메뉴 건너뛰기




Volumn 13, Issue 1, 2016, Pages 25-40

Novel immunotherapies in lymphoid malignancies

Author keywords

[No Author keywords available]

Indexed keywords

BENDAMUSTINE; BLINATUMOMAB; BRENTUXIMAB VEDOTIN; CARMUSTINE; CHECKPOINT KINASE INHIBITOR; CHIMERIC ANTIGEN RECEPTOR; CLOFARABINE; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; IMMUNOGLOBULIN; INTERLEUKIN 2; IPILIMUMAB; MELPHALAN; NIVOLUMAB; PEMBROLIZUMAB; PENTOSTATIN; PIDILIZUMAB; PREDNISONE; PROGRAMMED DEATH 1 LIGAND 1; RITUXIMAB; STEROID; TOCILIZUMAB; URELUMAB; VINCRISTINE; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY; MONOCLONAL ANTIBODY;

EID: 84951905956     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2015.187     Document Type: Review
Times cited : (215)

References (172)
  • 1
    • 0025100777 scopus 로고
    • Graft-versus-leukemia reactions after bone marrow transplantation
    • Horowitz, M. et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75, 555-562 (1990).
    • (1990) Blood , vol.75 , pp. 555-562
    • Horowitz, M.1
  • 2
    • 17144455839 scopus 로고    scopus 로고
    • IDEC-C2B8: Results of a phase i multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma
    • Maloney, D. G. et al. IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J. Clin. Oncol. 15, 3266-3274 (1997).
    • (1997) J. Clin. Oncol , vol.15 , pp. 3266-3274
    • Maloney, D.G.1
  • 3
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney, D. G. et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 90, 2188-2195 (1997).
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1
  • 4
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier, B. et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 235-242 (2002).
    • (2002) N. Engl. J. Med , vol.346 , pp. 235-242
    • Coiffier, B.1
  • 5
    • 84858683311 scopus 로고    scopus 로고
    • Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation
    • Doubrovina, E. et al. Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Blood 119, 2644-2656 (2012).
    • (2012) Blood , vol.119 , pp. 2644-2656
    • Doubrovina, E.1
  • 6
    • 84875975917 scopus 로고    scopus 로고
    • Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-Transplant patients
    • Chapuis, A. G. et al. Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-Transplant patients. Sci. Transl. Med. 5, 174ra27 (2013).
    • (2013) Sci. Transl. Med , vol.5 , pp. 174ra27
    • Chapuis, A.G.1
  • 7
    • 0032170108 scopus 로고    scopus 로고
    • Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients
    • Rooney, C. M. et al. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92, 1549-1555 (1998).
    • (1998) Blood , vol.92 , pp. 1549-1555
    • Rooney, C.M.1
  • 8
    • 77649221824 scopus 로고    scopus 로고
    • Long-Term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
    • Heslop, H. E. et al. Long-Term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood 115, 925-935 (2010).
    • (2011) Blood , vol.115 , pp. 925-935
    • Heslop, H.E.1
  • 9
    • 84898647949 scopus 로고    scopus 로고
    • Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins
    • Bollard, C. M. et al. Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins. J. Clin. Oncol. 32, 798-808 (2014).
    • (2014) J. Clin. Oncol , vol.32 , pp. 798-808
    • Bollard, C.M.1
  • 10
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors
    • Eshhar, Z., Waks, T., Gross, G. & Schindler, D. G. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc. Natl Acad. Sci. USA 90, 720-724 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 11
    • 0032534575 scopus 로고    scopus 로고
    • Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and FcεRI-signaling γ subunit
    • Annenkov, A. E., Moyes, S. P., Eshhar, Z., Mageed, R. A. & Chernajovsky, Y. Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and FcεRI-signaling γ subunit. J. Immunol. 161, 6604-6613 (1998).
    • (1998) J. Immunol , vol.161 , pp. 6604-6613
    • Annenkov, A.E.1    Moyes, S.P.2    Eshhar, Z.3    Mageed, R.A.4    Chernajovsky, Y.5
  • 12
    • 0035159470 scopus 로고    scopus 로고
    • Redirecting mouse CTL against colon carcinoma: Superior signaling efficacy of single-chain variable domain chimeras containing TCR-ζ vs FcεRI-γ
    • Haynes, N. M. et al. Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-ζ vs FcεRI-γ. J. Immunol. 166, 182-187 (2001).
    • (2001) J. Immunol , vol.166 , pp. 182-187
    • Haynes, N.M.1
  • 13
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-Type specificity
    • Gross, G., Waks, T. & Eshhar, Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-Type specificity. Proc. Natl Acad. Sci. USA 86, 10024-10028 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 14
    • 0024293979 scopus 로고
    • Single-chain antigen-binding proteins
    • Bird, R. E. et al. Single-chain antigen-binding proteins. Science 242, 423-426 (1988).
    • (1988) Science , vol.242 , pp. 423-426
    • Bird, R.E.1
  • 15
    • 0004198722 scopus 로고
    • Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
    • Huston, J. S. et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl Acad. Sci. USA 85, 5879-5883 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 5879-5883
    • Huston, J.S.1
  • 16
    • 1542698957 scopus 로고
    • Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
    • Orlandi, R., Gussow, D. H., Jones, P. T. & Winter, G. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl Acad. Sci. USA 86, 3833-3837 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 3833-3837
    • Orlandi, R.1    Gussow, D.H.2    Jones, P.T.3    Winter, G.4
  • 17
    • 63649112916 scopus 로고    scopus 로고
    • Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy
    • Hollyman, D. et al. Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J. Immunother. 32, 169-180 (2009).
    • (2009) J. Immunother , vol.32 , pp. 169-180
    • Hollyman, D.1
  • 18
    • 60749131428 scopus 로고    scopus 로고
    • Retroviral transduction of murine primary T lymphocytes
    • Lee, J., Sadelain, M. & Brentjens, R. Retroviral transduction of murine primary T lymphocytes. Methods Mol. Biol. 506, 83-96 (2009).
