Antibacterial agents that inhibit lipid a biosynthesis

Science

Volumn 274, Issue 5289, 1996, Pages 980-982

  Onishi, H Russell ^a   Pelak, Barbara A ^a   Gerckens, Lynn S ^a   Silver, Lynn L ^a   Kahan, Frederick M ^a   Chen, Meng Hsin ^a   Patchett, Arthur A ^a   Galloway, Susan M ^a   Hyland, Sheryl A ^a   Anderson, Matt S ^a   Raetz, Christian R H ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS; ANTIBIOTICS; BACTERIA; ENZYME INHIBITION; ENZYMES; GROWTH KINETICS; LIPIDS; MEMBRANES; MONOLAYERS; ORGANIC ACIDS;

ANTIBACTERIAL AGENTS; BACTERIAL GROWTH; BACTERIAL PATHOGENS; DEACETYLASE; GRAM NEGATIVE BACTERIA; HYDROXAMIC ACIDS; LIPID A BIOSYNTHESIS;

BIOSYNTHESIS;

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BACTERIUM LIPOPOLYSACCHARIDE; DEACETYLASE; L 159463; L 161240; L 573655; LIPID A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; ESCHERICHIA COLI; INTRAPERITONEAL DRUG ADMINISTRATION; LIPOGENESIS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMIDOHYDROLASES; ANIMALS; ANTI-BACTERIAL AGENTS; BINDING SITES; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GRAM-NEGATIVE BACTERIA; HYDROXAMIC ACIDS; LIPID A; MICE; MICROBIAL SENSITIVITY TESTS; OXAZOLES; PSEUDOMONAS; SERRATIA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 10544252685     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5289.980     Document Type: Article

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