Development of a receptor-targeted gene delivery system using CXCR4 ligand-conjugated cross-linking peptides

Journal of Gene Medicine

Volumn 16, Issue 11-12, 2014, Pages 336-351

  Egorova, Anna ^a   Bogacheva, Maria ^a   Shubina, Anastasia ^b   Baranov, Vladislav ^a,b   Kiselev, Anton ^a  

^a D O OTT RESEARCH INSTITUTE OF OBSTETRICS   (Russian Federation)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

Author keywords

Cancer cells; Cross linking peptides; CXCR4; Human mesenchymal stem cells; Targeted gene delivery

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHLORPROMAZINE; CLATHRIN; DEOXYRIBONUCLEASE I; DITHIOTHREITOL; DNA; GLYCOSAMINOGLYCAN; LIGAND; PEPTIDE DERIVATIVE; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1ALPHA; VALPROIC ACID; CROSS LINKING REAGENT; MACROMOLECULE; PEPTIDE; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; DNA BINDING; DNA PROTEIN COMPLEX; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG EFFICACY; ENDOCYTOSIS; FEMALE; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; KINETICS; MESENCHYMAL STEM CELL; NONHUMAN; PHYSICAL CHEMISTRY; POLYMERIZATION; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; ANIMAL; CELL SURVIVAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; HELA CELL LINE; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; PHARMACOLOGY; PLASMID;

AMINO ACID SEQUENCE; ANIMALS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CROSS-LINKING REAGENTS; DNA; HELA CELLS; HUMANS; LIGANDS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; PEPTIDES; PLASMIDS; PROTEIN BINDING; RECEPTORS, CXCR4; TRANSFECTION;

EID: 84916601598     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.2811     Document Type: Article

References (48)

