukemia. Hematology 17(Suppl. 1): S59–S62.
    • (2012) Hematology , vol.17 , Issue.Suppl. 1 , pp. S59-S62
    • Daver, N.1    Cortes, J.2
  • 28
    • 84878383491 scopus 로고    scopus 로고
    • Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
    • Deshpande A. Chen L. Fazio M. Sinha A. Bernt K. Banka D. et al. (2013) Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Blood 121:2533–2541.
    • (2013) Blood , vol.121 , pp. 2533-2541
    • Deshpande, A.1    Chen, L.2    Fazio, M.3    Sinha, A.4    Bernt, K.5    Banka, D.6
  • 29
    • 10744229449 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies
    • Di Joseph J. Armellino D. Boghaert E. Khandke K. Dougher M. Sridharan L. et al. (2004) Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies. Blood 103: 1807–1814.
    • (2004) Blood , vol.103 , pp. 1807-1814
    • Di Joseph, J.1    Armellino, D.2    Boghaert, E.3    Khandke, K.4    Dougher, M.5    Sridharan, L.6
  • 30
    • 35548931579 scopus 로고    scopus 로고
    • Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia
    • Dijoseph J. Dougher M. Armellino D. Evans D. Damle N. (2007) Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia. Leukemia 21 (11): 2240–2245.
    • (2007) Leukemia , vol.21 , Issue.11 , pp. 2240-2245
    • Dijoseph, J.1    Dougher, M.2    Armellino, D.3    Evans, D.4    Damle, N.5
  • 31
    • 70350506791 scopus 로고    scopus 로고
    • Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    • Fandy T. Herman J. Kerns P. Jiemjit A. Sugar E. Choi S. et al. (2009) Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 114: 2764–2773.
    • (2009) Blood , vol.114 , pp. 2764-2773
    • Fandy, T.1    Herman, J.2    Kerns, P.3    Jiemjit, A.4    Sugar, E.5    Choi, S.6
  • 32
    • 84875434050 scopus 로고    scopus 로고
    • Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: results of a phase I / II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab
    • Fayad L. Offner F. Smith M. Verhoef G. Johnson P. Kaufman J. et al. (2013) Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: results of a phase I / II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab. J Clin Oncol 31: 573–583.
    • (2013) J Clin Oncol , vol.31 , pp. 573-583
    • Fayad, L.1    Offner, F.2    Smith, M.3    Verhoef, G.4    Johnson, P.5    Kaufman, J.6
  • 33
    • 78049426367 scopus 로고    scopus 로고
    • Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
    • Fischer T. Stone R. Deangelo D. Galinsky I. Estey E. Lanza C. et al. (2010) Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. J Clin Oncol 28: 4339–4345.
    • (2010) J Clin Oncol , vol.28 , pp. 4339-4345
    • Fischer, T.1    Stone, R.2    Deangelo, D.3    Galinsky, I.4    Estey, E.5    Lanza, C.6
  • 34
    • 77955900071 scopus 로고    scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report
    • Fouladi M. Park J. Stewart C. Gilbertson R. Schaiquevich P. Sun J. et al. (2010) Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report. J Clin Oncol 28: 3623–3629.
    • (2010) J Clin Oncol , vol.28 , pp. 3623-3629
    • Fouladi, M.1    Park, J.2    Stewart, C.3    Gilbertson, R.4    Schaiquevich, P.5    Sun, J.6
  • 35
    • 84897548232 scopus 로고    scopus 로고
    • T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 (CTL019) produce significant in vivo proliferation, complete responses and long-term persistence without GVHD in children and adults with relapsed, refractory ALL
    • Frey N. Aplenc R. Barrett D. Chew A. Kalos M. Levine B. et al. (2013) T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 (CTL019) produce significant in vivo proliferation, complete responses and long-term persistence without GVHD in children and adults with relapsed, refractory ALL. Blood 122: 67.
    • (2013) Blood , vol.122 , pp. 67
    • Frey, N.1    Aplenc, R.2    Barrett, D.3    Chew, A.4    Kalos, M.5    Levine, B.6
  • 36
    • 51649110503 scopus 로고    scopus 로고
    • Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
    • Garcia-Manero G. Assouline S. Cortes J. Estrov Z. Kantarjian H. Yang H. et al. (2008) Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood 112: 981–989.
    • (2008) Blood , vol.112 , pp. 981-989
    • Garcia-Manero, G.1    Assouline, S.2    Cortes, J.3    Estrov, Z.4    Kantarjian, H.5    Yang, H.6
  • 37
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1 / 2 study of the combination of 5-aza-2’-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G. Kantarjian H. Sanchez-Gonzalez B. Yang H. Rosner G. Verstovsek S. et al. (2006) Phase 1 / 2 study of the combination of 5-aza-2’-deoxycytidine with valproic acid in patients with leukemia. Blood 108: 3271–3279.
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.2    Sanchez-Gonzalez, B.3    Yang, H.4    Rosner, G.5    Verstovsek, S.6
  • 38
    • 31344446955 scopus 로고    scopus 로고
    • Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies
    • Gore S. (2005) Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies. Nat Clin Pract Oncol 2(Suppl. 1): S30–S35.
    • (2005) Nat Clin Pract Oncol , vol.2 , Issue.Suppl. 1 , pp. S30-S35
    • Gore, S.1
  • 39
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore S. Baylin S. Sugar E. Carraway H. Miller C. Carducci M. et al. (2006) Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 66: 6361–6369.
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.1    Baylin, S.2    Sugar, E.3    Carraway, H.4    Miller, C.5    Carducci, M.6
  • 40
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp S. Kalos M. Barrett D. Aplenc R. Porter D. Rheingold S. et al. (2013) Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 368: 1509–1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.1    Kalos, M.2    Barrett, D.3    Aplenc, R.4    Porter, D.5    Rheingold, S.6
  • 41
    • 33845261567 scopus 로고    scopus 로고
    • Identification of candidate target antigens for antibody-based immunotherapy in childhood B-cell precursor ALL
    • Gudowius S. Recker K. Laws H. Dirksen U. Troger A. Wieczorek U. et al. (2006) Identification of candidate target antigens for antibody-based immunotherapy in childhood B-cell precursor ALL. Klin Padiatrie 218: 327–333.
