-
1
-
-
0025100777
-
Graft-versus-leukemia reactions after bone marrow transplantation
-
Horowitz, M. et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75, 555-562 (1990).
-
(1990)
Blood
, vol.75
, pp. 555-562
-
-
Horowitz, M.1
-
2
-
-
17144455839
-
IDEC-C2B8: Results of a phase i multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma
-
Maloney, D. G. et al. IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J. Clin. Oncol. 15, 3266-3274 (1997).
-
(1997)
J. Clin. Oncol
, vol.15
, pp. 3266-3274
-
-
Maloney, D.G.1
-
3
-
-
1842368507
-
IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
-
Maloney, D. G. et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 90, 2188-2195 (1997).
-
(1997)
Blood
, vol.90
, pp. 2188-2195
-
-
Maloney, D.G.1
-
4
-
-
0037165261
-
CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
-
Coiffier, B. et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 235-242 (2002).
-
(2002)
N. Engl. J. Med
, vol.346
, pp. 235-242
-
-
Coiffier, B.1
-
5
-
-
84858683311
-
Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation
-
Doubrovina, E. et al. Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Blood 119, 2644-2656 (2012).
-
(2012)
Blood
, vol.119
, pp. 2644-2656
-
-
Doubrovina, E.1
-
6
-
-
84875975917
-
Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-Transplant patients
-
Chapuis, A. G. et al. Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-Transplant patients. Sci. Transl. Med. 5, 174ra27 (2013).
-
(2013)
Sci. Transl. Med
, vol.5
, pp. 174ra27
-
-
Chapuis, A.G.1
-
7
-
-
0032170108
-
Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients
-
Rooney, C. M. et al. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92, 1549-1555 (1998).
-
(1998)
Blood
, vol.92
, pp. 1549-1555
-
-
Rooney, C.M.1
-
8
-
-
77649221824
-
Long-Term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
-
Heslop, H. E. et al. Long-Term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood 115, 925-935 (2010).
-
(2011)
Blood
, vol.115
, pp. 925-935
-
-
Heslop, H.E.1
-
9
-
-
84898647949
-
Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins
-
Bollard, C. M. et al. Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins. J. Clin. Oncol. 32, 798-808 (2014).
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 798-808
-
-
Bollard, C.M.1
-
10
-
-
0027471898
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors
-
Eshhar, Z., Waks, T., Gross, G. & Schindler, D. G. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc. Natl Acad. Sci. USA 90, 720-724 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 720-724
-
-
Eshhar, Z.1
Waks, T.2
Gross, G.3
Schindler, D.G.4
-
11
-
-
0032534575
-
Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and FcεRI-signaling γ subunit
-
Annenkov, A. E., Moyes, S. P., Eshhar, Z., Mageed, R. A. & Chernajovsky, Y. Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and FcεRI-signaling γ subunit. J. Immunol. 161, 6604-6613 (1998).
-
(1998)
J. Immunol
, vol.161
, pp. 6604-6613
-
-
Annenkov, A.E.1
Moyes, S.P.2
Eshhar, Z.3
Mageed, R.A.4
Chernajovsky, Y.5
-
12
-
-
0035159470
-
Redirecting mouse CTL against colon carcinoma: Superior signaling efficacy of single-chain variable domain chimeras containing TCR-ζ vs FcεRI-γ
-
Haynes, N. M. et al. Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-ζ vs FcεRI-γ. J. Immunol. 166, 182-187 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 182-187
-
-
Haynes, N.M.1
-
13
-
-
0024834988
-
Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-Type specificity
-
Gross, G., Waks, T. & Eshhar, Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-Type specificity. Proc. Natl Acad. Sci. USA 86, 10024-10028 (1989).
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 10024-10028
-
-
Gross, G.1
Waks, T.2
Eshhar, Z.3
-
14
-
-
0024293979
-
Single-chain antigen-binding proteins
-
Bird, R. E. et al. Single-chain antigen-binding proteins. Science 242, 423-426 (1988).
-
(1988)
Science
, vol.242
, pp. 423-426
-
-
Bird, R.E.1
-
15
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
-
Huston, J. S. et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl Acad. Sci. USA 85, 5879-5883 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
-
16
-
-
1542698957
-
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
-
Orlandi, R., Gussow, D. H., Jones, P. T. & Winter, G. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl Acad. Sci. USA 86, 3833-3837 (1989).
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 3833-3837
-
-
Orlandi, R.1
Gussow, D.H.2
Jones, P.T.3
Winter, G.4
-
17
-
-
63649112916
-
Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy
-
Hollyman, D. et al. Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J. Immunother. 32, 169-180 (2009).
-
(2009)
J. Immunother
, vol.32
, pp. 169-180
-
-
Hollyman, D.1
-
18
-
-
60749131428
-
Retroviral transduction of murine primary T lymphocytes
-
Lee, J., Sadelain, M. & Brentjens, R. Retroviral transduction of murine primary T lymphocytes. Methods Mol. Biol. 506, 83-96 (2009).
-
(2009)
Methods Mol. Biol
, vol.506
, pp. 83-96
-
-
Lee, J.1
Sadelain, M.2
Brentjens, R.3
-
19
-
-
37149001207
-
Multifactorial optimization of gammaretroviral gene transfer into human T lymphocytes for clinical application
-
Quintas-Cardama, A. et al. Multifactorial optimization of gammaretroviral gene transfer into human T lymphocytes for clinical application. Hum. Gene Ther. 18, 1253-1260 (2007).
-
(2007)
Hum. Gene Ther
, vol.18
, pp. 1253-1260
-
-
Quintas-Cardama, A.1
-
20
-
-
34848842554
-
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
-
Brentjens, R. J. et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin. Cancer Res. 13, 5426-5435 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 5426-5435
-
-
Brentjens, R.J.1
-
21
-
-
0037348324
-
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
-
Brentjens, R. J. et al. Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat. Med. 9, 279-286 (2003).
