메뉴 건너뛰기




Volumn 106, Issue 13, 2005, Pages 4043-4049

Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: A Children's Cancer Group study

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; CLINICAL FEATURE; COMPARATIVE STUDY; CORRELATION ANALYSIS; DOWN SYNDROME; HIGH RISK PATIENT; HUMAN; HUMAN CELL; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; NEWBORN; PRIORITY JOURNAL; RISK FACTOR; TIME SERIES ANALYSIS; TREATMENT OUTCOME;

EID: 28844446288     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2003-10-3446     Document Type: Article
Times cited : (119)

References (50)
  • 1
    • 0026574340 scopus 로고
    • Down syndrome and leukemia
    • Robison LL. Down syndrome and leukemia. Leukemia. 1992;6:5-7.
    • (1992) Leukemia , vol.6 , pp. 5-7
    • Robison, L.L.1
  • 2
    • 0015384314 scopus 로고
    • Down's syndrome and acute leukemia: Myeloblastic or lymphoblastic? Report of forty-three cases and review of the literature
    • Rosner F, Lee SL. Down's syndrome and acute leukemia: myeloblastic or lymphoblastic? report of forty-three cases and review of the literature. Am J Med. 1972;53:203-218.
    • (1972) Am J Med , vol.53 , pp. 203-218
    • Rosner, F.1    Lee, S.L.2
  • 3
    • 0021179588 scopus 로고
    • Down syndrome and acute leukemia in children: A 10-year retrospective survey from Children's Cancer Study Group
    • Robison LL, Nesbit ME, Sather HN, et al. Down syndrome and acute leukemia in children: a 10-year retrospective survey from Children's Cancer Study Group. J Pediatr. 1984;105:235-242.
    • (1984) J Pediatr , vol.105 , pp. 235-242
    • Robison, L.L.1    Nesbit, M.E.2    Sather, H.N.3
  • 4
    • 0023200187 scopus 로고
    • Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis
    • Fong CT, Brodeur GM. Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet. 1987;28:55-76.
    • (1987) Cancer Genet Cytogenet , vol.28 , pp. 55-76
    • Fong, C.T.1    Brodeur, G.M.2
  • 5
    • 0034525989 scopus 로고    scopus 로고
    • Children's Cancer Group trials in acute lymphoblastic leukemia: 1983-1995
    • Gaynon PS, Trigg ME, Heerema HA, et al. Children's Cancer Group trials in acute lymphoblastic leukemia: 1983-1995. Leukemia. 2000;14:2223-2233.
    • (2000) Leukemia , vol.14 , pp. 2223-2233
    • Gaynon, P.S.1    Trigg, M.E.2    Heerema, H.A.3
  • 6
    • 17744383161 scopus 로고    scopus 로고
    • Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital
    • Pui CH, Boyett JM, Rivera GK, et al. Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital. Leukemia. 2000;14:2286-2294.
    • (2000) Leukemia , vol.14 , pp. 2286-2294
    • Pui, C.H.1    Boyett, J.M.2    Rivera, G.K.3
  • 7
    • 0034517924 scopus 로고    scopus 로고
    • Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981-1995: Berlin-Frankfurt-Munster
    • Schrappe M, Reiter A, Zimmermann M, et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981-1995: Berlin-Frankfurt-Munster. Leukemia. 2000;14:2205-2222.
    • (2000) Leukemia , vol.14 , pp. 2205-2222
    • Schrappe, M.1    Reiter, A.2    Zimmermann, M.3
  • 8
    • 0034523201 scopus 로고    scopus 로고
    • Co-operative study group for childhood acute lymphoblastic leukemia (COALL): Long-term follow-up of trials 82, 85, 89, and 92
    • Harms DO, Janka-Schaub GE. Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89, and 92. Leukemia. 2000;14:2234-2239.
    • (2000) Leukemia , vol.14 , pp. 2234-2239
    • Harms, D.O.1    Janka-Schaub, G.E.2
  • 9
    • 17744380400 scopus 로고    scopus 로고
    • Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981-1995)
    • Silverman LB, Declerck L, Gelber RD, et al. Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981-1995). Leukemia. 2000;14:2247-2256.
