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Volumn 12, Issue 8, 2016, Pages 446-455

The metabolic role of the gut microbiota in health and rheumatic disease: Mechanisms and interventions

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CARNITINE; CHOLINE; POLYSACCHARIDE; PREBIOTIC AGENT; PROBIOTIC AGENT; ANTIRHEUMATIC AGENT; VOLATILE FATTY ACID;

EID: 84976337135     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2016.68     Document Type: Review
Times cited : (110)

References (124)
  • 1
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • The Human Microbiome Consortium Project.
    • The Human Microbiome Consortium Project. Structure, function and diversity of the healthy human microbiome. Nature 486, 207-214 (2012).
    • (2012) Nature , vol.486 , pp. 207-214
  • 2
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L. V., Littman, D. R., & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 3
    • 38149048556 scopus 로고    scopus 로고
    • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in A mouse model of arthritis
    • Abdollahi-Roodsaz, S., et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in A mouse model of arthritis. J. Clin. Invest. 118, 205-216 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 205-216
    • Abdollahi-Roodsaz, S.1
  • 4
    • 84860389063 scopus 로고    scopus 로고
    • The microbiome and rheumatoid arthritis
    • Scher, J. U., & Abramson, S. B. The microbiome and rheumatoid arthritis. Nat. Rev. Rheumatol. 7, 569-578 (2011).
    • (2011) Nat. Rev. Rheumatol. , vol.7 , pp. 569-578
    • Scher, J.U.1    Abramson, S.B.2
  • 5
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu, H. J., et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815-827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1
  • 6
    • 84921417572 scopus 로고    scopus 로고
    • The gut microbial endocrine organ: Bacterially derived signals driving cardiometabolic diseases
    • Brown, J. M., & Hazen, S. L. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu. Rev. Med. 66, 343-359 (2015).
    • (2015) Annu. Rev. Med. , vol.66 , pp. 343-359
    • Brown, J.M.1    Hazen, S.L.2
  • 7
    • 79960983258 scopus 로고    scopus 로고
    • Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
    • Kriegel, M. A., et al. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc. Natl Acad. Sci. USA 108, 11548-11553 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 11548-11553
    • Kriegel, M.A.1
  • 8
    • 77249096486 scopus 로고    scopus 로고
    • Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis
    • Ochoa-Reparaz, J., et al. Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J. Immunol. 183, 6041-6050 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 6041-6050
    • Ochoa-Reparaz, J.1
  • 9
    • 84905235179 scopus 로고    scopus 로고
    • Minireview: Gut microbiota: The neglected endocrine organ
    • Clarke, G., et al. Minireview: gut microbiota: the neglected endocrine organ. Mol. Endocrinol. 28, 1221-1238 (2014).
    • (2014) Mol. Endocrinol. , vol.28 , pp. 1221-1238
    • Clarke, G.1
  • 10
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with A host-specific microbiota
    • Chung, H., et al. Gut immune maturation depends on colonization with A host-specific microbiota. Cell 149, 1578-1593 (2012).
    • (2012) Cell , vol.149 , pp. 1578-1593
    • Chung, H.1
  • 11
    • 84910133100 scopus 로고    scopus 로고
    • Specialized metabolites from the microbiome in health and disease
    • Sharon, G., et al. Specialized metabolites from the microbiome in health and disease. Cell Metab. 20, 719-730 (2014).
    • (2014) Cell Metab. , vol.20 , pp. 719-730
    • Sharon, G.1
  • 12
    • 79960222400 scopus 로고    scopus 로고
    • Intestinal absorption of water-soluble vitamins in health and disease
    • Said, H. M. Intestinal absorption of water-soluble vitamins in health and disease. Biochem. J. 437, 357-372 (2011).
    • (2011) Biochem. J. , vol.437 , pp. 357-372
    • Said, H.M.1
  • 13
    • 80051535923 scopus 로고    scopus 로고
    • The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    • Bercik, P., et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141, 599-609.e1 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 599e1-599e1
    • Bercik, P.1
  • 14
    • 84863828999 scopus 로고    scopus 로고
    • Obesity and the risk of psoriatic arthritis: A population-based study
    • Love, T. J., et al. Obesity and the risk of psoriatic arthritis: A population-based study. Ann. Rheum. Dis. 71, 1273-1277 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1273-1277
    • Love, T.J.1
  • 15
    • 84921729108 scopus 로고    scopus 로고
    • Being overweight or obese and risk of developing rheumatoid arthritis among women: A prospective cohort study
    • Lu, B., et al. Being overweight or obese and risk of developing rheumatoid arthritis among women: A prospective cohort study. Ann. Rheum. Dis. 73, 1914-1922 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1914-1922
    • Lu, B.1
  • 16
    • 84919351846 scopus 로고    scopus 로고
    • Obesity as A risk and severity factor in rheumatic diseases (autoimmune chronic inflammatory diseases)
    • Gremese, E., Tolusso, B., Gigante, M. R., & Ferraccioli, G. Obesity as A risk and severity factor in rheumatic diseases (autoimmune chronic inflammatory diseases). Front. Immunol. 5, 576 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 576
    • Gremese, E.1    Tolusso, B.2    Gigante, M.R.3    Ferraccioli, G.4
  • 17
    • 84902657771 scopus 로고    scopus 로고
    • Diet, metabolites, and ?western-lifestyle? Inflammatory diseases
    • Thorburn, A. N., Macia, L., & Mackay, C. R. Diet, metabolites, and ?western-lifestyle? inflammatory diseases. Immunity 40, 833-842 (2014).
