메뉴 건너뛰기




Volumn 6, Issue 7, 2016, Pages

Antibacterial drug discovery targeting the lipopolysaccharide biosynthetic enzyme LpxC

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BACTERIUM LIPOPOLYSACCHARIDE; LIPID A; LPXC PROTEIN; UNCLASSIFIED DRUG; ACYLTRANSFERASE; AMIDASE; BACTERIAL PROTEIN; ENZYME INHIBITOR; LPXC DEACETYLASE, PSEUDOMONAS; LPXL PROTEIN, BACTERIA;

EID: 84977554126     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a025304     Document Type: Article
Times cited : (81)

References (79)
  • 2
    • 84977514081 scopus 로고    scopus 로고
    • Design of LpxC, UDP-(3-O-acyl)-N-acetylglucosamine deacetylase, inhibitors and their antibacterial activity
    • Chicago, September 14-17
    • Andersen NH. 2003. Design of LpxC, UDP-(3-O-acyl)-N-acetylglucosamine deacetylase, inhibitors and their antibacterial activity. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Chicago, September 14-17.
    • (2003) 43Rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
    • Andersen, N.H.1
  • 4
    • 0027304442 scopus 로고
    • UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable
    • Anderson MS, Bull HG, Galloway SM, Kelly TM, Mohan S, Radika K, Raetz CR. 1993. UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable. J Biol Chem 268: 19858-19865.
    • (1993) J Biol Chem , vol.268 , pp. 19858-19865
    • Anderson, M.S.1    Bull, H.G.2    Galloway, S.M.3    Kelly, T.M.4    Mohan, S.5    Radika, K.6    Raetz, C.R.7
  • 6
    • 36749037830 scopus 로고    scopus 로고
    • Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
    • Barb AW, Jiang L, Raetz CRH, Zhou P. 2007a. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci 104: 18433-18438.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 18433-18438
    • Barb, A.W.1    Jiang, L.2    Raetz, C.3    Zhou, P.4
  • 7
    • 33947676835 scopus 로고    scopus 로고
    • Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli
    • Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CRH. 2007b. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry 46: 3793-3802.
    • (2007) Biochemistry , vol.46 , pp. 3793-3802
    • Barb, A.W.1    McClerren, A.L.2    Snehelatha, K.3    Reynolds, C.M.4    Zhou, P.5    Raetz, C.R.H.6
  • 9
    • 0023608175 scopus 로고
    • Sequence analysis, transcrip-tional organization, and insertional mutagenesis of the envA gene of Escherichia coli
    • Beall B, Lutkenhaus J. 1987. Sequence analysis, transcrip-tional organization, and insertional mutagenesis of the envA gene of Escherichia coli. J Bacteriol 169: 5408-5415.
    • (1987) J Bacteriol , vol.169 , pp. 5408-5415
    • Beall, B.1    Lutkenhaus, J.2
  • 10
    • 84977586052 scopus 로고    scopus 로고
    • Hydroxamic acid derivatives as Gram-negative antibacterial agents
    • WO2010100475 (A1)
    • Benenato K, Choy A, Hale M, Hill P, Marone V, Miller M. 2010. Hydroxamic acid derivatives as Gram-negative antibacterial agents. Patent WO2010100475 (A1).
    • (2010) Patent
    • Benenato, K.1    Choy, A.2    Hale, M.3    Hill, P.4    Marone, V.5    Miller, M.6
  • 11
    • 77955396578 scopus 로고    scopus 로고
    • Antimicrobial activity of CHIR-090, an inhibitor of lipo-polysaccharide biosynthesis, against the Burkholderia cepacia complex
    • Bodewits K, Raetz CR, Govan JR, Campopiano DJ. 2010. Antimicrobial activity of CHIR-090, an inhibitor of lipo-polysaccharide biosynthesis, against the Burkholderia cepacia complex. Antimicrob Agents Chemother 54: 3531-3533.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3531-3533
    • Bodewits, K.1    Raetz, C.R.2    Govan, J.R.3    Campopiano, D.J.4
  • 15
    • 84977595950 scopus 로고    scopus 로고
    • Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
    • 2014038975 (A1)
    • Brown MF, Chen JM, Melnick MJ, Montgomery JI, Reilly U. 2014b. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents. U.S. Patent 2014038975 (A1).