-
(2003)
Nat. Med
, vol.9
, pp. 279-286
-
-
Brentjens, R.J.1
-
22
-
-
39849086801
-
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
-
Huang, X. et al. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol. Ther. 16, 580-589 (2008).
-
(2008)
Mol. Ther
, vol.16
, pp. 580-589
-
-
Huang, X.1
-
23
-
-
68449088813
-
Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor
-
Kochenderfer, J. N. et al. Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor. J. Immunother. 32, 689-702 (2009).
-
(2009)
J. Immunother
, vol.32
, pp. 689-702
-
-
Kochenderfer, J.N.1
-
24
-
-
79955517235
-
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
-
Savoldo, B. et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J. Clin. Invest. 121, 1822-1826 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1822-1826
-
-
Savoldo, B.1
-
25
-
-
84868221578
-
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale
-
Wang, X. et al. Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale. J. Immunother. 35, 689-701 (2012).
-
(2012)
J. Immunother
, vol.35
, pp. 689-701
-
-
Wang, X.1
-
26
-
-
70350726110
-
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
-
Milone, M. C. et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol. Ther. 17, 1453-1464 (2009).
-
(2009)
Mol. Ther
, vol.17
, pp. 1453-1464
-
-
Milone, M.C.1
-
27
-
-
84862954607
-
Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells
-
Terakura, S. et al. Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells. Blood 119, 72-82 (2012).
-
(2012)
Blood
, vol.119
, pp. 72-82
-
-
Terakura, S.1
-
28
-
-
0026339245
-
Preparation and characterization of a chimeric CD19 monoclonal antibody
-
Zola, H. et al. Preparation and characterization of a chimeric CD19 monoclonal antibody. Immunol. Cell Biol. 69, 411-422 (1991).
-
(1991)
Immunol. Cell Biol
, vol.69
, pp. 411-422
-
-
Zola, H.1
-
29
-
-
0029033815
-
Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen
-
Bejcek, B. E. et al. Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen. Cancer Res. 55, 2346-2351 (1995).
-
(1995)
Cancer Res
, vol.55
, pp. 2346-2351
-
-
Bejcek, B.E.1
-
30
-
-
0344157387
-
Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma
-
Nicholson, I. C. et al. Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma. Mol. Immunol. 34, 1157-1165 (1997).
-
(1997)
Mol. Immunol
, vol.34
, pp. 1157-1165
-
-
Nicholson, I.C.1
-
31
-
-
3042551216
-
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
-
Imai, C. et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 18, 676-684 (2004).
-
(2004)
Leukemia
, vol.18
, pp. 676-684
-
-
Imai, C.1
-
32
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
Till, B. G. et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 112, 2261-2271 (2008).
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
-
33
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
Jensen, M. C. et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol. Blood Marrow Transplant. 16, 1245-1256 (2010).
-
(2011)
Biol. Blood Marrow Transplant
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
-
34
-
-
34548485103
-
Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
-
Wang, J. et al. Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum. Gene Ther. 18, 712-725 (2007).
-
(2007)
Hum. Gene Ther
, vol.18
, pp. 712-725
-
-
Wang, J.1
-
35
-
-
0036137615
-
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor
-
Maher, J., Brentjens, R. J., Gunset, G., Riviere, I. & Sadelain, M. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor. Nat. Biotechnol. 20, 70-75 (2002).
-
(2002)
Nat. Biotechnol
, vol.20
, pp. 70-75
-
-
Maher, J.1
Brentjens, R.J.2
Gunset, G.3
Riviere, I.4
Sadelain, M.5
-
36
-
-
84890117209
-
Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 super-stimulation
-
Hombach, A. A., Rappl, G. & Abken, H. Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 "super-stimulation". Mol. Ther. 21, 2268-2277 (2013).
-
(2013)
Mol. Ther
, vol.21
, pp. 2268-2277
-
-
Hombach, A.A.1
Rappl, G.2
Abken, H.3
-
37
-
-
62549097817
-
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
-
Carpenito, C. et al. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc. Natl Acad. Sci. USA 106, 3360-3365 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3360-3365
-
-
Carpenito, C.1
-
38
-
-
76349087378
-
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
-
Zhong, X. S., Matsushita, M., Plotkin, J., Riviere, I. & Sadelain, M. Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol. Ther. 18, 413-420 (2010).
-
(2011)
Mol. Ther
, vol.18
, pp. 413-420
-
-
Zhong, X.S.1
Matsushita, M.2
Plotkin, J.3
Riviere, I.4
Sadelain, M.5
-
39
-
-
74949124101
-
4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies
-
Tammana, S. et al. 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies. Hum. Gene Ther. 21, 75-86 (2010).
-
(2011)
Hum. Gene Ther
, vol.21
, pp. 75-86
-
-
Tammana, S.1
-
40
-
-
84897542755
-
CD28z CARs and armored CARs
-
Pegram, H. J., Park, J. H. & Brentjens, R. J. CD28z CARs and armored CARs. Cancer J. 20, 127-133 (2014).
-
(2014)
Cancer J
, vol.20
, pp. 127-133
-
-
Pegram, H.J.1
Park, J.H.2
Brentjens, R.J.3
-
41
-
-
84926433030
-
Improving the safety of cell therapy products by suicide gene transfer
-
Jones, B. S., Lamb, L. S., Goldman, F. & Di Stasi, A. Improving the safety of cell therapy products by suicide gene transfer. Front. Pharmacol. 5, 254 (2014).
-
(2014)
Front. Pharmacol
, vol.5
, pp. 254
-
-
Jones, B.S.1
Lamb, L.S.2
Goldman, F.3
Di Stasi, A.4
-
42
-
-
67650638846
-
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
-
Di Stasi, A. et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood 113, 6392-6402 (2009).
-
(2009)
Blood
, vol.113
, pp. 6392-6402
-
-
Di Stasi, A.1
-
43
-
-
0036428790
-
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
-
Kershaw, M. H. et al. Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum. Gene Ther. 13, 1971-1980 (2002).
