Immune mechanisms linked to depression via oxidative stress and neuroprogression

Immunology

Volumn 144, Issue 3, 2015, Pages 365-373

  Bakunina, Nataliia ^a   Pariante, Carmine M ^a   Zunszain, Patricia A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Neuroinflammation; Neuroprogression; Reactive oxygen species; Signal transduction; Transcription factors

Indexed keywords

ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

ANTIOXIDANT ACTIVITY; BRAIN FUNCTION; DISEASE COURSE; HUMAN; IMMUNE RESPONSE; MAJOR DEPRESSION; META ANALYSIS (TOPIC); MOLECULAR BIOLOGY; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84977552497     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12443     Document Type: Review

References (105)

1. Moylan S, Maes M, Wray NR, Berk M. The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications. Mol Psychiatry 2013; 18:595-606.
2. Migliore L, Coppedè F. Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutat Res 2009; 674:73-84.
3. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408:239-47.
4. Shukla V, Mishra SK, Pant HC. Oxidative stress in neurodegeneration. Adv Pharmacol Sci 2011; 2011:13.
5. Li J, O W, Li W, Jiang Z-G, Ghanbari HA. Oxidative stress and neurodegenerative disorders. Int J Mol Sci 2013; 14:24438-75.
6. Myint AM, Kim YK. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med Hypotheses 2003; 61:519-25.
7. Maes M, Yirmyia R, Noraberg J et al. The inflammatory and neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 2009; 24:27-53.
8. Verhoeven JE, Revesz D, Epel ES, Lin J, Wolkowitz OM, Penninx BWJH. Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Mol Psychiatry 2014; 19:895-901.
9. Wolkowitz OW, Epel ES, Reus VI, Mellon SH. Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety 2010; 27:327-38.
10. Wolkowitz OM, Reus VI, Mellon SH. Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci 2011; 13:25-39.
11. Gili M, Comas A, García-García M, Monzón S, Antoni S-B, Roca M. Comorbidity between common mental disorders and chronic somatic diseases in primary care patients. Gen Hosp Psychiatry 2010; 32:240-5.
12. Krishnan KRR, Delong M, Kraemer H et al. Comorbidity of depression with other medical diseases in the elderly. Biol Psychiatry 2002; 52:559-88.
13. Maes M, Kubera M, Mihaylova I, Geffard M, Galecki P, Leunis J-C, Berk M. Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression. J Affect Disord 2013; 149:23-9.
14. Lopresti AL, Maker GL, Hood SD, Drummond PD. A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers. Prog Neuropsychopharmacol Biol Psychiatry 2014; 48:102-11.
15. Maes M, Fišar Z, Medina M, Scapagnini G, Nowak G, Berk M. New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. and new drug candidates-Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology 2012; 20:127-50.
16. Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, Reddy R, Aschner M, Lewis DA, Mirnics K. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry 2011; 16:751-62.
17. Chung CP, Schmidt D, Stein CM, Morrow JD, Salomon RM. Increased oxidative stress in patients with depression and its relationship to treatment. Psychiatry Res 2013; 206:213-6.
18. Stefanescu C, Ciobica A. The relevance of oxidative stress status in first episode and recurrent depression. J Affect Disord 2012; 143:34-8.
19. Palta P, Samuel LJ, Miller ER, Szanton SL. Depression and oxidative stress: results from a meta-analysis of observational studies. Psychosom Med 2014; 76:12-9.
20. Maes M, Galecki P, Chang YS, Berk M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35:676-92.
21. Yanik M, Erel O, Kati M. The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatr 2004; 16:200-3.
22. Lee CH, Park JH, Yoo K-Y et al. Pre-and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress. Exp Neurol 2011; 229:450-9.
23. Behr GA, Moreira JCF, Frey BN. Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder. Oxid Med Cell Longev 2012; 2012. doi:10.1155/2012/609421.
24. Lee S-Y, Lee S-J, Han C, Patkar AA, Masand PS, Pae C-U. Oxidative/nitrosative stress and antidepressants: targets for novel antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 2013; 46:224-35.
25. Herken H, Gurel A, Selek S et al. Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment. Arch Med Res 2007; 38:247-52.
26. Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev 2012; 2012:11.
27. Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003; 552:335-44.
28. Friedman J. Oxidative stress and free radical damage in neurology. In: Gadoth N, Göbel HH, eds. Oxidative Stress in Applied Basic Research and Clinical Practice. Totowa, NJ: Humana Press, 2011:19-27.
29. Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 2001; 11:173-86.
30. Hurd TR, DeGennaro M, Lehmann R. Redox regulation of cell migration and adhesion. Trends Cell Biol 2012; 22:107-15.