    • (2014) U.S. Patent
    • Brown, M.F.1    Chen, J.M.2    Melnick, M.J.3    Montgomery, J.I.4    Reilly, U.5
  • 18
    • 84977584275 scopus 로고    scopus 로고
    • 1,2-dihydro-3H-pyrrolo[1,2-C]imi-dazol-3-one derivatives and their use as antibacterial agents
    • WO2015132228 (A1)
    • Chapoux G, Gauvin J-C, Panchaud P, Specklin J-L, Surivet J- P, Schmitt C. 2015. 1,2-dihydro-3H-pyrrolo[1,2-C]imi-dazol-3-one derivatives and their use as antibacterial agents. Patent WO2015132228 (A1).
    • (2015) Patent
    • Chapoux, G.1    Gauvin, J.-C.2    Panchaud, P.3    Specklin, J.-L.4    Surivet, J.-P.5    Schmitt, C.6
  • 23
    • 84856485976 scopus 로고    scopus 로고
    • The Raetz pathway for lipid A biosynthesis: Christian Rudolf Hubert Raetz
    • MD PhD, 1946-2011
    • Dowhan W. 2011. The Raetz pathway for lipid A biosynthesis: Christian Rudolf Hubert Raetz, MD PhD, 1946-2011. J Lipid Res 52: 1857-1860.
    • (2011) J Lipid Res , vol.52 , pp. 1857-1860
    • Dowhan, W.1
  • 24
    • 84928794055 scopus 로고    scopus 로고
    • A complete pathway model for lipid A biosynthesis in Escherichia coli
    • e0121216
    • Emiola A, George J, Andrews SS. 2014. A complete pathway model for lipid A biosynthesis in Escherichia coli. PLoS ONE 10: e0121216.
    • (2014) Plos ONE , vol.10
    • Emiola, A.1    George, J.2    Rews, S.S.3
  • 25
    • 84977527887 scopus 로고    scopus 로고
    • LpxC inhibitors: New class of antibiotics for serious Gram-negative infections
    • Princeton, NJ, March 24-25
    • Erwin AL. 2003. LpxC inhibitors: New class of antibiotics for serious Gram-negative infections. In 8th International Antibacterial Drug Discovery & Development Summit, Princeton, NJ, March 24-25.
    • (2003) 8Th International Antibacterial Drug Discovery & Development Summit
    • Erwin, A.L.1
  • 26
    • 84977561322 scopus 로고    scopus 로고
    • Hydroxamic acid derivatives as Lpxc inhibitors for the treatment of bacterial infections
    • WO2014160649 (A1)
    • Fu J, Karur S, Madera AM, Pecchi S, Sweeney ZK, Tjandra M, Yifru A. 2014. Hydroxamic acid derivatives as Lpxc inhibitors for the treatment of bacterial infections. Patent WO2014160649 (A1).
    • (2014) Patent
    • Fu, J.1    Karur, S.2    Madera, A.M.3    Pecchi, S.4    Sweeney, Z.K.5    Tjandra, M.6    Yifru, A.7
  • 27
    • 84977573073 scopus 로고    scopus 로고
    • Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
    • WO2015066413 (A1)
    • Fu J, Lee P, Madera AM, Sweeney ZK. 2015. Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections. Patent WO2015066413 (A1).
    • (2015) Patent
    • Fu, J.1    Lee, P.2    Madera, A.M.3    Sweeney, Z.K.4
  • 28
    • 33645085050 scopus 로고    scopus 로고
    • The C-terminal end of LpxC is required for degradation by the FtsH protease
    • Fuhrer F, Langklotz S, Narberhaus F. 2006. The C-terminal end of LpxC is required for degradation by the FtsH protease. Mol Microbiol 59: 1025-1036.
    • (2006) Mol Microbiol , vol.59 , pp. 1025-1036
    • Fuhrer, F.1    Langklotz, S.2    Narberhaus, F.3
  • 32
    • 84977512782 scopus 로고    scopus 로고
    • N-hydrox- yamide derivatives possessing antibacterial activity
    • EP2338878 (A2)
    • Jain R, Gordeev M, Lewis J, Francavilla C. 2011. N-hydrox- yamide derivatives possessing antibacterial activity. Patent EP2338878 (A2).
    • (2011) Patent
    • Jain, R.1    Gordeev, M.2    Lewis, J.3    Francavilla, C.4
  • 35
    • 80052817477 scopus 로고    scopus 로고
    • The lipid A assembly pathway: The work of Christian Raetz
    • Kresge N, Simoni RD, Hill RL. 2011. The lipid A assembly pathway: The work of Christian Raetz. J Biol Chem 286: e6-e8.