-
(2002)
Hum. Gene Ther
, vol.13
, pp. 1971-1980
-
-
Kershaw, M.H.1
-
44
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-Targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
Brentjens, R. J. et al. Safety and persistence of adoptively transferred autologous CD19-Targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 118, 4817-4828 (2011).
-
(2011)
Blood
, vol.118
, pp. 4817-4828
-
-
Brentjens, R.J.1
-
45
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
-
Kalos, M. et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl. Med. 3, 95ra73 (2011).
-
(2011)
Sci. Transl. Med
, vol.3
, pp. 95ra73
-
-
Kalos, M.1
-
46
-
-
78549278144
-
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
-
Kochenderfer, J. N. et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116, 4099-4102 (2010).
-
(2011)
Blood
, vol.116
, pp. 4099-4102
-
-
Kochenderfer, J.N.1
-
47
-
-
84924799045
-
Manufacture of tumor-And virus-specific T lymphocytes for adoptive cell therapies
-
Wang, X. & Riviere, I. Manufacture of tumor-And virus-specific T lymphocytes for adoptive cell therapies. Cancer Gene Ther. 22, 85-94 (2015).
-
(2015)
Cancer Gene Ther
, vol.22
, pp. 85-94
-
-
Wang, X.1
Riviere, I.2
-
48
-
-
84876005284
-
CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
-
Brentjens, R. J. et al. CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci. Transl. Med. 5, 177ra38 (2013).
-
(2013)
Sci. Transl. Med
, vol.5
, pp. 177ra38
-
-
Brentjens, R.J.1
-
49
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila, M. L. et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med. 6, 224ra25 (2014).
-
(2014)
Sci. Transl. Med
, vol.6
, pp. 224ra25
-
-
Davila, M.L.1
-
50
-
-
84951908950
-
CD19-Targeted 19-28z CAR modified autologous T cells induce high rates of complete remission and durable responses in adult patients with relapsed, refractory B-cell ALL [abstract]
-
Park, J. H. et al. CD19-Targeted 19-28z CAR modified autologous T cells induce high rates of complete remission and durable responses in adult patients with relapsed, refractory B-cell ALL [abstract]. Blood 124, a382 (2014).
-
(2014)
Blood
, vol.124
, pp. a382
-
-
Park, J.H.1
-
51
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude, S. L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507-1517 (2014).
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
-
52
-
-
84923019006
-
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
-
Lee, D. W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial. Lancet 385, 517-528 (2015).
-
(2015)
Lancet
, vol.385
, pp. 517-528
-
-
Lee, D.W.1
-
53
-
-
33846869976
-
Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); An MRC UKALL12/ECOG 2993 study
-
Fielding, A. K. et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 109, 944-950 (2007).
-
(2007)
Blood
, vol.109
, pp. 944-950
-
-
Fielding, A.K.1
-
54
-
-
84866094086
-
Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation
-
Gökbuget, N. et al. Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation. Blood 120, 2032-2041 (2012).
-
(2012)
Blood
, vol.120
, pp. 2032-2041
-
-
Gökbuget, N.1
-
55
-
-
79955694768
-
Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission
-
Kantarjian, H. M. et al. Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. Leuk. Lymphoma 51, 475-480 (2010).
-
(2011)
Leuk. Lymphoma
, vol.51
, pp. 475-480
-
-
Kantarjian, H.M.1
-
56
-
-
84951909134
-
Validation of donor derived virus specific T-lymphocytes genetically modified to target the CD19 antigen for the treatment of relapsed Leukemia
-
Curran, K. J. et al. Validation of donor derived virus specific T-lymphocytes genetically modified to target the CD19 antigen for the treatment of relapsed Leukemia. Mol. Ther. 19, S90 (2011).
-
(2011)
Mol. Ther
, vol.19
, pp. S90
-
-
Curran, K.J.1
-
57
-
-
84890827981
-
Donor-derived CD19-Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
-
Kochenderfer, J. N. et al. Donor-derived CD19-Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood 122, 4129-4139 (2013).
-
(2013)
Blood
, vol.122
, pp. 4129-4139
-
-
Kochenderfer, J.N.1
-
58
-
-
84886583769
-
Impact of the conditioning chemotherapy on outcomes in adoptive T cell therapy: Results from a phase i clinical trial of autologous CD19-Targeted T cells for patients with relapsed CLL [abstract]
-
Park, J. H. et al. Impact of the conditioning chemotherapy on outcomes in adoptive T cell therapy: results from a phase I clinical trial of autologous CD19-Targeted T cells for patients with relapsed CLL [abstract]. Blood 120, a1797 (2012).
-
(2012)
Blood
, vol.120
, pp. a1797
-
-
Park, J.H.1
-
59
-
-
84941768764
-
Phase i trial of autologous CD19-Targeted CAR-modified T cells as consolidation after purine analog-based first-line therapy in patients with previously untreated CLL [abstract]
-
Park, J. H. et al. Phase I trial of autologous CD19-Targeted CAR-modified T cells as consolidation after purine analog-based first-line therapy in patients with previously untreated CLL [abstract]. J. Clin. Oncol. 32 (5s Suppl.), a7020 (2014).
-
(2014)
J. Clin. Oncol
, vol.32
, Issue.5
, pp. a7020
-
-
Park, J.H.1
-
60
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. & June, C. H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365, 725-733 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
Bagg, A.4
June, C.H.5
-
61
-
-
84897569379
-
Chimeric antigen receptor modified t cells directed against CD19 (CTL019 cells) have long-Term persistence and induce durable responses in relapsed, refractory CLL [abstract]
-
Porter, D. L. et al. Chimeric antigen receptor modified t cells directed against CD19 (CTL019 cells) have long-Term persistence and induce durable responses in relapsed, refractory CLL [abstract]. Blood 122, a4162 (2013).
-
(2013)
Blood
, vol.122
, pp. a4162
-
-
Porter, D.L.1
-
62
-
-
84927768738
-
Randomized, phase II dose optimization study of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed, refractory CLL [abstract]
-
Porter, D. L. et al. Randomized, phase II dose optimization study of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed, refractory CLL [abstract]. Blood 124, a1982 (2014).