    • (2006) Klin Padiatrie , vol.218 , pp. 327-333
    • Gudowius, S.1    Recker, K.2    Laws, H.3    Dirksen, U.4    Troger, A.5    Wieczorek, U.6
  • 42
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman M. Neering S. Upchurch D. Grimes B. Howard D. Rizzieri D. et al. (2001) Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 98: 2301–2307.
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.1    Neering, S.2    Upchurch, D.3    Grimes, B.4    Howard, D.5    Rizzieri, D.6
  • 44
    • 78651290248 scopus 로고    scopus 로고
    • Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
    • Handgretinger R. Zugmaier G. Henze G. Kreyenberg H. Lang P. von Stackelberg A. (2011) Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia 25: 181–184.
    • (2011) Leukemia , vol.25 , pp. 181-184
    • Handgretinger, R.1    Zugmaier, G.2    Henze, G.3    Kreyenberg, H.4    Lang, P.5    von Stackelberg, A.6
  • 45
    • 84864548693 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004
    • Hasle H. Abrahamsson J. Forestier E. Ha S. Heldrup J. Jahnukainen K. et al. (2012) Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004. Blood 120: 978–984.
    • (2012) Blood , vol.120 , pp. 978-984
    • Hasle, H.1    Abrahamsson, J.2    Forestier, E.3    Ha, S.4    Heldrup, J.5    Jahnukainen, K.6
  • 46
    • 84874027123 scopus 로고    scopus 로고
    • Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
    • Haso W. Lee D. Shah N. Stetler-Stevenson M. Yuan C. Pastan I. et al. (2013) Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood 121: 1165–1174.
    • (2013) Blood , vol.121 , pp. 1165-1174
    • Haso, W.1    Lee, D.2    Shah, N.3    Stetler-Stevenson, M.4    Yuan, C.5    Pastan, I.6
  • 47
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman J. Civin C. Issa J. Collector M. Sharkis S. Baylin S. (1997) Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 57: 837–841.
    • (1997) Cancer Res , vol.57 , pp. 837-841
    • Herman, J.1    Civin, C.2    Issa, J.3    Collector, M.4    Sharkis, S.5    Baylin, S.6
  • 48
    • 0027194197 scopus 로고
    • Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics
    • Hinman L. Hamann P. Wallace R. Menendez A. Durr F. Upeslacis J. (1993) Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res 53: 3336–3342.
    • (1993) Cancer Res , vol.53 , pp. 3336-3342
    • Hinman, L.1    Hamann, P.2    Wallace, R.3    Menendez, A.4    Durr, F.5    Upeslacis, J.6
  • 49
    • 33947362982 scopus 로고    scopus 로고
    • A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study
    • Horton T. Pati D. Plon S. Thompson P. Bomgaars L. Adamson P. et al. (2007) A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. Clin Cancer Res 13: 1516–1522.
    • (2007) Clin Cancer Res , vol.13 , pp. 1516-1522
    • Horton, T.1    Pati, D.2    Plon, S.3    Thompson, P.4    Bomgaars, L.5    Adamson, P.6
  • 50
    • 84863772728 scopus 로고    scopus 로고
    • Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group
    • Hunger S. Lu X. Devidas M. Camitta B. Gaynon P. Winick N. et al. (2012) Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group. J Clin Oncol 30: 1663–1669.
    • (2012) J Clin Oncol , vol.30 , pp. 1663-1669
    • Hunger, S.1    Lu, X.2    Devidas, M.3    Camitta, B.4    Gaynon, P.5    Winick, N.6
  • 51
    • 80052017961 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed / refractory leukemia
    • Inaba H. Rubnitz J. Coustan-Smith E. Li L. Furmanski B. Mascara G. et al. (2011) Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed / refractory leukemia. J Clin Oncol 29: 3293–3300.
    • (2011) J Clin Oncol , vol.29 , pp. 3293-3300
    • Inaba, H.1    Rubnitz, J.2    Coustan-Smith, E.3    Li, L.4    Furmanski, B.5    Mascara, G.6
  • 52
    • 0032931560 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT 3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan
    • Iwai T. Yokota S. Nakao M. Okamoto T. Taniwaki M. Onodera N. et al. (1999) Internal tandem duplication of the FLT 3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan. Leukemia 13: 38–43.
    • (1999) Leukemia , vol.13 , pp. 38-43
    • Iwai, T.1    Yokota, S.2    Nakao, M.3    Okamoto, T.4    Taniwaki, M.5    Onodera, N.6
  • 53
    • 58149380741 scopus 로고    scopus 로고
    • Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
    • Jabbour E. Kantarjian H. Jones D. Reddy N. O'Brien S. Garcia-Manero G. et al. (2008) Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Blood 112: 4839–4842.
    • (2008) Blood , vol.112 , pp. 4839-4842
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Reddy, N.4    O'Brien, S.5    Garcia-Manero, G.6
  • 54
    • 84993776129 scopus 로고    scopus 로고
    • In vitro growth inhibition, target modulation and drug synergy in pediatric leukemia by the novel proteasome inhibitor carfilzomib
    • Jayanthan A. Ruan Y. Hagerty M. Shah R. Truong T. Lewis V. et al. (2013) In vitro growth inhibition, target modulation and drug synergy in pediatric leukemia by the novel proteasome inhibitor carfilzomib. Blood 122: 2673–2674.
    • (2013) Blood , vol.122 , pp. 2673-2674
    • Jayanthan, A.1    Ruan, Y.2    Hagerty, M.3    Shah, R.4    Truong, T.5    Lewis, V.6
  • 55
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M. Levine B. Porter D. Katz S. Grupp S. Bagg A. et al. (2011) T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 3 (95): 95ra73.
    • (2011) Sci Transl Med , vol.3 , Issue.95 , pp. 95ra73
    • Kalos, M.1    Levine, B.2    Porter, D.3    Katz, S.4    Grupp, S.5    Bagg, A.6
  • 56
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    • Kantarjian H. Issa J. Rosenfeld C. Bennett J. Albitar M. DiPersio J. et al. (2006) Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106: 1794–1803.
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.2    Rosenfeld, C.3    Bennett, J.4    Albitar, M.5    DiPersio, J.6
  • 57
    • 84862786326 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study
    • Kantarjian H. Thomas D. Jorgensen J. Jabbour E. Kebriaei P. Rytting M. et al. (2012) Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study. The Lancet Oncology 13 (4): 403–411.
