Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 6, 2006, Pages 2178-2184

  Mdluli, Khisimuzi E ^a,d   Witte, Pamela R ^a,e   Kline, Toni ^a,f   Barb, Adam W ^b   Erwin, Alice L ^a,c   Mansfield, Bryce E ^a,f   McClerren, Amanda L ^b,g   Pirrung, Michael C ^b,h   Tumey, L Nathan ^b,i   Warrener, Paul ^a,j   Raetz, Christian R H ^b   Stover, C Kendall ^a,k  

^a Chiron Corporation   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

^e DeCODE Chemistry & Biostructures   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ WYETH RESEARCH   (United States)

^j ROSETTA INPHARMATICS   (United States)

^k PFIZER INC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; AMPICILLIN; ANTIINFECTIVE AGENT; ARABINOSE; BACTERIAL PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; GENTAMICIN; KANAMYCIN; L 161240; PROTEIN LPXC; TETRACYCLINE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE 3 O (3 HYDROXYMYRISTOYL) N ACETYLGLUCOSAMINE DEACETYLASE;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; DRUG POTENCY; DRUG TARGETING; ENZYME MECHANISM; ESCHERICHIA COLI; GENE ACTIVITY; GENE INACTIVATION; GRAM NEGATIVE BACTERIUM; LIPOGENESIS; LPXC GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PSEUDOMONAS AERUGINOSA; VALIDATION PROCESS;

AMIDOHYDROLASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CATALYSIS; CONSERVED SEQUENCE; ESCHERICHIA COLI; GENES, BACTERIAL; HISTIDINE; LIPID A; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; OXAZOLES; PHENYLALANINE; PROMOTER REGIONS (GENETICS); PSEUDOMONAS AERUGINOSA; REPRODUCIBILITY OF RESULTS; SEQUENCE HOMOLOGY, AMINO ACID; ZINC;

EID: 33744487392     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00140-06     Document Type: Article

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