Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

Life Sciences

Volumn 127, Issue , 2015, Pages 59-65

  Lu, Jiamei ^a   Shi, Jianhua ^a   Li, Manxiang ^a   Gui, Baosong ^a   Fu, Rongguo ^a   Yao, Ganglian ^a   Duan, Zhaoyang ^a   Lv, Zhian ^a   Yang, Yanyan ^a   Chen, Zhao ^a   Jia, Lining ^a   Tian, Lifang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Adenosine monophosphate activated; Collagen; Connective tissue growth factor (CTGF); protein kinase (AMPK); Renal fibroblasts; Transforming growth factor beta 1 (TGF 1)

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; COLLAGEN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; METFORMIN; PROTEIN KINASE; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; CTGF PROTEIN, MOUSE; CYCLIC AMP DEPENDENT PROTEIN KINASE; SMAD3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; FIBROBLAST; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; KIDNEY; METABOLISM; PHOSPHORYLATION; PRIMARY CELL CULTURE;

ANIMALS; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FIBROBLASTS; HYPOGLYCEMIC AGENTS; KIDNEY; METFORMIN; MICE; MICE, INBRED BALB C; PHOSPHORYLATION; PRIMARY CELL CULTURE; RNA, SMALL INTERFERING; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84924723896     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.01.042     Document Type: Article

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