31. Oh JI, Kaplan S. Redox signaling: globalization of gene expression. EMBO J 2000; 19:4237-47.
32. Ray PD, Huang B-W, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012; 24:981-90.
33. Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat Rev Immunol 2013; 13:349-61.
34. Walton NM, Shin R, Tajinda K et al. Adult neurogenesis transiently generates oxidative stress. PLoS One 2012; 7:e35264. doi:10.1371/journal.pone.0035264.
35. Woolley JF, Corcoran A, Groeger G, Landry WD, Cotter TG. Redox-regulated growth factor survival signaling. Antioxid Redox Signal 2013; 19:1815-27.
36. Gong Y, Chai Y, Ding J-H, Sun X-L, Hu G. Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett 2011; 488:76-80.
37. Gardner A, Johansson A, Wibom R, Nennesmo I, von Döbeln U, Hagenfeldt L, Hällström T. Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients. J Affect Disord 2003; 76:55-68.
38. Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009; 284:13291-5.
39. Petri S, Körner S, Kiaei M. Nrf2/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS. Neurol Res Int 2012; 2012. doi:10.1155/2012/878030.
40. Baird L, Dinkova-Kostova A. The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol 2011; 85:241-72.
41. de Vries HE, Witte M, Hondius D, Rozemuller AJM, Drukarch B, Hoozemans J, van Horssen J. Nrf2-induced antioxidant protection: a promising target to counteract ROSmediated damage in neurodegenerative disease? Free Radic Biol Med 2008; 45:1375-83.
42. Calkins MJ, Johnson DA, Townsend JA et al. The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 2009; 11:497-508.
43. Lee J-M, Shih AY, Murphy TH, Johnson JA. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem 2003; 278:37948-56.
44. Martín-de-Saavedra MD, Budni J, Cunha MP et al. Nrf2 participates in depressive disorders through an anti-inflammatory mechanism. Psychoneuroendocrinology 2013; 38:2010-22.
45. Zhu Y, Carvey PM, Ling Z. Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide. Neurochem Int 2007; 50:671-80.
46. Mohora M, Greabu M, Totan A, Mitrea N. Redox-sensitive signaling factors and antioxidants. Farmacia 2009; 57:399-411.
47. Gloire G, Legrand-Poels S, Piette J. NF-jB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006; 72:1493-505.
48. Rawdin BJ, Mellon SH, Dhabhar FS et al. Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav Immun 2013; 31:143-52.
49. Siomek A. NF-jB signaling pathway and free radical impact. Acta Biochim Pol 2012; 59:323-31.
50. Nakano H, Nakajima A, Sakon-Komazawa S, Piao J-H, Xue X, Okumura K. Reactive oxygen species mediate crosstalk between NF-jB and JNK. Cell Death Differ 2005; 13:730-7.
51. Perkins ND. Integrating cell-signalling pathways with NF-jB and IKK function. Nat Rev Mol Cell Biol 2007; 8:49-62.
52. Morgan MJ, Liu Z. Crosstalk of reactive oxygen species and NF-jB signaling. Cell Res 2011; 21:103-15.
53. Noubade R, Wong K, Ota N et al. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Nature 2014; 509:235-9.
54. Liu J, Zhang Z, Chai L, Che Y, Min S, Yang R. Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-jB activation. Biochem Biophys Res Commun 2013; 434:28-34.
55. Haneklaus M, O’Neill LAJ, Coll RC. Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr Opin Immunol 2013; 25:40-5.
56. Bauer ME, De la Fuente M. Oxidative stress, inflammaging, and immunosenescence. In: Rahman I, Bagchi D, eds. Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. Amsterdam, Netherlands: Elsevier, 2013:39-47.
57. Cruz CM, Rinna A, Forman HJ, Ventura ALM, Persechini PM, Ojcius DM. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 2007; 282:2871-9.
58. Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010; 10:210-5.
59. Baroja-Mazo A, Martin-Sanchez F, Gomez AI et al. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 2014; 15:738-48.
60. Leonard B, Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 2012; 36:764-85.
61. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease. J Affect Disord 2010; 125:287-94.
62. Gold PW, Pavlatou MG, Carlson PJ et al. Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A. Neurosci Lett 2012; 520:1-5.
63. Weismann D, Binder CJ. The innate immune response to products of phospholipid peroxidation. Biochim Biophys Acta 2012; 1818:2465-75.
64. Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R. The new ‘5-HT’ hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35:702-21.
65. Zunszain PA, Anacker C, Cattaneo A et al. Interleukin-1b: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology 2012; 37:939-49.
66. Müller A, Leichert LI. Redox proteomics. In: Jakob U, Reichmann D, eds. Oxidative Stress and Redox Regulation. Heidelberg: Springer, 2013:157-86.
67. Miller CL, Llenos IC, Dulay JR, Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 2006; 1073-1074:25-37.
