Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4784-4791

  Sun, Qi ^a   Peng, Da Yong ^a   Yang, Sheng Gang ^a   Zhu, Xiao Lei ^a   Yang, Wen Chao ^a   Yang, Guang Fu ^a,b  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b SynBio Research Platform   (China)

Author keywords

Acetylcholinesterase inhibitor; Alzheimer's disease; Butylcholinesterase inhibitor; Coumarin

Indexed keywords

2 OXO N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 2H CHROMENE 3 CARBOXAMIDE; 2 OXO N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 6 (TRIFLUOROMETHOXY) 2H CHROMENE 3 CARBOXAMIDE; 2 OXO N [6 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] 2H CHROMENE 3 CARBOXAMIDE; 2 OXO N [6 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] 6 (TRIFLUOROMETHOXY) 2H CHROMENE 3 CARBOXAMIDE; 2 OXO N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEPTYL] 6 (TRIFLUOROMETHOXY) 2H CHROMENE 3 CARBOXAMIDE; 2 OXO N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] 2H CHROMENE 3 CARBOXAMIDE; 6 METHOXY 2 OXO N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 2H CHROMENE 3 CARBOXAMIDE; 6 METHOXY 2 OXO N [6 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] 2H CHROMENE 3 CARBOXAMIDE; 6 METHOXY 2 OXO N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEPTYL]2H CHROMENE 3 CARBOXAMIDE; 6 METHYL 2 OXO N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 2H CHROMENE 3 CARBOXAMIDE; 6 METHYL 2 OXO N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEPTYL]2H CHROMENE 3 CARBOXAMIDE; 6,7 DIMETHOXY 2 OXO N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 2H CHROMENE 3 CARBOXAMIDE; 6,7 DIMETHOXY 2 OXO N [6 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] 2H CHROMENE 3 CARBOXAMIDE; 6,7 DIMETHOXY 2 OXO N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEPTYL]2H CHROMENE 3 CARBOXAMIDE; 7 METHOXY 2 OXO N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 2H CHROMENE 3 CARBOXAMIDE; 7 METHOXY 2 OXO N [6 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] 2H CHROMENE 3 CARBOXAMIDE; 7 METHOXY 2 OXO N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEPTYL]2H CHROMENE 3 CARBOXAMIDE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BETA SECRETASE; BUTYLCHOLINESTERASE; CHOLINESTERASE; COUMARIN; TACRINE; TACRINE 2 OXO 3H CHROMENE; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; ENZYME INHIBITOR; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; DISEASE COURSE; DRUG APPROVAL; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; IC 50; PROTEIN AGGREGATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; SYNTHESIS;

ACETYLCHOLINESTERASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84906936007     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.06.057     Document Type: Article

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