Disconnecting the Yin and Yang relation of epidermal growth factor receptor (EGFR)-mediated delivery: A fully synthetic, EGFR-targeted gene transfer system avoiding receptor activation

Human Gene Therapy

Volumn 22, Issue 12, 2011, Pages 1463-1473

  Schafer A ^a   Pahnke, A ^a   Schaffert, D ^a   Van Weerden, W M ^b   De Ridder, C M A ^b   Rodl W ^a   Vetter, A ^a   Spitzweg, C ^c   Kraaij, R ^b   Wagner, E ^a   Ogris, M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; POLYETHYLENEIMINE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL SURFACE; CONTROLLED STUDY; FLUORESCENCE; GENE TRANSFER; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; INCUBATION TIME; INTERNALIZATION; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PINOCYTOSIS; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TRANSGENE; TUMOR CELL; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; EPIDERMAL GROWTH FACTOR; FLOW CYTOMETRY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; PEPTIDE FRAGMENTS; POLYETHYLENEIMINE; PROSTATIC NEOPLASMS; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 79960368490     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2010.231     Document Type: Article

References (32)

1. Blessing, T., Kursa, M., Holzhauser, R., et al. (2001). Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug. Chem. 12, 529-537. (Pubitemid 32696226)
2. Boeckle, S., Von Gersdorff, K., Van Der Piepen, S., et al. (2004). Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. J. Gene Med. 6, 1102-1111. (Pubitemid 40228122)
3. Brunner, S., Sauer, T., Carotta, S., et al. (2000). Cell cycle dependence of gene transfer by lipoplex, polyplex and recom-binant adenovirus. Gene Ther. 7, 401-407. (Pubitemid 30156552)
4. Brunner, S., Furtbauer, E., Sauer, T., et al. (2002). Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation. Mol. Ther. 5, 80-86. (Pubitemid 34110484)
5. Bryant, D.M., Kerr, M.C., Hammond, L.A., et al. (2007). EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J. Cell Sci. 120, 1818-1828. (Pubitemid 46930420)
6. De Bruin, K., Ruthardt, N., Von Gersdorff, K., et al. (2007). Cellular dynamics of EGF receptor-targeted synthetic viruses. Mol. Ther. 15, 1297-1305. (Pubitemid 46965326)
7. De Bruin, K.G., Fella, C., Ogris, M., et al. (2008). Dynamics of photoinduced endosomal release of polyplexes. J. Control. Release 130, 175-182.
8. Diagaradjane, P., Orenstein-Cardona, J.M., Colon-Casasnovas, N.E., et al. (2008). Imaging epidermal growth factor receptor expression in vivo: Pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe. Clin. Cancer Res. 14, 731-741. (Pubitemid 351231154)
9. Erbacher, P., Bettinger, T., Belguise-Valladier, P., et al. (1999). Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized poly-ethylenimines (PEI). J. Gene Med. 1, 210-222. (Pubitemid 129631076)
10. Khalil, M.Y., Grandis, J.R., and Shin, D.M. (2003). Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer. Expert Rev. Anticancer Ther. 3, 367-380. (Pubitemid 36748047)
11. Kim, H., and Muller, W.J. (1999). The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis. Exp. Cell Res. 253, 78-87.
12. Kim, I.Y., Kang, Y.S., Lee, D.S., et al. (2009). Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice. J. Control. Release 140, 55-60.
13. Klutz, K., Schaffert, D., Willhauck, M.J., et al. (2011). Epidermal growth factor receptor-targeted 131I-therapy of liver cancer following systemic delivery of the sodium iodide symporter gene. Mol. Ther. 19, 676-685.
14. Komoriya, A., Hortsch, M., Meyers, C., et al. (1984). Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region. Proc. Natl. Acad. Sci. U.S.A. 81, 1351-1355. (Pubitemid 14173467)
15. Kraaij, R., van Weerden, W.M., De Ridder, C.M., et al. (2002). Validation of transrectal ultrasonographic volumetry for or-thotopic prostate tumours in mice. Lab. Anim. 36, 165-172. (Pubitemid 34311410)
16. Lemmon, M.A., Bu, Z., Ladbury, J.E., et al. (1997). Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J. 16, 281-294. (Pubitemid 27049386)
17. Li, Z., Zhao, R., Wu, X., et al. (2005). Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics. FASEB J. 19, 1978-1985. (Pubitemid 41759743)
18. Marques, R.B., van Weerden, W.M., Erkens-Schulze, S., et al. (2006). The human PC346 xenograft and cell line panel: a model system for prostate cancer progression. Eur. Urol. 49, 245-257. (Pubitemid 43197860)
19. Moon, W.S., Park, H.S., Yu, K.H., et al. (2006). Expression of betacellulin and epidermal growth factor receptor in hepato-cellular carcinoma: Implications for angiogenesis. Hum. Pa-thol. 37, 1324-1332. (Pubitemid 44380277)
20. Navarro, G., Maiwald, G., Haase, R., et al. (2010). Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery. J. Control. Release 146, 99-105.
21. Ogris, M., Steinlein, P., Carotta, S., et al. (2001). DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression. AAPS PharmSci. 3, E21.
22. Ogris, M., Walker, G., Blessing, T.,etal.(2003). Tumor-targeted gene therapy: Strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J. Control. Release 91, 173-181. (Pubitemid 37288888)
23. Peng, K.W., Pham, L., Ye, H., et al. (2001). Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors. Gene Ther. 8, 1456-1463. (Pubitemid 32994656)
24. Pereboeva, L., Komarova, S., Roth, J., et al. (2007). Targeting EGFR with metabolically biotinylated fiber-mosaic adeno-virus. Gene Ther. 14, 627-637. (Pubitemid 46585622)
25. Schaffert, D., Kiss, M., Rödl, W., et al. (2011). Poly(I:C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear poly-ethylenimine as carrier. Pharm. Res. 28, 731-741.
26. Schlessinger, J. (2002). Ligand-induced, receptor-mediated di-merization and activation of EGF receptor. Cell 110, 669-672. (Pubitemid 35283957)
27. Shir, A., Ogris, M., Wagner, E., and Levitzki, A. (2006). EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLoS Med. 3, e6.
28. Ungaro, F., De Rosa, G., Miro, A., and Quaglia, F. (2003). Spec-trophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations. J. Pharm. Biomed. Anal. 31, 143-149. (Pubitemid 36120628)
29. Van Weerden, W.M., De Ridder, C.M., Verdaasdonk, C.L., et al. (1996). Development of seven new human prostate tumor xenograft models and their histopathological characterization. Am. J. Pathol. 149, 1055-1062. (Pubitemid 26334187)
30. Walker, G.F., Fella, C., Pelisek, J., et al. (2005). Toward synthetic viruses: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Mol. Ther. 11, 418-425. (Pubitemid 40277318)
31. Wells, A. (1999). EGF receptor. Int. J. Biochem. Cell Biol. 31, 637-643. (Pubitemid 29248872)
32. Wolschek, M.F., Thallinger, C., Kursa, M., et al. (2002). Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology 36, 1106-1114. (Pubitemid 35253426)