Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 14, 2003, Pages 8146-8150

  Whittington, Douglas A ^a   Rusche, Kristin M ^b   Shin, Hyunshun ^a   Fierke, Carol A ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; ENZYME; FATTY ACID; LIPID A; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE [3 O (3 HYDROXYMYRISTOYL)] N ACETYLGLUCOSAMINE DEACETYLASE; ZINC;

AQUIFEX AEOLICUS; ARTICLE; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; FUSION GENE; GENE DUPLICATION; GRAM NEGATIVE BACTERIUM; HYDROPHOBICITY; NONHUMAN; OUTER MEMBRANE; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN MOTIF;

AMIDOHYDROLASES; AMINO ACID MOTIFS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROPHOBICITY; LIPID A; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

AQUIFEX AEOLICUS; BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0038154073     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1432990100     Document Type: Article

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