    • (2000) Leukemia , vol.14 , pp. 2247-2256
    • Silverman, L.B.1    Declerck, L.2    Gelber, R.D.3
  • 11
    • 0025580086 scopus 로고
    • Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome
    • Kalwinsky DK, Raimondi SC, Bunin NJ, et al. Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome. Am J Med Genet Suppl. 1990;7:267-271.
    • (1990) Am J Med Genet Suppl , vol.7 , pp. 267-271
    • Kalwinsky, D.K.1    Raimondi, S.C.2    Bunin, N.J.3
  • 12
    • 0026089497 scopus 로고
    • Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down's syndrome: A Pediatric Oncology Group study
    • Ragab AH, Abdel-Mageed A, Shuster JJ, et al. Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down's syndrome: a Pediatric Oncology Group study. Cancer. 1991;67:1057-1063.
    • (1991) Cancer , vol.67 , pp. 1057-1063
    • Ragab, A.H.1    Abdel-Mageed, A.2    Shuster, J.J.3
  • 13
    • 0027276321 scopus 로고
    • Immunophenotypes and karyotypes of leukemic cells in children with Down syndrome and acute lymphoblastic leukemia
    • Pui C-H, Raimondi SC, Borowitz MJ, et al. Immunophenotypes and karyotypes of leukemic cells in children with Down syndrome and acute lymphoblastic leukemia. J Clin Oncol. 1993;11:1361-1367.
    • (1993) J Clin Oncol , vol.11 , pp. 1361-1367
    • Pui, C.-H.1    Raimondi, S.C.2    Borowitz, M.J.3
  • 14
    • 17344365412 scopus 로고    scopus 로고
    • Down's syndrome in childhood acute lymphoblastic leukemia: Clinical characteristics and treatment outcome in four consecutive BFM trials: Berlin-Frankfurt-Munster Group
    • Dördelmann M, Schrappe M, Reiter A, et al. Down's syndrome in childhood acute lymphoblastic leukemia: clinical characteristics and treatment outcome in four consecutive BFM trials: Berlin-Frankfurt-Munster Group. Leukemia. 1998;12:645-651.
    • (1998) Leukemia , vol.12 , pp. 645-651
    • Dördelmann, M.1    Schrappe, M.2    Reiter, A.3
  • 15
    • 0034809324 scopus 로고    scopus 로고
    • Down's syndrome and acute lymphoblastic leukaemia: Clinical features and response to treatment
    • Chessells JM, Harrison G, Richards SM, et al. Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment. Arch Dis Child. 2001;85:321-325.
    • (2001) Arch Dis Child , vol.85 , pp. 321-325
    • Chessells, J.M.1    Harrison, G.2    Richards, S.M.3
  • 16
    • 0027406656 scopus 로고
    • Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: A Children's Cancer Group phase III trial
    • Tubergen DG, Gilchrist GS, O'Brien RT, et al. Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Children's Cancer Group phase III trial. J Clin Oncol. 1993;11:527-537.
    • (1993) J Clin Oncol , vol.11 , pp. 527-537
    • Tubergen, D.G.1    Gilchrist, G.S.2    O'Brien, R.T.3
  • 17
    • 0027494884 scopus 로고
    • Improved therapy for children with acute lymphoblastic leukemia and unfavorable presenting features: A follow-up report of the Childrens Cancer Group Study CCG-106
    • Gaynon PS, Steinherz PG, Bleyer WA, et al. Improved therapy for children with acute lymphoblastic leukemia and unfavorable presenting features: a follow-up report of the Childrens Cancer Group Study CCG-106. J Clin Oncol. 1993;11:2234-2242.
    • (1993) J Clin Oncol , vol.11 , pp. 2234-2242
    • Gaynon, P.S.1    Steinherz, P.G.2    Bleyer, W.A.3
  • 18
    • 0001151567 scopus 로고    scopus 로고
    • Should therapy be intensified for patients with good risk ALL?