    • (2014) Immunity , vol.40 , pp. 833-842
    • Thorburn, A.N.1    Macia, L.2    MacKay, C.R.3
  • 18
    • 84907563983 scopus 로고    scopus 로고
    • Altering the intestinal microbiota during A critical developmental window has lasting metabolic consequences
    • Cox, L. M., et al. Altering the intestinal microbiota during A critical developmental window has lasting metabolic consequences. Cell 158, 705-721 (2014).
    • (2014) Cell , vol.158 , pp. 705-721
    • Cox, L.M.1
  • 19
    • 55949091259 scopus 로고    scopus 로고
    • Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-Acid binding G protein-coupled receptor, Gpr41
    • Samuel, B. S., et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-Acid binding G protein-coupled receptor, Gpr41. Proc. Natl Acad. Sci. USA 105, 16767-16772 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16767-16772
    • Samuel, B.S.1
  • 20
    • 79251584066 scopus 로고    scopus 로고
    • Bifidobacteria can protect from enteropathogenic infection through production of acetate
    • Fukuda, S., et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469, 543-547 (2011).
    • (2011) Nature , vol.469 , pp. 543-547
    • Fukuda, S.1
  • 21
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides
    • Topping, D. L., & Clifton, P. M. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 81, 1031-1064 (2001).
    • (2001) Physiol. Rev. , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 22
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia, L., et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6734
    • Macia, L.1
  • 23
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
    • Arpaia, N., et al. Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation. Nature 504, 451-455 (2013).
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 24
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa, Y., et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504, 446-450 (2013).
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1
  • 25
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic TREG cell homeostasis
    • Smith, P. M., et al. The microbial metabolites, short-chain fatty acids, regulate colonic TREG cell homeostasis. Science 341, 569-573 (2013).
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 26
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski, K. M., et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461, 1282-1286 (2009).
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1
  • 27
    • 84929855038 scopus 로고    scopus 로고
    • A role for gut microbiota and the metabolite-sensing receptor GPR43 in A murine model of gout
    • Vieira, A. T., et al. A role for gut microbiota and the metabolite-sensing receptor GPR43 in A murine model of gout. Arthritis Rheumatol. 67, 1646-1656 (2015).
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 1646-1656
    • Vieira, A.T.1
  • 28
    • 84960128782 scopus 로고    scopus 로고
    • Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class i histone deacetylases
    • Cleophas, M. C., et al. Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases. Ann. Rheum. Dis. 75, 593-600 (2016).
    • (2016) Ann. Rheum. Dis. , vol.75 , pp. 593-600
    • Cleophas, M.C.1
  • 29
    • 84861381281 scopus 로고    scopus 로고
    • Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists
    • Liberato, M. V., et al. Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists. PLoS ONE 7, e36297 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e36297
    • Liberato, M.V.1
  • 30
    • 84857381354 scopus 로고    scopus 로고
    • Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR? to suppress colitis
    • Bassaganya-Riera, J., et al. Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR? to suppress colitis. PLoS ONE 7, e31238 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e31238
    • Bassaganya-Riera, J.1
  • 31
    • 84866613234 scopus 로고    scopus 로고
    • Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn?s disease
    • Bassaganya-Riera, J., et al. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn?s disease. Clin. Nutr. 31, 721-727 (2012).
    • (2012) Clin. Nutr. , vol.31 , pp. 721-727
    • Bassaganya-Riera, J.1
  • 32
    • 84919932773 scopus 로고    scopus 로고
    • Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease
    • Scher, J. U., et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol. 67, 128-139 (2015).
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 128-139
    • Scher, J.U.1
  • 33
    • 84922390026 scopus 로고    scopus 로고
    • Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD
    • De Preter, V., et al. Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut 64, 447-458 (2015).
    • (2015) Gut , vol.64 , pp. 447-458
    • De Preter, V.1
  • 34
    • 85039973538 scopus 로고    scopus 로고
    • HLA-B27 expression profoundly shapes the host-microbiota metabolome [abstract 2097]
    • Asquith, M. S., et al. HLA-B27 expression profoundly shapes the host-microbiota metabolome [abstract 2097]. Arthritis Rheumatol. 67 Suppl. S10), S2504-S2505(2015).
