Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives

Bioorganic Chemistry

Volumn 63, Issue , 2015, Pages 58-63

  Saeed, Aamer ^a   Zaib, Sumera ^b   Ashraf, Saba ^a   Iftikhar, Javeria ^b   Muddassar, Muhammad ^c,d   Zhang, Kam Y J ^c   Iqbal, Jamshed ^b  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b Centre for Advanced Drug Research COMSATS Institute of Information Technology ^*  (Pakistan)

^c RIKEN   (Japan)

^d Department of Biosciences COMSATS Institute of Information Technology ^*  (Pakistan)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Coumarin; Homology models; Molecular docking; Thioureas

Indexed keywords

1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (2 CHLOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (2 METHOXYPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (2 NITROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (2,3 DICHLOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (2,4 DICHLOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (3 CHLORO 4 FLUOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (3 CHLOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (3 FLUOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (3 METHOXYPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (3 METHYLPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (4 CHLOROPHENYL)THIOUREA; 1 (2 OXO 2H CHROMENE 3 CARBONYL) 3 (CYCLOHEXYL)THIOUREA; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; DONEPEZIL; NEOSTIGMINE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; COUMARIN; THIOUREA;

ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ELECTROPHORUS; HORSE; IC50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 84943388852     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2015.09.009     Document Type: Article

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