NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Nature

Volumn 509, Issue 7499, 2014, Pages 235-239

  Noubade, Rajkumar ^a,b   Wong, Kit ^a   Ota, Naruhisa ^a   Rutz, Sascha ^a   Eidenschenk, Celine ^a   Valdez, Patricia A ^a,c   Ding, Jiabing ^a   Peng, Ivan ^a   Sebrell, Andrew ^a   Caplazi, Patrick ^a   Devoss, Jason ^a   Soriano, Robert H ^a   Sai, Tao ^a   Lu, Rongze ^a   Modrusan, Zora ^a   Hackney, Jason ^a   Ouyang, Wenjun ^a  

^a GENENTECH INC   (United States)

^b Flexus Biosciences   (United States)

^c American Society for Biochemistry and Molecular Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOMER; NEGATIVE REGULATOR OF REACTIVE OXYGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

BACTERIAL DISEASE; FUNGAL DISEASE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNITY; INFECTIOUS DISEASE; OXYGEN; PROTEIN; RODENT; SIGNAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BACTERICIDAL ACTIVITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HOST RESISTANCE; INFLAMMATION; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE INJURY;

ANIMALS; AUTOIMMUNITY; BONE MARROW CELLS; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; FEMALE; INFLAMMATION; LISTERIA MONOCYTOGENES; MACROPHAGES; MALE; MICE; NADPH OXIDASE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHAGOCYTES; PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84899992126     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13152     Document Type: Article

References (40)

