Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6832-6838

  McAllister, Laura A ^a   Montgomery, Justin I ^a   Abramite, Joseph A ^a   Reilly, Usa ^a   Brown, Matthew F ^a   Chen, Jinshan M ^a   Barham, Rose A ^a   Che, Ye ^a   Chung, Seung Won ^a   Menard, Carol A ^a   Mitton Fry, Mark ^a   Mullins, Lisa M ^a   Noe, Mark C ^a   O'Donnell, John P ^a   Oliver III, Robert M ^a   Penzien, Joseph B ^a   Plummer, Mark ^a   Price, Loren M ^a   Shanmugasundaram, Veerabahu ^a   Tomaras, Andrew P ^a   Uccello, Daniel P ^a   more..

^a PFIZER INC   (United States)

Author keywords

Antibacterial; Gram negative; Heterocycle; Hydroxamic acid; LpxC inhibitors; Pseudomonas aeruginosa

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; HETEROCYCLIC METHYLSULFONE HYDROXAMATE DERIVATIVE; LIPOPOLYSACCHARIDE; LPXC ENZYME; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; GRAM-NEGATIVE BACTERIA; HETEROCYCLIC COMPOUNDS; HYDROXAMIC ACIDS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84867841679     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.058     Document Type: Article

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