    • (2015) Arthritis Rheumatol. , vol.67 , Issue.SUPPLS10 , pp. S2504-S2505
    • Asquith, M.S.1
  • 35
    • 84951209574 scopus 로고    scopus 로고
    • Implications of microbiota and bile acid in liver injury and regeneration
    • Liu, H. X., Keane, R., Sheng, L., & Wan, Y. Y. Implications of microbiota and bile acid in liver injury and regeneration. J. Hepatol. 63, 1502-1510 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 1502-1510
    • Liu, H.X.1    Keane, R.2    Sheng, L.3    Wan, Y.Y.4
  • 37
    • 34447098081 scopus 로고    scopus 로고
    • Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    • Kim, I., et al. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 28, 940-946 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 940-946
    • Kim, I.1
  • 38
    • 77955697988 scopus 로고    scopus 로고
    • Glycosylation of fibroblast growth factor receptor 4 is A key regulator of fibroblast growth factor 19 mediated down-regulation of cytochrome P450 7A1
    • Triantis, V., Saeland, E., Bijl, N., Oude-Elferink, R. P., & Jansen, P. L. Glycosylation of fibroblast growth factor receptor 4 is A key regulator of fibroblast growth factor 19 mediated down-regulation of cytochrome P450 7A1. Hepatology 52, 656-666 (2010).
    • (2010) Hepatology , vol.52 , pp. 656-666
    • Triantis, V.1    Saeland, E.2    Bijl, N.3    Oude-Elferink, R.P.4    Jansen, P.L.5
  • 39
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe, M., et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439, 484-489 (2006).
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1
  • 40
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • Pols, T. W., et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab. 14, 747-757 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 747-757
    • Pols, T.W.1
  • 41
    • 85015459213 scopus 로고    scopus 로고
    • Recent advances in the development of farnesoid X receptor agonists
    • Ali, A. H., Carey, E. J., & Lindor, K. D. Recent advances in the development of farnesoid X receptor agonists. Ann. Transl. Med. 3, 5 (2015).
    • (2015) Ann. Transl. Med. , vol.3 , pp. 5
    • Ali, A.H.1    Carey, E.J.2    Lindor, K.D.3
  • 42
    • 84957812743 scopus 로고    scopus 로고
    • The multiple-hit pathogenesis of non-Alcoholic fatty liver disease (NAFLD)
    • Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. The multiple-hit pathogenesis of non-Alcoholic fatty liver disease (NAFLD). Metabolism http://dx.doi. org/10.1016/j.metabol.2015.12.012 (2016).
    • (2016) Metabolism
    • Buzzetti, E.1    Pinzani, M.2    Tsochatzis, E.A.3
  • 43
    • 84952792542 scopus 로고    scopus 로고
    • Management of non-Alcoholic fatty liver disease in 2015
    • Malhotra, N., & Beaton, M. D. Management of non-Alcoholic fatty liver disease in 2015. World J. Hepatol. 7, 2962-2967 (2015).
    • (2015) World J. Hepatol. , vol.7 , pp. 2962-2967
    • Malhotra, N.1    Beaton, M.D.2
  • 44
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023 (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 45
    • 84954288595 scopus 로고    scopus 로고
    • The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
    • Boursier, J., et al. The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 63, 764-775 (2016).
    • (2016) Hepatology , vol.63 , pp. 764-775
    • Boursier, J.1
  • 46
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele, L., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49, 1877-1887 (2009).
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1
  • 47
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-Alcoholic steatohepatitis
    • Rivera, C. A., et al. Toll-like receptor 4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-Alcoholic steatohepatitis. J. Hepatol. 47, 571-579 (2007).
    • (2007) J. Hepatol. , vol.47 , pp. 571-579
    • Rivera, C.A.1
  • 48
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani, P. D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772 (2007).
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1
  • 49
    • 47949095562 scopus 로고    scopus 로고
    • Susceptibility to gut leakiness: A possible mechanism for endotoxaemia in non-Alcoholic steatohepatitis
    • Farhadi, A., et al. Susceptibility to gut leakiness: A possible mechanism for endotoxaemia in non-Alcoholic steatohepatitis. Liver Int. 28, 1026-1033 (2008).
    • (2008) Liver Int. , vol.28 , pp. 1026-1033
    • Farhadi, A.1
  • 50
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals A contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • Dumas, M. E., et al. Metabolic profiling reveals A contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc. Natl Acad. Sci. USA 103, 12511-12516 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12511-12516
    • Dumas, M.E.1
  • 51
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L carnitine, A nutrient in red meat, promotes atherosclerosis
    • Koeth, R. A., et al. Intestinal microbiota metabolism of L carnitine, A nutrient in red meat, promotes atherosclerosis. Nat. Med. 19, 576-585 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 52
    • 84952637806 scopus 로고    scopus 로고
    • Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: Translational and clinical evidence
    • Federico, A., Dallio, M., Godos, J., Loguercio, C., & Salomone, F. Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence. Transl. Res. 167, 116-124 (2016).
    • (2016) Transl. Res. , vol.167 , pp. 116-124
    • Federico, A.1    Dallio, M.2    Godos, J.3    Loguercio, C.4    Salomone, F.5
  • 53
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang, Z., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63 (2011).
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1
  • 54
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang, W. H., et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368, 1575-1584 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1575-1584
    • Tang, W.H.1
  • 56
    • 84899492903 scopus 로고    scopus 로고
    • Fish consumption and risk of rheumatoid arthritis: A dose-response meta-Analysis
    • Di Giuseppe, D., Crippa, A., Orsini, N., & Wolk, A. Fish consumption and risk of rheumatoid arthritis: A dose-response meta-Analysis. Arthritis Res. Ther. 16, 446 (2014).