    • (2012) The Lancet Oncology , vol.13 , Issue.4 , pp. 403-411
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3    Jabbour, E.4    Kebriaei, P.5    Rytting, M.6
  • 58
    • 84880574025 scopus 로고    scopus 로고
    • Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia
    • Kantarjian H. Thomas D. Jorgensen J. Kebriaei P. Jabbour E. Rytting M. et al. (2013) Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. Cancer 119: 2728–2736.
    • (2013) Cancer , vol.119 , pp. 2728-2736
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3    Kebriaei, P.4    Jabbour, E.5    Rytting, M.6
  • 59
    • 84863522243 scopus 로고    scopus 로고
    • Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
    • Klinger M. Brandl C. Zugmaier G. Hijazi Y. ÍBargou R. Topp M. et al. (2012) Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood 119: 6226–6233.
    • (2012) Blood , vol.119 , pp. 6226-6233
    • Klinger, M.1    Brandl, C.2    Zugmaier, G.3    Hijazi, Y.4    ÍBargou, R.5    Topp, M.6
  • 60
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT 3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • Knapper S. Burnett A. Littlewood T. Kell W. Agrawal S. Chopra R. et al. (2006) A phase 2 trial of the FLT 3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 108: 3262–3270.
    • (2006) Blood , vol.108 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.2    Littlewood, T.3    Kell, W.4    Agrawal, S.5    Chopra, R.6
  • 61
    • 0032757551 scopus 로고    scopus 로고
    • Prognostic value of internal tandem duplication of the FLT 3 gene in childhood acute myelogenous leukemia
    • Kondo M. Horibe K. Takahashi Y. Matsumoto K. Fukuda M. Inaba J. et al. (1999) Prognostic value of internal tandem duplication of the FLT 3 gene in childhood acute myelogenous leukemia. Med Pediatric Oncol 33: 525–529.
    • (1999) Med Pediatric Oncol , vol.33 , pp. 525-529
    • Kondo, M.1    Horibe, K.2    Takahashi, Y.3    Matsumoto, K.4    Fukuda, M.5    Inaba, J.6
  • 62
    • 43249104204 scopus 로고    scopus 로고
    • Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha
    • Kramer O. Muller S. Buchwald M. Reichardt S. Heinzel T. (2008) Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. FASEB J 22: 1369–1379.
    • (2008) FASEB J , vol.22 , pp. 1369-1379
    • Kramer, O.1    Muller, S.2    Buchwald, M.3    Reichardt, S.4    Heinzel, T.5
  • 63
    • 0034048735 scopus 로고    scopus 로고
    • Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias
    • Kreitman R. Margulies I. Stetler-Stevenson M. Wang Q. FitzGerald D. Pastan I. (2000) Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias. Clin Cancer Res 6: 1476–1487.
    • (2000) Clin Cancer Res , vol.6 , pp. 1476-1487
    • Kreitman, R.1    Margulies, I.2    Stetler-Stevenson, M.3    Wang, Q.4    FitzGerald, D.5    Pastan, I.6
  • 64
    • 54549083228 scopus 로고    scopus 로고
    • H3K79 methylation profiles define murine and human MLL-AF4 leukemias
    • Krivtsov A. Feng Z. Lemieux M. Faber J. Vempati S. Sinha A. et al. (2008) H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14: 355–368.
    • (2008) Cancer Cell , vol.14 , pp. 355-368
    • Krivtsov, A.1    Feng, Z.2    Lemieux, M.3    Faber, J.4    Vempati, S.5    Sinha, A.6
  • 65
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov A. Twomey D. Feng Z. Stubbs M. Wang Y. Faber J. et al. (2006) Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442: 818–822.
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.1    Twomey, D.2    Feng, Z.3    Stubbs, M.4    Wang, Y.5    Faber, J.6
  • 66
    • 0037163016 scopus 로고    scopus 로고
    • Disruptor of telomeric silencing-1 is a chromatin-specific histone H 3 methyltransferase
    • Lacoste N. Utley R. Hunter J. Poirier G. Cote J. (2002) Disruptor of telomeric silencing-1 is a chromatin-specific histone H 3 methyltransferase. J Biol Chem 277: 30421–30424.
    • (2002) J Biol Chem , vol.277 , pp. 30421-30424
    • Lacoste, N.1    Utley, R.2    Hunter, J.3    Poirier, G.4    Cote, J.5
  • 67
    • 77949423718 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy
    • Leclerc G. Mou C. Leclerc G. Mian A. Barredo J. (2010) Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia 24: 552–562.
    • (2010) Leukemia , vol.24 , pp. 552-562
    • Leclerc, G.1    Leclerc, G.2    Mou, C.3    Mian, A.4    Barredo, J.5
  • 68
    • 84875635430 scopus 로고    scopus 로고
    • Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed / Refractory Acute Myeloid Leukemia After Second-Line Chemotherapy or Hematopoietic Stem Cell Transplantation
    • Levis M. Perl A. Dombret H. Dohner H. Steffen B. Rousselot P. et al. (2012) Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed / Refractory Acute Myeloid Leukemia After Second-Line Chemotherapy or Hematopoietic Stem Cell Transplantation. ASH Annual Meeting Abstracts 120 (21): 673.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 673
    • Levis, M.1    Perl, A.2    Dombret, H.3    Dohner, H.4    Steffen, B.5    Rousselot, P.6
  • 69
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT 3 mutant AML in first relapse
    • Levis M. Ravandi F. Wang E. Baer M. Perl A. Coutre S. et al. (2011) Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT 3 mutant AML in first relapse. Blood 117: 3294–3301.
    • (2011) Blood , vol.117 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.3    Baer, M.4    Perl, A.5    Coutre, S.6
  • 70
    • 0343415665 scopus 로고    scopus 로고
    • A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
    • Loffler A. Kufer P. Lutterbuse R. Zettl F. Daniel P. Schwenkenbecher J. et al. (2000) A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood 95: 2098–2103.
    • (2000) Blood , vol.95 , pp. 2098-2103
    • Loffler, A.1    Kufer, P.2    Lutterbuse, R.3    Zettl, F.4    Daniel, P.5    Schwenkenbecher, J.6
  • 71
    • 77956194142 scopus 로고    scopus 로고
    • The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo
    • Lucas D. Alinari L. West D. Davis M. Edwards R. Johnson A. et al. (2010) The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. PloS ONE 5 (6): e10941.
