Peptide modules for overcoming barriers of nucleic acids transport to cells

Current Topics in Medicinal Chemistry

Volumn 16, Issue 3, 2016, Pages 330-342

  Egorova, Anna A ^a   Kiselev, Anton V ^a  

^a D O OTT RESEARCH INSTITUTE OF OBSTETRICS   (Russian Federation)

Author keywords

Cell penetrating peptides; Cross linking peptides; DNA condensing peptides; Dynein binding peptides; Endosomolytic peptides; Non viral nucleic acids delivery; Nuclear localization signals; Receptor mediated delivery

Indexed keywords

DENDRIMER; NUCLEIC ACID BINDING PROTEIN; DRUG CARRIER; NUCLEIC ACID; PEPTIDE;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DNA TRANSFECTION; GENE THERAPY; GENE TRANSFER; HUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEIC ACID TRANSPORT; PHAGE DISPLAY; PLASMID; PROTEIN INTERACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; ANIMAL; CELLS; CHEMISTRY; METABOLISM;

ANIMALS; CELLS; DRUG CARRIERS; HUMANS; NUCLEIC ACIDS; PEPTIDES;

EID: 84974603268     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026615666150812120755     Document Type: Article

References (162)

1. Young, L.S.; Searle, P.F.; Onion, D.; Mautner, V. Viral Gene Therapy Strategies: From Basic Science to Clinical Application. J. Pathol., 2006, 208, 299-318
2. Mastrobattista, E.; van der Aa, M.A.E.M.; Hennink, W.E.; Crommelin, D.J.A. Artificial Viruses: A Nanotechnological Approach to Gene Delivery. Nat. Rev. Drug Discov., 2006, 5, 115-121
3. Ginn, S.L.; Alexander, I.E.; Edelstein, M.L.; Abedi, M.R.; Wixon, J. Gene Therapy Clinical Trials Worldwide to 2012 - an Update. J. Gene Med., 2013, 15, 65-77
4. Al-Dosari, M.S.; Gao, X. Nonviral Gene Delivery: Principle, Limitations, and Recent Progress. AAPS J., 2009, 11, 671-681
5. Niidome, T.; Urakawa, M.; Takaji, K.; Matsuo, Y.; Ohmori, N.; Wada, A; Hirayama, T.; Aoyagi, H. Influence of Lipophilic Groups in Cationic Alpha-Helical Peptides on Their Abilities to Bind with DNA and Deliver Genes into Cells. J. Pept. Res., 1999, 54, 361-367
6. Männistö, M.; Vanderkerken, S.; Toncheva, V.; Elomaa, M.; Ruponen, M.; Schacht, E.; Urtti, A. Structure-activity Relationships of Poly(l-Lysines): Effects of Pegylation and Molecular Shape on Physicochemical and Biological Properties in Gene Delivery. J. Control. Release, 2002, 83, 169-182
7. Gottschalk, S.; Sparrow, J.T.; Hauer, J.; Mims, M.P.; Leland, F.E.; Woo, S.L.C.; Smith, L.C. A Novel DNA-Peptide Complex for Efficient Gene Transfer and Expression in Mammalian Cells. Gene Ther., 1996, 3, 448-457
8. Wadhwa, M.S.; Collard, W.T.; Adami, R.C.; McKenzie, D.L.; Rice, K.G. Peptide-Mediated Gene Delivery: Influence of Peptide Structure on Gene Expression. Bioconjug. Chem., 1997, 8, 81-88
9. Raad, M.; Teunissen, T.A.; Mastrobattista, E. Peptide Vectors for Gene Delivery: From Single Peptides to Multifunctional Peptide Nanocarriers.Nanomed, (Lond.),2014, 9, 2217-2232
10. Xu, L.; Anchordoquy, T. Drug Delivery Trends in Clinical Trials and Translational Medicine: Challenges and Opportunities in the Delivery of Nucleic Acid-Based Therapeutics. J. Pharm. Sci., 2011, 100, 38-52
11. He, S.; Arscott, P.G.; Bloomfield, V.A. Condensation of DNA by Multivalent Cations: Experimental Studies of Condensation Kinetics. Biopolymers, 2000, 53, 329-341
12. Lu, Y.; Weers, B.; Stellwagen, N.C. DNA Persistence Length Revisited. Biopolymers, 2001, 61, 261-275
13. Rubinstein, M.; Colby, R.H. Polymer Physics; Oxford University Press: Oxford, 2003
14. Rippe, K.; Mucke, N.; Langowski, J. Superhelix Dimensions of a 1868 Base Pair Plasmid Determined by Scanning Force Microscopy in Air and in Aqueous Solution. Nucleic Acids Res., 1997, 25, 1736-1744
15. Hagerman, P.J. Flexibility of RNA. Annu. Rev. Biophys. Biomol. Struct., 1997, 26, 139-156
16. Kebbekus, P. Persistence Length of RNA. Biochemistry, 1995, 34, 4354-4357
17. Spagnou, S.; Miller, A.D.; Keller, M. Lipidic Carriers of siRNA: Differences in the Formulation, Cellular Uptake, and Delivery with Plasmid DNA. Biochemistry, 2004, 43, 13348-13356
18. Midoux, P.; Kichler, A.; Boutin, V.; Maurizot, J.C.; Monsigny, M. Membrane Permeabilization and Efficient Gene Transfer by a Peptide Containing Several Histidines. Bioconjug. Chem., 1998, 9, 260-267
19. Putnam, D.; Zelikin, A.N.; Izumrudov, V.; Langer, R. Polyhistidine-PEG:DNA Nanocomposites for Gene Delivery. Biomaterials, 2003, 24, 4425-4433