    • (2014) Arthritis Res. Ther. , vol.16 , pp. 446
    • Di Giuseppe, D.1    Crippa, A.2    Orsini, N.3    Wolk, A.4
  • 57
    • 84879508142 scopus 로고    scopus 로고
    • Long term alcohol intake and risk of rheumatoid arthritis in women: A population based cohort study
    • Di Giuseppe, D., Alfredsson, L., Bottai, M., Askling, J., & Wolk, A. Long term alcohol intake and risk of rheumatoid arthritis in women: A population based cohort study. BMJ 345, e4230 (2012).
    • (2012) BMJ , vol.345 , pp. e4230
    • Di Giuseppe, D.1    Alfredsson, L.2    Bottai, M.3    Askling, J.4    Wolk, A.5
  • 58
    • 84881174082 scopus 로고    scopus 로고
    • Alcohol consumption as A preventive factor for developing rheumatoid arthritis: A dose-response meta-Analysis of prospective studies
    • Jin, Z., Xiang, C., Cai, Q., Wei, X., & He, J. Alcohol consumption as A preventive factor for developing rheumatoid arthritis: A dose-response meta-Analysis of prospective studies. Ann. Rheum. Dis. 73, 1962-1967 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1962-1967
    • Jin, Z.1    Xiang, C.2    Cai, Q.3    Wei, X.4    He, J.5
  • 59
    • 84899951948 scopus 로고    scopus 로고
    • Weight loss and achievement of minimal disease activity in patients with psoriatic arthritis starting treatment with tumour necrosis factor α blockers
    • Di Minno, M. N., et al. Weight loss and achievement of minimal disease activity in patients with psoriatic arthritis starting treatment with tumour necrosis factor α blockers. Ann. Rheum. Dis. 73, 1157-1162 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1157-1162
    • Di Minno, M.N.1
  • 60
    • 34548192176 scopus 로고    scopus 로고
    • A pilot study of A Mediterranean-Type diet intervention in female patients with rheumatoid arthritis living in areas of social deprivation in Glasgow
    • McKellar, G., et al. A pilot study of A Mediterranean-Type diet intervention in female patients with rheumatoid arthritis living in areas of social deprivation in Glasgow. Ann. Rheum. Dis. 66, 1239-1243 (2007).
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 1239-1243
    • McKellar, G.1
  • 61
    • 0037370766 scopus 로고    scopus 로고
    • An experimental study of A Mediterranean diet intervention for patients with rheumatoid arthritis
    • Skoldstam, L., Hagfors, L., & Johansson, G. An experimental study of A Mediterranean diet intervention for patients with rheumatoid arthritis. Ann. Rheum. Dis. 62, 208-214 (2003).
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 208-214
    • Skoldstam, L.1    Hagfors, L.2    Johansson, G.3
  • 62
    • 84928525360 scopus 로고    scopus 로고
    • Mediterranean diet and incidence of rheumatoid arthritis in women
    • Hu, Y., et al. Mediterranean diet and incidence of rheumatoid arthritis in women. Arthritis Care Res. (Hoboken) 67, 597-606 (2015).
    • (2015) Arthritis Care Res. (Hoboken) , vol.67 , pp. 597-606
    • Hu, Y.1
  • 63
    • 84904989006 scopus 로고    scopus 로고
    • Alcohol consumption and risk of incident rheumatoid arthritis in women: A prospective study
    • Lu, B., Solomon, D. H., Costenbader, K. H., & Karlson, E. W. Alcohol consumption and risk of incident rheumatoid arthritis in women: A prospective study. Arthritis Rheumatol. 66, 1998-2005 (2014).
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 1998-2005
    • Lu, B.1    Solomon, D.H.2    Costenbader, K.H.3    Karlson, E.W.4
  • 64
    • 28444472052 scopus 로고    scopus 로고
    • Fat intake and composition of fatty acids in serum phospholipids in A randomized, controlled, Mediterranean dietary intervention study on patients with rheumatoid arthritis
    • Hagfors, L., Nilsson, I., Skoldstam, L., & Johansson, G. Fat intake and composition of fatty acids in serum phospholipids in A randomized, controlled, Mediterranean dietary intervention study on patients with rheumatoid arthritis. Nutr. Metab. (Lond.) 2, 26 (2005).
    • (2005) Nutr. Metab. (Lond.) , vol.2 , pp. 26
    • Hagfors, L.1    Nilsson, I.2    Skoldstam, L.3    Johansson, G.4
  • 65
    • 2542522612 scopus 로고    scopus 로고
    • Antioxidant intake, plasma antioxidants and oxidative stress in A randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis
    • Hagfors, L., Leanderson, P., Skoldstam, L., Andersson, J., & Johansson, G. Antioxidant intake, plasma antioxidants and oxidative stress in A randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis. Nutr. J. 2, 5 (2003).