    • (2010) PloS ONE , vol.5 , Issue.6 , pp. e10941
    • Lucas, D.1    Alinari, L.2    West, D.3    Davis, M.4    Edwards, R.5    Johnson, A.6
  • 72
    • 0035866805 scopus 로고    scopus 로고
    • Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling
    • Maestre N. Tritton T. Laurent G. Jaffrezou J. (2001) Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling. Cancer Res 61: 2558–2561.
    • (2001) Cancer Res , vol.61 , pp. 2558-2561
    • Maestre, N.1    Tritton, T.2    Laurent, G.3    Jaffrezou, J.4
  • 73
    • 84868528389 scopus 로고    scopus 로고
    • Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
    • Maude S. Tasian S. Vincent T. Hall J. Sheen C. Roberts K. et al. (2012) Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 120: 3510–3518.
    • (2012) Blood , vol.120 , pp. 3510-3518
    • Maude, S.1    Tasian, S.2    Vincent, T.3    Hall, J.4    Sheen, C.5    Roberts, K.6
  • 75
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt 3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S. Woods W. Stirewalt D. Sweetser D. Buckley J. Tjoa T. et al. (2001) Prevalence and prognostic significance of Flt 3 internal tandem duplication in pediatric acute myeloid leukemia. Blood 97: 89–94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.2    Stirewalt, D.3    Sweetser, D.4    Buckley, J.5    Tjoa, T.6
  • 76
    • 77955108100 scopus 로고    scopus 로고
    • Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium
    • Messinger Y. Gaynon P. Raetz E. Hutchinson R. Dubois S. Glade-Bender J. et al. (2010) Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium. Pediatric Blood Cancer 55: 254–259.
    • (2010) Pediatric Blood Cancer , vol.55 , pp. 254-259
    • Messinger, Y.1    Gaynon, P.2    Raetz, E.3    Hutchinson, R.4    Dubois, S.5    Glade-Bender, J.6
  • 77
    • 84864045203 scopus 로고    scopus 로고
    • Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: therapeutic advances in childhood leukemia & lymphoma (TACL) study
    • Messinger Y. Gaynon P. Sposto R. van der Giessen J. Eckroth E. Malvar J. et al. (2012) Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: therapeutic advances in childhood leukemia & lymphoma (TACL) study. Blood 120: 285–290.
    • (2012) Blood , vol.120 , pp. 285-290
    • Messinger, Y.1    Gaynon, P.2    Sposto, R.3    van der Giessen, J.4    Eckroth, E.5    Malvar, J.6
  • 78
    • 0037513474 scopus 로고    scopus 로고
    • Constitutive phosphorylation of Akt / PKB protein in acute myeloid leukemia: its significance as a prognostic variable
    • Min Y. Eom J. Cheong J. Maeng H. Kim J. Jeung H. et al. (2003) Constitutive phosphorylation of Akt / PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 17 (5): 995–997.
    • (2003) Leukemia , vol.17 , Issue.5 , pp. 995-997
    • Min, Y.1    Eom, J.2    Cheong, J.3    Maeng, H.4    Kim, J.5    Jeung, H.6
  • 79
    • 39649084473 scopus 로고    scopus 로고
    • A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
    • Mueller D. Bach C. Zeisig D. Garcia-Cuellar M. Monroe S. Sreekumar A. et al. (2007) A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood 110: 4445–4454.
    • (2007) Blood , vol.110 , pp. 4445-4454
    • Mueller, D.1    Bach, C.2    Zeisig, D.3    Garcia-Cuellar, M.4    Monroe, S.5    Sreekumar, A.6
  • 81
    • 77954566553 scopus 로고    scopus 로고
    • Cytotoxicity of the anti-CD22 immunotoxin HA 22 (CAT-8015) against paediatric acute lymphoblastic leukaemia
    • Mussai F. Campana D. Bhojwani D. Stetler-Stevenson M. Steinberg S. Wayne A. et al. (2010) Cytotoxicity of the anti-CD22 immunotoxin HA 22 (CAT-8015) against paediatric acute lymphoblastic leukaemia. Br J Haematol 150: 352–358.
    • (2010) Br J Haematol , vol.150 , pp. 352-358
    • Mussai, F.1    Campana, D.2    Bhojwani, D.3    Stetler-Stevenson, M.4    Steinberg, S.5    Wayne, A.6
  • 82
    • 79959493965 scopus 로고    scopus 로고
    • DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
    • Nguyen A. Taranova O. He J. Zhang Y. (2011) DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood 117: 6912–6922.
    • (2011) Blood , vol.117 , pp. 6912-6922
    • Nguyen, A.1    Taranova, O.2    He, J.3    Zhang, Y.4
  • 83
    • 84887079391 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia
    • O'Hear C. Inaba H. Pounds S. Shi L. Dahl G. Bowman W. et al. (2013) Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia. Cancer 119: 4036–4043.
    • (2013) Cancer , vol.119 , pp. 4036-4043
    • O'Hear, C.1    Inaba, H.2    Pounds, S.3    Shi, L.4    Dahl, G.5    Bowman, W.6
  • 84
    • 17444375685 scopus 로고    scopus 로고
    • hDOT1L links histone methylation to leukemogenesis
    • Okada Y. Feng Q. Lin Y. Jiang Q. Li Y. Coffield V. et al. (2005) hDOT1L links histone methylation to leukemogenesis. Cell 121: 167–178.
    • (2005) Cell , vol.121 , pp. 167-178
    • Okada, Y.1    Feng, Q.2    Lin, Y.3    Jiang, Q.4    Li, Y.5    Coffield, V.6
  • 85
    • 78650168918 scopus 로고    scopus 로고
    • Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial
    • Parker C. Waters R. Leighton C. Hancock J. Sutton R. Moorman A. et al. (2010) Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet 376: 2009–2017.
    • (2010) Lancet , vol.376 , pp. 2009-2017
    • Parker, C.1    Waters, R.2    Leighton, C.3    Hancock, J.4    Sutton, R.5    Moorman, A.6
  • 87
    • 51649111035 scopus 로고    scopus 로고
    • Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia
    • Porkka K. Koskenvesa P. Lundan T. Rimpilainen J. Mustjoki S. Smykla R. et al. (2008) Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. Blood 112: 1005–1012.