20. Asayama, S.; Kumagai, T.; Kawakami, H. Synthesis and Characterization of Methylated poly(L-Histidine) to Control the Stability of Its siRNA Polyion Complexes for RNAi. Bioconjug. Chem., 2012, 23, 1437-1442
21. Bloomfield, V.A. DNA Condensation by Multivalent Cations. Biopolymers, 1997, 44, 269-282
22. Duguid, J.G.; Li, C.; Shi, M.; Logan, M.J.; Alila, H.; Rolland, A.; Tomlinson, E.; Sparrow, J.T.; Smith, L.C. A Physicochemical Approach for Predicting the Effectiveness of Peptide - Based Gene Delivery Systems for Use in Plasmid-Based Gene Therapy. Biophys. J., 1998, 74, 2802-2814
23. Keller, M.; Tagawa, T.; Preuss, M.; Miller, A.D. Biophysical Characterization of the DNA Binding and Condensing Properties of Adenoviral Core Peptide µ (mu). Biochemistry, 2002, 41, 652-59
24. Rajagopalan, R.; Xavier, J.; Rangaraj, N.; Rao, N.M.; Gopal, V. Recombinant Fusion Proteins TAT-Mu, Mu and Mu-Mu Mediate Efficient Non-Viral Gene Delivery. J. Gene Med., 2007, 9, 275-286
25. Plank, C.; Tang, M.X.; Wolfe, A.R.; Szoka, F.C. Branched Cationic Peptides for Gene Delivery: Role of Type and Number of Cationic Residues in Formation and in vitro Activity of DNA Polyplexes. Hum. Gene Ther., 1999, 10, 319-332
26. Toth, I.; Sakthivel, T.; Wilderspin, A.F.; Bayele, H.; O’Donnell, M.; Perry, D.J.; Pasi, K.J.; Lee, C.A.; Florence, A.T. Novel Cationic Lipidic Peptide Dendrimer Vectors in vitro Gene Delivery. S.T.P. Pharma Sci., 1999, 9, 93-99
27. Shah, D.S.; Sakthivel, T.; Toth, I.; Florence, A.T.; Wilderspin, A.F. DNA Transfection and Transfected Cell Viability Using Amphipathic Asymmetric Dendrimers. Int. J. Pharm., 2000, 208, 41-48
28. Bayele, H.K.; Sakthivel, T.; O’Donell, M.; Pasi, K.J.; Wilderspin, A.F.; Lee, C. A.; Toth, I.; Florence, A.T. Versatile Peptide Dendrimers for Nucleic Acid Delivery. J. Pharm. Sci., 2005, 94, 446-457
29. Vlasov, G.P.; Korol’kov, V.I.; Pankova, G.A.; Tarasenko, I.I.; Baranov, A.N.; Glazkov, P.B.; Kiselev, A. V.; Ostapenko, O. V.; Lesina, E.A.; Baranov, V.S. Lysine Dendrimers and Their Starburst Polymer Derivatives: Possible Application for DNA Compaction and in vitro Delivery of Genetic Constructs. Russ. J. Bioorganic Chem., 2004, 30, 12-20
30. Yang, S.; Coles, D.J.; Esposito, A.; Mitchell, D.J.; Toth, I.; Minchin, R.F. Cellular Uptake of Self-Assembled Cationic Peptide - DNA Complexes: Multifunctional Role of the Enhancer Chloroquine. J. Control. Release, 2009, 135, 159-165
31. Kiselev, A. V.; Il’ina, P.L.; Egorova, A.A.; Baranov, A.N.; Guryanov, I.A.; Bayanova, N. V.; Tarasenko, I.I.; Lesina, E.A.; Vlasov, G.P.; Baranov, V.S. Lysine Dendrimers as Vectors for Delivery of Genetic Constructs to Eukaryotic Cells. Russ. J. Genet., 2007, 43, 593-600
32. Ohsaki, M.; Okuda, T.; Wada, A.; Hirayama, T.; Niidome, T.; Aoyagi, H. In vitro Gene Transfection Using Dendritic Poly(L - Lysine). Bioconjug. Chem., 2002, 13, 510-517
33. Yamagata, M.; Kawano, T.; Shiba, K.; Mori, T.; Katayama, Y.; Niidome, T. Structural Advantage of Dendritic Poly(l-Lysine) for Gene Delivery into Cells. Bioorganic Med. Chem., 2007, 15, 526-532
34. Watanabe, K.; Harada-Shiba, M.; Suzuki, A.; Gokuden, R.; Kurihara, R.; Sugao, Y.; Mori, T.; Katayama, Y.; Niidome, T. In vivo siRNA Delivery with Dendritic poly(L-Lysine) for the Treatment of Hypercholesterolemia. Mol. Biosyst., 2009, 5, 1306-1310
35. Okuda, T.; Sugiyama, A.; Niidome, T.; Aoyagi, H. Characters of Dendritic Poly(l-Lysine) Analogues with the Terminal Lysines Replaced with Arginines and Histidines as Gene Carriers in vitro. Biomaterials, 2004, 25, 537-544
36. Joliot, A.; Pernelle, C.; Deagostini-Bazin, H.; Prochiantz, A. Antennapedia Homeobox Peptide Regulates Neural Morphogenesis. Proc. Natl. Acad. Sci. U. S. A., 1991, 88, 1864-1868
37. Milletti, F. Cell-Penetrating Peptides: Classes, Origin, and Current Landscape. Drug Discov. Today, 2012, 17, 850-860
38. Derossi, D.; Joliot, A.H.; Chassaing, G.; Prochiantz, A. The Third Helix of the Antennapedia Homeodomain Translocates through Biological Membranes. J. Biol. Chem., 1994, 269, 10444-10450
39. Vives, E.; Brodin, P.; Lebleu, B. A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus. J. Biol. Chem., 1997, 272, 16010-16017