68. Gabbay V, Klein RG, Katz Y et al. The possible role of the kynurenine pathway in adolescent depression with melancholic features. J Child Psychol Psychiatry 2010; 51:935-43.
69. Repetto M, Semprine J, Boveris A. Lipid peroxidation: chemical mechanism, biological implications and analytical determination. In: Catala A, ed. Lipid Peroxidation. Croatia: In Tech, 2012.
70. Zunszain PA, Hepgul N, Pariante CM. Inflammation and depression. Curr Top Behav Neurosci 2013; 14:135-51.
71. Su K-P, Huang S-Y, Peng C-Y, Lai H-C, Huang C-L, Chen Y-C, Aitchison KJ, Pariante CM. Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferona-induced depression by regulating polyunsaturated fatty acids levels. Biol Psychiatry 2010; 67:550-7.
72. Catalá A. Lipid peroxidation modifies the picture of membranes from the ‘Fluid Mosaic Model’ to the ‘Lipid Whisker Model’. Biochimie 2012; 94:101-9.
73. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014; 2014. doi:10.1155/2014/360438.
74. Gałecki P, Szemraj J, Bieńkiewicz M, Florkowski A, Gałecka E. Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment. Pharmacol Rep 2009; 61:436-47.
75. Sarandol A, Sarandol E, Eker SS, Erdinc S, Vatansever E, Kirli S. Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum Psychopharmacol 2007; 22:67-73.
76. Dimopoulos N, Piperi C, Psarra V, Lea RW, Kalofoutis A. Increased plasma levels of 8-iso-PGF2a and IL-6 in an elderly population with depression. Psychiatry Res 2008; 161:59-66.
77. Yager S, Forlenza MJ, Miller GE. Depression and oxidative damage to lipids. Psychoneuroendocrinology 2010; 35:1356-62.
78. Kohen R, Nyska A. Invited review: oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 2002; 30:620-50.
79. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature 2010; 464:529-35.
80. Forlenza MJ, Miller GE. Increased serum levels of 8-hydroxy-2’-deoxyguanosine in clinical depression. Psychosom Med 2006; 68:1-7.
81. Irie M, Miyata M, Kasai H. Depression and possible cancer risk due to oxidative DNA damage. J Psychiatr Res 2005; 39:553-60.
82. Simon NM, Smoller JW, McNamara KL et al. Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry 2006; 60:432-5.
83. Richter T, von Zglinicki T. A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 2007; 42:1039-42.
84. Kawanishi S, Oikawa S. Mechanism of telomere shortening by oxidative stress. Ann N Y Acad Sci 2004; 1019:278-84.
85. Aonurm-Helm A, Berezin V, Bock E, Zharkovsky A. NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice. Brain Res 2010; 1309:1-8.
86. Fujita-Hamabe W, Tokuyama S. The involvement of cleavage of neural cell adhesion molecule in neuronal death under oxidative stress conditions in cultured cortical neurons. Biol Pharm Bull 2012; 35:624-8.
87. Bartosz G. Reactive oxygen species: destroyers or messengers? Biochem Pharmacol 2009; 77:1303-15.
88. Forman H, Torres M, Fukuto J. Redox signaling. Mol Cell Biochem 2002; 234-235:49-62.
89. McCubrey JA, LaHair MM, Franklin RA. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 2006; 8:1775-89.
90. Corcoran A, Cotter TG. Redox regulation of protein kinases. FEBS J 2013; 280:1944-65.
91. Buelna-Chontal M, Zazueta C. Redox activation of Nrf2 and NF-jB: a double end sword? Cell Signal 2013; 25:2548-57.
92. Apel K, Hirt H. Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol 2004; 55:373-99.
93. Uranga RM, Katz S, Salvador GA. Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem 2013; 288:19773-84.
94. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002; 192:1-15.
95. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell 2011; 144:926-39.
96. Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, Choi AMK. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 2007; 9:49-89.
97. Tan S. Oxytosis: a novel form of programmed cell death. Curr Top Med Chem 2001; 1:497-506.
98. Henke N, Albrecht P, Bouchachia I et al. The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress. Cell Death Dis 2013; 4:e470.
99. Kepp O, Galluzzi L, Zitvogel L, Kroemer G. Pyroptosis-a cell death modality of its kind? Eur J Immunol 2010; 40:627-30.
100. Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 2014; 15:135-47.
101. Valencia A, Morán J. Reactive oxygen species induce different cell death mechanisms in cultured neurons. Free Radic Biol Med 2004; 36:1112-25.
102. Higgins G, Devenish R, Beart P, Nagley P. Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death. Cell Mol Life Sci 2011; 68:3725-40.
103. Bierhaus A, Humpert PM, Nawroth PP. NF-jB as a molecular link between psychosocial stress and organ dysfunction. Pediatr Nephrol 2004; 19:1189-91.
104. Juster R-P, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 2010; 35:2-16.
105. McKinnon MC, Yucel K, Nazarov A, MacQueen GM. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 2009; 34:41.