    • (2009) Methods Mol. Biol , vol.506 , pp. 83-96
    • Lee, J.1    Sadelain, M.2    Brentjens, R.3
  • 19
    • 37149001207 scopus 로고    scopus 로고
    • Multifactorial optimization of gammaretroviral gene transfer into human T lymphocytes for clinical application
    • Quintas-Cardama, A. et al. Multifactorial optimization of gammaretroviral gene transfer into human T lymphocytes for clinical application. Hum. Gene Ther. 18, 1253-1260 (2007).
    • (2007) Hum. Gene Ther , vol.18 , pp. 1253-1260
    • Quintas-Cardama, A.1
  • 20
    • 34848842554 scopus 로고    scopus 로고
    • Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
    • Brentjens, R. J. et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin. Cancer Res. 13, 5426-5435 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 5426-5435
    • Brentjens, R.J.1
  • 21
    • 0037348324 scopus 로고    scopus 로고
    • Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
    • Brentjens, R. J. et al. Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat. Med. 9, 279-286 (2003).
    • (2003) Nat. Med , vol.9 , pp. 279-286
    • Brentjens, R.J.1
  • 22
    • 39849086801 scopus 로고    scopus 로고
    • Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
    • Huang, X. et al. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol. Ther. 16, 580-589 (2008).
    • (2008) Mol. Ther , vol.16 , pp. 580-589
    • Huang, X.1
  • 23
    • 68449088813 scopus 로고    scopus 로고
    • Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor
    • Kochenderfer, J. N. et al. Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor. J. Immunother. 32, 689-702 (2009).
    • (2009) J. Immunother , vol.32 , pp. 689-702
    • Kochenderfer, J.N.1
  • 24
    • 79955517235 scopus 로고    scopus 로고
    • CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
    • Savoldo, B. et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J. Clin. Invest. 121, 1822-1826 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 1822-1826
    • Savoldo, B.1
  • 25
    • 84868221578 scopus 로고    scopus 로고
    • Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale
    • Wang, X. et al. Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale. J. Immunother. 35, 689-701 (2012).
    • (2012) J. Immunother , vol.35 , pp. 689-701
    • Wang, X.1
  • 26
    • 70350726110 scopus 로고    scopus 로고
    • Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
    • Milone, M. C. et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol. Ther. 17, 1453-1464 (2009).
    • (2009) Mol. Ther , vol.17 , pp. 1453-1464
    • Milone, M.C.1
  • 27
    • 84862954607 scopus 로고    scopus 로고
    • Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells
    • Terakura, S. et al. Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells. Blood 119, 72-82 (2012).
    • (2012) Blood , vol.119 , pp. 72-82
    • Terakura, S.1
  • 28
    • 0026339245 scopus 로고
    • Preparation and characterization of a chimeric CD19 monoclonal antibody
    • Zola, H. et al. Preparation and characterization of a chimeric CD19 monoclonal antibody. Immunol. Cell Biol. 69, 411-422 (1991).
    • (1991) Immunol. Cell Biol , vol.69 , pp. 411-422
    • Zola, H.1
  • 29
    • 0029033815 scopus 로고
    • Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen
    • Bejcek, B. E. et al. Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen. Cancer Res. 55, 2346-2351 (1995).
    • (1995) Cancer Res , vol.55 , pp. 2346-2351
    • Bejcek, B.E.1
  • 30
    • 0344157387 scopus 로고    scopus 로고
    • Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma
    • Nicholson, I. C. et al. Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma. Mol. Immunol. 34, 1157-1165 (1997).
    • (1997) Mol. Immunol , vol.34 , pp. 1157-1165
    • Nicholson, I.C.1
  • 31
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai, C. et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 18, 676-684 (2004).
    • (2004) Leukemia , vol.18 , pp. 676-684
    • Imai, C.1
  • 32
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till, B. G. et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 112, 2261-2271 (2008).
    • (2008) Blood , vol.112 , pp. 2261-2271
    • Till, B.G.1
  • 33
    • 77955510549 scopus 로고    scopus 로고
    • Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
    • Jensen, M. C. et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol. Blood Marrow Transplant. 16, 1245-1256 (2010).
    • (2011) Biol. Blood Marrow Transplant , vol.16 , pp. 1245-1256
    • Jensen, M.C.1
  • 34
    • 34548485103 scopus 로고    scopus 로고
    • Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
    • Wang, J. et al. Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum. Gene Ther. 18, 712-725 (2007).
    • (2007) Hum. Gene Ther , vol.18 , pp. 712-725
    • Wang, J.1
  • 35
    • 0036137615 scopus 로고    scopus 로고
    • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor
    • Maher, J., Brentjens, R. J., Gunset, G., Riviere, I. & Sadelain, M. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor. Nat. Biotechnol. 20, 70-75 (2002).
    • (2002) Nat. Biotechnol , vol.20 , pp. 70-75
    • Maher, J.1    Brentjens, R.J.2    Gunset, G.3    Riviere, I.4    Sadelain, M.5
  • 36
    • 84890117209 scopus 로고    scopus 로고
    • Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 super-stimulation
    • Hombach, A. A., Rappl, G. & Abken, H. Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 "super-stimulation". Mol. Ther. 21, 2268-2277 (2013).
    • (2013) Mol. Ther , vol.21 , pp. 2268-2277
    • Hombach, A.A.1    Rappl, G.2    Abken, H.3
  • 37
    • 62549097817 scopus 로고    scopus 로고
    • Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
    • Carpenito, C. et al. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc. Natl Acad. Sci. USA 106, 3360-3365 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3360-3365
    • Carpenito, C.1
  • 38
    • 76349087378 scopus 로고    scopus 로고
    • Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
    • Zhong, X. S., Matsushita, M., Plotkin, J., Riviere, I. & Sadelain, M. Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol. Ther. 18, 413-420 (2010).
    • (2011) Mol. Ther , vol.18 , pp. 413-420
    • Zhong, X.S.1    Matsushita, M.2    Plotkin, J.3    Riviere, I.4    Sadelain, M.5
  • 39
    • 74949124101 scopus 로고    scopus 로고
    • 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies
    • Tammana, S. et al. 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies. Hum. Gene Ther. 21, 75-86 (2010).