    • Hutchinson R, Neerhout R, Bertolone S, et al. Should therapy be intensified for patients with good risk ALL? [abstract] Blood. 1996;88:668a.
    • (1996) Blood , vol.88
    • Hutchinson, R.1    Neerhout, R.2    Bertolone, S.3
  • 19
    • 0029978820 scopus 로고    scopus 로고
    • Randomized comparison of moderate-dose methotrexate infusions to oral methotrexate in children with intermediate risk acute lymphoblastic leukemia: A Childrens Cancer Group study
    • Lange BJ, Blatt J, Sather HN, Meadows AT. Randomized comparison of moderate-dose methotrexate infusions to oral methotrexate in children with intermediate risk acute lymphoblastic leukemia: a Childrens Cancer Group study. Med Pediatr Oncol. 1996;27:15-20.
    • (1996) Med Pediatr Oncol , vol.27 , pp. 15-20
    • Lange, B.J.1    Blatt, J.2    Sather, H.N.3    Meadows, A.T.4
  • 20
    • 0030915171 scopus 로고    scopus 로고
    • Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: A report from the Children's Cancer Group
    • Nachman J, Sather HN, Gaynon PS, Lukens JN, Wolff L, Trigg ME. Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group. J Clin Oncol. 1997;15:2222-2230.
    • (1997) J Clin Oncol , vol.15 , pp. 2222-2230
    • Nachman, J.1    Sather, H.N.2    Gaynon, P.S.3    Lukens, J.N.4    Wolff, L.5    Trigg, M.E.6
  • 21
    • 0030903602 scopus 로고    scopus 로고
    • Clinical features and treatment outcome of childhood Tlineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: A Children's Cancer Group study
    • Uckun FM, Gaynon PS, Sensel MG, et al. Clinical features and treatment outcome of childhood Tlineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study. J Clin Oncol. 1997;15:2214-2221.
    • (1997) J Clin Oncol , vol.15 , pp. 2214-2221
    • Uckun, F.M.1    Gaynon, P.S.2    Sensel, M.G.3
  • 22
    • 0001190801 scopus 로고    scopus 로고
    • Dexamethasone (DEX) decreases central nervous system (CNS) relapse and improves event-free survival (EFS) in lower risk acute lymphoblastic leukemia (ALL)
    • Bostrom B, Gaynon P, Sather H, et al. Dexamethasone (DEX) decreases central nervous system (CNS) relapse and improves event-free survival (EFS) in lower risk acute lymphoblastic leukemia (ALL) [abstract]. Proc Am Soc Clin Oncol. 1998;17:527a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Bostrom, B.1    Gaynon, P.2    Sather, H.3
  • 23
    • 0032006243 scopus 로고    scopus 로고
    • Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features: Randomized controlled trial from the Children's Cancer Group
    • Steinherz PG, Gaynon PS, Breneman JC, et al. Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features: randomized controlled trial from the Children's Cancer Group. Cancer. 1998;82:600-612.
    • (1998) Cancer , vol.82 , pp. 600-612
    • Steinherz, P.G.1    Gaynon, P.S.2    Breneman, J.C.3
  • 24
    • 0033015207 scopus 로고    scopus 로고
    • Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group
    • Reaman GH, Sposto R, Sensel MG, et al. Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group. J Clin Oncol. 1999;17:445-455.
    • (1999) J Clin Oncol , vol.17 , pp. 445-455
    • Reaman, G.H.1    Sposto, R.2    Sensel, M.G.3
  • 25
    • 0033780541 scopus 로고    scopus 로고
    • The management of neoplastic disorders of haematopoiesis in children with Down's syndrome
    • Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Brit J Haematol. 2000;110:512-524.
    • (2000) Brit J Haematol , vol.110 , pp. 512-524
    • Lange, B.1
  • 26
    • 0036464595 scopus 로고    scopus 로고
    • Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: A report from the Children's Cancer Group
    • Lange BJ, Bostrom BC, Cherlow JM, et al. Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood. 2002;99:825-833.
