Structure of the LpxC deacetylase with a bound substrate-analog inhibitor

Nature Structural Biology

Volumn 10, Issue 8, 2003, Pages 645-651

  Coggins, Brian E ^a   Li, Xuechen ^b   McClerren, Amanda L ^a   Hindsgaul, Ole ^b   Raetz, Christian R H ^a   Zhou, Pei ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; AMIDASE; ANTIBIOTIC AGENT; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE 3 O ACYL N ACETYLGLUCOSAMINE DEACETYLASE;

AQUIFEX AEOLICUS; ARTICLE; BACTERIAL SURVIVAL; CATALYSIS; CATALYST; CONTROLLED STUDY; DRUG DESIGN; ENZYME STRUCTURE; GRAM NEGATIVE BACTERIUM; HYDROPHOBICITY; LIPOGENESIS; MAMMAL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; SEQUENCE HOMOLOGY;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; ZINC;

AQUIFEX AEOLICUS; BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA;

EID: 0042123525     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb948     Document Type: Article

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