    • (2011) Hum. Gene Ther , vol.21 , pp. 75-86
    • Tammana, S.1
  • 41
    • 84926433030 scopus 로고    scopus 로고
    • Improving the safety of cell therapy products by suicide gene transfer
    • Jones, B. S., Lamb, L. S., Goldman, F. & Di Stasi, A. Improving the safety of cell therapy products by suicide gene transfer. Front. Pharmacol. 5, 254 (2014).
    • (2014) Front. Pharmacol , vol.5 , pp. 254
    • Jones, B.S.1    Lamb, L.S.2    Goldman, F.3    Di Stasi, A.4
  • 42
    • 67650638846 scopus 로고    scopus 로고
    • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
    • Di Stasi, A. et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood 113, 6392-6402 (2009).
    • (2009) Blood , vol.113 , pp. 6392-6402
    • Di Stasi, A.1
  • 43
    • 0036428790 scopus 로고    scopus 로고
    • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
    • Kershaw, M. H. et al. Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum. Gene Ther. 13, 1971-1980 (2002).
    • (2002) Hum. Gene Ther , vol.13 , pp. 1971-1980
    • Kershaw, M.H.1
  • 44
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-Targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens, R. J. et al. Safety and persistence of adoptively transferred autologous CD19-Targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 118, 4817-4828 (2011).
    • (2011) Blood , vol.118 , pp. 4817-4828
    • Brentjens, R.J.1
  • 45
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos, M. et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl. Med. 3, 95ra73 (2011).
    • (2011) Sci. Transl. Med , vol.3 , pp. 95ra73
    • Kalos, M.1
  • 46
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    • Kochenderfer, J. N. et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116, 4099-4102 (2010).
    • (2011) Blood , vol.116 , pp. 4099-4102
    • Kochenderfer, J.N.1
  • 47
    • 84924799045 scopus 로고    scopus 로고
    • Manufacture of tumor-And virus-specific T lymphocytes for adoptive cell therapies
    • Wang, X. & Riviere, I. Manufacture of tumor-And virus-specific T lymphocytes for adoptive cell therapies. Cancer Gene Ther. 22, 85-94 (2015).
    • (2015) Cancer Gene Ther , vol.22 , pp. 85-94
    • Wang, X.1    Riviere, I.2
  • 48
    • 84876005284 scopus 로고    scopus 로고
    • CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens, R. J. et al. CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci. Transl. Med. 5, 177ra38 (2013).
    • (2013) Sci. Transl. Med , vol.5 , pp. 177ra38
    • Brentjens, R.J.1
  • 49
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • Davila, M. L. et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med. 6, 224ra25 (2014).
    • (2014) Sci. Transl. Med , vol.6 , pp. 224ra25
    • Davila, M.L.1
  • 50
    • 84951908950 scopus 로고    scopus 로고
    • CD19-Targeted 19-28z CAR modified autologous T cells induce high rates of complete remission and durable responses in adult patients with relapsed, refractory B-cell ALL [abstract]
    • Park, J. H. et al. CD19-Targeted 19-28z CAR modified autologous T cells induce high rates of complete remission and durable responses in adult patients with relapsed, refractory B-cell ALL [abstract]. Blood 124, a382 (2014).
    • (2014) Blood , vol.124 , pp. a382
    • Park, J.H.1
  • 51
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude, S. L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507-1517 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 1507-1517
    • Maude, S.L.1
  • 52
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
    • Lee, D. W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial. Lancet 385, 517-528 (2015).
    • (2015) Lancet , vol.385 , pp. 517-528
    • Lee, D.W.1
  • 53
    • 33846869976 scopus 로고    scopus 로고
    • Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); An MRC UKALL12/ECOG 2993 study
    • Fielding, A. K. et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 109, 944-950 (2007).
    • (2007) Blood , vol.109 , pp. 944-950
    • Fielding, A.K.1
  • 54
    • 84866094086 scopus 로고    scopus 로고
    • Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation
    • Gökbuget, N. et al. Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation. Blood 120, 2032-2041 (2012).
    • (2012) Blood , vol.120 , pp. 2032-2041
    • Gökbuget, N.1
  • 55
    • 79955694768 scopus 로고    scopus 로고
    • Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission
    • Kantarjian, H. M. et al. Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. Leuk. Lymphoma 51, 475-480 (2010).
    • (2011) Leuk. Lymphoma , vol.51 , pp. 475-480
    • Kantarjian, H.M.1
  • 56
    • 84951909134 scopus 로고    scopus 로고
    • Validation of donor derived virus specific T-lymphocytes genetically modified to target the CD19 antigen for the treatment of relapsed Leukemia
    • Curran, K. J. et al. Validation of donor derived virus specific T-lymphocytes genetically modified to target the CD19 antigen for the treatment of relapsed Leukemia. Mol. Ther. 19, S90 (2011).
    • (2011) Mol. Ther , vol.19 , pp. S90
    • Curran, K.J.1
  • 57
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived CD19-Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • Kochenderfer, J. N. et al. Donor-derived CD19-Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood 122, 4129-4139 (2013).
    • (2013) Blood , vol.122 , pp. 4129-4139
    • Kochenderfer, J.N.1
  • 58
    • 84886583769 scopus 로고    scopus 로고
    • Impact of the conditioning chemotherapy on outcomes in adoptive T cell therapy: Results from a phase i clinical trial of autologous CD19-Targeted T cells for patients with relapsed CLL [abstract]
    • Park, J. H. et al. Impact of the conditioning chemotherapy on outcomes in adoptive T cell therapy: results from a phase I clinical trial of autologous CD19-Targeted T cells for patients with relapsed CLL [abstract]. Blood 120, a1797 (2012).
    • (2012) Blood , vol.120 , pp. a1797
    • Park, J.H.1
  • 59
    • 84941768764 scopus 로고    scopus 로고
    • Phase i trial of autologous CD19-Targeted CAR-modified T cells as consolidation after purine analog-based first-line therapy in patients with previously untreated CLL [abstract]
    • Park, J. H. et al. Phase I trial of autologous CD19-Targeted CAR-modified T cells as consolidation after purine analog-based first-line therapy in patients with previously untreated CLL [abstract]. J. Clin. Oncol. 32 (5s Suppl.), a7020 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.5 , pp. a7020
    • Park, J.H.1
  • 60
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. & June, C. H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365, 725-733 (2011).
