Synthesis, structure, and SAR of tetrahydropyran-based LpxC inhibitors

ACS Medicinal Chemistry Letters

Volumn 5, Issue 11, 2014, Pages 1213-1218A

  Murphy Benenato, Kerry E ^a   Olivier, Nelson ^b   Choy, Allison ^a   Ross, Philip L ^b   Miller, Matthew D ^a   Thresher, Jason ^a   Gao, Ning ^b   Hale, Michael R ^a  

^a Department of Chemistry Infection Innovative Medicines ^*  (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Antibacterial; Aquifex aeolicus; Gram negative bacteria; hydrophobe; LpxC; MMP; Pseudomonas aeruginosa

Indexed keywords

ACYLTRANSFERASE INHIBITOR; ANTIINFECTIVE AGENT; TETRAHYDROPYRAN DERIVATIVE;

ALKYLATION; ANTIBACTERIAL ACTIVITY; AQUIFEX AEOLICUS; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROGEN BOND; IC50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION;

AQUIFEX AEOLICUS; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84927638324     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500210x     Document Type: Article

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