Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

Journal of Affective Disorders

Volumn 149, Issue 1-3, 2013, Pages 23-29

  Maes, Michael ^a   Kubera, Marta ^b   Mihaylova, Ivana ^c   Geffard, Michel ^d   Galecki, Piotr ^e   Leunis, Jean Clude ^f   Berk, Michael ^g  

^a Maes Clinics at TRIA   (Thailand)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c Foundation Biological Psychiatry   (Bulgaria)

^d Association Institute for Research and Development in Human Pathology and Therapy   (France)

^e UNIVERSITY OF LODZ   (Poland)

^f Laboratoire Ategis   (Belgium)

^g DEAKIN UNIVERSITY   (Australia)

Author keywords

Autoimmune; Chronic fatigue; Cytokines; Inflammation; Neuroprogression; Oxidative and nitrosative stress

Indexed keywords

ARGININE; AZELAIC ACID; CYSTEINYLDOPA; IMMUNOGLOBULIN M ANTIBODY; MALONALDEHYDE; NITRIC OXIDE; OLEIC ACID; PHOSPHATIDYLINOSITOL; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; TRYPTOPHAN; TYROSINE;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CHRONIC DISEASE; CONJUGATION; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NITROSATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADULT; AUTOIMMUNITY; CHRONIC DISEASE; DEPRESSIVE DISORDER, MAJOR; EPITOPES; FATTY ACIDS; FEMALE; HUMANS; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; NITRIC OXIDE; OXIDATIVE STRESS;

EID: 84878490165     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.06.039     Document Type: Article

References (64)