40. Wender, P.A.; Mitchell, D.J.; Pattabiraman, K.; Pelkey, E.T.; Steinman, L.; Rothbard, J.B. The Design, Synthesis, and Evaluation of Molecules That Enable or Enhance Cellular Uptake: Peptoid Molecular Transporters. Proc. Natl. Acad. Sci. U. S. A., 2000, 97, 13003-13008
41. Futaki, S.; Suzuki, T.; Ohashi, W.; Yagami, T.; Tanaka, S.; Ueda, K.; Sugiura, Y. Arginine-Rich Peptides. An Abundant Source of Membrane-Permeable Peptides Having Potential as Carriers for Intracellular Protein Delivery. J. Biol. Chem., 2001, 276, 5836-5840
42. Futaki, S. Membrane-Permeable Arginine-Rich Peptides and the Translocation Mechanisms. Adv. Drug Deliv. Rev., 2005, 57, 547-558
43. Futaki, S.; Nakase, I.; Suzuki, T.; Youjun, Z.; Sugiura, Y. Translocation of Branched-Chain Arginine Peptides through Cell Membranes: Flexibility in the Spatial Disposition of Positive Charges in Membrane-Permeable Peptides. Biochemistry, 2002, 41, 7925-7930
44. Guryanov, I.A.; Vlasov, G.P.; Lesina, E.A.; Kiselev, A. V.; Baranov, V.S.; Avdeeva, E. V.; Vorob'ev, V.I. Cationic Oligopeptides Modified with Lipophilic Fragments: Use for DNA Delivery to Cells. Russ. J. Bioorganic Chem., 2005, 31, 18-26
45. Tarwadi T.; Jazayeri, J.; Prankerd, R.J.; Pouton, C.W. Preparation and in vitro Evaluation of Novel Lipopeptide Transfection Agents for Efficient Gene Delivery. Bioconjug. Chem., 2008, 19, 940-950
46. Futaki, S.; Suzuki, T.; Ohashi, W.; Yagami, T.; Tanaka, S.; Ueda, K.; Sugiura, Y. Arginine-Rich Peptides. An Abundant Source of Membrane-Permeable Peptides Having Potential as Carriers for Intracellular Protein Delivery. J. Biol. Chem., 2001, 276, 5836-5840
47. Futaki, S.; Ohashi, W.; Suzuki, T.; Niwa, M.; Tanaka, S.; Ueda, K.; Harashima, H.; Sugiura, Y. Stearylated Arginine-Rich Peptides: A New Class of Transfection Systems. Bioconjug. Chem., 2001, 12, 1005-1011
48. Khalil, I. A; Futaki, S.; Niwa, M.; Baba, Y.; Kaji, N.; Kamiya, H.; Harashima, H. Mechanism of Improved Gene Transfer by the N- Terminal Stearylation of Octaarginine: Enhanced Cellular Association by Hydrophobic Core Formation. Gene Ther., 2004, 11, 636-644
49. Lehto, T.; Simonson, O.E.; Mäger, I.; Ezzat, K.; Sork, H.; Copolovici, D.-M.; Viola, J.R.; Zaghloul, E.M.; Lundin, P.; Moreno, P.M.D.; Mäe, M.; Oskolkov, N.; Suhorutšenko, J.; Smith, C.I.E.; Andaloussi, S.E.L. A Peptide-Based Vector for Efficient Gene Transfer in vitro and in vivo. Mol. Ther., 2011, 19, 1457-1467
50. Tanaka, K.; Kanazawa, T.; Ogawa, T.; Takashima, Y.; Fukuda, T.; Okada, H. Disulfide Crosslinked Stearoyl Carrier Peptides Containing Arginine and Histidine Enhance siRNA Uptake and Gene Silencing. Int. J. Pharm., 2010, 398, 219-224
51. Trubetskoy, V. Self-Assembly of DNA-Polymer Complexes Using Template Polymerization. Nucleic Acids Res., 1998, 26, 4178-4185
52. McKenzie, D.L.; Smiley, E.; Kwok, K.Y.; Rice, K.G. Low Molecular Weight Disulfide Cross-Linking Peptides as Nonviral Gene Delivery Carriers. Bioconjug. Chem., 2000, 11, 901-909
53. Oupický, D.; Parker, A.L.; Seymour, L.W. Laterally Stabilized Complexes of DNA with Linear Reducible Polycations: Strategy for Triggered Intracellular Activation of DNA Delivery Vectors. J. Am. Chem. Soc., 2002, 124, 8-9
54. Trentin, D.; Hall, H.; Wechsler, S.; Hubbell, J.A. Peptide-Matrix-Mediated Gene Transfer of an Oxygen-Insensitive Hypoxia-Inducible Factor-1alpha Variant for Local Induction of Angiogenesis. Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 2506-2511
55. Read, M.L.; Bremner, K.H.; Oupický, D.; Green, N.K.; Searle, P.F.; Seymour, L.W. Vectors Based on Reducible Polycations Facilitate Intracellular Release of Nucleic Acids. J. Gene Med., 2003, 5, 232-245
56. Parker, A.L.; Eckley, L.; Singh, S.; Preece, J.A.; Collins, L.; Fabre, J.W. (LYS)(16)-Based Reducible Polycations Provide Stable Polyplexes with Anionic Fusogenic Peptides and Efficient Gene Delivery to Post Mitotic Cells. Biochim. Biophys. Acta, 2007, 1770, 1331-1337
57. Soundara Manickam, D.; Bisht, H.S.; Wan, L.; Mao, G.; Oupicky, D. Influence of TAT-Peptide Polymerization on Properties and Transfection Activity of TAT/DNA Polyplexes. J. Control. Release, 2005, 102, 293-306
58. Hyun, H.; Won, Y.W.; Kim, K.M.; Lee, J.; Lee, M.; Kim, Y.H. Therapeutic Effects of a Reducible Poly (oligo-D-Arginine) Carrier with the Heme Oxygenase-1 Gene in the Treatment of Hypoxic-Ischemic Brain Injury. Biomaterials, 2010, 31, 9128-9134