    • (2008) Blood , vol.112 , pp. 1005-1012
    • Porkka, K.1    Koskenvesa, P.2    Lundan, T.3    Rimpilainen, J.4    Mustjoki, S.5    Smykla, R.6
  • 88
    • 77955714871 scopus 로고    scopus 로고
    • A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias
    • Pratz K. Cho E. Levis M. Karp J. Gore S. McDevitt M. et al. (2010) A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias. Leukemia 24: 1437–1444.
    • (2010) Leukemia , vol.24 , pp. 1437-1444
    • Pratz, K.1    Cho, E.2    Levis, M.3    Karp, J.4    Gore, S.5    McDevitt, M.6
  • 89
    • 0024341614 scopus 로고
    • Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies
    • Press O. Farr A. Borroz K. Anderson S. Martin P. (1989) Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies. Cancer Res 49: 4906–4912.
    • (1989) Cancer Res , vol.49 , pp. 4906-4912
    • Press, O.1    Farr, A.2    Borroz, K.3    Anderson, S.4    Martin, P.5
  • 90
    • 79952078495 scopus 로고    scopus 로고
    • Biology, risk stratification, and therapy of pediatric acute leukemias: an update
    • Pui C. Carroll W. Meshinchi S. Arceci R. (2011 a) Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol 29: 551–565.
    • (2011) J Clin Oncol , vol.29 , pp. 551-565
    • Pui, C.1    Carroll, W.2    Meshinchi, S.3    Arceci, R.4
  • 92
    • 84897494651 scopus 로고    scopus 로고
    • The addition of sirolimus to tacrolimus / methotrexate GVHD prophylaxis in children with ALL: a phase 3 children's oncology group / pediatric blood and marrow transplant consortium trial
    • Pulsipher M. Langholz B. Wall D. Schultz K. Bunin N. Carroll W. et al. (2014) The addition of sirolimus to tacrolimus / methotrexate GVHD prophylaxis in children with ALL: a phase 3 children's oncology group / pediatric blood and marrow transplant consortium trial. Blood 123: 2017–2025.
    • (2014) Blood , vol.123 , pp. 2017-2025
    • Pulsipher, M.1    Langholz, B.2    Wall, D.3    Schultz, K.4    Bunin, N.5    Carroll, W.6
  • 93
    • 84859159818 scopus 로고    scopus 로고
    • Reinduction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL) in children, adolescents and young adults: results from children's oncology group (COG) study ADVL04P2
    • Raetz E. Cairo M. Borowitz M. Lu X. Devidas M. Reid J. et al. (2011) Reinduction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL) in children, adolescents and young adults: results from children's oncology group (COG) study ADVL04P2. ASH Annual Meeting Abstracts 118 (21): 573.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 573
    • Raetz, E.1    Cairo, M.2    Borowitz, M.3    Lu, X.4    Devidas, M.5    Reid, J.6
  • 94
    • 14544303662 scopus 로고    scopus 로고
    • Proteasome inhibition as a novel therapeutic target in human cancer
    • Rajkumar S. Richardson P. Hideshima T. Anderson K. (2005) Proteasome inhibition as a novel therapeutic target in human cancer. J Clin Oncol 23: 630–639.
    • (2005) J Clin Oncol , vol.23 , pp. 630-639
    • Rajkumar, S.1    Richardson, P.2    Hideshima, T.3    Anderson, K.4
  • 95
    • 77951645227 scopus 로고    scopus 로고
    • Phase I / II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • Ravandi F. Cortes J. Jones D. Faderl S. Garcia-Manero G. Konopleva M. et al. (2010) Phase I / II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 28: 1856–1862.
    • (2010) J Clin Oncol , vol.28 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.2    Jones, D.3    Faderl, S.4    Garcia-Manero, G.5    Konopleva, M.6
  • 98
    • 27744507024 scopus 로고    scopus 로고
    • mTOR, a new therapeutic target in acute myeloid leukemia
    • Recher C. Dos Santos C. Demur C. Payrastre B. (2005 b) mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 4: 1540–1549.
    • (2005) Cell Cycle , vol.4 , pp. 1540-1549
    • Recher, C.1    Dos Santos, C.2    Demur, C.3    Payrastre, B.4
  • 99
    • 84907080295 scopus 로고    scopus 로고
    • Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
    • Roberts K. Li Y. Payne-Turner D. Harvey R. Yang Y. Pei D. et al. (2014) Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 371: 1005–1015.
    • (2014) N Engl J Med , vol.371 , pp. 1005-1015
    • Roberts, K.1    Li, Y.2    Payne-Turner, D.3    Harvey, R.4    Yang, Y.5    Pei, D.6
  • 100
    • 26444515033 scopus 로고    scopus 로고
    • Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia
    • Roman E. Cooney E. Harrison L. Militano O. Wolownik K. Hawks R. et al. (2005) Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia. Clin Cancer Res 11: 7164s–7170s.
    • (2005) Clin Cancer Res , vol.11 , pp. 7164s-7170s
    • Roman, E.1    Cooney, E.2    Harrison, L.3    Militano, O.4    Wolownik, K.5    Hawks, R.6
  • 101
    • 84993695209 scopus 로고    scopus 로고
    • Abstract C205: Cytotoxicity and target modulation in pediatric solid tumors by the proteasome inhibitor carfilzomib
    • Ruan Y. Liu D. Jayanthan A. Truong T. Boklan J. Narendran A. (2013) Abstract C205: Cytotoxicity and target modulation in pediatric solid tumors by the proteasome inhibitor carfilzomib. Mol Cancer Ther 12(Suppl. 11): C205–C205.
    • (2013) Mol Cancer Ther , vol.12 , Issue.Suppl. 11 , pp. C205-C205
    • Ruan, Y.1    Liu, D.2    Jayanthan, A.3    Truong, T.4    Boklan, J.5    Narendran, A.6
  • 102
    • 77953483479 scopus 로고    scopus 로고
    • Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML 02 multicentre trial
    • Rubnitz J. Inaba H. Dahl G. Ribeiro R. Bowman W. Taub J. et al. (2010) Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML 02 multicentre trial. Lancet Oncol 11: 543–552.
    • (2010) Lancet Oncol , vol.11 , pp. 543-552
    • Rubnitz, J.1    Inaba, H.2    Dahl, G.3    Ribeiro, R.4    Bowman, W.5    Taub, J.6
  • 103
    • 84890875516 scopus 로고    scopus 로고
    • Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphoblastic leukemia
    • Rytting M. Triche L. Thomas D. O'Brien S. Kantarjian H. (2014) Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphoblastic leukemia. Pediatric Blood Cancer 61: 369–372.