1. Bedard, K. & Krause, K. H. The NOX family of ROS-generating NADPH oxidases:physiology and pathophysiology. Physiol. Rev. 87, 245-313 (2007).
2. Lambeth, J. D. NOX enzymes and the biology of reactive oxygen. Nature Rev.Immunol. 4, 181-189 (2004).
3. West, A. P. et al. TLRsignalling augmentsmacrophage bactericidal activity throughmitochondrial ROS. Nature 472, 476-480 (2011).
4. Honda, F. et al. The kinase Btk negatively regulates the production of reactiveoxygen species and stimulation-induced apoptosis in human neutrophils. NatureImmunol. 13, 369-378 (2012).
5. Wang, G. et al. Cutting edge: Slamf8 is a negative regulator of Nox2 activity inmacrophages. J. Immunol. 188, 5829-5832 (2012).
6. Di, A. et al. The redox-sensitive cation channel TRPM2 modulates phagocyte ROSproduction and inflammation. Nature Immunol. 13, 29-34 (2012).
7. McPhail, L. C., Clayton, C. C. & Snyderman, R. The NADPH oxidase of humanpolymorphonuclear leukocytes. Evidence for regulation bymultiple signals. J. Biol.Chem. 259, 5768-5775 (1984).
8. El-Benna, J., Dang, P. M. & Gougerot-Pocidalo, M. A. Priming of the neutrophilNADPH oxidase activation: role of p47phox phosphorylation and NOX2mobilization to the plasma membrane. Semin. Immunopathol. 30, 279-289(2008).
9. Anrather, J., Racchumi, G. & Iadecola, C. NF-kB regulates phagocytic NADPHoxidase by inducing the expression of gp91phox. J. Biol. Chem. 281, 5657-5667(2006).
10. Dinauer, M. C., Deck, M. B. & Unanue, E. R. Mice lacking reduced nicotinamideadenine dinucleotide phosphate oxidase activity show increased susceptibility toearly infection with Listeria monocytogenes. J. Immunol. 158, 5581-5583 (1997)
11. Shiloh, M. U. et al. Phenotype of mice and macrophages deficient in bothphagocyte oxidase and inducible nitric oxide synthase. Immunity 10, 29-38(1999).
12. Nik?́c, I. et al. A reversible form of axon damage in experimental autoimmuneencephalomyelitis and multiple sclerosis. Nature Med. 17, 495-499 (2011).
13. Tse, H. M. et al. NADPH oxidase deficiency regulates Th lineage commitment andmodulates autoimmunity. J. Immunol. 185, 5247-5258 (2010).
14. Ouyang, W., Kolls, J. K. & Zheng, Y. The biological functions of T helper 17 celleffector cytokines in inflammation. Immunity 28, 454-467 (2008).
15. Wa?llberg, M., Bergquist, J., Achour, A., Breij, E. & Harris, R. A. Malondialdehydemodification of myelin oligodendrocyte glycoprotein leads to increasedimmunogenicity and encephalitogenicity. Eur. J. Immunol. 37, 1986-1995 (2007).
16. Sheppard, F. R. et al. Structural organization of the neutrophil NADPH oxidase:phosphorylation and translocation during priming and activation. J. Leukoc. Biol.78, 1025-1042 (2005).
17. DeLeo, F. R. et al. Processing and maturation of flavocytochrome b558 includeincorporation of heme as a prerequisite for heterodimer assembly. J. Biol. Chem.275, 13986-13993 (2000).
18. Parkos, C. A., Dinauer, M. C., Jesaitis, A. J., Orkin, S. H. & Curnutte, J. T. Absence ofboth the 91kD and 22kD subunits of human neutrophil cytochrome b in twogenetic forms of chronic granulomatous disease. Blood 73, 1416-1420 (1989).
19. Chen, F. et al. Hsp90 regulates NADPH oxidase activity and is necessary forsuperoxide but not hydrogen peroxide production. Antioxid. Redox Signal. 14,2107-2119 (2011).
20. Pollock, J. D. et al. Mouse model of X-linked chronic granulomatous disease, aninherited defect in phagocyte superoxide production. Nature Genet. 9, 202-209(1995).
21. Lewis, V. et al. Glycoproteins of the lysosomal membrane. J. Cell Biol. 100,1839-1847 (1985).
22. Chen, F. et al. Opposing actions of heat shock protein 90 and 70 regulate nicotinamideadenine dinucleotide phosphate oxidase stability and reactive oxygenspecies production. Arterioscler. Thromb. Vasc. Biol. 32, 2989-2999 (2012).
23. Casbon, A. J., Allen, L. A., Dunn, K. W.& Dinauer, M. C.Macrophage NADPH oxidaseflavocytochrome B localizes to the plasma membrane and Rab11-positiverecycling endosomes. J. Immunol. 182, 2325-2339 (2009).
24. Brodsky, J. L. Cleaning up: ER-associated degradation to the rescue. Cell 151,1163-1167 (2012).
25. Tang, T. et al. Amouse knockout library for secreted and transmembrane proteins.Nature Biotechnol. 28, 749-755 (2010).
26. Mantei, A. et al. siRNA stabilization prolongs gene knockdown in primary Tlymphocytes. Eur. J. Immunol. 38, 2616-2625 (2008).
27. Irizarry, R. A. et al. Exploration, normalization, and summaries of high densityoligonucleotide array probe level data. Biostatistics 4, 249-264 (2003).
28. Bourgon, R., Gentleman, R. & Huber, W. Independent filtering increases detectionpower for high-throughput experiments. Proc. Natl Acad. Sci. USA 107,9546-9551 (2010).
29. Smyth, G. K. Linearmodels and empirical bayesmethods for assessing differentialexpression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, Article3(2004).
30. Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical andpowerful approach to multiple testing. 57, 289-300 J. Roy. Stat. Soc. B (1995).
31. Abbas, A. R. et al. Immune response in silico (IRIS): immune-specific genesidentified from a compendium of microarray expression data. Genes Immun. 6,319-331 (2005).
32. Sayers, E. W. et al. Database resources of the National Center for BiotechnologyInformation. Nucleic Acids Res. 40, D13-D25 (2012).
33. Li, Y. et al. Enrichment of endoplasmic reticulum with cholesterol inhibitssarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel withincreased order of membrane lipids: implications for depletion of endoplasmicreticulum calcium stores and apoptosis in cholesterol-loaded macrophages.J. Biol. Chem. 279, 37030-37039 (2004).
34. DeLeo, F. R. et al. Processing and maturation of flavocytochrome b558 includeincorporation of heme as a prerequisite for heterodimer assembly. J. Biol. Chem.275, 13986-13993 (2000).
35. Barry, K. C., Fontana, M. F., Portman, J. L., Dugan, A. S. & Vance, R. E. IL-1a signalinginitiates the inflammatory response to virulent Legionella pneumophila in vivo.J. Immunol. 190, 6329-6339 (2013).
36. Green, S. A., Zimmer, K. P., Griffiths, G. & Mellman, I. Kinetics of intracellulartransport and sorting of lysosomal membrane and plasma membrane proteins.J. Cell Biol. 105, 1227-1240 (1987).
37. Czuprynski, C. J., Canono, B. P., Henson, P. M. & Campbell, P. A. Geneticallydetermined resistance to listeriosis is associated with increased accumulation ofinflammatory neutrophils and macrophages which have enhanced listericidalactivity. Immunology 55, 511-518 (1985).
38. Nikić, I. et al. A reversible form of axon damage in experimentalautoimmune encephalomyelitis and multiple sclerosis. Nature Med. 17, 495-499(2011).
39. Hu, Y. et al. IL-17RC is required for IL-17A-and IL-17F-dependent signaling andthe pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol.184, 4307-4316 (2010).
40. Barabutis, N. & Schally, A. V. Antioxidant activity of growth hormone-releasinghormone antagonists in LNCaP human prostate cancer line. Proc. Natl Acad. Sci.USA 105, 20470-20475 (2008).