    • (2011) J Biol Chem , vol.286 , pp. e6-e8
    • Kresge, N.1    Simoni, R.D.2    Hill, R.L.3
  • 36
    • 79951634603 scopus 로고    scopus 로고
    • Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in enterobacteria but not in all Gram-negative bacteria
    • Langklotz S, Schakermann M, Narberhaus F. 2011. Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in enterobacteria but not in all Gram-negative bacteria. J Bacteriol 193: 1090-1097.
    • (2011) J Bacteriol , vol.193 , pp. 1090-1097
    • Langklotz, S.1    Schakermann, M.2    Narberhaus, F.3
  • 39
    • 0016138377 scopus 로고
    • The barrier function of the gram-negative envelope
    • Leive L. 1974. The barrier function of the gram-negative envelope. Ann NY Acad Sci 235: 109-129.
    • (1974) Ann NY Acad Sci , vol.235 , pp. 109-129
    • Leive, L.1
  • 41
    • 84884274025 scopus 로고    scopus 로고
    • Synthesis, structure and antibiotic activity of aryl-substituted LpxC inhibitors
    • Liang X, Lee C-J, Zhao J, Toone EJ, Zhou P. 2013. Synthesis, structure and antibiotic activity of aryl-substituted LpxC inhibitors. J Med Chem 56: 6954-6966.
    • (2013) J Med Chem , vol.56 , pp. 6954-6966
    • Liang, X.1    Lee, C.-J.2    Zhao, J.3    Toone, E.J.4    Zhou, P.5
  • 47
    • 29244445498 scopus 로고    scopus 로고
    • A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin
    • McClerren AL, Endsley S, Bowman JL, Andersen NH, Guan Z, Rudolph J, Raetz CRH. 2005. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. Biochemistry 44: 16574-16583.
    • (2005) Biochemistry , vol.44 , pp. 16574-16583
    • McClerren, A.L.1    Endsley, S.2    Bowman, J.L.3    Ersen, N.H.4    Guan, Z.5    Rudolph, J.6    Raetz, C.R.H.7
  • 49
    • 39549112496 scopus 로고    scopus 로고
    • Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor
    • Mochalkin I, Knafels JD, Lightle S. 2008. Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor. Protein Sci 17: 450-457.
    • (2008) Protein Sci , vol.17 , pp. 450-457
    • Mochalkin, I.1    Knafels, J.D.2    Lightle, S.3
  • 53
    • 0014478053 scopus 로고
    • Mutant of Escherichia coli with anomalous cell division and ability to de-crease episomally and chromosomally mediated resistance to ampicillin and several other antibiotics
    • Normark S, Boman HG, Matsson E. 1969. Mutant of Escherichia coli with anomalous cell division and ability to de-crease episomally and chromosomally mediated resistance to ampicillin and several other antibiotics. J Bacteriol 97: 1334-1342.
    • (1969) J Bacteriol , vol.97 , pp. 1334-1342
    • Normark, S.1    Boman, H.G.2    Matsson, E.3
  • 54
    • 0345523771 scopus 로고    scopus 로고
    • Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli
    • Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K, Young K, Su LH, Fierke CA, Jackman JE, Raetz CR, et al. 1999. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Mol Microbiol 31: 833-844.
    • (1999) Mol Microbiol , vol.31 , pp. 833-844
    • Ogura, T.1    Inoue, K.2    Tatsuta, T.3    Suzaki, T.4    Karata, K.5    Young, K.6    Su, L.H.7    Fierke, C.A.8    Jackman, J.E.9    Raetz, C.R.10
  • 56
    • 0015523247 scopus 로고
    • Mechanism of assembly of the outer membrane of Salmonella typhimurium. Site of synthesis of lipopolysaccharide
    • Osborn MJ, Gander JE, Parisi E. 1972. Mechanism of assembly of the outer membrane of Salmonella typhimurium. Site of synthesis of lipopolysaccharide. J Biol Chem 247: 3973-3986.
    • (1972) J Biol Chem , vol.247 , pp. 3973-3986
    • Osborn, M.J.1    Gander, J.E.2    Parisi, E.3
  • 60
    • 0027255391 scopus 로고
    • Bacterial endotoxins: Extraordinary lipids that activate eucaryotic signal transduction
    • Raetz CR. 1993. Bacterial endotoxins: Extraordinary lipids that activate eucaryotic signal transduction. J Bacteriol 175: 5745-5753.