1. D. Akin, D.H. Manier, E. Sanders-Bush, and R.C. Shelton Decreased serotonin 5-HT2A receptor-stimulated phosphoinositide signaling in fibroblasts from melancholic depressed patients Neuropsychopharmacology 29 11 2004 2081 2087
2. B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J.D. Watson Molecular Biology of the Cell third ed. 1994 Garland New York 1994
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders fourth ed. 2002 Text Revision (DSM-IV-TR) Washington DC 2002
4. B. Ananthanarayanan, Q. Ni, and J. Zhang Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity Proceedings of the National Academy of Sciences United States of America 102 42 2005 15081 15086 pp
5. A.I. Barkai, D.L. Dunner, H.A. Gross, P. Mayo, and R.R. Fieve Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder Biological Psychiatry 13 1 1978 65 72
6. M. Berk, P. Conus, N. Lucas, K. Hallam, G.S. Malhi, S. Dodd, L.N. Yatham, A. Yung, and P. McGorry Setting the stage: from prodrome to treatment resistance in bipolar disorder Bipolar Disorders 9 7 2007 671 678
7. M. Berk, K.T. Hallam, and P.D. McGorry The potential utility of a staging model as a course specifier: a bipolar disorder perspective Journal of Affective Disorders 100 1-3 2007 279 281
8. M. Berk, K. Hallam, G.S. Malhi, L. Henry, M. Hasty, C. Macneil, M. Yucel, C. Pantelis, B. Murphy, E. Vieta, S. Dodd, and P.D. McGorry Evidence and implications for early intervention in bipolar disorder Journal of Mental Health 19 2 2010 113 126
9. D. Bodet, G. Glaize, M.P. Dabadie, and M. Geffard Immunological follow-up for multiple slerosis Immuno-Analyse & Biologie Special 19 2004 138 147
10. A. Boullerne, K.G. Petry, and M. Geffard Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis Journal of Neuroimmunology 65 1 1996 75 81
11. P.C. Calder, P. Yaqoob, D.J. Harvey, A. Watts, and E.A. Newsholme Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity Biochemistry Journal 300 Pt 2 1994 509 518
12. M. Catena-Dell'Osso, C. Bellantuono, G. Consoli, S. Baroni, F. Rotella, and D. Marazziti Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development? Current Medical Chemistry 18 2 2011 245 255
13. P. Daverat, M. Geffard, and J.M. Orgogozo Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis Journal of Neuroimmunology 22 2 1989 129 134
14. N. Dimopoulos, C. Piperi, V. Psarra, R.W. Lea, and A. Kalofoutis Increased plasma levels of 8-iso-PGF2alpha and IL-6 in an elderly population with depression Psychiatry Research 161 1 2008 59 66
15. P. Gałecki, J. Szemraj, M. Bieńkiewicz, A. Florkowski, and E. Gałecka Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment Pharmacology Reports 61 3 2009 436 447
16. P. Gałecki, A. Florkowski, K. Bobinska, J. Smiegielski, M. Bieńkiewicz, and J. Szemraj Functional polymorphism of the myeloperoxidase gene (G-463A) in depressive patients Acta Neuropsychiatrica 22 2010 218 222
17. P. Gałecki, M. Maes, A. Florkowski, A. Lewiński, E. Gałecka, M. Bieńkiewicz, and J. Szemraj An inducible nitric oxide synthase polymorphism is associated with the risk of recurrent depressive disorder Neuroscience Letters 486 3 2010 184 187
18. P. Gałecki, J. Smigielski, A. Florkowski, K. Bobińska, T. Pietras, and J. Szemraj Analysis of two polymorphisms of the manganese superoxide dismutase gene (Ile-58Thr and Ala-9Val) in patients with recurrent depressive disorder Psychiatry Research 179 1 2010 43 46
19. P. Gałecki, M. Maes, A. Florkowski, A. Lewiński, E. Gałecka, M. Bieńkiewicz, and J. Szemraj Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder Journal of Affective Disorders 129 1-3 2011 175 182
20. C.M. Geffard, D. Bodet, Y. Martinet, and M.-P. Dabadie Detection of the specific IgM and IgA circulating in sera of multiple sclerosis patients: interest and perspectives Immuno-Analyse & Biologie Special 17 2002 302 310
21. M. Geffard, D. Bodet, M.P. Dabadie, and L. Arnould Identification of antibodies in sera of breast cancer patients Immuno-Analyse & Biologie Special 18 2003 248 253
22. N. Ghosh, R. Ghosh, and S.C. Mandal Antioxidant protection: a promising therapeutic intervention in neurodegenerative disease Free Radical Research 45 8 2011 888 905
23. B. Granda, A. Tabernero, V. Tello, and J.M. Medina Oleic acid induces GAP-43 expression through a protein kinase C-mediated mechanism that is independent of NGF but synergistic with NT-3 and NT-4/5 Brain Research 988 1-2 2003 1 8
24. H.R. Griffiths Is the generation of neoantigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmunity Reviews 7 2008 544 549
25. M. Hamilton A rating scale for depression Journal of Neurology, Neurosurgery and Psychiatry 23 1960 56 61
26. H. Herken, A. Gurel, S. Selek, F. Armutcu, M.E. Ozen, M. Bulut, O. Kap, M. Yumru, H.A. Savas, and O. Akyol Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment Archives of Medical Research 38 2 2007 247 252
27. F.N. Jacka, J.A. Pasco, A. Mykletun, L.J. Williams, A.M. Hodge, S.L. O'Reilly, G.C. Nicholson, M.A. Kotowicz, and M. Berk Association of western and traditional diets with depression and anxiety in women American Journal of Psychiatry 167 3 2010 305 311
28. M. Kapadia, and B. Sakic Autoimmune and inflammatory mechanisms of CNS damage Progress in Neurobiology 95 3 2011 301 333
29. S.D. Khanzode, G.N. Dakhale, S.S. Khanzode, A. Saoji, and R. Palasodkar Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors Redox Reports 8 6 2003 365 370
30. J. Kodydková, L. Vávrová, M. Zeman, R. Jirák, J. Macásek, B. Stanková, E. Tvrzická, and A. Zák Antioxidative enzymes and increased oxidative stress in depressive women Clinical Biochemistry 42 13-14 2009 1368 1374
31. M. Kubera, E. Obuchowicz, L. Goehler, J. Brzeszcz, and M. Maes In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression Progress in Neuropsychopharmacology and Biological Psychiatry 35 3 2011 744 759
32. B.T. Kurien, and R.H. Scofield Autoimmunity and oxidatively modified autoantigens Autoimmunity Reviews 7 7 2008 567 573
33. B. Leonard, and M. Maes Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression Neuroscience Biobehavioral Reviews 36 2 2012 764 785
