Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress

Experimental Neurology

Volumn 229, Issue 2, 2011, Pages 450-459

  Lee, Choong Hyun ^a   Park, Joon Ha ^b   Yoo, Ki Yeon ^c   Choi, Jung Hoon ^b   Hwang, In Koo ^a   Ryu, Pan Dong ^a   Kim, Do Hoon ^d   Kwon, Young Guen ^e   Kim, Young Myeong ^b   Won, Moo Ho ^b  

^a Seoul National University   (South Korea)

^b Kangwon National University   (South Korea)

^c Gangneung Wonju National University   (South Korea)

^d Hallym University   (South Korea)

^e Yonsei University   (South Korea)

Author keywords

Delayed neuronal death; Escitalopram; Hippocampus; Microglia activation; Neuroprotection; Oxidative stress; Selective serotonin re uptake inhibitors; Transient cerebral ischemia

Indexed keywords

4 HYDROXYNONENAL; BRAIN DERIVED NEUROTROPHIC FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE; ESCITALOPRAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN LEVEL; CELL ACTIVATION; CONTROLLED STUDY; HIPPOCAMPAL CA1 REGION; IMMUNOREACTIVITY; MALE; MICROGLIA; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPERFUSION INJURY; TRANSIENT ISCHEMIC ATTACK;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CA1 REGION, HIPPOCAMPAL; CITALOPRAM; GERBILLINAE; LIPID PEROXIDATION; MALE; MICROGLIA; NEURONS; OXIDATIVE STRESS; SEROTONIN UPTAKE INHIBITORS; SUPEROXIDE DISMUTASE;

EID: 79956155995     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.03.015     Document Type: Article

References (46)