59. Won, Y.-W.; Yoon, S.-M.; Lee, K.-M.; Kim, Y.-H. Poly(oligo-D-Arginine) with Internal Disulfide Linkages as a Cytoplasm-Sensitive Carrier for siRNA Delivery. Mol. Ther., 2011, 19, 372-380
60. Won, Y.-W.; Kim, K.-M.; An, S.S.; Lee, M.; Ha, Y.; Kim, Y.-H. Suicide Gene Therapy Using Reducible Poly (oligo-D-Arginine) for the Treatment of Spinal Cord Tumors. Biomaterials, 2011, 32, 9766-9775
61. Iversen, T.G.; Skotland, T.; Sandvig, K. Endocytosis and Intracellular Transport of Nanoparticles: Present Knowledge and Need for Future Studies. Nano Today, 2011, 6, 176-185
62. Nomani, A.; Hyvönen, Z.; Pulkkinen, E.; Hiekkala, M.; Ruponen, M. Intracellular Gene Delivery Is Dependent on the Type of Non-Viral Carrier and Defined by the Cell Surface Glycosaminoglycans. J. Control. Release, 2014, 187, 59-65
63. Ruponen, M.; Ylä-Herttuala, S.; Urtti, A. Interactions of Polymeric and Liposomal Gene Delivery Systems with Extracellular Glycosaminoglycans: Physicochemical and Transfection Studies. Biochim. Biophys. Acta - Biomembr., 1999, 1415, 331-341
64. Pouton, C.W.; Seymour, L.W. Key Issues in Non-Viral Gene delivery1PII of Original Article: S0169-409X(98)00048-9. The Article Was Originally Published in Advanced Drug Delivery Reviews 34 (1998) 3-19.1. Adv. Drug Deliv. Rev., 2001, 46, 187-203
65. Perales, J.C.; Grossmann, G.A.; Molas, M.; Liu, G.; Ferkol, T.; Harpst, J.; Oda, H.; Hanson, R.W. Biochemical and Functional Characterization of DNA Complexes Capable of Targeting Genes to Hepatocytes via the Asialoglycoprotein Receptor. J. Biol. Chem., 1997, 272, 7398-7407
66. Mann, A.; Richa, R.; Ganguli, M. DNA Condensation by Poly-L-Lysine at the Single Molecule Level: Role of DNA Concentration and Polymer Length. J. Control. Release, 2008, 125, 252-262
67. Loughran, S.P.; McCrudden, C.M.; McCarthy, H.O. Designer Peptide Delivery Systems for Gene Therapy. Eur. J. Nanomedicine, 2015, 7, 85-96
68. Gräslund, A.; Madani, F.; Lindberg, S.; Langel, Ü.; Futaki, S. Mechanisms of Cellular Uptake of Cell-Penetrating Peptides. J. Biophys., 2011, 2011
69. Ignatovich, I.A.; Dizhe, E.B.; Pavlotskaya, A. V; Akifiev, B.N.; Burov, S. V; Orlov, S. V; Perevozchikov, A.P. Complexes of Plasmid DNA with Basic Domain 47-57 of the HIV-1 Tat Protein Are Transferred to Mammalian Cells by Endocytosis-Mediated Pathways. J. Biol. Chem., 2003, 278, 42625-42636
70. Swanson, J.A.; Watts, C. Macropinocytosis. Trends Cell Biol., 1995, 5, 424-428
71. Tanaka, G.; Nakase, I.; Fukuda, Y.; Masuda, R.; Oishi, S.; Shimura, K.; Kawaguchi, Y.; Takatani-Nakase, T.; Langel, U.; Gräslund, A.; Okawa, K.; Matsuoka, M.; Fujii, N.; Hatanaka, Y.; Futaki, S. CXCR4 Stimulates Macropinocytosis: Implications for Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and HIV. Chem. Biol., 2012, 19, 1437-1446
72. Morris, M. A New Peptide Vector for Efficient Delivery of Oligonucleotides into Mammalian Cells. Nucleic Acids Res., 1997, 25, 2730-2736
73. Simeoni, F. Insight into the Mechanism of the Peptide-Based Gene Delivery System MPG: Implications for Delivery of siRNA into Mammalian Cells. Nucleic Acids Res., 2003, 31, 2717-2724
74. Rittner, K.; Benavente, A.; Bompard-Sorlet, A.; Heitz, F.; Divita, G.; Brasseur, R.; Jacobs, E. New Basic Membrane-Destabilizing Peptides for Plasmid-Based Gene Delivery in vitro and in vivo. Mol. Ther., 2002, 5, 104-114
75. Crombez, L.; Aldrian-Herrada, G.; Konate, K.; Nguyen, Q.N.; McMaster, G.K.; Brasseur, R.; Heitz, F.; Divita, G. A New Potent Secondary Amphipathic Cell-Penetrating Peptide for siRNA Delivery into Mammalian Cells. Mol. Ther., 2009, 17, 95-103
76. Rydström, A.; Deshayes, S.; Konate, K.; Crombez, L.; Padari, K.; Boukhaddaoui, H.; Aldrian, G.; Pooga, M.; Divita, G. Direct Translocation as Major Cellular Uptake for CADY Self-Assembling Peptide-Based Nanoparticles. PLoS One, 2011, 6, e25924
77. Konate, K.; Rydstrom, A.; Divita, G.; Deshayes, S. Everything you always wanted to know about CADY-mediated siRNA delivery* (* But afraid to ask) Curr. Pharm. Des., 2013, 19, 2869-2877
78. Brown, K. New Approaches for Cell-Specific Targeting: Identification of Cell-Selective Peptides from Combinatorial Libraries. Curr. Opin. Chem. Biol., 2000, 4, 16-21
79. Yamada, K.M.; Kennedy, D.W. Dualistic Nature of Adhesive Protein Function: Fibronectin and Its Biologically Active Peptide Fragments Can Autoinhibit Fibronectin Function. J. Cell Biol., 1984, 99, 29-36