    • (2014) Pediatric Blood Cancer , vol.61 , pp. 369-372
    • Rytting, M.1    Triche, L.2    Thomas, D.3    O'Brien, S.4    Kantarjian, H.5
  • 104
    • 0000418476 scopus 로고
    • Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
    • Santi D. Norment A. Garrett C. (1984) Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci USA 81: 6993–6997.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 6993-6997
    • Santi, D.1    Norment, A.2    Garrett, C.3
  • 105
    • 84855604981 scopus 로고    scopus 로고
    • A phase I study of gemtuzumab ozogamicin (GO) in combination with busulfan and cyclophosphamide (Bu/Cy) and allogeneic stem cell transplantation in children with poor-risk CD33+ AML: a new targeted immunochemotherapy myeloablative conditioning (MAC) regimen
    • Satwani P. Bhatia M. Garvin J. Jr George D. Dela Cruz F. Le Gall J. et al. (2012) A phase I study of gemtuzumab ozogamicin (GO) in combination with busulfan and cyclophosphamide (Bu/Cy) and allogeneic stem cell transplantation in children with poor-risk CD33+ AML: a new targeted immunochemotherapy myeloablative conditioning (MAC) regimen. Biol Blood Marrow Transplant 18: 324–329.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 324-329
    • Satwani, P.1    Bhatia, M.2    Garvin, J.3    George, D.4    Dela Cruz, F.5    Le Gall, J.6
  • 106
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study
    • Schultz K. Bowman W. Aledo A. Slayton W. Sather H. Devidas M. et al. (2009) Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol 27: 5175–5181.
    • (2009) J Clin Oncol , vol.27 , pp. 5175-5181
    • Schultz, K.1    Bowman, W.2    Aledo, A.3    Slayton, W.4    Sather, H.5    Devidas, M.6
  • 107
    • 84904036473 scopus 로고    scopus 로고
    • Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: children's oncology group study AALL0031
    • Schultz K. Carroll A. Heerema N. Bowman W. Aledo A. Slayton W. et al. (2014) Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: children's oncology group study AALL0031. Leukemia 28: 1467–1471.
    • (2014) Leukemia , vol.28 , pp. 1467-1471
    • Schultz, K.1    Carroll, A.2    Heerema, N.3    Bowman, W.4    Aledo, A.5    Slayton, W.6
  • 108
    • 0037269185 scopus 로고    scopus 로고
    • Methylation of the hMLH 1 promoter and its association with microsatellite instability in acute myeloid leukemia
    • Seedhouse C. Das-Gupta E. Russell N. (2003) Methylation of the hMLH 1 promoter and its association with microsatellite instability in acute myeloid leukemia. Leukemia 17: 83–88.
    • (2003) Leukemia , vol.17 , pp. 83-88
    • Seedhouse, C.1    Das-Gupta, E.2    Russell, N.3
  • 109
    • 84903442808 scopus 로고    scopus 로고
    • Nilotinib monotherapy induced complete remission in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to imatinib and dasatinib
    • Sekimizu M. Yamashita Y. Ueki H. Akita N. Hattori H. Maeda N. et al. (2013) Nilotinib monotherapy induced complete remission in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to imatinib and dasatinib. Leukemia Lymphoma 55: 1652–1653.
    • (2013) Leukemia Lymphoma , vol.55 , pp. 1652-1653
    • Sekimizu, M.1    Yamashita, Y.2    Ueki, H.3    Akita, N.4    Hattori, H.5    Maeda, N.6
  • 110
    • 84867295563 scopus 로고    scopus 로고
    • A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    • Siegel D. Martin T. Wang M. Vij R. Jakubowiak A. Lonial S. et al. (2012) A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood 120: 2817–2825.
    • (2012) Blood , vol.120 , pp. 2817-2825
    • Siegel, D.1    Martin, T.2    Wang, M.3    Vij, R.4    Jakubowiak, A.5    Lonial, S.6
  • 111
    • 0033151526 scopus 로고    scopus 로고
    • Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate
    • Sievers E. Appelbaum F. Spielberger R. Forman S. Flowers D. Smith F. et al. (1999) Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 93: 3678–3684.
    • (1999) Blood , vol.93 , pp. 3678-3684
    • Sievers, E.1    Appelbaum, F.2    Spielberger, R.3    Forman, S.4    Flowers, D.5    Smith, F.6
  • 112
    • 0035397980 scopus 로고    scopus 로고
    • Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
    • Sievers E. Larson R. Stadtmauer E. Estey E. Lowenberg B. Dombret H. et al. (2001) Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol 19: 3244–3254.
    • (2001) J Clin Oncol , vol.19 , pp. 3244-3254
    • Sievers, E.1    Larson, R.2    Stadtmauer, E.3    Estey, E.4    Lowenberg, B.5    Dombret, H.6
  • 113
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
    • Silverman L. Demakos E. Peterson B. Kornblith A. Holland J. Odchimar-Reissig R. et al. (2002) Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 20: 2429–2440.
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.1    Demakos, E.2    Peterson, B.3    Kornblith, A.4    Holland, J.5    Odchimar-Reissig, R.6
  • 114
    • 0027955112 scopus 로고
    • STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor / stem cells
    • Small D. Levenstein M. Kim E. Carow C. Amin S. Rockwell P. et al. (1994) STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor / stem cells. Proc Natl Acad Sci USA 91: 459–463.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 459-463
    • Small, D.1    Levenstein, M.2    Kim, E.3    Carow, C.4    Amin, S.5    Rockwell, P.6
  • 115
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT 3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • Smith B. Levis M. Beran M. Giles F. Kantarjian H. Berg K. et al. (2004) Single-agent CEP-701, a novel FLT 3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 103: 3669–3676.
    • (2004) Blood , vol.103 , pp. 3669-3676
    • Smith, B.1    Levis, M.2    Beran, M.3    Giles, F.4    Kantarjian, H.5    Berg, K.6
  • 116
    • 34948845116 scopus 로고    scopus 로고
    • Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
    • Soriano A. Yang H. Faderl S. Estrov Z. Giles F. Ravandi F. et al. (2007) Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood 110: 2302–2308.