    • (2003) Nutr. J. , vol.2 , pp. 5
    • Hagfors, L.1    Leanderson, P.2    Skoldstam, L.3    Andersson, J.4    Johansson, G.5
  • 66
    • 84955613013 scopus 로고    scopus 로고
    • Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production
    • Wu, G. D., et al. Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut 65, 63-72 (2016).
    • (2016) Gut , vol.65 , pp. 63-72
    • Wu, G.D.1
  • 67
    • 84992533219 scopus 로고    scopus 로고
    • High-level adherence to A Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
    • De Filippis, F., et al. High-level adherence to A Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut http://dx.doi.org/10.1136/gutjnl-2015-309957 (2015).
    • (2015) Gut
    • De Filippis, F.1
  • 68
    • 74549158781 scopus 로고    scopus 로고
    • Dietary fish and fish oil and the risk of rheumatoid arthritis
    • Rosell, M., et al. Dietary fish and fish oil and the risk of rheumatoid arthritis. Epidemiology 20, 896-901 (2009).
    • (2009) Epidemiology , vol.20 , pp. 896-901
    • Rosell, M.1
  • 69
    • 0032795847 scopus 로고    scopus 로고
    • Dietary factors in relation to rheumatoid arthritis: A role for olive oil and cooked vegetables?
    • Linos, A., et al. Dietary factors in relation to rheumatoid arthritis: A role for olive oil and cooked vegetables?. Am. J. Clin. Nutr. 70, 1077-1082 (1999).
    • (1999) Am. J. Clin. Nutr. , vol.70 , pp. 1077-1082
    • Linos, A.1
  • 70
    • 0029970651 scopus 로고    scopus 로고
    • Diet and rheumatoid arthritis in women: A possible protective effect of fish consumption
    • Shapiro, J. A., et al. Diet and rheumatoid arthritis in women: A possible protective effect of fish consumption. Epidemiology 7, 256-263 (1996).
    • (1996) Epidemiology , vol.7 , pp. 256-263
    • Shapiro, J.A.1
  • 71
    • 0028818261 scopus 로고
    • Validation of A meta-Analysis: The effects of fish oil in rheumatoid arthritis
    • Fortin, P. R., et al. Validation of A meta-Analysis: the effects of fish oil in rheumatoid arthritis. J. Clin. Epidemiol. 48, 1379-1390 (1995).
    • (1995) J. Clin. Epidemiol. , vol.48 , pp. 1379-1390
    • Fortin, P.R.1
  • 72
    • 84918837536 scopus 로고    scopus 로고
    • Fish oil in recent onset rheumatoid arthritis: A randomised, double-blind controlled trial within algorithm-based drug use
    • Proudman, S. M., et al. Fish oil in recent onset rheumatoid arthritis: A randomised, double-blind controlled trial within algorithm-based drug use. Ann. Rheum. Dis. 74, 89-95 (2015).
    • (2015) Ann. Rheum. Dis. , vol.74 , pp. 89-95
    • Proudman, S.M.1
  • 73
    • 84866156844 scopus 로고    scopus 로고
    • Omega 3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: A meta-Analysis
    • Lee, Y. H., Bae, S. C., & Song, G. G. Omega 3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: A meta-Analysis. Arch. Med. Res. 43, 356-362 (2012).
    • (2012) Arch. Med. Res. , vol.43 , pp. 356-362
    • Lee, Y.H.1    Bae, S.C.2    Song, G.G.3
  • 74
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
    • Serhan, C. N., Chiang, N., & van Dyke, T. E. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349-361 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 75
    • 84879115613 scopus 로고    scopus 로고
    • The role of omega 3 derived resolvins in arthritis
    • Norling, L. V., & Perretti, M. The role of omega 3 derived resolvins in arthritis. Curr. Opin. Pharmacol. 13, 476-481 (2013).
    • (2013) Curr. Opin. Pharmacol. , vol.13 , pp. 476-481
    • Norling, L.V.1    Perretti, M.2
  • 76
    • 84957434822 scopus 로고    scopus 로고
    • Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis
    • Rosillo, M. A., et al. Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis. Eur. J. Nutr. 55, 315-325 (2016).
    • (2016) Eur. J. Nutr. , vol.55 , pp. 315-325
    • Rosillo, M.A.1
  • 77
    • 84925341472 scopus 로고    scopus 로고
    • Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis
    • Silva, S., et al. Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. J. Nutr. Biochem. 26, 360-368 (2015).
    • (2015) J. Nutr. Biochem. , vol.26 , pp. 360-368
    • Silva, S.1
  • 78
    • 84943454450 scopus 로고    scopus 로고
    • Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling
    • Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Backhed, F. Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling. Cell Metab. 22, 658-668 (2015).
    • (2015) Cell Metab. , vol.22 , pp. 658-668
    • Caesar, R.1    Tremaroli, V.2    Kovatcheva-Datchary, P.3    Cani, P.D.4    Backhed, F.5
  • 79
    • 0037442116 scopus 로고    scopus 로고
    • Antioxidant micronutrients and risk of rheumatoid arthritis in A cohort of older women
    • Cerhan, J. R., et al. Antioxidant micronutrients and risk of rheumatoid arthritis in A cohort of older women. Am. J. Epidemiol. 157, 345-354 (2003).