-
(2014)
Blood
, vol.124
, pp. a1982
-
-
Porter, D.L.1
-
63
-
-
84863337890
-
B-cell depletion and remissions of malignancy along with cytokine-Associated toxicity in a clinical trial of anti-CD19 chimeric-Antigen-receptor-Transduced T cells
-
Kochenderfer, J. N. et al. B-cell depletion and remissions of malignancy along with cytokine-Associated toxicity in a clinical trial of anti-CD19 chimeric-Antigen-receptor-Transduced T cells. Blood 119, 2709-2720 (2012).
-
(2012)
Blood
, vol.119
, pp. 2709-2720
-
-
Kochenderfer, J.N.1
-
64
-
-
84923118622
-
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
-
Kochenderfer, J. N. et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J. Clin. Oncol. 33, 540-549 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 540-549
-
-
Kochenderfer, J.N.1
-
65
-
-
84927653490
-
Anti-CD19 CAR T cells administered after low-dose chemotherapy can induce remissions of chemotherapy-refractory diffuse large B-cell lymphoma [abstract]
-
Kochenderfer, J. N. et al. Anti-CD19 CAR T cells administered after low-dose chemotherapy can induce remissions of chemotherapy-refractory diffuse large B-cell lymphoma [abstract]. Blood 124, a550 (2014).
-
(2014)
Blood
, vol.124
, pp. a550
-
-
Kochenderfer, J.N.1
-
66
-
-
84944875841
-
Phase IIa trial of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+ lymphomas [abstract]
-
Schuster, S. J. et al. Phase IIa trial of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+ lymphomas [abstract]. Blood 124, a3087 (2014).
-
(2014)
Blood
, vol.124
, pp. a3087
-
-
Schuster, S.J.1
-
67
-
-
84937437102
-
Interim safety analysis: A phase i trial of high dose therapy and autologous stem cell transplantation followed by infusion of chimeric antigen receptor modified T-cells (19-28z CAR-T) directed against CD19+ B-cells for relapsed and refractory aggressive B cell non-Hodgkin lymphoma (B-NHL) [abstract]
-
Sauter, C. S. et al. Interim safety analysis: A phase I trial of high dose therapy and autologous stem cell transplantation followed by infusion of chimeric antigen receptor modified T-cells (19-28z CAR-T) directed against CD19+ B-cells for relapsed and refractory aggressive B cell non-Hodgkin lymphoma (B-NHL) [abstract]. Blood 124, a677 (2014).
-
(2014)
Blood
, vol.124
, pp. a677
-
-
Sauter, C.S.1
-
68
-
-
84904097189
-
Current concepts in the diagnosis and management of cytokine release syndrome
-
Lee, D. W. et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood 124, 188-195 (2014).
-
(2014)
Blood
, vol.124
, pp. 188-195
-
-
Lee, D.W.1
-
69
-
-
84897568616
-
Managing cytokine release syndrome associated with novel T cell-engaging therapies
-
Maude, S. L., Barrett, D., Teachey, D. T. & Grupp, S. A. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 20, 119-122 (2014).
-
(2014)
Cancer J
, vol.20
, pp. 119-122
-
-
Maude, S.L.1
Barrett, D.2
Teachey, D.T.3
Grupp, S.A.4
-
70
-
-
84897533766
-
CD19-CAR trials
-
Ramos, C. A., Savoldo, B. & Dotti, G. CD19-CAR trials. Cancer J. 20, 112-118 (2014).
-
(2014)
Cancer J
, vol.20
, pp. 112-118
-
-
Ramos, C.A.1
Savoldo, B.2
Dotti, G.3
-
71
-
-
84933510694
-
CD19-Targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
-
Maude, S. L., Teachey, D. T., Porter, D. L. & Grupp, S. A. CD19-Targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood 125, 4017-4023 (2015).
-
(2015)
Blood
, vol.125
, pp. 4017-4023
-
-
Maude, S.L.1
Teachey, D.T.2
Porter, D.L.3
Grupp, S.A.4
-
72
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
Grupp, S. A. et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 368, 1509-1518 (2013).
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 1509-1518
-
-
Grupp, S.A.1
-
73
-
-
84951905321
-
Immunotherapy with CD19-specific chimeric antigen receptor (CAR)-modified T cells of defined subset composition [abstract]
-
Turtle, C. J. et al. Immunotherapy with CD19-specific chimeric antigen receptor (CAR)-modified T cells of defined subset composition [abstract]. J. Clin. Oncol. 33 (Suppl.), a3006 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. a3006
-
-
Turtle, C.J.1
-
74
-
-
80051589534
-
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
-
Wang, X. et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood 118, 1255-1263 (2011).
-
(2011)
Blood
, vol.118
, pp. 1255-1263
-
-
Wang, X.1
-
75
-
-
80455162464
-
Inducible apoptosis as a safety switch for adoptive cell therapy
-
Di Stasi, A. et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N. Engl. J. Med. 365, 1673-1683 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 1673-1683
-
-
Di Stasi, A.1
-
76
-
-
79955980426
-
Vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
-
Giordano Attianese, G. M. et al. In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood 117, 4736-4745 (2011).
-
(2011)
Blood
, vol.117
, pp. 4736-4745
-
-
Giordano Attianese, G.M.1
-
77
-
-
84962304846
-
Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells
-
Berger, C. et al. Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells. Cancer Immunol. Res. 3, 206-216 (2015).
-
(2015)
Cancer Immunol. Res
, vol.3
, pp. 206-216
-
-
Berger, C.1
-
78
-
-
84874027123
-
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
-
Haso, W. et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood 121, 1165-1174 (2013).
-
(2013)
Blood
, vol.121
, pp. 1165-1174
-
-
Haso, W.1
-
79
-
-
33845256434
-
T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
-
Vera, J. et al. T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood 108, 3890-3897 (2006).
