Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis

Journal of Biological Chemistry

Volumn 288, Issue 8, 2013, Pages 5475-5486

  Zeng, Daina ^a   Zhao, Jinshi ^a   Chung, Hak Suk ^a,b   Guan, Ziqiang ^a   Raetz, Christian R H ^b   Zhou, Pei ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; CELLULAR GROWTH; CELLULAR HOMEOSTASIS; LIPID A; OUTER MEMBRANE; PROTEIN BIOSYNTHESIS; REBALANCING;

BIOCHEMISTRY; BIOSYNTHESIS;

PHYSIOLOGY;

ENZYME INHIBITOR; ENZYME LPXC INHIBITOR; HYDROLASE; LIPID A; UDP 3 O (HYDROXYMYRISTOYL) N ACETYLGLUCOSAMINE DEACETYLASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; FABZ GENE; GENE; HOMEOSTASIS; IN VITRO STUDY; LIPOGENESIS; MINIMUM INHIBITORY CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; THRS GENE; WILD TYPE;

AMIDOHYDROLASES; CHROMATOGRAPHY, LIQUID; ESCHERICHIA COLI; FATTY ACIDS; HOMEOSTASIS; LIPID A; LIPIDS; LIPOPOLYSACCHARIDES; MASS SPECTROMETRY; MODELS, CHEMICAL; MUTATION; PHOSPHOLIPIDS; POINT MUTATION; RNA; THREONINE-TRNA LIGASE;

EID: 84874307225     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.447607     Document Type: Article

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