    • (2011) N. Engl. J. Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 61
    • 84897569379 scopus 로고    scopus 로고
    • Chimeric antigen receptor modified t cells directed against CD19 (CTL019 cells) have long-Term persistence and induce durable responses in relapsed, refractory CLL [abstract]
    • Porter, D. L. et al. Chimeric antigen receptor modified t cells directed against CD19 (CTL019 cells) have long-Term persistence and induce durable responses in relapsed, refractory CLL [abstract]. Blood 122, a4162 (2013).
    • (2013) Blood , vol.122 , pp. a4162
    • Porter, D.L.1
  • 62
    • 84927768738 scopus 로고    scopus 로고
    • Randomized, phase II dose optimization study of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed, refractory CLL [abstract]
    • Porter, D. L. et al. Randomized, phase II dose optimization study of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed, refractory CLL [abstract]. Blood 124, a1982 (2014).
    • (2014) Blood , vol.124 , pp. a1982
    • Porter, D.L.1
  • 63
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-Associated toxicity in a clinical trial of anti-CD19 chimeric-Antigen-receptor-Transduced T cells
    • Kochenderfer, J. N. et al. B-cell depletion and remissions of malignancy along with cytokine-Associated toxicity in a clinical trial of anti-CD19 chimeric-Antigen-receptor-Transduced T cells. Blood 119, 2709-2720 (2012).
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1
  • 64
    • 84923118622 scopus 로고    scopus 로고
    • Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
    • Kochenderfer, J. N. et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J. Clin. Oncol. 33, 540-549 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. 540-549
    • Kochenderfer, J.N.1
  • 65
    • 84927653490 scopus 로고    scopus 로고
    • Anti-CD19 CAR T cells administered after low-dose chemotherapy can induce remissions of chemotherapy-refractory diffuse large B-cell lymphoma [abstract]
    • Kochenderfer, J. N. et al. Anti-CD19 CAR T cells administered after low-dose chemotherapy can induce remissions of chemotherapy-refractory diffuse large B-cell lymphoma [abstract]. Blood 124, a550 (2014).
    • (2014) Blood , vol.124 , pp. a550
    • Kochenderfer, J.N.1
  • 66
    • 84944875841 scopus 로고    scopus 로고
    • Phase IIa trial of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+ lymphomas [abstract]
    • Schuster, S. J. et al. Phase IIa trial of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+ lymphomas [abstract]. Blood 124, a3087 (2014).
    • (2014) Blood , vol.124 , pp. a3087
    • Schuster, S.J.1
  • 67
    • 84937437102 scopus 로고    scopus 로고
    • Interim safety analysis: A phase i trial of high dose therapy and autologous stem cell transplantation followed by infusion of chimeric antigen receptor modified T-cells (19-28z CAR-T) directed against CD19+ B-cells for relapsed and refractory aggressive B cell non-Hodgkin lymphoma (B-NHL) [abstract]
    • Sauter, C. S. et al. Interim safety analysis: A phase I trial of high dose therapy and autologous stem cell transplantation followed by infusion of chimeric antigen receptor modified T-cells (19-28z CAR-T) directed against CD19+ B-cells for relapsed and refractory aggressive B cell non-Hodgkin lymphoma (B-NHL) [abstract]. Blood 124, a677 (2014).
    • (2014) Blood , vol.124 , pp. a677
    • Sauter, C.S.1
  • 68
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee, D. W. et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood 124, 188-195 (2014).
    • (2014) Blood , vol.124 , pp. 188-195
    • Lee, D.W.1
  • 69
    • 84897568616 scopus 로고    scopus 로고
    • Managing cytokine release syndrome associated with novel T cell-engaging therapies
    • Maude, S. L., Barrett, D., Teachey, D. T. & Grupp, S. A. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 20, 119-122 (2014).
    • (2014) Cancer J , vol.20 , pp. 119-122
    • Maude, S.L.1    Barrett, D.2    Teachey, D.T.3    Grupp, S.A.4
  • 71
    • 84933510694 scopus 로고    scopus 로고
    • CD19-Targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
    • Maude, S. L., Teachey, D. T., Porter, D. L. & Grupp, S. A. CD19-Targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood 125, 4017-4023 (2015).
    • (2015) Blood , vol.125 , pp. 4017-4023
    • Maude, S.L.1    Teachey, D.T.2    Porter, D.L.3    Grupp, S.A.4
  • 72
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp, S. A. et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 368, 1509-1518 (2013).
    • (2013) N. Engl. J. Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1
  • 73
    • 84951905321 scopus 로고    scopus 로고
    • Immunotherapy with CD19-specific chimeric antigen receptor (CAR)-modified T cells of defined subset composition [abstract]
    • Turtle, C. J. et al. Immunotherapy with CD19-specific chimeric antigen receptor (CAR)-modified T cells of defined subset composition [abstract]. J. Clin. Oncol. 33 (Suppl.), a3006 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. a3006
    • Turtle, C.J.1
  • 74
    • 80051589534 scopus 로고    scopus 로고
    • A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
    • Wang, X. et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood 118, 1255-1263 (2011).
    • (2011) Blood , vol.118 , pp. 1255-1263
    • Wang, X.1
  • 75
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi, A. et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N. Engl. J. Med. 365, 1673-1683 (2011).
    • (2011) N. Engl. J. Med , vol.365 , pp. 1673-1683
    • Di Stasi, A.1
  • 76
    • 79955980426 scopus 로고    scopus 로고
    • Vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
    • Giordano Attianese, G. M. et al. In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood 117, 4736-4745 (2011).
    • (2011) Blood , vol.117 , pp. 4736-4745
    • Giordano Attianese, G.M.1
  • 77
    • 84962304846 scopus 로고    scopus 로고
    • Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells
    • Berger, C. et al. Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells. Cancer Immunol. Res. 3, 206-216 (2015).