80. Shroff, K.; Kokkoli, E. PEGylated Liposomal Doxorubicin Targeted to α5β1-Expressing MDA-MB-231 Breast Cancer Cells. Langmuir, 2012, 28, 4729-4736
81. Hersel, U.; Dahmen, C.; Kessler, H. RGD Modified Polymers: Biomaterials for Stimulated Cell Adhesion and beyond. Biomaterials, 2003, 24, 4385-4415
82. Xiong, X.-B.; Uludağ, H.; Lavasanifar, A. Virus-Mimetic Polymeric Micelles for Targeted siRNA Delivery. Biomaterials, 2010, 31, 5886-5893
83. Egorova, A.; Bogacheva, M.; Shubina, A.; Baranov, V.; Kiselev, A. Development of a Receptor-Targeted Gene Delivery System Using CXCR4 Ligand-Conjugated Cross-Linking Peptides. J. Gene Med., 2014, 16, 336-351
84. Patel, S.; Zhang, X.; Collins, L.; Fabre, J.W. A Small, Synthetic Peptide for Gene Delivery via the Serpin-Enzyme Complex Receptor. J. Gene Med., 2001, 3, 271-279
85. Kim, S.H.; Jeong, J.H.; Lee, S.H.; Kim, S.W.; Park, T.G. LHRH Receptor-Mediated Delivery of siRNA Using Polyelectrolyte Complex Micelles Self-Assembled from siRNA-PEG-LHRH Conjugate and PEI. Bioconjug. Chem., 2008, 19, 2156-2162
86. Nah, J.-W.; Yu, L.; Han, S.; Ahn, C.-H.; Kim, S.W. Artery Wall Binding Peptide-Poly(ethylene Glycol)-Grafted-Poly(l-Lysine)-Based Gene Delivery to Artery Wall Cells. J. Control. Release, 2002, 78, 273-284
87. Zeng, J.; Too, H.-P.; Ma, Y.; Luo, E.S.E.; Wang, S. A Synthetic Peptide Containing Loop 4 of Nerve Growth Factor for Targeted Gene Delivery. J. Gene Med., 2004, 6, 1247-1256
88. Barrett, G.L.; Trieu, J.; Naim, T. The Identification of Leptin-Derived Peptides That Are Taken up by the Brain. Regul. Pept., 2009, 155, 55-61
89. Alvarez-Erviti, L.; Seow, Y.; Yin, H.; Betts, C.; Lakhal, S.; Wood, M.J.A. Delivery of siRNA to the Mouse Brain by Systemic Injection of Targeted Exosomes. Nat. Biotechnol., 2011, 29, 341-345
90. Castillo-Rodríguez, R.A.; Arango-Rodríguez, M.L.; Escobedo, L.; Hernandez-Baltazar, D.; Gompel, A.; Forgez, P.; Martínez-Fong, D. Suicide HSVtk Gene Delivery by Neurotensin-Polyplex Nanoparticles via the Bloodstream and GCV Treatment Specifically Inhibit the Growth of Human MDA-MB-231 Triple Negative Breast Cancer Tumors Xenografted in Athymic Mice. PLoS One, 2014, 9, e97151
91. Hart, S.L. Integrin-Mediated Vectors for Gene Transfer and Therapy. Curr. Opin. Mol. Ther., 1999, 1, 197-203
92. Hynes, R.O. Integrins: Versatility, Modulation, and Signaling in Cell Adhesion. Cell, 1992, 69, 11-25
93. Brooks, P.C.; Clark, R.A.F.; Cheresh, D.A. Requirement of Vascular Integrin αvβ3 for Angiogenesis. Science, 1994, 264, 569-571
94. Kagaya, H.; Oba, M.; Miura, Y.; Koyama, H.; Ishii, T.; Shimada, T.; Takato, T.; Kataoka, K.; Miyata, T. Impact of Polyplex Micelles Installed with Cyclic RGD Peptide as Ligand on Gene Delivery to Vascular Lesions. Gene Ther., 2012, 19, 61-69
95. Hart, S.L.; Harbottle, R.P.; Cooper, R.; Miller, A.; Williamson, R.; Coutelle, C. Gene Delivery and Expression Mediated by an Integrin binding Peptide. Gene Ther., 1995, 2, 552-554
96. Harbottle, R.P.; Cooper, R.G.; Hart, S.L.; Ladhoff, A.; Mckay, T.; Knight, A.M.; Wagner, E.; Miller, A.D.; Coutelle, C. An RGD-Oligolysine Peptide: A Prototype Construct for Integrin-Mediated Gene Delivery. Hum. Gene Ther., 1998, 9, 1037-1047
97. Sobers, C.J.; Wood, S.E.; Mrksich, M. A Gene Expression-Based Comparison of Cell Adhesion to Extracellular Matrix and RGD-Terminated Monolayers. Biomaterials, 2015, 52, 385-394
98. Haubner, R.; Wester, H.J.; Reuning, U.; Senekowitsch-Schmidtke, R.; Diefenbach, B.; Kessler, H.; Stöcklin, G.; Schwaiger, M. Radiolabeled α(ν)β3 Integrin Antagonists: A New Class of Tracers for Tumor Targeting. J. Nucl. Med., 1999, 40, 1061-1071
99. Sancey, L.; Lucie, S.; Garanger, E.; Elisabeth, G.; Foillard, S.; Stéphanie, F.; Schoehn, G.; Guy, S.; Hurbin, A.; Amandine, H.; Albiges-Rizo, C.; Corinne, A.-R.; Boturyn, D.; Didier, B.; Souchier, C.; Catherine, S.; Grichine, A.; Alexeï, G.; Dumy, P.; Pascal, D.; Coll, J.-L.; Jean-Luc, C. Clustering and Internalization of Integrin alphavbeta3 with a Tetrameric RGD-Synthetic Peptide. Mol. Ther., 2009, 17, 837-843
100. Le Bon, B.; Van Craynest, N.; Daoudi, J.-M.; Di Giorgio, C.; Domb, A.J.; Vierling, P. AMD3100 Conjugates as Components of Targeted Nonviral Gene Delivery Systems: Synthesis and in vitro Transfection Efficiency of CXCR4-Expressing Cells. Bioconjug. Chem., 2004, 15, 413-423