34. T.H. Lu, S.Y. Hsieh, C.C. Yen, H.C. Wu, K.L. Chen, D.Z. Hung, C.H. Chen, C.C. Wu, Y.C. Su, Y.W. Chen, S.H. Liu, and C.F. Huang Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury Toxicology Letters 204 1 2011 71 80
35. M. Maes Functional or psychosomatic symptoms, e.g., a flu-like malaise, aches and pain and fatigue, are major features of major and in particular of melancholic depression Neuro Endocrinology Letters 30 5 2009 564 573
36. M. Maes, N. De Vos, R. Pioli, P. Demedts, A. Wauters, H. Neels, and A. Christophe Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness Journal of Affective Disorders 58 3 2000 241 246
37. M. Maes, I. Mihaylova, and J.C. Leunis Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins Neuro Endocrinology Letters 27 5 2006 615 621
38. M. Maes, I. Mihaylova, and J.C. Leunis Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression Neuro Endocrinology Letters 28 6 2007 861 867
39. M. Maes, I. Mihaylova, M. Kubera, M. Uytterhoeven, N. Vrydags, and E. Bosmans Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder Neuro Endocrinology Letters 30 4 2009 470 476
40. M. Maes, R. Yirmyia, J. Noraberg, S. Brene, J. Hibbeln, G. Perini, M. Kubera, P. Bob, B. Lerer, and M. Maj The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression Metabolic Brain Disease 24 1 2009 27 53
41. M. Maes, I. Mihaylova, M. Kubera, M. Uytterhoeven, N. Vrydags, and E. Bosmans Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease Journal of Affective Disorders 125 2010 287 294
42. M. Maes, P. Galecki, Y.S. Chang, and M. Berk A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness Progress in Neuropsychopharmacology and Biological Psychiatry 35 3 2011 676 692
43. M. Maes, B. Leonard, A. Fernandez, M. Kubera, G. Nowak, R. Veerhuis, A. Gardner, P. Ruckoanich, M. Geffard, C. Altamura, P. Galecki, and M. Berk (Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: from antioxidants to kinase inhibitors Progress in Neuropsychopharmacology and Biological Psychiatry 35 3 2011 659 663
44. M. Maes, I. Mihaylova, M. Kubera, J.-C. Leunis, and M. Geffard IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology Journal of Affective Disorders 135 1-3 2011 141 418
45. M. Maes, I. Mihaylova, M. Kubera, M. Uytterhoeven, N. Vrydags, and E. Bosmans Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis/chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression Neuro Endocrinology Letters 32 2011 2
46. Maes, M., Mihaylova, I., Kubera, M., Leunis, J.C., Twisk, F.N., Geffard, M., 2012. IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression. Metabolic Brain Disease May 22. [Epub ahead of print] PubMed PMID: 22614823.
47. Moylan, S., Maes, M., Wray, N.R., Berk, M., 2012. The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications. Molecular Psychiatry in press.
48. Y.I. Miller, S.H. Choi, P. Wiesner, L. Fang, R. Harkewicz, K. Hartvigsen, A. Boullier, A. Gonen, C.J. Diehl, X. Que, E. Montano, P.X. Shaw, S. Tsimikas, C.J. Binder, and J.L. Witztum Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity Circulation Research 108 2 2011 235 248
49. G. Nakos, E. Tziakou, L. Maneta-Peyret, C. Nassis, and M.E. Lekka Anti-phospholipid antibodies in serum from patients with Guillain-Barre syndrome Intensive Care Medicine 31 10 2005 1401 1408
50. G. Nowak, B. Szewczyk, and A. Pilc Zinc and depression. An update Pharmacological Reports 57 6 2005 713 718
51. S. Riemer, M. Maes, A. Christophe, and W. Rief Lowered omega-3 PUFAs are related to major depression, but not to somatization syndrome Journal of Affective Disorders 123 1-3 2010 173 180
52. C. Song, A.A. Killeen, and B.E. Leonard Catalase, superoxide dismutase and glutathione peroxidase activity in neutrophils of sham-operated and olfactory-bulbectomised rats following chronic treatment with desipramine and lithium chloride Neuropsychobiology 30 1 1994 24 28
53. C. Song, and H. Wang Cytokines mediated inflammation and decreased neurogenesis in animal models of depression Progress in Neuropsychopharmacology and Biological Psychiatry 35 3 2011 760 768
54. B. Szewczyk, M. Kubera, and G. Nowak The role of zinc in neurodegenerative inflammatory pathways in depression Progress in Neuropsychopharmacology and Biological Psychiatry 35 3 2011 693 701
55. A. Tabernero, E.M. Lavado, B. Granda, A. Velasco, and J.M. Medina Neuronal differentiation is triggered by oleic acid synthesized and released by astrocytes Journal of Neurochemistry 79 3 2001 606 616
56. K. Toyoda, R. Nagae, M. Akagawa, K. Ishino, T. Shibata, S. Ito, N. Shibata, T. Yamamoto, M. Kobayashi, Y. Takasaki, T. Matsuda, and K. Uchida Protein-bound 4-hydroxy-2-nonenal: an endogenous triggering antigen of antI-DNA response Journal of Biological Chemistry 282 35 2007 25769 25778
57. A.J. Owen, M.J. Batterham, Y.C. Probst, B.F. Grenyer, and L.C. Tapsell Low plasma vitamin E levels in major depression: diet or disease? European Journal of Clinical Nutrition 59 2 2005 304 306
58. M.E. Ozcan, M. Gulec, E. Ozerol, R. Polat, and O. Akyol Antioxidant enzyme activities and oxidative stress in affective disorders International Clinical Psychopharmacology 19 2 2004 89 95
59. C.J. Vanderlugt, and S.D. Miller Epitope spreading Current Opinion in Immunology 8 6 1996 831 836
60. A. Velasco, A. Tabernero, and J.M. Medina Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain Brain Research 977 1 2003 103 111
61. J.F. Wang, L. Shao, X. Sun, and L.T. Young Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia Bipolar Disorders 11 5 2009 523 529
62. G. Watfa, C. Dragonas, T. Brosche, R. Dittrich, C.C. Sieber, C. Alecu, A. Benetos, and R. Nzietchueng Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease Journal of Nutrition and Healthy Aging 15 4 2011 277 281
63. O. Zachrisson, B. Regland, M. Jahreskog, M. Kron, and C.G. Gottfries A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale) Journal of Psychosomatic Research 52 6 2002 501 509
64. D. Zhang, L. Cheng, D.W. Craig, M. Redman, and C. Liu Cerebellar telomere length and psychiatric disorders Behavioral Genetics 40 2 2010 250 254