Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display

Biomaterials

Volumn 32, Issue 26, 2011, Pages 6324-6332

  Pi, Yanbin ^a   Zhang, Xin ^a   Shi, Junjun ^a   Zhu, Jinxian ^a   Chen, Wenqing ^a   Zhang, Chenguang ^b   Gao, Weiwei ^b   Zhou, Chunyan ^b   Ao, Yingfang ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cartilage targeting; Gene therapy; Peptide modified polyethylenimine; Phage display

Indexed keywords

CARTILAGE-TARGETING; CHONDROCYTES; CONFOCAL MICROSCOPES; EXTRACELLULAR MATRICES; IN-VIVO; KNEE JOINT; LUCIFERASE GENES; NONVIRAL VECTORS; PHAGE DISPLAY; PHAGE DISPLAY TECHNOLOGY; POLYETHYLENIMINES; RABBIT KNEES; TARGET GENES; TARGETED DELIVERY; TRANSFECTION EFFICIENCY;

BODY FLUIDS; CARTILAGE; GENE THERAPY; GENETIC ENGINEERING; ORGANIC POLYMERS; PEPTIDES; VECTORS;

JOINTS (ANATOMY);

CHONDROCYTE AFFINITY PEPTIDE; DNA; FLUORESCEIN ISOTHIOCYANATE; GREEN FLUORESCENT PROTEIN; LUCIFERASE; PEPTIDE; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOPANNING; CARTILAGE; CARTILAGE CELL; CELL HOMING; CONFOCAL MICROSCOPY; CONJUGATION; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; KNEE; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHAGE DISPLAY; PRIORITY JOURNAL; RABBIT; SPECIES;

ANIMALS; CARTILAGE; CELLS, CULTURED; CHONDROCYTES; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC VECTORS; HUMANS; MALE; MIDDLE AGED; PEPTIDE LIBRARY; PEPTIDES; POLYETHYLENEIMINE; RABBITS;

ORYCTOLAGUS CUNICULUS;

EID: 79959906654     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.05.017     Document Type: Article

References (27)

1. D'Lima D.D., Colweell C.W. Clinical objectives for cartilage repair. Clin Orthop Relat Res 2001, 391:S402-S405.
2. Bouwmeester P.S., Kuijer R., Homminga G.N., Bulstra S.K., Geesink R.G. A retrospective analysis of two independent prospective cartilage repair studies: autogenous perichondrial grafting versus subchondral drilling 10 years post-surgery. J Orthop Res 2002, 20:2671-2673.
3. O'Driscoll S.W., Fitzsimmons J.S. The role of periosteum in cartilage repair. Clin Orthop Relat Res 2001, 391:S190-S207.
4. Zhang W., Moskowitz R.W., Nuki G., Abramson S., Altman R.D., Arden N., et al. OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008, 16:137-162.
5. Qvistgaard E., Christensen R., Torp-Pedersen S., Bliddal H. Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline. Osteoarthritis Cartilage 2005, 14:163-170.
6. Gidwani S., Fairbank A. The orthopaedic approach to managing osteoarthritis of the knee. BMJ 2004, 329:1220-1224.
7. Trippel S.B., Ghivizzani S.C., Nixon A.J. Gene-based approaches for the repair of articular cartilage. Gene Ther 2004, 11:351-359.
8. Evans C.H., Gouze J.N., Gouze E., Robbins P.D., Ghivizzani S.C. Osteoarthritis gene therapy. Gene Ther 2004, 11:379-389.
9. Bakker A.C., van de Loo F.A., van Beuningen H.M., Sime P., van Lent P.L.E.M., van der Kraan P.M., et al. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. Osteoarthritis Cartilage 2001, 9:128-136.
10. Bessis N., Garcia-Cozar F.J., Boissier M.C. Immune responses to gene therapy vectors: influence on vector function and effector mechanisms. Gene Ther 2004, 11:S10-S17.
11. Gouze E., Gouze J.N., Palmer G.D., Pilapil C., Evans C.H., Ghivizzani S.C. Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther 2007, 15:1114-1120.
12. Nicklin S.A., White S.J., Watkins S.J., Hawkins R.E., Baker A.H. Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display. Circulation 2000, 102:231-237.
13. Kelly K.A., Bardeesy N., Anbazhagan R., Gurumurthy S., Berger J., Alencar H., et al. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med 2008, 5:657-688.
14. Wan X.M., Chen Y.P., Xu W.R., Yang W.J., Wen L.P. Identification of nose-to-brain homing peptide through phage display. Peptides 2009, 30:343-350.
15. Ho I.A., Hui K.M., Lam P.Y. Isolation of peptide ligands that interact specifically with human glioma cells. Peptides 2010, 31:644-650.
16. Yu D.H., Lu Q., Xie J., Fang C., Chen H.Z. Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature. Biomaterials 2010, 31:2278-2292.
17. Rothenfluh D.A., Bermudez H., O'Neil C.P., Hubbell J.A. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater 2008, 7:248-254.
18. Hughes C., Faurholm B., Dell'Accio F., Manzo A., Seed M., Eltawil N., et al. Human single-chain variable fragment that specifically targets arthritic cartilage. Arthritis Rheum 2010, 62:1007-1016.
19. Swamia A., Goyal R., Tripathi S.K., Singh N. Effect of homobifunctional crosslinkers on nucleic acids delivery ability of PEI nanoparticles. Int J Pharmaceutics 2009, 374:125-138.
20. Yang J., Zhang P., Tang L., Sun P. Temperature-tuned DNA condensation and gene transfection by PEI-g-(PMEO2MA-b-PHEMA) copolymer-based nonviral vectors. Biomaterials 2010, 31:144-155.
21. Nam H.Y., McGinn A., Kim P.H., Kim S.W., Bull D.A. Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium. Biomaterials 2010, 31:8081-8087.
22. Kwon E.J., Lasiene J., Jacobson B.E., Park I.K., Horner P.J., Pun S.H. Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials 2010, 31:2417-2424.
23. Harrison P.E., Ashton I.K., Johnson W.E.B., Turner S.L., Richardson J.B., Ashton B.A. The in vitro growth of human chondrocytes. Cell Tissue Bank 2000, 1:255-260.
24. McGuire M.J., Li S.Z., Brown K.C. Biopanning of phage displayed peptide libraries for the Isolation of cell-specific ligands. Methods in molecular biology: biosensors and biodetection 2009, 291-321. Humana Press LLC, New York. A. Rasooly, K.E. Herold (Eds.).
25. Alexis F., Zeng J.M., Shu W. PEI nanoparticles for targeted gene delivery. Gene transfer: delivery and expression of DNA and RNA a laboratory manual 2007, 473-477. Cold Spring Harbor Laboratory Press, New York. T. Friedmann, J. Rossi (Eds.).
26. Chen Y., Shen Y., Guo X., Zhang C., Yang W., Ma M., et al. Transdermal protein delivery by a coadministered peptide identified via phage display. Nat Biotechnol 2006, 24:455-460.
27. Michelfelder S., Kohlschütter J., Skorupa A., Pfennings S., Müller O., Kleinschmidt J.A., et al. Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries. PLoS One 2009, 4:1-13.