Synthesis, antimicrobial evaluation and QSAR analysis of novel nalidixic acid based 1,2,4-triazole derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4089-4099

  Aggarwal, Nisha ^a,b   Kumar, Rajesh ^a   Dureja, Prem ^a   Khurana, J M ^b  

^a INDIAN AGRICULTURAL RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

1,2,4 Triazole; Antimicrobial activity; Nalidixic acid; QSAR

Indexed keywords

1 ETHYL 3 [4 (4 ETHYLBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [4 (4 FLUOROBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [4 (4 HYDROXYBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [4 (4 ISOPROPYLBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [5 MERCAPTO 4 (3 NITROBENZYLIDENEAMINO) 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [5 MERCAPTO 4 (4 METHOXYBENZYLIDENEAMINO) 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [5 MERCAPTO 4 (4 METHYLBENZYLIDENEAMINO) 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [5 MERCAPTO 4 (4 NITROBENZYLIDENEAMINO) 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [5 MERCAPTO 4 [4 (METHYLTHIO)BENZYLIDENEAMINO] 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1 ETHYL 3 [5 MERCAPTO 4 [4 (TRIFLUOROMETHYL)BENZYLIDENEAMINO] 4H 1,2,4 TRIAZOL 3 YL] 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 1,2,4 TRIAZOLE DERIVATIVE; 3 (4 AMINO 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL) 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (2,4 DICHLOROBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (2,6 DICHLOROBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (3 BROMOBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (4 BROMOBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (4 CHLOROBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (4 ETHOXYBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 (4 TERT BUTYLBENZYLIDENEAMINO) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [4 [4 (DIMETHYLAMINO)BENZYLIDENEAMINO] 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 3 [6 (2 CHLOROPHENYL) 1,2,4 TRIAZOLO (3,4 B) (1,3,4)THIADIAZOL 3 YL] 1 ETHYL 7 METHYL 1,8 NAPHTHYRIDIN 4(1H) ONE; 4 [[3 (1 ETHYL 7 METHYL 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDIN 3 YL) 5 MERCAPTO 4H 1,2,4 TRIAZOL 4 YLIMINO]METHYL]BENZONITRILE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CIPROFLOXACIN; HEXACONAZOLE; N [3 (1 ETHYL 7 METHYL 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDIN 3 YL) 5 MERCAPTO 4H 1,2,4 TRIAZOL 4 YL]ACETAMIDE; N [3 (1 ETHYL 7 METHYL 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDIN 3 YL) 5 MERCAPTO 4H 1,2,4 TRIAZOL 4 YL]BENZAMIDE; STREPTOMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FUSARIUM OXYSPORUM; HYDROPHOBICITY; KLEBSIELLA PNEUMONIAE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; BACTERIA; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; NALIDIXIC ACID; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; TRIAZOLES;

EID: 80052929520     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.009     Document Type: Article

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