    • (2002) Blood , vol.99 , pp. 825-833
    • Lange, B.J.1    Bostrom, B.C.2    Cherlow, J.M.3
  • 27
    • 9044226139 scopus 로고    scopus 로고
    • Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia
    • Smith M, Arthur D, Camitta B, et al. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol. 1996;14:18-24.
    • (1996) J Clin Oncol , vol.14 , pp. 18-24
    • Smith, M.1    Arthur, D.2    Camitta, B.3
  • 28
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 29
    • 0017365573 scopus 로고
    • Design and analysis of randomized clinical trials requiring prolonged observation of each patient, II: Analysis and examples
    • Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient, II: analysis and examples. Brit J Cancer. 1977;35:1-39.
    • (1977) Brit J Cancer , vol.35 , pp. 1-39
    • Peto, R.1    Pike, M.C.2    Armitage, P.3
  • 31
    • 0026808789 scopus 로고
    • Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: Experience on Pediatric Oncology Group AML Study 8498
    • Ravindranath Y, Abella E, Krischer JP, et al. Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498. Blood. 1992;80:2210-2214.
    • (1992) Blood , vol.80 , pp. 2210-2214
    • Ravindranath, Y.1    Abella, E.2    Krischer, J.P.3
  • 32
    • 16744366910 scopus 로고    scopus 로고
    • Distinctive demography, biology and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down Syndrome: Children's Cancer Group Studies 2861 and 2891
    • Lange BJ, Kobrinsky N, Barnard DR, et al. Distinctive demography, biology and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down Syndrome: Children's Cancer Group Studies 2861 and 2891. Blood. 1998;91:608-615.
    • (1998) Blood , vol.91 , pp. 608-615
    • Lange, B.J.1    Kobrinsky, N.2    Barnard, D.R.3
  • 33
    • 0024389385 scopus 로고
    • Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia
    • Pui CH, Raimondi SC, Dodge RK, et al. Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia. Blood. 1989;73:1963-1967.
    • (1989) Blood , vol.73 , pp. 1963-1967
    • Pui, C.H.1    Raimondi, S.C.2    Dodge, R.K.3
  • 34
    • 0025188811 scopus 로고
    • Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia
    • Pui CH, Crist WM, Look AT. Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood. 1990;76:1449-1463.
    • (1990) Blood , vol.76 , pp. 1449-1463
    • Pui, C.H.1    Crist, W.M.2    Look, A.T.3
  • 35
    • 0028762431 scopus 로고
    • The molecular basis of leukemia
    • Cline MJ. The molecular basis of leukemia. N Engl J Med. 1994;330:328-336.
    • (1994) N Engl J Med , vol.330 , pp. 328-336
    • Cline, M.J.1
  • 36
    • 0027420667 scopus 로고
    • Detection of ALL-1/AF4 fusion transcript by reverse transcription- polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation
    • Biondi A, Rambaldi A, Rossi V, et al. Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation. Blood. 1993;82:2943-2947.
    • (1993) Blood , vol.82 , pp. 2943-2947
    • Biondi, A.1    Rambaldi, A.2    Rossi, V.3
  • 37
    • 13344282725 scopus 로고
    • TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
    • Shurtleff SA, Buijs A, Behm FG, et al. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia. 1995;9:1985-1989.
    • (1995) Leukemia , vol.9 , pp. 1985-1989
    • Shurtleff, S.A.1    Buijs, A.2    Behm, F.G.3
  • 38
    • 0007055492 scopus 로고    scopus 로고
    • TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
    • McLean TW, Ringold S, Neuberg D, et al. TEL/ AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood. 1996;88:4252-4258.
    • (1996) Blood , vol.88 , pp. 4252-4258
    • McLean, T.W.1    Ringold, S.2    Neuberg, D.3
  • 39
    • 16944363891 scopus 로고    scopus 로고
    • The common TEL-AML1 rearrangement does not represent a frequent event in acute lymphoblastic leukaemia occurring in children with Down syndrome
    • Lanza C, Volpe G, Basso G, et al. The common TEL-AML1 rearrangement does not represent a frequent event in acute lymphoblastic leukaemia occurring in children with Down syndrome. Leukemia. 1997;11:820-821.
