Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase

ACS Catalysis

Volumn 6, Issue 3, 2016, Pages 1590-1597

  Sun, Zhoutong ^a,b   Lonsdale, Richard ^a,b   Wu, Lian ^c   Li, Guangyue ^a,b   Li, Aitao ^a,b   Wang, Jianbo ^a,b   Zhou, Jiahai ^c   Reetz, Manfred T ^a,b  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

amino acid alphabet; directed evolution; epoxide hydrolases; saturation mutagenesis; stereoselectivity; triple code

Indexed keywords

AMINO ACIDS; BINDING SITES; CELL IMMOBILIZATION; CODES (SYMBOLS); ENCODING (SYMBOLS); HYDROLASES; LIBRARIES; MUTAGENESIS; RANDOM PROCESSES; STEREOCHEMISTRY; STEREOSELECTIVITY; SUBSTRATES;

DIRECTED EVOLUTION; ELECTROSTATIC CHARACTERISTICS; EPOXIDE HYDROLASES; LIMONENE EPOXIDE HYDROLASE; REDUCED AMINO ACID ALPHABETS; SATURATION MUTAGENESIS; STEREOSELECTIVE CATALYSTS; TRIPLE CODE;

ENZYMES;

EID: 84960153203     PISSN: None     EISSN: 21555435     Source Type: Journal    
DOI: 10.1021/acscatal.5b02751     Document Type: Article

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