1. Young LS, Searle PF, Onion D, Mautner V. Viral gene therapy strategies: from basic science to clinical application. J Pathol 2006; 208: 299-318.
2. Mastrobattista E, van der Aa M, Hennink W, Crommelin D. Artificial viruses: a nanotechnological approach to gene delivery. Nat Rev Drug Discovery 2006; 5: 115-121.
3. Boussif O, Lezoualch F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
4. Tang MX, Roedemann CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996; 7: 703-714.
5. Midoux P, Monsigny M. Efficient gene transfer by histidylated polylysine/pDNA complexes. Bioconjug Chem 1999; 10: 406-411.
6. Kiselev AV, Il'ina PL, Egorova AA, et al. Lysine dendrimers as vectors for delivery of genetic constructs to eukaryotic cells. Russ J Genet 2007; 43: 593-600.
7. Juarez J, Bendall L, Bradstock K. Chemokines and their receptors as therapeutic targets: the role of the SDF-1/CXCR4 axis. Curr Pharm Des 2004; 10: 1245-1259.
8. Kucia M, Reca R, Miekus K, et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005; 23: 879-894.
9. Wynn RF, Hart CA, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 2004; 104: 2643-2645.
10. Ruiz A, Salvo VA, Ruiz LA, Báez P, García M, Flores I. Basal and steroid hormone-regulated expression of CXCR4 in human endometrium and endometriosis. Reprod Sci 2010; 17: 894-903.
11. Peled A, Petit I, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999; 283: 845-848.
12. Le Bon B, Van Craynest N, Daoudi JM, Di Giorgio C, Domb AJ, Vierling P. AMD3100 conjugates as components of targeted nonviral gene delivery systems: synthesis and in vitro transfection efficiency of CXCR4-expressing cells. Bioconjugate Chem 2004; 15: 413-423.
13. Li J, Zhu Y, Hazeldine ST, Li C, Oupický D. Dual-function CXCR4 antagonist polyplexes to deliver gene therapy and inhibit cancer cell invasion. Angew Chem Int Ed Engl 2012; 51: 8740-8743.
14. Wang Y, Li J, Oupický D. Polymeric plerixafor: effect of PEGylation on CXCR4 antagonism, cancer cell invasion, and DNA transfection. Pharm Res 2014; 31: 3538-3548.
15. Driessen WH, Fujii N, Tamamura H, Sullivan SM. Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells. Mol Ther 2008; 16: 516-24.
16. Egorova A, Kiselev A, Hakli M, Ruponen M, Baranov V, Urtti A. Chemokine-derived peptides as carriers for gene delivery to CXCR4 expressing cells. J Gene Med 2009; 11: 772-781.
17. McKenzie DL, Smiley E, Kwok KY, Rice KG. Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers. Bioconjug Chem 2000; 11: 901-909.
18. Baranov VS, Tarasenko OV, Baranov AN, et al. Expression of the human dystrophin gene in mdx mouse muscle after transfer with liposomes or synthetic oligopeptide complex vectors. Genetika 1998; 34: 876-882.
19. Read ML, Singh S, Ahmed Z, et al. A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids. Nucleic Acids Res 2005; 33: E86.
20. Egorova AA, Kiselev AV, Tarasenko II, et al. Hyperbranched polylysines modified with histidine and arginine: the optimization of their DNA compacting and endosomolytic properties. Russ J Bioorg Chem 2009; 35: 483-492.
21. Kiselev A, Egorova A, Laukkanen A, Baranov V, Urtti A. Characterization of reducible peptide oligomers as carriers for gene delivery. Int J Pharm 2013; 441: 736-747.
22. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA 1983; 80: 3734-3737.
23. Grigorian AS, Kruglyakov PV, Taminkina UA, et al. Alterations of cytological and karyological profile of human mesenchymal stem cells during in vitro culturing. Bull Exp Biol Med 2010; 150: 125-130.
24. Aitken A, Learmonth M. Estimation of disulfide bonds using Ellman's regent. In Protein Protocol Handbook, Walker JM (ed.). Humana Press Inc.: Totowa, NJ, 1996; 487-494.
25. Tsai LK, Leng Y, Wang Z, Leeds P, Chuang DM. The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology 2010; 35: 2225-2237.
26. Ruponen M, Yla-Herttuala S, Urtti A. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. Biochim Biophys Acta 1999; 1415: 331-341.
27. Huth S, Hoffmann F, von Gersdorff K, et al. Interaction of polyamine gene vectors with RNA leads to the dissociation of plasmid DNA-carrier complexes. J Gene Med 2006; 8: 1416-1424.
28. Drake MT, Shenoy SK, Lefkowitz RJ. Trafficking of G protein-coupled receptors. Circ Res 2006; 99: 570-582.
29. Marchese A, Benovic JL. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 2001; 276: 45509-45512.
30. Niidome T, Urakawa M, Takaji K, et al. Influence of lipophilic groups in cationic alpha-helical peptides on their abilities to bind with DNA and deliver genes into cells. J Pept Res 1999; 54: 361-367.
31. Guryanov IA, Vlasov GP, Lesina EA, et al. Cationic oligopeptides modified with lipophilic fragments: Use for DNA delivery to cells. Russ J Bioorg Chem 2005; 31: 18-26.
32. Tanaka K, Kanazawa T, Ogawa T, Takashima Y, Fukuda T, Okada H. Disulfide crosslinked stearoyl carrier peptides containing arginine and histidine enhance siRNA uptake and gene silencing. Int J Pharm 2010; 398: 219-224.
33. Bloomfield VA. DNA condensation with multivalent cations. Biopolymers 1997; 44: 269-282.
34. Zhang H, Vinogradov SV. Short biodegradable polyamines for gene delivery and transfection of brain capillary endothelial cells. J Control Release 2010; 143: 359-366.
35. Kunath K, Merdan T, Hegener O, Haberlein H, Kissel T. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J Gene Med 2003; 5: 588-599.
36. Wiethoff CM, Smith JG, Koe GS, Middaugh CR. The potential role of proteoglycans in cationic lipid DNA complexes with model glycosaminoglycans. J Biol Chem 2001; 276: 32806-32813.
37. Belting M. Heparan sulfate proteoglycan as a plasma membrane carrier. Trends Biochem Sci 2003; 28: 145-151.
38. Edgell CS, Curiel DT, Hu P, Marr HS. Efficient gene transfer to human endothelial cells using DNA complexed to adenovirus particles. BioTechniques 1998; 25: 264-272.
39. Wang LH, Rothberg KG, Anderson RG. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol 1993; 123: 1107-1117.
40. Llina P, Hyvonen Z, Saura M, Sandvig K, Yliperttula M, Ruponen M. Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems. J Control Release 2012; 163: 385-395.
41. Kim NY, Choi YB, Kang CI, Kim HH, Yang JM, Shin S. A hydrophobically modified arginine peptide vector system effectively delivers DNA into human mesenchymal stem cells and maintains transgene expression with differentiation. J Gene Med 2010; 12: 779-789.
42. King WJ, Kouris NA, Choi S, Ogle BM, Murphy WL. Environmental parameters influence non-viral transfection of human mesenchymal stem cells for tissue engineering applications. Cell Tissue Res 2012; 347: 689-699.
43. Potapova IA, Brink PR, Cohen IS, Doronin SV. Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. J Biol Chem 2008; 283: 13100-13107.
44. Hattori Y, Fukushima M, Maitani Y. Non-viral delivery of the connexin 43 gene with histone deacetylase inhibitor to human nasopharyngeal tumour cells enhances gene expression and inhibits in vivo tumour growth. Int J Oncol 2007; 30: 1427-1439.
45. Ishii Y, Hattori Y, Yamada T, Uesato S, Maitani Y, Nagaoka Y. Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells. Eur J Med Chem 2009; 44: 4603-4610.
46. Barua S, Rege K. The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. Biomaterials 2010; 31: 5894-5902.
47. Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 2001; 276: 36734-36741.
48. Gul H, Marquez-Curtis LA, Jahroudi N, Lo J, Turner AR, Janowska-Wieczorek A. Valproic acid increases CXCR4 expression in haematopoietic stem/progenitor cells by chromatin remodelling. Stem Cells Dev 2009; 18: 831-838.