New Concepts for Increasing the Efficiency in Directed Evolution of Stereoselective Enzymes

Chemistry - A European Journal

Volumn 22, Issue 15, 2016, Pages 5046-5054

  Sun, Zhoutong ^a,b   Wikmark, Ylva ^c   Bäckvall, Jan E ^c   Reetz, Manfred T ^a,b  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

directed evolution; enzymes; high throughput screening; saturation mutagenesis; stereoselectivity

Indexed keywords

AMINO ACIDS; BINDING SITES; ITERATIVE METHODS; MUTAGENESIS; RANDOM PROCESSES; STEREOSELECTIVITY;

ASYMMETRIC TRANSFORMATIONS; BUILDING BLOCKES; DIRECTED EVOLUTION; ENANTIOSELECTIVE EPOXIDE; HIGH THROUGHPUT SCREENING; ORGANIC CHEMISTRY; SATURATION MUTAGENESIS; STEREO-SELECTIVE;

ENZYMES;

AMINO ACID; EPOXIDE HYDROLASE; TRIACYLGLYCEROL LIPASE;

CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; METABOLISM; MUTAGENESIS; PROCEDURES; STEREOISOMERISM;

AMINO ACIDS; CATALYSIS; DIRECTED MOLECULAR EVOLUTION; EPOXIDE HYDROLASES; LIPASE; MODELS, MOLECULAR; MUTAGENESIS; STEREOISOMERISM;

EID: 84977861254     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201504406     Document Type: Article

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