Unraveling the Alkaline Phosphatase Inhibition, Anticancer, and Antileishmanial Potential of Coumarin–Triazolothiadiazine Hybrids: Design, Synthesis, and Molecular Docking Analysis

Archiv der Pharmazie

Volumn , Issue , 2016, Pages 553-565

  Ibrar, Aliya ^a   Zaib, Sumera ^b   Jabeen, Farukh ^c,d   Iqbal, Jamshed ^b   Saeed, Aamer ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b COMSATS Institute of Information Technology ^*  (Pakistan)

^c University of Florida   (United States)

^d NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Coumarin; Cytotoxicity; Heterocycles; Leishmaniasis; Triazolothiadiazine

Indexed keywords

3 [6 (4 ACETYLPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 BROMOPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 CHLOROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 DICHLOROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 FLUOROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 METHOXYPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 METHYLPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (4 NITROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3 [6 (BIPHENYL 4 YL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL] 2H CHROMEN 2 ONE; 3,3' (7H [1,2,4]TRIAZOLO[3,4,B][1,3,4]THIADIAZINE 3,6 DIYL)BIS(2H CHROMEN 2 ONE); ALKALINE PHOSPHATASE; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; COUMARIN DERIVATIVE; COUMARINYL TRIAZOLOTHIADIAZINE DERIVATIVE; ESTERASE INHIBITOR; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BHK CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYCLIZATION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; IC50; IN VITRO STUDY; INFRARED SPECTROSCOPY; LEISHMANIA MAJOR; LUNG CANCER CELL LINE; LUNG CARCINOMA; MOLECULAR DOCKING; MOLECULAR HYBRIDIZATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROMASTIGOTE;

EID: 84977567102     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201500392     Document Type: Article

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