Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

Protein Science

Volumn 17, Issue 3, 2008, Pages 450-457

  Mochalkin, Igor ^a   Knafels, John D ^a   Lightle, Sandra ^a  

^a PFIZER INC   (United States)

Author keywords

Active sites; Antibacterial inhibitor; Enzyme inhibitors; LpxC; Metalloproteins; Structure

Indexed keywords

ACETIC ACID; ANTIBIOTIC AGENT; BB 78485; ENZYME INHIBITOR; GLUCOSAMINE DERIVATIVE; LIPID A; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; URIDINE DIPHOSPHATE 3 O (3 HYDROXYMYRISTOYL) N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE 3 O (3 HYDROXYMYRISTOYL) N ACETYLGLUCOSAMINE DEACETYLASE; URIDINE DIPHOSPHATE 3 O (3 HYDROXYMYRISTOYL)GLUCOSAMINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVE SITE; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TREATMENT OUTCOME;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; NAPHTHALENES; SULFONAMIDES;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 39549112496     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.073324108     Document Type: Article

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