-
(2006)
Blood
, vol.108
, pp. 3890-3897
-
-
Vera, J.1
-
80
-
-
34948860624
-
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
-
Savoldo, B. et al. Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 110, 2620-2630 (2007).
-
(2007)
Blood
, vol.110
, pp. 2620-2630
-
-
Savoldo, B.1
-
81
-
-
84969420302
-
Novel chimeric antigen receptor T cells for the treatment of Hodgkin lymphoma [abstract]
-
Ruella, M. et al. Novel chimeric antigen receptor T cells for the treatment of Hodgkin lymphoma [abstract]. Blood 124, a806 (2014).
-
(2014)
Blood
, vol.124
, pp. a806
-
-
Ruella, M.1
-
82
-
-
84863230570
-
Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice
-
Chinnasamy, D. et al. Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice. Clin. Cancer Res. 18, 1672-1683 (2012).
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 1672-1683
-
-
Chinnasamy, D.1
-
83
-
-
77958063691
-
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
-
Craddock, J. A. et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J. Immunother. 33, 780-788 (2010).
-
(2011)
J. Immunother
, vol.33
, pp. 780-788
-
-
Craddock, J.A.1
-
84
-
-
84880923283
-
Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy
-
Karlsson, S. C. et al. Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy. Cancer Gene Ther. 20, 386-393 (2013).
-
(2013)
Cancer Gene Ther
, vol.20
, pp. 386-393
-
-
Karlsson, S.C.1
-
85
-
-
84951907684
-
Immunomodulatory agent lenalidomide enhances antitumor functions of chimeric receptor-modified t cells in vitro and in vivo [abstract]
-
Pavel, O. et al. Immunomodulatory agent lenalidomide enhances antitumor functions of chimeric receptor-modified t cells in vitro and in vivo [abstract]. Blood 124, a805 (2014).
-
(2014)
Blood
, vol.124
, pp. a805
-
-
Pavel, O.1
-
86
-
-
84886397930
-
Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells
-
John, L. B. et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin. Cancer Res. 19, 5636-5646 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 5636-5646
-
-
John, L.B.1
-
87
-
-
84930458778
-
Infusion of donor-derived CD19-redirected-virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase i study [abstract]
-
Cruz, C. R. et al. Infusion of donor-derived CD19-redirected-virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase I study [abstract]. Blood 122, a152 (2013).
-
(2013)
Blood
, vol.122
, pp. a152
-
-
Cruz, C.R.1
-
88
-
-
84937406305
-
Therapy of B cell malignancies with CD19-specific chimeric antigen receptor-modified T cells of defined subset composition [abstract]
-
Turtle, C. J. et al. Therapy of B cell malignancies with CD19-specific chimeric antigen receptor-modified T cells of defined subset composition [abstract]. Blood 124, a384 (2014).
-
(2014)
Blood
, vol.124
, pp. a384
-
-
Turtle, C.J.1
-
89
-
-
84951905160
-
Multiplex genome editing as a platform for off-The-shelf" adoptive CAR T-cell immunotherapies [abstract]
-
Derniame, S. et al. Multiplex genome editing as a platform for "off-The-shelf" adoptive CAR T-cell immunotherapies [abstract]. Blood 124, a1111 (2014).
-
(2014)
Blood
, vol.124
, pp. a1111
-
-
Derniame, S.1
-
90
-
-
84862496486
-
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-Antigen-receptor and eliminate expression of endogenous TCR
-
Torikai, H. et al. A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-Antigen-receptor and eliminate expression of endogenous TCR. Blood 119, 5697-5705 (2012).
-
(2012)
Blood
, vol.119
, pp. 5697-5705
-
-
Torikai, H.1
-
91
-
-
84925607772
-
Adoptive cellular therapy: A race to the finish line
-
June, C. H., Riddell, S. R. & Schumacher, T. N. Adoptive cellular therapy: A race to the finish line. Sci. Transl. Med. 7, 280ps7 (2015).
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 280ps7
-
-
June, C.H.1
Riddell, S.R.2
Schumacher, T.N.3
-
92
-
-
0029148633
-
A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
-
Mack, M., Riethmuller, G. & Kufer, P. A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. Natl Acad. Sci. USA 92, 7021-7025 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7021-7025
-
-
Mack, M.1
Riethmuller, G.2
Kufer, P.3
-
93
-
-
0343415665
-
A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
-
Loffler, A. et al. A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood 95, 2098-2103 (2000).
-
(2000)
Blood
, vol.95
, pp. 2098-2103
-
-
Loffler, A.1
-
94
-
-
0037143806
-
Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody
-
Dreier, T. et al. Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody. Int. J. Cancer 100, 690-697 (2002).
-
(2002)
Int. J. Cancer
, vol.100
, pp. 690-697
-
-
Dreier, T.1
-
95
-
-
28944434529
-
Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells
-
Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P. & Baeuerle, P. A. Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells. Mol. Immunol. 43, 763-771 (2006).
-
(2006)
Mol. Immunol
, vol.43
, pp. 763-771
-
-
Offner, S.1
Hofmeister, R.2
Romaniuk, A.3
Kufer, P.4
Baeuerle, P.A.5
-
96
-
-
33645007038
-
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
-
Schlereth, B. et al. T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct. Cancer Immunol. Immunother. 55, 503-514 (2006).
-
(2006)
Cancer Immunol. Immunother
, vol.55
, pp. 503-514
-
-
Schlereth, B.1
-
97
-
-
3142652578
-
Minimal costimulatory requirements for T cell priming and TH1 differentiation: Activation of naive human T lymphocytes by tumor cells armed with bifunctional antibody constructs
-
Kufer, P. et al. Minimal costimulatory requirements for T cell priming and TH1 differentiation: Activation of naive human T lymphocytes by tumor cells armed with bifunctional antibody constructs. Cancer Immun. 1, 10 (2001).
-
(2001)
Cancer Immun
, vol.1
, pp. 10
-
-
Kufer, P.1
-
98
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou, R. et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321, 974-977 (2008).