    • (2015) Cancer Immunol. Res , vol.3 , pp. 206-216
    • Berger, C.1
  • 78
    • 84874027123 scopus 로고    scopus 로고
    • Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
    • Haso, W. et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood 121, 1165-1174 (2013).
    • (2013) Blood , vol.121 , pp. 1165-1174
    • Haso, W.1
  • 79
    • 33845256434 scopus 로고    scopus 로고
    • T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
    • Vera, J. et al. T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood 108, 3890-3897 (2006).
    • (2006) Blood , vol.108 , pp. 3890-3897
    • Vera, J.1
  • 80
    • 34948860624 scopus 로고    scopus 로고
    • Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
    • Savoldo, B. et al. Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 110, 2620-2630 (2007).
    • (2007) Blood , vol.110 , pp. 2620-2630
    • Savoldo, B.1
  • 81
    • 84969420302 scopus 로고    scopus 로고
    • Novel chimeric antigen receptor T cells for the treatment of Hodgkin lymphoma [abstract]
    • Ruella, M. et al. Novel chimeric antigen receptor T cells for the treatment of Hodgkin lymphoma [abstract]. Blood 124, a806 (2014).
    • (2014) Blood , vol.124 , pp. a806
    • Ruella, M.1
  • 82
    • 84863230570 scopus 로고    scopus 로고
    • Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice
    • Chinnasamy, D. et al. Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice. Clin. Cancer Res. 18, 1672-1683 (2012).
    • (2012) Clin. Cancer Res , vol.18 , pp. 1672-1683
    • Chinnasamy, D.1
  • 83
    • 77958063691 scopus 로고    scopus 로고
    • Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
    • Craddock, J. A. et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J. Immunother. 33, 780-788 (2010).
    • (2011) J. Immunother , vol.33 , pp. 780-788
    • Craddock, J.A.1
  • 84
    • 84880923283 scopus 로고    scopus 로고
    • Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy
    • Karlsson, S. C. et al. Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy. Cancer Gene Ther. 20, 386-393 (2013).
    • (2013) Cancer Gene Ther , vol.20 , pp. 386-393
    • Karlsson, S.C.1
  • 85
    • 84951907684 scopus 로고    scopus 로고
    • Immunomodulatory agent lenalidomide enhances antitumor functions of chimeric receptor-modified t cells in vitro and in vivo [abstract]
    • Pavel, O. et al. Immunomodulatory agent lenalidomide enhances antitumor functions of chimeric receptor-modified t cells in vitro and in vivo [abstract]. Blood 124, a805 (2014).
    • (2014) Blood , vol.124 , pp. a805
    • Pavel, O.1
  • 86
    • 84886397930 scopus 로고    scopus 로고
    • Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells
    • John, L. B. et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin. Cancer Res. 19, 5636-5646 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 5636-5646
    • John, L.B.1
  • 87
    • 84930458778 scopus 로고    scopus 로고
    • Infusion of donor-derived CD19-redirected-virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase i study [abstract]
    • Cruz, C. R. et al. Infusion of donor-derived CD19-redirected-virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase I study [abstract]. Blood 122, a152 (2013).
    • (2013) Blood , vol.122 , pp. a152
    • Cruz, C.R.1
  • 88
    • 84937406305 scopus 로고    scopus 로고
    • Therapy of B cell malignancies with CD19-specific chimeric antigen receptor-modified T cells of defined subset composition [abstract]
    • Turtle, C. J. et al. Therapy of B cell malignancies with CD19-specific chimeric antigen receptor-modified T cells of defined subset composition [abstract]. Blood 124, a384 (2014).
    • (2014) Blood , vol.124 , pp. a384
    • Turtle, C.J.1
  • 89
    • 84951905160 scopus 로고    scopus 로고
    • Multiplex genome editing as a platform for off-The-shelf" adoptive CAR T-cell immunotherapies [abstract]
    • Derniame, S. et al. Multiplex genome editing as a platform for "off-The-shelf" adoptive CAR T-cell immunotherapies [abstract]. Blood 124, a1111 (2014).
    • (2014) Blood , vol.124 , pp. a1111
    • Derniame, S.1
  • 90
    • 84862496486 scopus 로고    scopus 로고
    • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-Antigen-receptor and eliminate expression of endogenous TCR
    • Torikai, H. et al. A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-Antigen-receptor and eliminate expression of endogenous TCR. Blood 119, 5697-5705 (2012).
    • (2012) Blood , vol.119 , pp. 5697-5705
    • Torikai, H.1
  • 91
    • 84925607772 scopus 로고    scopus 로고
    • Adoptive cellular therapy: A race to the finish line
    • June, C. H., Riddell, S. R. & Schumacher, T. N. Adoptive cellular therapy: A race to the finish line. Sci. Transl. Med. 7, 280ps7 (2015).
    • (2015) Sci. Transl. Med , vol.7 , pp. 280ps7
    • June, C.H.1    Riddell, S.R.2    Schumacher, T.N.3
  • 92
    • 0029148633 scopus 로고
    • A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
    • Mack, M., Riethmuller, G. & Kufer, P. A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. Natl Acad. Sci. USA 92, 7021-7025 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 7021-7025
    • Mack, M.1    Riethmuller, G.2    Kufer, P.3
  • 93
    • 0343415665 scopus 로고    scopus 로고
    • A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
    • Loffler, A. et al. A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood 95, 2098-2103 (2000).
    • (2000) Blood , vol.95 , pp. 2098-2103
    • Loffler, A.1
  • 94
    • 0037143806 scopus 로고    scopus 로고
    • Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody
    • Dreier, T. et al. Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody. Int. J. Cancer 100, 690-697 (2002).
    • (2002) Int. J. Cancer , vol.100 , pp. 690-697
    • Dreier, T.1
  • 95
    • 28944434529 scopus 로고    scopus 로고
    • Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells
    • Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P. & Baeuerle, P. A. Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells. Mol. Immunol. 43, 763-771 (2006).