101. Juarez, J.; Bendall, L.; Bradstock, K. Chemokines and Their Receptors as Therapeutic Targets: The Role of the SDF-1/CXCR4 Axis. Curr. Pharm. Des., 2004, 10, 1245-1259
102. Egorova, A.; Kiselev, A.; Hakli, M.; Ruponen, M.; Baranov, V.; Urtti, A. Chemokine-Derived Peptides as Carriers for Gene Delivery to CXCR4 Expressing Cells. J. Gene Med., 2009, 11, 772-781
103. Driessen, W.H.P.; Fujii, N.; Tamamura, H.; Sullivan, S.M. Development of Peptide-Targeted Lipoplexes to CXCR4-Expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells. Mol. Ther., 2008, 16, 516-524
104. Schäfer, A.; Pahnke, A.; Schaffert, D.; van Weerden, W.M.; de Ridder, C.M.; Rödl, W.; Vetter, A.; Spitzweg, C.; Kraaij, R.; Wagner, E.; Ogris, M. Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation. Hum. Gene Ther., 2011, 22, 1463-1473
105. Smith, G.P. Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface. Science, 1985, 228, 1315-1317
106. Gray, B.P.; Brown, K.C. Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides. Chem. Rev., 2014, 114, 1020-1081
107. Maruta, F.; Parker, A.L.; Fisher, K.D.; Hallissey, M.T.; Ismail, T.; Rowlands, D.C.; Chandler, L.A.; Kerr, D.J.; Seymour, L.W. Identification of FGF Receptor-Binding Peptides for Cancer Gene Therapy. Cancer Gene Ther., 2002, 9, 543-552
108. Parker, A.L.; Fisher, K.D.; Oupicky, D.; Read, M.L.; Nicklin, S.A.; Baker, A.H.; Seymour, L.W. Enhanced Gene Transfer Activity of Peptide-Targeted Gene-Delivery Vectors. J. Drug Target., 2005, 13, 39-51
109. Lu, Z.X.; Liu, L.T.; Qi, X.R. Development of Small Interfering RNA Delivery System Using PEI-PEG-APRPG Polymer for Antiangiogenic Vascular Endothelial Growth Factor Tumor-Targeted Therapy. Int. J. Nanomed., 2011, 6, 1661-1673
110. Blackburn, W.H.; Dickerson, E.B.; Smith, M.H.; McDonald, J.F.; Lyon, L.A. Peptide-Functionalized Nanogels for Targeted siRNA Delivery. Bioconjug. Chem., 2009, 20, 960-968
111. Joseph, S.C. Poly(Arginine) Derived Cancer-Targeting Peptides for the Development of a Cancer-Targeted Gene Therapy Approach in HepG2 Liver Cancer Cells; Paper 1988, Seton Hall University Dissertations and Theses (ETDs), 2014
112. Nie, Y.; Schaffert, D.; Rödl, W.; Ogris, M.; Wagner, E.; Günther, M. Dual-Targeted Polyplexes: One Step towards a Synthetic Virus for Cancer Gene Therapy. J. Control Release, 2011, 152, 127-134
113. Park, I.-K.; Lasiene, J.; Chou, S.-H.; Horner, P.J.; Pun, S.H. Neuron-Specific Delivery of Nucleic Acids Mediated by Tet1-Modified Poly(ethylenimine). J. Gene Med., 2007, 9, 691-702
114. Waterhouse, J.E.; Harbottle, R.P.; Keller, M.; Kostarelos, K.; Coutelle, C.; Jorgensen, M.R.; Miller, A.D. Synthesis and Application of Integrin Targeting Lipopeptides in Targeted Gene Delivery. ChemBioChem, 2005, 6, 1212-1223
115. Writer, M.J.; Marshall, B.; Pilkington-Miksa, M.A.; Barker, S.E.; Jacobsen, M.; Kritz, A.; Bell, P.C.; Lester, D.H.; Tabor, A.B.; Hailes, H.C.; Klein, N.; Hart, S.L. Targeted Gene Delivery to Human Airway Epithelial Cells with Synthetic Vectors Incorporating Novel Targeting Peptides Selected by Phage Display. J. Drug Target., 2004, 12, 185-193
116. Tagalakis, A.D.; McAnulty, R.J.; Devaney, J.; Bottoms, S.E.; Wong, J.B.; Elbs, M.; Writer, M.J.; Hailes, H.C.; Tabor, A.B.; O’Callaghan, C.; Jaffe, A.; Hart, S.L. A Receptor-Targeted Nanocomplex Vector System Optimized for Respiratory Gene Transfer. Mol. Ther., 2008, 16, 907-915
117. Pi, Y.; Zhang, X.; Shi, J.; Zhu, J.; Chen, W.; Zhang, C.; Gao, W.; Zhou, C.; Ao, Y. Targeted Delivery of Non-Viral Vectors to Cartilage in vivo Using a Chondrocyte-Homing Peptide Identified by Phage Display. Biomaterials, 2011, 32, 6324-6332
118. Santos, J.L.; Pandita, D.; Rodrigues, J.; Pêgo, A.P.; Granja, P.L.; Balian, G.; Tomás, H. Receptor-Mediated Gene Delivery Using PAMAM Dendrimers Conjugated with Peptides Recognized by Mesenchymal Stem Cells. Mol. Pharm., 2010, 7, 763-774
119. Smith, L.C.; Duguid, J.; Wadhwa, M.S.; Logan, M.J.; Tung, C.H.; Edwards, V.; Sparrow, J.T. Synthetic Peptide-Based DNA Complexes for Nonviral Gene Delivery. Adv. Drug Deliv. Rev., 1998, 30, 115-131
120. Wagner, E.; Plank, C.; Zatloukal, K.; Cotten, M.; Birnstiel, M.L. Influenza Virus Hemagglutinin HA-2 N-Terminal Fusogenic Peptides Augment Gene Transfer by Transferrin-Polylysine-DNA Complexes: Toward a Synthetic Virus-like Gene-Transfer Vehicle. Proc. Natl. Acad. Sci. U. S. A., 1992, 89, 7934-7938