    • (2003) Am. J. Epidemiol. , vol.157 , pp. 345-354
    • Cerhan, J.R.1
  • 80
    • 10444261976 scopus 로고    scopus 로고
    • Dietary risk factors for the development of inflammatory polyarthritis: Evidence for A role of high level of red meat consumption
    • Pattison, D. J., et al. Dietary risk factors for the development of inflammatory polyarthritis: evidence for A role of high level of red meat consumption. Arthritis Rheum. 50, 3804-3812 (2004).
    • (2004) Arthritis Rheum. , vol.50 , pp. 3804-3812
    • Pattison, D.J.1
  • 81
    • 33847403922 scopus 로고    scopus 로고
    • Protein, iron, and meat consumption and risk for rheumatoid arthritis: A prospective cohort study
    • Benito-Garcia, E., Feskanich, D., Hu, F. B., Mandl, L. A., & Karlson, E. W. Protein, iron, and meat consumption and risk for rheumatoid arthritis: A prospective cohort study. Arthritis Res. Ther. 9, R16 (2007).
    • (2007) Arthritis Res. Ther. , vol.9 , pp. R16
    • Benito-Garcia, E.1    Feskanich, D.2    Hu, F.B.3    Mandl, L.A.4    Karlson, E.W.5
  • 82
    • 0022641206 scopus 로고
    • Relationship between iron deposits and tissue damage in the synovium: An ultrastructural study
    • Morris, C. J., et al. Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study. Ann. Rheum. Dis. 45, 21-26 (1986).
    • (1986) Ann. Rheum. Dis. , vol.45 , pp. 21-26
    • Morris, C.J.1
  • 83
    • 84938149885 scopus 로고    scopus 로고
    • Monoclonal antibody against citrullinated peptides obtained from rheumatoid arthritis patients reacts with numerous citrullinated microbial and food proteins
    • Tsuda, R., et al. Monoclonal antibody against citrullinated peptides obtained from rheumatoid arthritis patients reacts with numerous citrullinated microbial and food proteins. Arthritis Rheumatol. 67, 2020-2031 (2015).
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 2020-2031
    • Tsuda, R.1
  • 84
    • 84904299650 scopus 로고    scopus 로고
    • Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: A randomized double-blind clinical trial
    • Alipour, B., et al. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: A randomized double-blind clinical trial. Int. J. Rheum. Dis. 17, 519-527 (2014).
    • (2014) Int. J. Rheum. Dis. , vol.17 , pp. 519-527
    • Alipour, B.1
  • 85
    • 10744221767 scopus 로고    scopus 로고
    • Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis-A pilot study
    • Hatakka, K., et al. Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis-A pilot study. Scand. J. Rheumatol. 32, 211-215 (2003).
    • (2003) Scand. J. Rheumatol. , vol.32 , pp. 211-215
    • Hatakka, K.1
  • 86
    • 79958729747 scopus 로고    scopus 로고
    • A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis
    • Pineda Mde, L., et al. A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis. Med. Sci. Monit. 17, CR347-CR354 (2011).
    • (2011) Med. Sci. Monit. , vol.17 , pp. CR347-CR354
    • Pineda Mde, L.1
  • 87
    • 84922817126 scopus 로고    scopus 로고
    • The potential of probiotics to prevent Clostridium difficile infection
    • Allen, S. J. The potential of probiotics to prevent Clostridium difficile infection. Infect. Dis. Clin. North Am. 29, 135-144 (2015).
    • (2015) Infect. Dis. Clin. North Am. , vol.29 , pp. 135-144
    • Allen, S.J.1
  • 88
    • 84942102435 scopus 로고    scopus 로고
    • Targeting the microbiome in inflammatory bowel disease: Critical evaluation of current concepts and moving to new horizons
    • Bejaoui, M., Sokol, H., & Marteau, P. Targeting the microbiome in inflammatory bowel disease: critical evaluation of current concepts and moving to new horizons. Dig. Dis. 33 (Suppl. 1), 105-112 (2015).
    • (2015) Dig. Dis. , vol.33 , Issue.SUPPL1 , pp. 105-112
    • Bejaoui, M.1    Sokol, H.2    Marteau, P.3
  • 89
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • van Nood, E., et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407-415 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 407-415
    • Van Nood, E.1
  • 90
    • 84931295496 scopus 로고    scopus 로고
    • Update on fecal microbiota transplantation 2015: Indications, methodologies, mechanisms, and outlook
    • Kelly, C. R., et al. Update on fecal microbiota transplantation 2015: indications, methodologies, mechanisms, and outlook. Gastroenterology 149, 223-237 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 223-237
    • Kelly, C.R.1
  • 91
    • 84908681868 scopus 로고    scopus 로고
    • Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
    • Youngster, I., et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312, 1772-1778 (2014).
    • (2014) JAMA , vol.312 , pp. 1772-1778
    • Youngster, I.1
  • 92
    • 0024498413 scopus 로고
    • Treatment of ulcerative colitis by implantation of normal colonic flora
    • Bennet, J. D., & Brinkman, M. Treatment of ulcerative colitis by implantation of normal colonic flora. Lancet 1, 164 (1989).