    • (2006) Mol. Immunol , vol.43 , pp. 763-771
    • Offner, S.1    Hofmeister, R.2    Romaniuk, A.3    Kufer, P.4    Baeuerle, P.A.5
  • 96
    • 33645007038 scopus 로고    scopus 로고
    • T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
    • Schlereth, B. et al. T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct. Cancer Immunol. Immunother. 55, 503-514 (2006).
    • (2006) Cancer Immunol. Immunother , vol.55 , pp. 503-514
    • Schlereth, B.1
  • 97
    • 3142652578 scopus 로고    scopus 로고
    • Minimal costimulatory requirements for T cell priming and TH1 differentiation: Activation of naive human T lymphocytes by tumor cells armed with bifunctional antibody constructs
    • Kufer, P. et al. Minimal costimulatory requirements for T cell priming and TH1 differentiation: Activation of naive human T lymphocytes by tumor cells armed with bifunctional antibody constructs. Cancer Immun. 1, 10 (2001).
    • (2001) Cancer Immun , vol.1 , pp. 10
    • Kufer, P.1
  • 98
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou, R. et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321, 974-977 (2008).
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1
  • 99
    • 64649103924 scopus 로고    scopus 로고
    • Mode of cytotoxic action of T cell-engaging BiTE antibody MT110
    • Haas, C. et al. Mode of cytotoxic action of T cell-engaging BiTE antibody MT110. Immunobiology 214, 441-453 (2009).
    • (2009) Immunobiology , vol.214 , pp. 441-453
    • Haas, C.1
  • 100
    • 3042802506 scopus 로고    scopus 로고
    • T-cell-mediated lysis of B cells induced by a CD19 × CD3 bispecific single-chain antibody is perforin dependent and death receptor independent
    • Gruen, M., Bommert, K. & Bargou, R. C. T-cell-mediated lysis of B cells induced by a CD19 × CD3 bispecific single-chain antibody is perforin dependent and death receptor independent. Cancer Immunol. Immunother. 53, 625-632 (2004).
    • (2004) Cancer Immunol. Immunother , vol.53 , pp. 625-632
    • Gruen, M.1    Bommert, K.2    Bargou, R.C.3
  • 101
    • 84863522243 scopus 로고    scopus 로고
    • Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
    • Klinger, M. et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood 119, 6226-6233 (2012).
    • (2012) Blood , vol.119 , pp. 6226-6233
    • Klinger, M.1
  • 103
    • 84929875600 scopus 로고    scopus 로고
    • Final results from a phase 1 study of blinatumomab in patients with relapsed/refractory non-Hodgkin's lymphoma
    • Goebeler, M. E. et al. Final results from a phase 1 study of blinatumomab in patients with relapsed/refractory non-Hodgkin's lymphoma. Hematol. Oncol. 31, 197 (2013).
    • (2013) Hematol. Oncol , vol.31 , pp. 197
    • Goebeler, M.E.1
  • 105
    • 84871491706 scopus 로고    scopus 로고
    • Long-Term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • Topp, M. S. et al. Long-Term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 120, 5185-5187 (2012).
    • (2012) Blood , vol.120 , pp. 5185-5187
    • Topp, M.S.1
  • 106
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp, M. S. et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J. Clin. Oncol. 29, 2493-2498 (2011).
    • (2011) J. Clin. Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1
  • 107
    • 84916639631 scopus 로고    scopus 로고
    • Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia
    • Topp, M. S. et al. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J. Clin. Oncol. 32, 4134-4140 (2014).
    • (2014) J. Clin. Oncol , vol.32 , pp. 4134-4140
    • Topp, M.S.1
  • 108
    • 84926099033 scopus 로고    scopus 로고
    • Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-Arm, phase 2 study
    • Topp, M. S. et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-Arm, phase 2 study. Lancet Oncol. 16, 57-66 (2015).
    • (2015) Lancet Oncol , vol.16 , pp. 57-66
    • Topp, M.S.1
  • 109
    • 84925719974 scopus 로고    scopus 로고
    • Treatment of relapsed/refractory diffuse large B-cell lymphoma with the Bispecific T-cell Engager (BiTE®) antibody construct blinatumomab: Primary analysis results from an open-label, phase 2 study [abstract]
    • Viardot, A. et al. Treatment of relapsed/refractory diffuse large B-cell lymphoma with the Bispecific T-cell Engager (BiTE®) antibody construct blinatumomab: primary analysis results from an open-label, phase 2 study [abstract]. Blood 124, a4460 (2014).
    • (2014) Blood , vol.124 , pp. a4460
    • Viardot, A.1
  • 110
    • 84925461494 scopus 로고    scopus 로고
    • Long-Term follow-up of serum immunoglobulin levels in blinatumomab-Treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia
    • Zugmaier, G. et al. Long-Term follow-up of serum immunoglobulin levels in blinatumomab-Treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia. Blood Cancer J. 4, 244 (2014).
    • (2014) Blood Cancer J , vol.4 , pp. 244
    • Zugmaier, G.1
  • 111
    • 79952280278 scopus 로고    scopus 로고
    • CD3/CD19 bispecific BiTE antibody blinatumomab treatment of non-Hodgkin lymphoma (NHL) patients: 60 μg/m2/d by continuous infusion is tolerable and results in durable responses [abstract 0559]
    • Goebeler, M. et al. CD3/CD19 bispecific BiTE antibody blinatumomab treatment of non-Hodgkin lymphoma (NHL) patients: 60 μg/m2/d by continuous infusion is tolerable and results in durable responses [abstract 0559]. Haematologica 95 (Suppl. 2), 230 (2010).
    • (2011) Haematologica , vol.95 , pp. 230
    • Goebeler, M.1
  • 112
    • 84873077857 scopus 로고    scopus 로고
    • Treatment of patients with non-Hodgkin lymphoma (NHL) with CD19/CD3 bispecific antibody blinatumomab (MT103): Double-step dose increase to continuous infusion of 60 μg/m2/d is tolerable and highly effective [abstract]
    • Viardot, A. et al. Treatment of patients with non-Hodgkin lymphoma (NHL) with CD19/CD3 bispecific antibody blinatumomab (MT103): double-step dose increase to continuous infusion of 60 μg/m2/d is tolerable and highly effective [abstract]. Blood 116, a2880 (2010).