-
(2008)
Science
, vol.321
, pp. 974-977
-
-
Bargou, R.1
-
99
-
-
64649103924
-
Mode of cytotoxic action of T cell-engaging BiTE antibody MT110
-
Haas, C. et al. Mode of cytotoxic action of T cell-engaging BiTE antibody MT110. Immunobiology 214, 441-453 (2009).
-
(2009)
Immunobiology
, vol.214
, pp. 441-453
-
-
Haas, C.1
-
100
-
-
3042802506
-
T-cell-mediated lysis of B cells induced by a CD19 × CD3 bispecific single-chain antibody is perforin dependent and death receptor independent
-
Gruen, M., Bommert, K. & Bargou, R. C. T-cell-mediated lysis of B cells induced by a CD19 × CD3 bispecific single-chain antibody is perforin dependent and death receptor independent. Cancer Immunol. Immunother. 53, 625-632 (2004).
-
(2004)
Cancer Immunol. Immunother
, vol.53
, pp. 625-632
-
-
Gruen, M.1
Bommert, K.2
Bargou, R.C.3
-
101
-
-
84863522243
-
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
-
Klinger, M. et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood 119, 6226-6233 (2012).
-
(2012)
Blood
, vol.119
, pp. 6226-6233
-
-
Klinger, M.1
-
102
-
-
84867858547
-
Blinatumomab: A historical perspective
-
Nagorsen, D., Kufer, P., Baeuerle, P. A. & Bargou, R. Blinatumomab: A historical perspective. Pharmacol. Ther. 136, 334-342 (2012).
-
(2012)
Pharmacol. Ther
, vol.136
, pp. 334-342
-
-
Nagorsen, D.1
Kufer, P.2
Baeuerle, P.A.3
Bargou, R.4
-
103
-
-
84929875600
-
Final results from a phase 1 study of blinatumomab in patients with relapsed/refractory non-Hodgkin's lymphoma
-
Goebeler, M. E. et al. Final results from a phase 1 study of blinatumomab in patients with relapsed/refractory non-Hodgkin's lymphoma. Hematol. Oncol. 31, 197 (2013).
-
(2013)
Hematol. Oncol
, vol.31
, pp. 197
-
-
Goebeler, M.E.1
-
105
-
-
84871491706
-
Long-Term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
-
Topp, M. S. et al. Long-Term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 120, 5185-5187 (2012).
-
(2012)
Blood
, vol.120
, pp. 5185-5187
-
-
Topp, M.S.1
-
106
-
-
79959312575
-
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Topp, M. S. et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J. Clin. Oncol. 29, 2493-2498 (2011).
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2493-2498
-
-
Topp, M.S.1
-
107
-
-
84916639631
-
Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia
-
Topp, M. S. et al. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J. Clin. Oncol. 32, 4134-4140 (2014).
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 4134-4140
-
-
Topp, M.S.1
-
108
-
-
84926099033
-
Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-Arm, phase 2 study
-
Topp, M. S. et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-Arm, phase 2 study. Lancet Oncol. 16, 57-66 (2015).
-
(2015)
Lancet Oncol
, vol.16
, pp. 57-66
-
-
Topp, M.S.1
-
109
-
-
84925719974
-
Treatment of relapsed/refractory diffuse large B-cell lymphoma with the Bispecific T-cell Engager (BiTE®) antibody construct blinatumomab: Primary analysis results from an open-label, phase 2 study [abstract]
-
Viardot, A. et al. Treatment of relapsed/refractory diffuse large B-cell lymphoma with the Bispecific T-cell Engager (BiTE®) antibody construct blinatumomab: primary analysis results from an open-label, phase 2 study [abstract]. Blood 124, a4460 (2014).
-
(2014)
Blood
, vol.124
, pp. a4460
-
-
Viardot, A.1
-
110
-
-
84925461494
-
Long-Term follow-up of serum immunoglobulin levels in blinatumomab-Treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia
-
Zugmaier, G. et al. Long-Term follow-up of serum immunoglobulin levels in blinatumomab-Treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia. Blood Cancer J. 4, 244 (2014).
-
(2014)
Blood Cancer J
, vol.4
, pp. 244
-
-
Zugmaier, G.1
-
111
-
-
79952280278
-
CD3/CD19 bispecific BiTE antibody blinatumomab treatment of non-Hodgkin lymphoma (NHL) patients: 60 μg/m2/d by continuous infusion is tolerable and results in durable responses [abstract 0559]
-
Goebeler, M. et al. CD3/CD19 bispecific BiTE antibody blinatumomab treatment of non-Hodgkin lymphoma (NHL) patients: 60 μg/m2/d by continuous infusion is tolerable and results in durable responses [abstract 0559]. Haematologica 95 (Suppl. 2), 230 (2010).
-
(2011)
Haematologica
, vol.95
, pp. 230
-
-
Goebeler, M.1
-
112
-
-
84873077857
-
Treatment of patients with non-Hodgkin lymphoma (NHL) with CD19/CD3 bispecific antibody blinatumomab (MT103): Double-step dose increase to continuous infusion of 60 μg/m2/d is tolerable and highly effective [abstract]
-
Viardot, A. et al. Treatment of patients with non-Hodgkin lymphoma (NHL) with CD19/CD3 bispecific antibody blinatumomab (MT103): double-step dose increase to continuous infusion of 60 μg/m2/d is tolerable and highly effective [abstract]. Blood 116, a2880 (2010).
-
(2011)
Blood
, vol.116
, pp. a2880
-
-
Viardot, A.1
-
113
-
-
0027197493
-
Diabodies: Small bivalent and bispecific antibody fragments
-
Holliger, P., Prospero, T. & Winter, G. "Diabodies": small bivalent and bispecific antibody fragments. Proc. Natl Acad. Sci. USA 90, 6444-6448 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6444-6448
-
-
Holliger, P.1
Prospero, T.2
Winter, G.3
-
114
-
-
79955970356
-
Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
-
Moore, P. A. et al. Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood 117, 4542-4551 (2011).
