A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid a biosynthesis with antibiotic activity comparable to ciprofloxacin

Biochemistry

Volumn 44, Issue 50, 2005, Pages 16574-16583

  McClerren, Amanda L ^a   Endsley, Stephanie ^b   Bowman, Jason L ^b   Andersen, Niels H ^b   Guan, Ziqiang ^a   Rudolph, Johannes ^a   Raetz, Christian R H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOASSAY; BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; LIPIDS; MASS SPECTROMETRY; MODIFICATION;

CIPROFLOXACIN; DEACETYLATION; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; NANOMOLAR CONCENTRATIONS;

ENZYME INHIBITION;

ACYLTRANSFERASE; ANTIBIOTIC AGENT; BB 78485; CHIR 090; CIPROFLOXACIN; HYDROXAMIC ACID DERIVATIVE; L 161240; LIPID A; N ACETYLGLUCOSAMINE; THREONINE HYDROXAMIC ACID; TOBRAMYCIN; TU 514; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE 3 O ACYL N ACETYLGLUCOSAMINE; ZINC DEPENDENT DEACETYLASE LPXC;

ANTIMICROBIAL ACTIVITY; AQUIFEX AEOLICUS; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DEACETYLATION; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; DRUG TARGETING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME MODIFICATION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HALF LIFE TIME; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; ENZYME INHIBITORS; LIPID A; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; ZINC;

AQUIFEX AEOLICUS; CHIRON; ESCHERICHIA COLI; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA;

EID: 29244445498     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0518186     Document Type: Article

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