    • (2011) Blood , vol.116 , pp. a2880
    • Viardot, A.1
  • 113
    • 0027197493 scopus 로고
    • Diabodies: Small bivalent and bispecific antibody fragments
    • Holliger, P., Prospero, T. & Winter, G. "Diabodies": small bivalent and bispecific antibody fragments. Proc. Natl Acad. Sci. USA 90, 6444-6448 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 114
    • 79955970356 scopus 로고    scopus 로고
    • Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
    • Moore, P. A. et al. Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood 117, 4542-4551 (2011).
    • (2011) Blood , vol.117 , pp. 4542-4551
    • Moore, P.A.1
  • 115
    • 0033569478 scopus 로고    scopus 로고
    • Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics
    • Kipriyanov, S. M. et al. Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics. J. Mol. Biol. 293, 41-56 (1999).
    • (1999) J. Mol. Biol , vol.293 , pp. 41-56
    • Kipriyanov, S.M.1
  • 116
  • 117
    • 77954757304 scopus 로고    scopus 로고
    • Effector cell recruitment with novel Fv-based dual-Affinity re-Targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion
    • Johnson, S. et al. Effector cell recruitment with novel Fv-based dual-Affinity re-Targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion. J. Mol. Biol. 399, 436-449 (2010).
    • (2011) J. Mol. Biol , vol.399 , pp. 436-449
    • Johnson, S.1
  • 118
    • 84933505755 scopus 로고    scopus 로고
    • A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma
    • Rothe, A. et al. A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma. Blood 125, 4024-4031 (2015).
    • (2015) Blood , vol.125 , pp. 4024-4031
    • Rothe, A.1
  • 119
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 120
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-Associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong, H. et al. Tumor-Associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat. Med. 8, 793-800 (2002).
    • (2002) Nat. Med , vol.8 , pp. 793-800
    • Dong, H.1
  • 121
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel, T. J. et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9, 562-567 (2003).
    • (2003) Nat. Med , vol.9 , pp. 562-567
    • Curiel, T.J.1
  • 122
    • 0024556845 scopus 로고
    • Phenotypic expression of histocompatibility antigens in human primary tumours and metastases
    • Ruiz-Cabello, F. et al. Phenotypic expression of histocompatibility antigens in human primary tumours and metastases. Clin. Exp. Metastasis 7, 213-226 (1989).
    • (1989) Clin. Exp. Metastasis , vol.7 , pp. 213-226
    • Ruiz-Cabello, F.1
  • 123
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 124
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
    • Linsley, P. S. et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4, 535-543 (1996).
    • (1996) Immunity , vol.4 , pp. 535-543
    • Linsley, P.S.1
  • 125
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley, P. S. et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1, 793-801 (1994).
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1
  • 126
    • 16044371193 scopus 로고    scopus 로고
    • CD28/B7 regulation of TH1 and TH2 subsets in the development of autoimmune diabetes
    • Lenschow, D. J. et al. CD28/B7 regulation of TH1 and TH2 subsets in the development of autoimmune diabetes. Immunity 5, 285-293 (1996).
    • (1996) Immunity , vol.5 , pp. 285-293
    • Lenschow, D.J.1
  • 127
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry, R. V. et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell Biol. 25, 9543-9553 (2005).
    • (2005) Mol. Cell Biol , vol.25 , pp. 9543-9553
    • Parry, R.V.1
  • 128
    • 3242677686 scopus 로고    scopus 로고
    • PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
    • Latchman, Y. E. et al. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl Acad. Sci. USA 101, 10691-10696 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 10691-10696
    • Latchman, Y.E.1
  • 129
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999).
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 130
    • 34948904394 scopus 로고    scopus 로고
    • Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice
    • Gotsman, I. et al. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J. Clin. Invest. 117, 2974-2982 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 2974-2982
    • Gotsman, I.1
  • 131
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 132
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1
  • 133
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    • Green, M. R. et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 116, 3268-3277 (2010).
    • (2011) Blood , vol.116 , pp. 3268-3277
    • Green, M.R.1
  • 134
    • 84879866976 scopus 로고    scopus 로고
    • PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-Associated malignancies
    • Chen, B. J. et al. PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-Associated malignancies. Clin. Cancer Res. 19, 3462-3473 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 3462-3473
    • Chen, B.J.1
  • 135
    • 79960318715 scopus 로고    scopus 로고
    • Programmed death ligand 1 is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-Associated T cells
    • Andorsky, D. J. et al. Programmed death ligand 1 is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-Associated T cells. Clin. Cancer Res. 17, 4232-4244 (2011).
    • (2011) Clin. Cancer Res , vol.17 , pp. 4232-4244
    • Andorsky, D.J.1
  • 137
    • 84858206832 scopus 로고    scopus 로고
    • Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: Implications for targeted therapy
    • Green, M. R. et al. Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy. Clin. Cancer Res. 18, 1611-1618 (2012).
    • (2012) Clin. Cancer Res , vol.18 , pp. 1611-1618
    • Green, M.R.1
  • 138
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
    • Spranger, S. et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci. Transl. Med. 5, 200ra116 (2013).
    • (2013) Sci. Transl. Med , vol.5 , pp. 200ra116
    • Spranger, S.1
  • 139
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube, J. M. et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin. Cancer Res. 20, 5064-5074 (2014).
    • (2014) Clin. Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1
  • 140
    • 79952816655 scopus 로고    scopus 로고
    • MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
    • Steidl, C. et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature 471, 377-381 (2011).
    • (2011) Nature , vol.471 , pp. 377-381
    • Steidl, C.1
  • 141
    • 0343820067 scopus 로고    scopus 로고
    • Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells
    • Joos, S. et al. Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res. 60, 549-552 (2000).
    • (2000) Cancer Res , vol.60 , pp. 549-552
    • Joos, S.1
  • 142
    • 49649114804 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger, R. et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 14, 3044-3051 (2008).
    • (2008) Clin. Cancer Res , vol.14 , pp. 3044-3051
    • Berger, R.1
  • 143
    • 84890096527 scopus 로고    scopus 로고
    • Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: Results of an international phase II trial
    • Armand, P. et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. J. Clin. Oncol. 31, 4199-4206 (2013).