-
(2011)
Blood
, vol.117
, pp. 4542-4551
-
-
Moore, P.A.1
-
115
-
-
0033569478
-
Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics
-
Kipriyanov, S. M. et al. Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics. J. Mol. Biol. 293, 41-56 (1999).
-
(1999)
J. Mol. Biol
, vol.293
, pp. 41-56
-
-
Kipriyanov, S.M.1
-
116
-
-
0027183934
-
A recombinant immunotoxin containing a disulfide-stabilized Fv fragment
-
Brinkmann, U., Reiter, Y., Jung, S. H., Lee, B. & Pastan, I. A recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Proc. Natl Acad. Sci. USA 90, 7538-7542 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 7538-7542
-
-
Brinkmann, U.1
Reiter, Y.2
Jung, S.H.3
Lee, B.4
Pastan, I.5
-
117
-
-
77954757304
-
Effector cell recruitment with novel Fv-based dual-Affinity re-Targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion
-
Johnson, S. et al. Effector cell recruitment with novel Fv-based dual-Affinity re-Targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion. J. Mol. Biol. 399, 436-449 (2010).
-
(2011)
J. Mol. Biol
, vol.399
, pp. 436-449
-
-
Johnson, S.1
-
118
-
-
84933505755
-
A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma
-
Rothe, A. et al. A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma. Blood 125, 4024-4031 (2015).
-
(2015)
Blood
, vol.125
, pp. 4024-4031
-
-
Rothe, A.1
-
119
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
120
-
-
18544380239
-
Tumor-Associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong, H. et al. Tumor-Associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat. Med. 8, 793-800 (2002).
-
(2002)
Nat. Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
-
121
-
-
0038273853
-
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
-
Curiel, T. J. et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9, 562-567 (2003).
-
(2003)
Nat. Med
, vol.9
, pp. 562-567
-
-
Curiel, T.J.1
-
122
-
-
0024556845
-
Phenotypic expression of histocompatibility antigens in human primary tumours and metastases
-
Ruiz-Cabello, F. et al. Phenotypic expression of histocompatibility antigens in human primary tumours and metastases. Clin. Exp. Metastasis 7, 213-226 (1989).
-
(1989)
Clin. Exp. Metastasis
, vol.7
, pp. 213-226
-
-
Ruiz-Cabello, F.1
-
123
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
124
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
Linsley, P. S. et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4, 535-543 (1996).
-
(1996)
Immunity
, vol.4
, pp. 535-543
-
-
Linsley, P.S.1
-
125
-
-
0028675006
-
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
-
Linsley, P. S. et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1, 793-801 (1994).
-
(1994)
Immunity
, vol.1
, pp. 793-801
-
-
Linsley, P.S.1
-
126
-
-
16044371193
-
CD28/B7 regulation of TH1 and TH2 subsets in the development of autoimmune diabetes
-
Lenschow, D. J. et al. CD28/B7 regulation of TH1 and TH2 subsets in the development of autoimmune diabetes. Immunity 5, 285-293 (1996).
-
(1996)
Immunity
, vol.5
, pp. 285-293
-
-
Lenschow, D.J.1
-
127
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry, R. V. et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell Biol. 25, 9543-9553 (2005).
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
-
128
-
-
3242677686
-
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
-
Latchman, Y. E. et al. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl Acad. Sci. USA 101, 10691-10696 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10691-10696
-
-
Latchman, Y.E.1
-
129
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999).
-
(1999)
Immunity
, vol.11
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
130
-
-
34948904394
-
Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice
-
Gotsman, I. et al. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J. Clin. Invest. 117, 2974-2982 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2974-2982
-
-
Gotsman, I.1
-
131
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
-
132
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol, E. A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
-
133
-
-
78049370405
-
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
-
Green, M. R. et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 116, 3268-3277 (2010).
-
(2011)
Blood
, vol.116
, pp. 3268-3277
-
-
Green, M.R.1
-
134
-
-
84879866976
-
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-Associated malignancies
-
Chen, B. J. et al. PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-Associated malignancies. Clin. Cancer Res. 19, 3462-3473 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 3462-3473
-
-
Chen, B.J.1
-
135
-
-
79960318715
-
Programmed death ligand 1 is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-Associated T cells
-
Andorsky, D. J. et al. Programmed death ligand 1 is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-Associated T cells. Clin. Cancer Res. 17, 4232-4244 (2011).
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 4232-4244
-
-
Andorsky, D.J.1
-
136
-
-
84901413409
-
Immune checkpoint blockade
-
Naidoo, J., Page, D. B. & Wolchok, J. D. Immune checkpoint blockade. Hematol. Oncol. Clin. North Am. 28, 585-600 (2014).
-
(2014)
Hematol. Oncol. Clin. North Am
, vol.28
, pp. 585-600
-
-
Naidoo, J.1
Page, D.B.2
Wolchok, J.D.3
-
137
-
-
84858206832
-
Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: Implications for targeted therapy
-
Green, M. R. et al. Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy. Clin. Cancer Res. 18, 1611-1618 (2012).
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 1611-1618
-
-
Green, M.R.1
-
138
-
-
84883863501
-
Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
-
Spranger, S. et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci. Transl. Med. 5, 200ra116 (2013).
-
(2013)
Sci. Transl. Med
, vol.5
, pp. 200ra116
-
-
Spranger, S.1
-
139
-
-
84904024273
-
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
-
Taube, J. M. et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin. Cancer Res. 20, 5064-5074 (2014).
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 5064-5074
-
-
Taube, J.M.1
-
140
-
-
79952816655
-
MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
-
Steidl, C. et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature 471, 377-381 (2011).
-
(2011)
Nature
, vol.471
, pp. 377-381
-
-
Steidl, C.1
-
141
-
-
0343820067
-
Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells
-
Joos, S. et al. Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res. 60, 549-552 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 549-552
-
-
Joos, S.1
-
142
-
-
49649114804
-
Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger, R. et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 14, 3044-3051 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
-
143
-
-
84890096527
-
Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: Results of an international phase II trial
-
Armand, P. et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. J. Clin. Oncol. 31, 4199-4206 (2013).