1. Aggarwal A., Gaur V., Kumar A. Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. Life Sci. 2010, 86:928-935.
2. Anderson I.M. SSRIS versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability. Depress. Anxiety 1998, 7(Suppl 1):11-17.
3. Candelario-Jalil E., Alvarez D., Merino N., Leon O.S. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neurosci. Res. 2003, 47:245-253.
4. Chan P.H. Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia. Neurochem. Res. 2004, 29:1943-1949.
5. Chang Y.C., Tzeng S.F., Yu L., Huang A.M., Lee H.T., Huang C.C., Ho C.J. Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups. Neurobiol. Dis. 2006, 24:101-113.
6. Cheng B., Mattson M.P. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res. 1994, 640:56-67.
7. Edwards J.G., Anderson I. Systematic review and guide to selection of selective serotonin reuptake inhibitors. Drugs 1999, 57:507-533.
8. Eren I., Naziroǧlu M., Demirdas A. Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain. Neurochem. Res. 2007, 32:1188-1195.
9. Gabaizadeh R., Staecker H., Liu W., Van De Water T.R. BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione. Brain Res. Mol. Brain Res. 1997, 50:71-78.
10. Gaur V., Aggarwal A., Kumar A. Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. Eur. J. Pharmacol. 2009, 616:147-154.
11. Gaur V., Kumar A. Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: possible involvement of nitric oxide-cyclic guanosine monophosphate study pathway. Brain Res. Bull. 2010, 82:57-64.
12. Gaur V., Kumar A. Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: possible involvement of NO-cGMP pathway. Brain Res. 2010, 1353:204-212.
13. Globus M.Y., Busto R., Martinez E., Valdes I., Dietrich W.D., Ginsberg M.D. Comparative effect of transient global ischemia on extracellular levels of glutamate, glycine, and gamma-aminobutyric acid in vulnerable and nonvulnerable brain regions in the rat. J. Neurochem. 1991, 57:470-478.
14. Haynes L.E., Barber D., Mitchell I.J. Chronic antidepressant medication attenuates dexamethasone-induced neuronal death and sublethal neuronal damage in the hippocampus and striatum. Brain Res. 2004, 1026:157-167.
15. Hwang I.K., Yoo K.Y., Kim D.W., Choi S.Y., Kang T.C., Kim Y.S., Won M.H. Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/reperfusion. Neurochem. Res. 2006, 31:957-965.
16. Hwang I.K., Yoo K.Y., Li H., Park O.K., Lee C.H., Choi J.H., Jeong Y.G., Lee Y.L., Kim Y.M., Kwon Y.G., Won M.H. Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus. J. Neurosci. Res. 2009, 87:2126-2137.
17. Jin Y., Lim C.M., Kim S.W., Park J.Y., Seo J.S., Han P.L., Yoon S.H., Lee J.K. Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. Brain Res. 2009, 1281:108-116.
18. Khanzode S.D., Dakhale G.N., Khanzode S.S., Saoji A., Palasodkar R. Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Rep. 2003, 8:365-370.
19. Kimdo H., Li H., Yoo K.Y., Lee B.H., Hwang I.K., Won M.H. Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia. Exp. Neurol. 2007, 204:748-758.
20. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 1982, 239:57-69.
21. Kumar A., Garg R. Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations. Fundam. Clin. Pharmacol. 2009, 23:89-95.
22. Larsson E., Nanobashvili A., Kokaia Z., Lindvall O. Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 1999, 19:1220-1228.
23. Lim C.M., Kim S.W., Park J.Y., Kim C., Yoon S.H., Lee J.K. Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect. J. Neurosci. Res. 2009, 87:1037-1045.
24. Lin C.S., Polsky K., Nadler J.V., Crain B.J. Selective neocortical and thalamic cell death in the gerbil after transient ischemia. Neuroscience 1990, 35:289-299.
25. Mattson M.P., Maudsley S., Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004, 27:589-594.
26. Maya Vetencourt J.F., Sale A., Viegi A., Baroncelli L., De Pasquale R., O'Leary O.F., Castren E., Maffei L. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 2008, 320:385-388.
27. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 1985, 312:159-163.
28. McKracken E., Graham D.I., Nilsen M., Stewart J., Nicoll J.A., Horsburgh K. 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia. Brain Pathol. 2001, 11:414-421.
29. Montgomery S.A., Loft H., Sanchez C., Reines E.H., Papp M. Escitalopram (S-enantiomer of citalopram): clinical efficacy and onset of action predicted from a rat model. Pharmacol. Toxicol. 2001, 88:282-286.
30. Moro M.A., Almeida A., Bolanos J.P., Lizasoain I. Mitochondrial respiratory chain and free radical generation in stroke. Free Radic. Biol. Med. 2005, 39:1291-1304.
31. Nagao T., Ibayashi S., Sadoshima S., Izumi J., Fujishima M. Citalopram, a serotonin reuptake inhibitor, and brain ischemia in SHR. Brain Res. Bull. 1995, 38:49-52.
32. Nakata N., Kato H., Kogure K. Protective effects of serotonin reuptake inhibitors, citalopram and clomipramine, against hippocampal CA1 neuronal damage following transient ischemia in the gerbil. Brain Res. 1992, 590:48-52.
33. Nakata N., Suda H., Izumi J., Tanaka Y., Ikeda Y., Kato H., Itoyama Y., Kogure K. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behav. Brain Res. 1997, 83:217-220.
34. Naziroǧlu M. Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem. Res. 2009, 34:2181-2191.
35. Nibuya M., Nestler E.J., Duman R.S. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci. 1996, 16:2365-2372.
36. Paolucci S., Antonucci G., Grasso M.G., Morelli D., Troisi E., Coiro P., De Angelis D., Rizzi F., Bragoni M. Post-stroke depression, antidepressant treatment and rehabilitation results. A case-control study. Cerebrovasc. Dis. 2001, 12:264-271.
37. Rastogi L., Godbole M.M., Ray M., Rathore P., Pradhan S., Gupta S.K., Pandey C.M. Reduction in oxidative stress and cell death explains hypothyroidism induced neuroprotection subsequent to ischemia/reperfusion insult. Exp. Neurol. 2006, 200:290-300.
38. Robinson R.G., Jorge R.E., Moser D.J., Acion L., Solodkin A., Small S.L., Fonzetti P., Hegel M., Arndt S. Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA 2008, 299:2391-2400.
39. Sas K., Csete K., Vezekenyi Z., Sztriha L., Vecseil L., Papp J.G. Effects of citalopram and fluoxetine on the corticocerebral blood flow in conscious rabbits. Acta Physiol. Hung. 2007, 94:167-177.
40. Schmued L.C., Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 2000, 874:123-130.
41. Stoll G., Jander S., Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 1998, 56:149-171.
42. Sugawara T., Lewen A., Noshita N., Gasche Y., Chan P.H. Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J. Neurotrauma 2002, 19:85-98.
43. Urabe T., Yamasaki Y., Hattori N., Yoshikawa M., Uchida K., Mizuno Y. Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain. Neuroscience 2000, 100:241-250.
44. Wiart L., Petit H., Joseph P.A., Mazaux J.M., Barat M. Fluoxetine in early poststroke depression: a double-blind placebo-controlled study. Stroke 2000, 31:1829-1832.
45. Yan B., He J., Xu H., Zhang Y., Bi X., Thakur S., Gendron A., Kong J., Li X.M. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice. Behav. Brain Res. 2007, 182:36-41.
46. Yilmaz H.R., Uz E., Yucel N., Altuntas I., Ozcelik N. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J. Biochem. Mol. Toxicol. 2004, 18:234-238.