121. Vlasov, G.P.; Lesina, E.A.; Korol’kov, V.I.; Gur’yanov, I.A.; Bayanova, N. V.; Baranov, A.N.; Kiselev, A. V.; Baranov, V.S. Optimization of Transfection Properties of DNA-Lysine Dendrimer Complexes. Russ. J. Bioorg. Chem., 2005, 31, 153-159
122. Midoux, P.; Monsigny, M. Efficient Gene Transfer by Histidylated polylysine/pDNA Complexes. Bioconjug. Chem., 1999, 10, 406-411
123. Lo, S.L.; Wang, S. An Endosomolytic Tat Peptide Produced by Incorporation of Histidine and Cysteine Residues as a Nonviral Vector for DNA Transfection. Biomaterials, 2008, 29, 2408-2414
124. Shai, Y. Mechanism of the Binding, Insertion and Destabilization of Phospholipid Bilayer Membranes by Α-Helical Antimicrobial and Cell Non-Selective Membrane-Lytic Peptides. Biochim. Biophys. Acta - Biomembr., 1999, 1462, 55-70
125. Lear, J.D.; DeGrado, W.F. Membrane Binding and Conformational Properties of Peptides Representing the NH2 Terminus of Influenza HA-2. J. Biol. Chem., 1987, 262, 6500-6505
126. Subbarao, N.K. PH-Dependent Bilayer Destabilization by an Amphipathic Peptide. Biochemistry, 1987, 26, 2964-2972
127. Parente, R.A.; Nir, S.; Szoka, F.C. Mechanism of Leakage of Phospholipid Vesicle Contents Induced by the Peptide GALA. Biochemistry, 1990, 29, 8720-8728
128. Wyman, T.B.; Nicol, F.; Zelphati, O.; Scaria, P. V; Plank, C.; Szoka, F.C. Design, Synthesis, and Characterization of a Cationic Peptide That Binds to Nucleic Acids and Permeabilizes Bilayers. Biochemistry, 1997, 36, 3008-3017
129. Sato, Y.; Nakamura, T.; Yamada, Y.; Akita, H.; Harashima, H. Multifunctional Enveloped Nanodevices (MENDs). Adv. Genet., 2014, 88, 139-204
130. Baranov, V.S.; Tarasenko, O. V.; Baranov, A.N.; Kiselev, A. V.; Ivashchenko, T.E.; Evgrafov, O. V.; Mikhailov, V.M.; Dickson, G. Expression of the Human Dystrophin Gene in Mdc Mouse Muscle after Transfer with Liposomes or Synthetic Oligopeptide Complex Vectors. Genetika, 1998, 34, 876-882
131. Boussif, O.; Lezoualc’h, F.; Zanta, M.A.; Mergny, M.D.; Scherman, D.; Demeneix, B.; Behr, J.P. A Versatile Vector for Gene and Oligonucleotide Transfer into Cells in Culture and in vivo: Polyethylenimine. Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 7297-7301
132. Chen, Q.R.; Zhang, L.; Luther, P.W.; Mixson, A.J. Optimal Transfection with the HK Polymer Depends on Its Degree of Branching and the pH of Endocytic Vesicles. Nucleic Acids Res., 2002, 30, 1338-1345
133. Read, M.L.; Singh, S.; Ahmed, Z.; Stevenson, M.; Briggs, S.S.; Oupicky, D.; Barrett, L.B.; Spice, R.; Kendall, M.; Berry, M.; Preece, J.A.; Logan, A.; Seymour, L.W. A Versatile Reducible Polycation-Based System for Efficient Delivery of a Broad Range of Nucleic Acids. Nucleic Acids Res., 2005, 33
134. Egorova, A.A.; Kiselev, A. V.; Tarasenko, I.I.; Il’ina, P.L.; Pankova, G.A.; Il’ina, I.E.; Baranov, V.C.; Vlasov, G.P. Hyperbranched Polylysines Modified with Histidine and Arginine: The Optimization of Their DNA Compacting and Endosomolytic Properties. Russ. J. Bioorganic Chem., 2009, 35, 437-445
135. Kiselev, A.; Egorova, A.; Laukkanen, A.; Baranov, V.; Urtti, A. Characterization of Reducible Peptide Oligomers as Carriers for Gene Delivery. Int. J. Pharm., 2013, 441, 736-747
136. Mann, A.; Shukla, V.; Khanduri, R.; Dabral, S.; Singh, H.; Ganguli, M. Linear Short Histidine and Cysteine Modified Arginine Peptides Constitute a Potential Class of DNA Delivery Agents. Mol. Pharm., 2014, 11, 683-696
137. Zhou, J.; Li, Y.; Dong, H.; Yuan, H.; Ren, T.; Li, Y. Effect of Monomer Sequence of Poly(histidine/lysine) Catiomers on Gene Packing Capacity and Delivery Efficiency. RSC Adv., 2015, 5, 14138-14146
138. Kichler, A.; Leborgne, C.; März, J.; Danos, O.; Bechinger, B. Histidine-Rich Amphipathic Peptide Antibiotics Promote Efficient Delivery of DNA into Mammalian Cells. Proc. Natl. Acad. Sci. U. S. A., 2003, 100, 1564-1568
139. Langlet-Bertin, B.; Leborgne, C.; Scherman, D.; Bechinger, B.; Mason, A. J.; Kichler, A. Design and Evaluation of Histidine-Rich Amphipathic Peptides for siRNA Delivery. Pharm. Res., 2010, 27, 1426-1436
140. Kichler, A.; Mason, A. J.; Bechinger, B. Cationic Amphipathic Histidine-Rich Peptides for Gene Delivery. Biochim. Biophys. Acta - Biomembr., 2006, 1758, 301-307