    • (2007) Blood , vol.110 , pp. 2302-2308
    • Soriano, A.1    Yang, H.2    Faderl, S.3    Estrov, Z.4    Giles, F.5    Ravandi, F.6
  • 117
    • 84899422233 scopus 로고    scopus 로고
    • Drug resistance and BCR-ABL kinase domain mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia from the imatinib to the second-generation tyrosine kinase inhibitor era: The main changes are in the type of mutations, but not in the frequency of mutation involvement
    • Soverini S. de Benedittis C. Papayannidis C. Paolini S. Venturi C. Iacobucci I. et al. (2014) Drug resistance and BCR-ABL kinase domain mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia from the imatinib to the second-generation tyrosine kinase inhibitor era: The main changes are in the type of mutations, but not in the frequency of mutation involvement. Cancer 120: 1002–1009.
    • (2014) Cancer , vol.120 , pp. 1002-1009
    • Soverini, S.1    de Benedittis, C.2    Papayannidis, C.3    Paolini, S.4    Venturi, C.5    Iacobucci, I.6
  • 118
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT 3 respond to a small-molecule FLT 3 tyrosine kinase inhibitor, PKC412
    • Stone R. de Angelo D. Klimek V. Galinsky I. Estey E. Nimer S. et al. (2005) Patients with acute myeloid leukemia and an activating mutation in FLT 3 respond to a small-molecule FLT 3 tyrosine kinase inhibitor, PKC412. Blood 105: 54–60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.1    de Angelo, D.2    Klimek, V.3    Galinsky, I.4    Estey, E.5    Nimer, S.6
  • 119
    • 54049147814 scopus 로고    scopus 로고
    • Azacytidine causes complex DNA methylation responses in myeloid leukemia
    • Stresemann C. Bokelmann I. Mahlknecht U. Lyko F. (2008) Azacytidine causes complex DNA methylation responses in myeloid leukemia. Mol Cancer Ther 7: 2998–3005.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2998-3005
    • Stresemann, C.1    Bokelmann, I.2    Mahlknecht, U.3    Lyko, F.4
  • 120
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann C. Brueckner B. Musch T. Stopper H. Lyko F. (2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 66: 2794–2800.
    • (2006) Cancer Res , vol.66 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3    Stopper, H.4    Lyko, F.5
  • 121
    • 84859633464 scopus 로고    scopus 로고
    • Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia
    • Stumpel D. Schneider P. Seslija L. Osaki H. Williams O. Pieters R. et al. (2012) Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia. Leukemia 26: 682–692.
    • (2012) Leukemia , vol.26 , pp. 682-692
    • Stumpel, D.1    Schneider, P.2    Seslija, L.3    Osaki, H.4    Williams, O.5    Pieters, R.6
  • 122
    • 2442533724 scopus 로고    scopus 로고
    • Acute promyelocytic leukemia as a paradigm for targeted therapy
    • Tallman M. (2004) Acute promyelocytic leukemia as a paradigm for targeted therapy. Sem Hematol 41(2 Suppl. 4): 27–32.
    • (2004) Sem Hematol , vol.41 , Issue.2 , pp. 27-32
    • Tallman, M.1
  • 123
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M. Shah N. Kantarjian H. Donato N. Nicoll J. Paquette R. et al. (2006) Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354: 2531–2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.2    Kantarjian, H.3    Donato, N.4    Nicoll, J.5    Paquette, R.6
  • 124
    • 52649149525 scopus 로고    scopus 로고
    • mTOR inhibitors are synergistic with methotrexate: an effective combination totreat acute lymphoblastic leukemia
    • Teachey D. Sheen C. Hall J. Ryan T. Brown V. Fish J. et al. (2008) mTOR inhibitors are synergistic with methotrexate: an effective combination totreat acute lymphoblastic leukemia. Blood 112: 2020–2023.
    • (2008) Blood , vol.112 , pp. 2020-2023
    • Teachey, D.1    Sheen, C.2    Hall, J.3    Ryan, T.4    Brown, V.5    Fish, J.6
  • 125
    • 84871491706 scopus 로고    scopus 로고
    • Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • Topp M. Gokbuget N. Zugmaier G. Degenhard E. Goebeler M. Klinger M. et al. (2012) Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 120: 5185–5187.
    • (2012) Blood , vol.120 , pp. 5185-5187
    • Topp, M.1    Gokbuget, N.2    Zugmaier, G.3    Degenhard, E.4    Goebeler, M.5    Klinger, M.6
  • 126
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp M. Kufer P. Gokbuget N. Goebeler M. Klinger M. Neumann S. et al. (2011) Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 29: 2493–2498.
    • (2011) J Clin Oncol , vol.29 , pp. 2493-2498
    • Topp, M.1    Kufer, P.2    Gokbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6
  • 127
    • 0042440852 scopus 로고    scopus 로고
    • Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements
    • Tsutsumi S. Taketani T. Nishimura K. Ge X. Taki T. Sugita K. et al. (2003) Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements. Cancer Res 63: 4882–4887.
    • (2003) Cancer Res , vol.63 , pp. 4882-4887
    • Tsutsumi, S.1    Taketani, T.2    Nishimura, K.3    Ge, X.4    Taki, T.5    Sugita, K.6
  • 128
    • 0033604457 scopus 로고    scopus 로고
    • Induction of apoptosis in U 937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53
    • Vrana J. Decker R. Johnson C. Wang Z. Jarvis W. Richon V. et al. (1999) Induction of apoptosis in U 937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. Oncogene 18: 7016–7025.
    • (1999) Oncogene , vol.18 , pp. 7016-7025
    • Vrana, J.1    Decker, R.2    Johnson, C.3    Wang, Z.4    Jarvis, W.5    Richon, V.6
  • 129
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappa B
    • Wang C. Mayo M. Baldwin A. Jr (1996) TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappa B. Science 274: 784–787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.1    Mayo, M.2    Baldwin, A.3
  • 130
    • 84887609779 scopus 로고    scopus 로고
    • Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • Wang M. Martin T. Bensinger W. Alsina M. Siegel D. Kavalerchik E. et al. (2013) Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Blood 122: 3122–3128.