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 4199-4206
-
-
Armand, P.1
-
144
-
-
84891373595
-
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
-
Westin, J. R. et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial. Lancet Oncol. 15, 69-77 (2014).
-
(2014)
Lancet Oncol
, vol.15
, pp. 69-77
-
-
Westin, J.R.1
-
145
-
-
84951908515
-
Nivolumab in patients with relapsed or refractory lymphoid malignancies and classical Hodgkin lymphoma: Updated results of a phase i study (CA209-039) [abstract]
-
Timmerman, J. et al. Nivolumab in patients with relapsed or refractory lymphoid malignancies and classical Hodgkin lymphoma: updated results of a phase I study (CA209-039) [abstract]. Hematol. Oncol. 33, a010 (2015).
-
(2015)
Hematol. Oncol
, vol.33
, pp. a010
-
-
Timmerman, J.1
-
146
-
-
84938602784
-
A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies [abstract]
-
Garcia-Manero, G. et al. A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies [abstract]. J. Clin. Oncol. 32 (5s Suppl.), TPS3116 (2014).
-
(2014)
J. Clin. Oncol
, vol.32
, Issue.5
, pp. TPS3116
-
-
Garcia-Manero, G.1
-
147
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01953692 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
148
-
-
84925221855
-
PD-1 Blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
Ansell, S. M. et al. PD-1 Blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372, 311-319 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 311-319
-
-
Ansell, S.M.1
-
149
-
-
84929410618
-
Nivolumab in patients with relapsed or refractory Hodgkin lymphoma-preliminary safety, efficacy and biomarker results of a phase i study [abstract]
-
Armand, P. et al. Nivolumab in patients with relapsed or refractory Hodgkin lymphoma-preliminary safety, efficacy and biomarker results of a phase I study [abstract]. Blood 124, a289 (2014).
-
(2014)
Blood
, vol.124
, pp. a289
-
-
Armand, P.1
-
150
-
-
84925717350
-
PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical Hodgkin lymphoma after brentuximab vedotin failure: Preliminary results from a phase 1b study (KEYNOTE-013) [abstract]
-
Moskowitz, C. H. et al. PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical Hodgkin lymphoma after brentuximab vedotin failure: preliminary results from a phase 1b study (KEYNOTE-013) [abstract]. Blood 124, a290 (2014).
-
(2014)
Blood
, vol.124
, pp. a290
-
-
Moskowitz, C.H.1
-
151
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
-
152
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02220842?term=NCT02220842&rank=1 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
153
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01775631 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
154
-
-
70350244852
-
Phase i study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma
-
Ansell, S. M. et al. Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. Clin. Cancer Res. 15, 6446-6453 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 6446-6453
-
-
Ansell, S.M.1
-
155
-
-
84915804784
-
Practical management of immune-related adverse events from immune checkpoint protein antibodies for the oncologist
-
Weber, J. S. Practical management of immune-related adverse events from immune checkpoint protein antibodies for the oncologist. Am. Soc. Clin. Oncol. Educ. Book 2012, 174-177 (2012).
-
(2012)
Am. Soc. Clin. Oncol. Educ. Book
, vol.2012
, pp. 174-177
-
-
Weber, J.S.1
-
156
-
-
84937605130
-
Toxicities of immunotherapy for the practitioner
-
Weber, J. S., Yang, J. C., Atkins, M. B. & Disis, M. L. Toxicities of immunotherapy for the practitioner. J. Clin. Oncol. 33, 2092-2099 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 2092-2099
-
-
Weber, J.S.1
Yang, J.C.2
Atkins, M.B.3
Disis, M.L.4
-
157
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23-34 (2015).
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 23-34
-
-
Larkin, J.1
-
158
-
-
84951906917
-
-
Bristol-Myers Squibb Yervoy (ipilimumab)
-
Bristol-Myers Squibb Yervoy (ipilimumab): Immune-mediated adverse reaction management guide [online], https://www.hcp.yervoy.com/pdf/rems-management-guide.pdf.
-
Immune-mediated Adverse Reaction Management Guide
-
-
-
159
-
-
84925587926
-
Preliminary results of a phase i study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies [abstract]
-
Lesokhin, A. M. et al. Preliminary results of a phase I study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies [abstract]. Blood 124, a291 (2014).
-
(2014)
Blood
, vol.124
, pp. a291
-
-
Lesokhin, A.M.1
-
160
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02038946?term=NCT02038946&rank=1 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
161
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02038933?term=NCT02038933&rank=1 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
162
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02181738?term=NCT02181738&rank=1 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
163
-
-
37249013214
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01592370?term=NCT01592370&rank=1 (2015).
-
(2015)
ClinicalTrials.gov
-
-
-
164
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon, E. B. et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N. Engl. J. Med. 372, 2018-2028 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
-
165
-
-
84939227614
-
Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers
-
Carbognin, L. et al. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS ONE 10, e0130142 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0130142
-
-
Carbognin, L.1
-
166
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189-2199 (2014).
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
-
167
-
-
84928761118
-
Cancer immunology Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N. A. et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
-
168
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568-571 (2014).
-
(2014)
Nature
, vol.515
, pp. 568-571
-
-
Tumeh, P.C.1
-
169
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
170
-
-
84923268725
-
Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells
-
Reichel, J. et al. Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells. Blood 125, 1061-1072 (2015).
-
(2015)
Blood
, vol.125
, pp. 1061-1072
-
-
Reichel, J.1
-
171
-
-
84926620551
-
Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1
-
Lin, J. H. et al. Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1. Blood 125, 2228-2238 (2015).
-
(2015)
Blood
, vol.125
, pp. 2228-2238
-
-
Lin, J.H.1
-
172
-
-
61849165013
-
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
-
Bashey, A. et al. CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Blood 113, 1581-1588 (2009).
-
(2009)
Blood
, vol.113
, pp. 1581-1588
-
-
Bashey, A.1
|