141. Iacobucci, V.; Di Giuseppe, F.; Bui, T.T.; Vermeer, L.S.; Patel, J.; Scherman, D.; Kichler, A.; Drake, A.F.; Mason, A.J. Control of pH Responsive Peptide Self-Association during Endocytosis Is Required for Effective Gene Transfer. Biochim. Biophys. Acta, 2012, 1818, 1332-1341
142. Lechardeur, D.; Verkman, A.S.; Lukacs, G.L. Intracellular Routing of Plasmid DNA during Non-Viral Gene Transfer. Adv. Drug Deliv. Rev., 2005, 57, 755-767
143. Lukacs, G.L.; Haggie, P.; Seksek, O.; Lechardeur, D.; Freedman, N.; Verkman, A.S. Size-Dependent DNA Mobility in Cytoplasm and Nucleus. J. Biol. Chem., 2000, 275, 1625-1629
144. Lechardeur, D.; Sohn, K.J.; Haardt, M.; Joshi, P.B.; Monck, M.; Graham, R.W.; Beatty, B.; Squire, J.; O’Brodovich, H.; Lukacs, G.L. Metabolic Instability of Plasmid DNA in the Cytosol: A Potential Barrier to Gene Transfer. Gene Ther., 1999, 6, 482-497
145. Huth, S.; Hoffmann, F.; von Gersdorff, K.; Laner, A.; Reinhardt, D.; Rosenecker, J.; Rudolph, C. Interaction of Polyamine Gene Vectors with RNA Leads to the Dissociation of Plasmid DNA-Carrier Complexes. J. Gene Med., 2006, 8, 1416-1424
146. Miyazawa, N.; Crystal, R.G.; Leopold, P.L. Adenovirus Serotype 7 Retention in a Late Endosomal Compartment prior to Cytosol Escape Is Modulated by Fiber Protein. J. Virol., 2001, 75, 1387-1400
147. Suh, J.; An, Y.; Tang, B.C.; Dempsey, C.; Huang, F.; Hanes, J. Real-Time Gene Delivery Vector Tracking in the Endo-Lysosomal Pathway of Live Cells. Microsc. Res. Tech., 2012, 75, 691-697
148. Milisav, I. Dynein and Dynein-Related Genes. Cell Motil. Cytoskeleton, 1998, 39, 261-272
149. Tanaka, K.; Kanazawa, T.; Sugawara, K.; Horiuchi, S.; Takashima, Y.; Okada, H. A Cytoplasm-Sensitive Peptide Vector Cross-Linked with Dynein Light Chain Association Sequence (DLCAS) Enhances Gene Expression. Int. J. Pharm., 2011, 419, 231-234
150. Pigeon, L.; Gonçalves, C.; Gosset, D.; Pichon, C.; Midoux, P. An E3-14.7K Peptide That Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency. Small, 2013, 9, 3845-3851
151. Tachibana, R.; Harashima, H.; Ide, N.; Ukitsu, S.; Ohta, Y.; Suzuki, N.; Kikuchi, H.; Shinohara, Y.; Kiwada, H. Quantitative Analysis of Correlation between Number of Nuclear Plasmids and Gene Expression Activity after Transfection with Cationic Liposomes. Pharm. Res., 2002, 19, 377-381
152. Rolland, A. Nuclear Gene Delivery: The Trojan Horse Approach. Expert Opin. Drug Deliv., 2006, 3, 1-10
153. Goldfarb, D.S.; Gariépy, J.; Schoolnik, G.; Kornberg, R.D. Synthetic Peptides as Nuclear Localization Signals. Nature, 1986, 322, 641-644
154. Zanta, M.A.; Belguise-Valladier, P.; Behr, J.-P. Gene Delivery: A Single Nuclear Localization Signal Peptide Is Sufficient to Carry DNA to the Cell Nucleus. Proc. Natl. Acad. Sci., 1999, 96, 91-96
155. Kim, B.K.; Kang, H.; Doh, K.O.; Lee, S.H.; Park, J.W.; Lee, S.J.; Lee, T.J. Homodimeric SV40 NLS Peptide Formed by Disulfide Bond as Enhancer for Gene Delivery. Bioorganic Med. Chem. Lett., 2012, 22, 5415-5418
156. Yang, J.; Lei, Q.; Han, K.; Gong, Y.-H.; Chen, S.; Cheng, H.; Cheng, S.-X.; Zhuo, R.-X.; Zhang, X.-Z. Reduction-Sensitive Polypeptides Incorporated with Nuclear Localization Signal Sequences for Enhanced Gene Delivery. J. Mater. Chem., 2012, 22, 13591
157. Pouton, C.W. Nuclear Import of Polypeptides, Polynucleotides and Supramolecular Complexes. Adv. Drug Deliv. Rev., 1998, 34, 51-64
158. Matschke, J.; Bohla, A.; Maucksch, C.; Mittal, R.; Rudolph, C.; Rosenecker, J. Characterization of Ku70(2)-NLS as Bipartite Nuclear Localization Sequence for Non-Viral Gene Delivery. PLoS One, 2012, 7, e24615
159. Jung, J.; Lee, J.; Kim, T.; Yang, B.S.; Lee, E.; Kim, Y. PAMAM Dendrimer Conjugated with N-Terminal Oligopeptides of Mouse Fibroblast Growth Factor 3 as a Novel Gene Carrier. Bull. Korean Chem. Soc., 2014, 35, 1036-1042
160. Matthew Michael, W.; Choi, M.; Dreyfuss, G. A Nuclear Export Signal in hnRNP A1: A Signal-Mediated, Temperature-Dependent Nuclear Protein Export Pathway. Cell, 1995, 83, 415-422
161. Ma, H.; Zhu, J.; Maronski, M.; Kotzbauer, P.T.; Lee, V.M.Y.; Dichter, M. A.; Diamond, S.L. Non-Classical Nuclear Localization Signal Peptides for High Efficiency Lipofection of Primary Neurons and Neuronal Cell Lines. Neuroscience, 2002, 112, 1-5
162. Pouton, C.; Wagstaff, K.; Roth, D.; Moseley, G.; Jans, D. Targeted Delivery to the Nucleus. Adv. Drug Deliv. Rev., 2007, 59, 698-717