    • (1989) Lancet , vol.1 , pp. 164
    • Bennet, J.D.1    Brinkman, M.2
  • 93
    • 0024970366 scopus 로고
    • Bowel-flora alteration: A potential cure for inflammatory bowel disease and irritable bowel syndrome?
    • Borody, T. J., et al. Bowel-flora alteration: A potential cure for inflammatory bowel disease and irritable bowel syndrome?. Med. J. Aust. 150, 604 (1989).
    • (1989) Med. J. Aust. , vol.150 , pp. 604
    • Borody, T.J.1
  • 94
    • 84918584474 scopus 로고    scopus 로고
    • Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-Analysis
    • Colman, R. J., & Rubin, D. T. Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-Analysis. J. Crohns Colitis 8, 1569-1581 (2014).
    • (2014) J. Crohns Colitis , vol.8 , pp. 1569-1581
    • Colman, R.J.1    Rubin, D.T.2
  • 95
    • 84931469899 scopus 로고    scopus 로고
    • Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in A randomized controlled trial
    • e6
    • Moayyedi, P., et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in A randomized controlled trial. Gastroenterology 149, 102-109.e6 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 102-109
    • Moayyedi, P.1
  • 96
    • 84931423571 scopus 로고    scopus 로고
    • Findings from A randomized controlled trial of fecal transplantation for patients with ulcerative colitis
    • Rossen, N. G., et al. Findings from A randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 149, 110-118.e4 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 110e4-110e4
    • Rossen, N.G.1
  • 97
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian, S. K., Round, J. L., & Kasper, D. L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453, 620-625 (2008).
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 98
    • 84881477044 scopus 로고    scopus 로고
    • Treg induction by A rationally selected mixture of Clostridia strains from the human microbiota
    • Atarashi, K., et al. Treg induction by A rationally selected mixture of Clostridia strains from the human microbiota. Nature 500, 232-236 (2013).
    • (2013) Nature , vol.500 , pp. 232-236
    • Atarashi, K.1
  • 99
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA 4 blockade relies on the gut microbiota
    • Vetizou, M., et al. Anticancer immunotherapy by CTLA 4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vetizou, M.1
  • 100
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti PD L1 efficacy
    • Sivan, A., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti PD L1 efficacy. Science 350, 1084-1089 (2015).
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 101
    • 84867656021 scopus 로고    scopus 로고
    • Outer membrane vesicles of A human commensal mediate immune regulation and disease protection
    • Shen, Y., et al. Outer membrane vesicles of A human commensal mediate immune regulation and disease protection. Cell Host Microbe 12, 509-520 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 509-520
    • Shen, Y.1
  • 102
    • 84924350477 scopus 로고    scopus 로고
    • Drugging the gut microbiome
    • Garber, K. Drugging the gut microbiome. Nat. Biotechnol. 33, 228-231 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 228-231
    • Garber, K.1
  • 103
    • 84964693545 scopus 로고    scopus 로고
    • Microbial cocktails join fecal transplants in IBD treatment trials
    • Ratner, M. Microbial cocktails join fecal transplants in IBD treatment trials. Nat. Biotechnol. 33, 787-788 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 787-788
    • Ratner, M.1
  • 104
    • 84877249773 scopus 로고    scopus 로고
    • Medicines from microbiota
    • Olle, B. Medicines from microbiota. Nat. Biotechnol. 31, 309-315 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 309-315
    • Olle, B.1
  • 105
    • 78649294933 scopus 로고    scopus 로고
    • The Human Microbiome Project, personalized medicine and the birth of pharmacomicrobiomics
    • Rizkallah, M. R. S., R., & Aziz, R. K. The Human Microbiome Project, personalized medicine and the birth of pharmacomicrobiomics. Curr. Pharmacogenomics Person. Med. 8, 182-193 (2010).
    • (2010) Curr. Pharmacogenomics Person. Med. , vol.8 , pp. 182-193
    • Rizkallah, M.R.S.R.1    Aziz, R.K.2
  • 106
    • 0019442903 scopus 로고
    • Inactivation of digoxin by the gut flora: Reversal by antibiotic therapy
    • Lindenbaum, J., et al. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. N. Engl. J. Med. 305, 789-794 (1981).
    • (1981) N. Engl. J. Med. , vol.305 , pp. 789-794
    • Lindenbaum, J.1
  • 107
    • 84880439384 scopus 로고    scopus 로고
    • Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
    • Haiser, H. J., et al. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science 341, 295-298 (2013).
    • (2013) Science , vol.341 , pp. 295-298
    • Haiser, H.J.1
  • 108
    • 74949136754 scopus 로고    scopus 로고
    • In vitro interaction of L Dopa with bacterial adhesins of Helicobacter pylori: An explanation for clinicial differences in bioavailability?
    • Niehues, M., & Hensel, A. In vitro interaction of L Dopa with bacterial adhesins of Helicobacter pylori: an explanation for clinicial differences in bioavailability?. J. Pharm. Pharmacol. 61, 1303-1307 (2009).
