Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 2, 2011, Pages 852-860

  Liang, Xiaofei ^a,b   Lee, Chul Jin ^b,c   Chen, Xin ^b   Chung, Hak Suk ^c   Zeng, Daina ^c   Raetz, Christian R H ^c   Li, Yaoxian ^a   Zhou, Pei ^b,c   Toone, Eric J ^b,c  

^a JILIN UNIVERSITY   (China)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

1,4 Diphenyl 1,3 butadiyne; Antibiotic; Diphenyl diacetylene; Hydroxamate; Inhibitor; LpxC

Indexed keywords

2 [4' [(2'' AMINOPHENYL)BUTA 1',3' DIYNYL]BENZAMIDO] 1,3 DIHYDROXY BUTANAMIDE; 2 [4' [(3'' AMINOPHENYL)BUTA 1',3' DIYNYL]BENZAMIDO] 1,3 DIHYDROXY BUTANAMIDE; 2 [4' [(4'' AMINOPHENYL)BUTA 1',3' DIYNYL]BENZAMIDO] 1,3 DIHYDROXY BUTANAMIDE; ACETYLENE DERIVATIVE; ANTIBIOTIC AGENT; DIPHENYL DIACETYLENE (1,4 DIPHENYL 1,3 BUTADIYNE)THREONYL HYDROXAMATE; METHYL 2 [(4' ETHYNYLPHENYL)FORMAMIDO] 3 HYDROXYBUTANOATE; METHYL 2 [4' [(2'' AMINOPHENYL)BUTA 1',3' DIYNYL]BENZAMIDO] 3 HYDROXY BUTANOATE; METHYL 2 [4' [(3'' AMINOPHENYL)BUTA 1',3' DIYNYL]BENZAMIDO] 3 HYDROXY BUTANOATE; METHYL 2 [4' [(4'' AMINOPHENYL)BUTA 1',3' DIYNYL]BENZAMIDO] 3 HYDROXY BUTANOATE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE 3 O (ACYL) N ACETYLGLUCOSAMINE DEACETYLASE INHIBITOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; RHIZOBIUM LEGUMINOSARUM; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

NEGIBACTERIA;

EID: 78651477706     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.017     Document Type: Article

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