Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC

Journal of Medicinal Chemistry

Volumn 45, Issue 14, 2002, Pages 3112-3129

  Kline, Toni ^a,b   Andersen, Niels H ^c   Harwood, Eric A ^a   Bowman, Jason ^c   Malanda, Andre ^c   Endsley, Stephanie ^c   Erwin, Alice L ^a   Doyle, Michael ^d   Fong, Susan ^d   Harris, Alex L ^d   Mendelsohn, Brian ^b,c   Mdluli, Khisimuzi ^a   Raetz, Christian R H ^e   Stover, C Kendall ^a,f   Witte, Pamela R ^a   Yabannavar, Asha ^d   Zhu, Shuguang ^a  

^a Chiron Corporation   (United States)

^b SEATTLE GENETICS INC   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; DEACETYLASE; ENZYME INHIBITOR; LIPID A; N ACETYLGLUCOSAMINE; OXAZOLINE DERIVATIVE; PROTEIN LPXC; UNCLASSIFIED DRUG;

ARTICLE; DEACETYLATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; OXAZINES; OXAZOLES; PSEUDOMONAS AERUGINOSA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0037019270     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010579r     Document Type: Article

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