    • (1997) Leukemia , vol.11 , pp. 820-821
    • Lanza, C.1    Volpe, G.2    Basso, G.3
  • 40
    • 0029939156 scopus 로고    scopus 로고
    • Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: A contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia
    • Taub JW, Matherly LH, Stout ML, Buck SA, Gurney JG, Ravindranath Y. Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia. Blood. 1996;87:3395-3403.
    • (1996) Blood , vol.87 , pp. 3395-3403
    • Taub, J.W.1    Matherly, L.H.2    Stout, M.L.3    Buck, S.A.4    Gurney, J.G.5    Ravindranath, Y.6
  • 41
    • 0033566994 scopus 로고    scopus 로고
    • Expression of chromosome 21-localized genes in acute myeloid leukemia: Differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin
    • Taub JW, Huang X, Matherly LH, et al. Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin. Blood. 1999;94:1393-1400.
    • (1999) Blood , vol.94 , pp. 1393-1400
    • Taub, J.W.1    Huang, X.2    Matherly, L.H.3
  • 42
    • 0023006905 scopus 로고
    • Excessive chemotherapy-related myelotoxicity in children with Down syndrome and acute lymphoblastic leukemia
    • Blatt J, Albo V, Prin W, Orlando S, Wollman M. Excessive chemotherapy-related myelotoxicity in children with Down syndrome and acute lymphoblastic leukemia [letter]. Lancet. 1986;2:914.
    • (1986) Lancet , vol.2 , pp. 914
    • Blatt, J.1    Albo, V.2    Prin, W.3    Orlando, S.4    Wollman, M.5
  • 43
    • 12944285288 scopus 로고
    • Excessive drug toxicity in children with Down's syndrome (DS) treated for acute lymphocytic leukemia (ALL) despite similarity of clinical and biological features to other patients
    • Frankel LS, Pullen J, Boyett J, et al. Excessive drug toxicity in children with Down's syndrome (DS) treated for acute lymphocytic leukemia (ALL) despite similarity of clinical and biological features to other patients [abstract]. Proc Am Soc Clin Oncol. 1986;5:161.
    • (1986) Proc Am Soc Clin Oncol , vol.5 , pp. 161
    • Frankel, L.S.1    Pullen, J.2    Boyett, J.3
  • 44
    • 0023200576 scopus 로고
    • Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia
    • Garré ML, Relling MV, Kalwinsky D, et al. Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia. J Pediatr. 1987;111:606-612.
    • (1987) J Pediatr , vol.111 , pp. 606-612
    • Garré, M.L.1    Relling, M.V.2    Kalwinsky, D.3
  • 45
    • 0023187384 scopus 로고
    • Down syndrome and leukemia: Unusual clinical aspects and unexpected methotrexate sensitivity
    • Peeters M, Poon A. Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity. Eur J Pediatr. 1987;146:416-422.
    • (1987) Eur J Pediatr , vol.146 , pp. 416-422
    • Peeters, M.1    Poon, A.2
  • 46
    • 0015521803 scopus 로고
    • Leucocyte function in Down's syndrome and acute leukaemia
    • Gregory L, Williams R, Thompson E. Leucocyte function in Down's syndrome and acute leukaemia. Lancet. 1972;1:1359-1361.
    • (1972) Lancet , vol.1 , pp. 1359-1361
    • Gregory, L.1    Williams, R.2    Thompson, E.3
  • 48
    • 0031754835 scopus 로고    scopus 로고
    • Population-based study of congenital heart defects in Down Syndrome
    • Freeman SB, Taft LF, Dooley KJ, et al: Population-based study of congenital heart defects in Down Syndrome. Am J Med Genet. 1998;80:213-217.
    • (1998) Am J Med Genet , vol.80 , pp. 213-217
    • Freeman, S.B.1    Taft, L.F.2    Dooley, K.J.3
  • 49
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286:531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 50
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet. 2002;30:41-47.
    • (2002) Nat Genet , vol.30 , pp. 41-47
    • Armstrong, S.A.1    Staunton, J.E.2    Silverman, L.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.