    • (1993) J Bacteriol , vol.175 , pp. 5745-5753
    • Raetz, C.R.1
  • 65
    • 69249230732 scopus 로고    scopus 로고
    • Transport of lipopoly-saccharide across the cell envelope: The long road of discovery
    • Ruiz N, Kahne D, Silhavy TJ. 2009. Transport of lipopoly-saccharide across the cell envelope: The long road of discovery. Nat Rev Microbiol 7: 677-683.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 677-683
    • Ruiz, N.1    Kahne, D.2    Silhavy, T.J.3
  • 66
    • 0024690869 scopus 로고
    • Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability
    • Sampson BA, Misra R, Benson SA. 1989. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability. Genetics 122: 491-501.
    • (1989) Genetics , vol.122 , pp. 491-501
    • Sampson, B.A.1    Misra, R.2    Benson, S.A.3
  • 69
    • 0029908978 scopus 로고    scopus 로고
    • Regulation of UDP-3-O-[R-3-hy- droxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid A biosynthesis
    • Sorensen PG, Lutkenhaus J, Young K, Eveland SS, Anderson MS, Raetz CR. 1996. Regulation of UDP-3-O-[R-3-hy- droxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid A biosynthesis. J Biol Chem 271: 25898-25905.
    • (1996) J Biol Chem , vol.271 , pp. 25898-25905
    • Sorensen, P.G.1    Lutkenhaus, J.2    Young, K.3    Eveland, S.S.4    Erson, M.S.5    Raetz, C.R.6
  • 73
  • 74
    • 0029586501 scopus 로고
    • The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP- 3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine de- acetylase
    • Young K, Silver LL, Bramhill D, Cameron P, Eveland SS, Raetz CR, Hyland SA, Anderson MS. 1995. The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP- 3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine de- acetylase. J Biol Chem 270: 30384-30391.
    • (1995) J Biol Chem , vol.270 , pp. 30384-30391
    • Young, K.1    Silver, L.L.2    Bramhill, D.3    Cameron, P.4    Eveland, S.S.5    Raetz, C.R.6    Hyland, S.A.7    Erson, M.S.8
  • 75
    • 84874307225 scopus 로고    scopus 로고
    • Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis
    • Zeng D, Zhao J, Chung HS, Guan Z, Raetz CRH, Zhou P. 2013. Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. J Biol Chem 288: 5475-5486.
    • (2013) J Biol Chem , vol.288 , pp. 5475-5486
    • Zeng, D.1    Zhao, J.2    Chung, H.S.3    Guan, Z.4    Raetz, C.5    Zhou, P.6
  • 76
    • 84977499717 scopus 로고    scopus 로고
    • 2-Piperidinyl substituted N,3-dihydroxybutanamides
    • WO2015024016(A2)
    • Zhou P, Toone E, Nicholas R. 2015a. 2-Piperidinyl substituted N,3-dihydroxybutanamides. Patent WO2015024016(A2).
    • (2015) Patent
    • Zhou, P.1    Toone, E.2    Nicholas, R.3
  • 77
    • 84977580739 scopus 로고    scopus 로고
    • Antibacterial compounds
    • WO2015024021 (A2)
    • Zhou P, Toone E, Nicholas R. 2015b. Antibacterial compounds. Patent WO2015024021 (A2).
    • (2015) Patent
    • Zhou, P.1    Toone, E.2    Nicholas, R.3
  • 78
    • 84977523175 scopus 로고    scopus 로고
    • Substituted hydroxamic acid compounds
    • WO2015024010 (A2)
    • Zhou P, Toone E, Nicholas R. 2015c. Substituted hydroxamic acid compounds. Patent WO2015024010 (A2).
    • (2015) Patent
    • Zhou, P.1    Toone, E.2    Nicholas, R.3
  • 79
    • 0018944402 scopus 로고
    • Penetration of b-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: Comparison of a highly sensitive mutant with its parent strain
    • Zimmermann W. 1980. Penetration of b-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: Comparison of a highly sensitive mutant with its parent strain. Antimicrob Agents Chemother 18: 94-100.
    • (1980) Antimicrob Agents Chemother , vol.18 , pp. 94-100
    • Zimmermann, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.