    • (2013) Blood , vol.122 , pp. 3122-3128
    • Wang, M.1    Martin, T.2    Bensinger, W.3    Alsina, M.4    Siegel, D.5    Kavalerchik, E.6
  • 131
    • 84859156821 scopus 로고    scopus 로고
    • A novel anti-CD22 immunotoxin, moxetumomab pasudotox: phase I study in pediatric acute lymphoblastic leukemia (ALL)
    • Wayne A. Bhojwani D. Silverman L. Richards K. Stetler-Stevenson M. Shah N. et al. (2011) A novel anti-CD22 immunotoxin, moxetumomab pasudotox: phase I study in pediatric acute lymphoblastic leukemia (ALL). ASH Annual Meeting Abstracts 118 (21): 248.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 248
    • Wayne, A.1    Bhojwani, D.2    Silverman, L.3    Richards, K.4    Stetler-Stevenson, M.5    Shah, N.6
  • 132
    • 77949679970 scopus 로고    scopus 로고
    • Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial
    • Wayne A. Kreitman R. Findley H. Lew G. Delbrook C. Steinberg S. et al. (2010) Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial. Clin Cancer Res 16: 1894–1903.
    • (2010) Clin Cancer Res , vol.16 , pp. 1894-1903
    • Wayne, A.1    Kreitman, R.2    Findley, H.3    Lew, G.4    Delbrook, C.5    Steinberg, S.6
  • 133
    • 33749443714 scopus 로고    scopus 로고
    • Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL 1 and glucocorticoid resistance
    • Wei G. Twomey D. Lamb J. Schlis K. Agarwal J. Stam R. et al. (2006) Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL 1 and glucocorticoid resistance. Cancer Cell 10: 331–342.
    • (2006) Cancer Cell , vol.10 , pp. 331-342
    • Wei, G.1    Twomey, D.2    Lamb, J.3    Schlis, K.4    Agarwal, J.5    Stam, R.6
  • 134
    • 84860805385 scopus 로고    scopus 로고
    • Immunotoxin resistance via reversible methylation of the DPH 4 promoter is a unique survival strategy
    • Wei H. Xiang L. Wayne A. Chertov O. FitzGerald D. Bera T. et al. (2012) Immunotoxin resistance via reversible methylation of the DPH 4 promoter is a unique survival strategy. Proc Natl Acad Sci USA 109: 6898–6903.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 6898-6903
    • Wei, H.1    Xiang, L.2    Wayne, A.3    Chertov, O.4    FitzGerald, D.5    Bera, T.6
  • 135
    • 84867398454 scopus 로고    scopus 로고
    • Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT 3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors
    • Weisberg E. Liu Q. Nelson E. Kung A. Christie A. Bronson R. et al. (2012) Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT 3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors. Leukemia 26: 2233–2244.
    • (2012) Leukemia , vol.26 , pp. 2233-2244
    • Weisberg, E.1    Liu, Q.2    Nelson, E.3    Kung, A.4    Christie, A.5    Bronson, R.6
  • 136
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI 3 kinase activation
    • Xu Q. Simpson S. Scialla T. Bagg A. Carroll M. (2003) Survival of acute myeloid leukemia cells requires PI 3 kinase activation. Blood 102: 972–980.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.2    Scialla, T.3    Bagg, A.4    Carroll, M.5
  • 137
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D 835 within the activation loop of FLT 3 in human hematologic malignancies
    • Yamamoto Y. Kiyoi H. Nakano Y. Suzuki R. Kodera Y. Miyawaki S. et al. (2001) Activating mutation of D 835 within the activation loop of FLT 3 in human hematologic malignancies. Blood 97:2434–2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3    Suzuki, R.4    Kodera, Y.5    Miyawaki, S.6
  • 138
    • 80053148350 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats
    • Yang J. Wang Z. Fang Y. Jiang J. Zhao F. Wong H. et al. (2011) Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats. Drug Metab Disposition 39: 1873–1882.
    • (2011) Drug Metab Disposition , vol.39 , pp. 1873-1882
    • Yang, J.1    Wang, Z.2    Fang, Y.3    Jiang, J.4    Zhao, F.5    Wong, H.6
  • 139
    • 33749002279 scopus 로고    scopus 로고
    • Phase I / II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee K. Zeng Z. Konopleva M. Verstovsek S. Ravandi F. Ferrajoli A. et al. (2006) Phase I / II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 12: 5165–5173.
    • (2006) Clin Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.1    Zeng, Z.2    Konopleva, M.3    Verstovsek, S.4    Ravandi, F.5    Ferrajoli, A.6
  • 140
    • 76349118080 scopus 로고    scopus 로고
    • A higher-order complex containing AF 4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
    • Yokoyama A. Lin M. Naresh A. Kitabayashi I. Cleary M. (2010) A higher-order complex containing AF 4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell 17: 198–212.
    • (2010) Cancer Cell , vol.17 , pp. 198-212
    • Yokoyama, A.1    Lin, M.2    Naresh, A.3    Kitabayashi, I.4    Cleary, M.5
  • 141
    • 0023820894 scopus 로고
    • Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically
    • Zein N. Sinha A. McGahren W. Ellestad G. (1988) Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically. Science 240: 1198–1201.
    • (1988) Science , vol.240 , pp. 1198-1201
    • Zein, N.1    Sinha, A.2    McGahren, W.3    Ellestad, G.4
  • 142
  • 143
    • 33745873838 scopus 로고    scopus 로고
    • Dot1a-AF9 complex mediates histone H 3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner
    • Zhang W. Xia X. Reisenauer M. Hemenway C. Kone B. (2006) Dot1a-AF9 complex mediates histone H 3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. J Biol Chem 281: 18059–18068.
    • (2006) J Biol Chem , vol.281 , pp. 18059-18068
    • Zhang, W.1    Xia, X.2    Reisenauer, M.3    Hemenway, C.4    Kone, B.5
  • 144
    • 84900991744 scopus 로고    scopus 로고
    • A phase 1 / 2 study of blinatumomab in pediatric patients with relapsed / refractory B-cell precursor acute lymphoblastic leukemia
    • Zugmaier G. Handgretinger R. Locatelli F. Rizzari C. Trippett T. Borkhardt A. et al. (2013) A phase 1 / 2 study of blinatumomab in pediatric patients with relapsed / refractory B-cell precursor acute lymphoblastic leukemia. Blood 122 (21): 70.
    • (2013) Blood , vol.122 , Issue.21 , pp. 70
    • Zugmaier, G.1    Handgretinger, R.2    Locatelli, F.3    Rizzari, C.4    Trippett, T.5    Borkhardt, A.6


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