    • (2013) J. Clin. Oncol , vol.31 , pp. 4199-4206
    • Armand, P.1
  • 144
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
    • Westin, J. R. et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial. Lancet Oncol. 15, 69-77 (2014).
    • (2014) Lancet Oncol , vol.15 , pp. 69-77
    • Westin, J.R.1
  • 145
    • 84951908515 scopus 로고    scopus 로고
    • Nivolumab in patients with relapsed or refractory lymphoid malignancies and classical Hodgkin lymphoma: Updated results of a phase i study (CA209-039) [abstract]
    • Timmerman, J. et al. Nivolumab in patients with relapsed or refractory lymphoid malignancies and classical Hodgkin lymphoma: updated results of a phase I study (CA209-039) [abstract]. Hematol. Oncol. 33, a010 (2015).
    • (2015) Hematol. Oncol , vol.33 , pp. a010
    • Timmerman, J.1
  • 146
    • 84938602784 scopus 로고    scopus 로고
    • A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies [abstract]
    • Garcia-Manero, G. et al. A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies [abstract]. J. Clin. Oncol. 32 (5s Suppl.), TPS3116 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.5 , pp. TPS3116
    • Garcia-Manero, G.1
  • 147
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01953692 (2015).
    • (2015) ClinicalTrials.gov
  • 148
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 Blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell, S. M. et al. PD-1 Blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372, 311-319 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 311-319
    • Ansell, S.M.1
  • 149
    • 84929410618 scopus 로고    scopus 로고
    • Nivolumab in patients with relapsed or refractory Hodgkin lymphoma-preliminary safety, efficacy and biomarker results of a phase i study [abstract]
    • Armand, P. et al. Nivolumab in patients with relapsed or refractory Hodgkin lymphoma-preliminary safety, efficacy and biomarker results of a phase I study [abstract]. Blood 124, a289 (2014).
    • (2014) Blood , vol.124 , pp. a289
    • Armand, P.1
  • 150
    • 84925717350 scopus 로고    scopus 로고
    • PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical Hodgkin lymphoma after brentuximab vedotin failure: Preliminary results from a phase 1b study (KEYNOTE-013) [abstract]
    • Moskowitz, C. H. et al. PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical Hodgkin lymphoma after brentuximab vedotin failure: preliminary results from a phase 1b study (KEYNOTE-013) [abstract]. Blood 124, a290 (2014).
    • (2014) Blood , vol.124 , pp. a290
    • Moskowitz, C.H.1
  • 151
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 152
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02220842?term=NCT02220842&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 153
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01775631 (2015).
    • (2015) ClinicalTrials.gov
  • 154
    • 70350244852 scopus 로고    scopus 로고
    • Phase i study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma
    • Ansell, S. M. et al. Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. Clin. Cancer Res. 15, 6446-6453 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 6446-6453
    • Ansell, S.M.1
  • 155
    • 84915804784 scopus 로고    scopus 로고
    • Practical management of immune-related adverse events from immune checkpoint protein antibodies for the oncologist
    • Weber, J. S. Practical management of immune-related adverse events from immune checkpoint protein antibodies for the oncologist. Am. Soc. Clin. Oncol. Educ. Book 2012, 174-177 (2012).
    • (2012) Am. Soc. Clin. Oncol. Educ. Book , vol.2012 , pp. 174-177
    • Weber, J.S.1
  • 156
    • 84937605130 scopus 로고    scopus 로고
    • Toxicities of immunotherapy for the practitioner
    • Weber, J. S., Yang, J. C., Atkins, M. B. & Disis, M. L. Toxicities of immunotherapy for the practitioner. J. Clin. Oncol. 33, 2092-2099 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. 2092-2099
    • Weber, J.S.1    Yang, J.C.2    Atkins, M.B.3    Disis, M.L.4
  • 157
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23-34 (2015).
    • (2015) N. Engl. J. Med , vol.373 , pp. 23-34
    • Larkin, J.1
  • 158
    • 84951906917 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Yervoy (ipilimumab)
    • Bristol-Myers Squibb Yervoy (ipilimumab): Immune-mediated adverse reaction management guide [online], https://www.hcp.yervoy.com/pdf/rems-management-guide.pdf.
    • Immune-mediated Adverse Reaction Management Guide
  • 159
    • 84925587926 scopus 로고    scopus 로고
    • Preliminary results of a phase i study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies [abstract]
    • Lesokhin, A. M. et al. Preliminary results of a phase I study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies [abstract]. Blood 124, a291 (2014).
    • (2014) Blood , vol.124 , pp. a291
    • Lesokhin, A.M.1
  • 160
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02038946?term=NCT02038946&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 161
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02038933?term=NCT02038933&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 162
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02181738?term=NCT02181738&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 163
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01592370?term=NCT01592370&rank=1 (2015).
    • (2015) ClinicalTrials.gov
  • 164
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon, E. B. et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N. Engl. J. Med. 372, 2018-2028 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1
  • 165
    • 84939227614 scopus 로고    scopus 로고
    • Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers
    • Carbognin, L. et al. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS ONE 10, e0130142 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0130142
    • Carbognin, L.1
  • 166
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189-2199 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 2189-2199
    • Snyder, A.1
  • 167
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A. et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1
  • 168
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568-571 (2014).
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1
  • 169
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 170
    • 84923268725 scopus 로고    scopus 로고
    • Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells
    • Reichel, J. et al. Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells. Blood 125, 1061-1072 (2015).
    • (2015) Blood , vol.125 , pp. 1061-1072
    • Reichel, J.1
  • 171
    • 84926620551 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1
    • Lin, J. H. et al. Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1. Blood 125, 2228-2238 (2015).
    • (2015) Blood , vol.125 , pp. 2228-2238
    • Lin, J.H.1
  • 172
    • 61849165013 scopus 로고    scopus 로고
    • CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
    • Bashey, A. et al. CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Blood 113, 1581-1588 (2009).
    • (2009) Blood , vol.113 , pp. 1581-1588
    • Bashey, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.