    • (2009) J. Pharm. Pharmacol. , vol.61 , pp. 1303-1307
    • Niehues, M.1    Hensel, A.2
  • 109
    • 84859987078 scopus 로고    scopus 로고
    • Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice
    • LoGuidice, A., Wallace, B. D., Bendel, L., Redinbo, M. R., & Boelsterli, U. A. Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. J. Pharmacol. Exp. Ther. 341, 447-454 (2012).
    • (2012) J. Pharmacol. Exp. Ther. , vol.341 , pp. 447-454
    • LoGuidice, A.1    Wallace, B.D.2    Bendel, L.3    Redinbo, M.R.4    Boelsterli, U.A.5
  • 110
    • 70349108406 scopus 로고    scopus 로고
    • Intestinal microbiota regulate xenobiotic metabolism in the liver
    • Bjorkholm, B., et al. Intestinal microbiota regulate xenobiotic metabolism in the liver. PLoS ONE 4, e6958 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e6958
    • Bjorkholm, B.1
  • 111
    • 84871837954 scopus 로고    scopus 로고
    • Microbial conversion of choline to trimethylamine requires A glycyl radical enzyme
    • Craciun, S., & Balskus, E. P. Microbial conversion of choline to trimethylamine requires A glycyl radical enzyme. Proc. Natl Acad. Sci. USA 109, 21307-21312 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 21307-21312
    • Craciun, S.1    Balskus, E.P.2
  • 112
    • 0030985696 scopus 로고    scopus 로고
    • Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2 bromovinyl)uracil that increases the level and toxicity of 5 fluorouracil
    • Nakayama, H., et al. Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2 bromovinyl)uracil that increases the level and toxicity of 5 fluorouracil. Pharmacogenetics 7, 35-43 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 35-43
    • Nakayama, H.1
  • 113
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of A significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., & Nicholson, J. K. Pharmacometabonomic identification of A significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl Acad. Sci. USA 106, 14728-14733 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 114
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • Viaud, S., et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971-976 (2013).
    • (2013) Science , vol.342 , pp. 971-976
    • Viaud, S.1
  • 115
    • 84871538443 scopus 로고    scopus 로고
    • Gut Pharmacomicrobiomics: The tip of an iceberg of complex interactions between drugs and gut-Associated microbes
    • Saad, R., Rizkallah, M. R., & Aziz, R. K. Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-Associated microbes. Gut Pathog. 4, 16 (2012).
    • (2012) Gut Pathog. , vol.4 , pp. 16
    • Saad, R.1    Rizkallah, M.R.2    Aziz, R.K.3
  • 116
    • 0015348162 scopus 로고
    • The role of intestinal bacteria in the metabolism of salicylazosulfapyridine
    • Peppercorn, M. A., & Goldman, P. The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J. Pharmacol. Exp. Ther. 181, 555-562 (1972).
    • (1972) J. Pharmacol. Exp. Ther. , vol.181 , pp. 555-562
    • Peppercorn, M.A.1    Goldman, P.2
  • 117
    • 84872535919 scopus 로고    scopus 로고
    • Xenobiotics shape the physiology and gene expression of the active human gut microbiome
    • Maurice, C. F., Haiser, H. J., & Turnbaugh, P. J. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell 152, 39-50 (2013).
    • (2013) Cell , vol.152 , pp. 39-50
    • Maurice, C.F.1    Haiser, H.J.2    Turnbaugh, P.J.3
  • 118
    • 84904012264 scopus 로고    scopus 로고
    • Pharmacomicrobiomics: The impact of human microbiome variations on systems pharmacology and personalized therapeutics
    • ElRakaiby, M., et al. Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics. OMICS 18, 402-414 (2014).
    • (2014) OMICS , vol.18 , pp. 402-414
    • ElRakaiby, M.1
  • 120
    • 84910122098 scopus 로고    scopus 로고
    • Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology
    • Patterson, A. D., & Turnbaugh, P. J. Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology. Cell Metab. 20, 761-768 (2014).
    • (2014) Cell Metab. , vol.20 , pp. 761-768
    • Patterson, A.D.1    Turnbaugh, P.J.2
  • 121
    • 84890597306 scopus 로고    scopus 로고
    • Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease
    • Dumas, M. E., Kinross, J., & Nicholson, J. K. Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology 146, 46-62 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 46-62
    • Dumas, M.E.1    Kinross, J.2    Nicholson, J.K.3
  • 123
    • 77954256613 scopus 로고    scopus 로고
    • MSEA: A web-based tool to identify biologically meaningful patterns in quantitative metabolomic data
    • Xia, J., & Wishart, D. S. MSEA: A web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Res. 38, W71-W77 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. W71-W77
    • Xia, J.1    Wishart, D.S.2
  • 124
    • 84937523343 scopus 로고    scopus 로고
    • Metabolomics in the pharmaceutical industry
    • Reily, M. D., & Tymiak, A. A. Metabolomics in the pharmaceutical industry. Drug Discov. Today Technol. 13, 25-31 (2015).
    • (2015) Drug Discov. Today Technol. , vol.13 , pp. 25-31
    • Reily, M.D.1    Tymiak, A.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.