Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC

ACS Chemical Biology

Volumn 9, Issue 1, 2014, Pages 237-246

  Lee, Chul Jin ^a,b   Liang, Xiaofei ^b   Gopalaswamy, Ramesh ^b   Najeeb, Javaria ^a,b   Ark, Eugene D ^c   Toone, Eric J ^a,b   Zhou, Pei ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; BB 78485; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; L 161240; LPXC PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; ENANTIOMER; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME REPRESSION; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR RECOGNITION; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MODELS, MOLECULAR; NAPHTHALENES; OXAZOLES; PROTEIN BINDING; PROTEIN CONFORMATION; SULFONAMIDES;

EID: 84900396878     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400067g     Document Type: Article

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