A cytoplasm-sensitive peptide vector cross-linked with dynein light chain association sequence (DLCAS) enhances gene expression

International Journal of Pharmaceutics

Volumn 419, Issue 1-2, 2011, Pages 231-234

  Tanaka, Ko ^a   Kanazawa, Takanori ^a   Sugawara, Ken ^a   Horiuchi, Shogo ^a   Takashima, Yuuki ^a   Okada, Hiroaki ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Disulfide cross linkage; Dynein light chain association sequence; Peptide gene vector

Indexed keywords

CYTOPLASM PROTEIN; CYTOPLASMIC DYNEIN; DISULFIDE; MOLECULAR MOTOR; NOCODAZOLE; PLASMID DNA; STEAROYL COENZYME A;

ARTICLE; DYNEIN LIGHT CHAIN ASSOCIATION SEQUENCE; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSFECTION; INTRACELLULAR TRANSPORT; LIGHT CHAIN; MICROTUBULE ASSEMBLY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CYTOPLASM; DNA, COMPLEMENTARY; DYNEINS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MICE; NOCODAZOLE; PLASMIDS; TRANSFECTION; TUBULIN MODULATORS;

EID: 80053575362     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.07.007     Document Type: Article

References (12)

1. E. Barbar Dynein light chain LC8 is a dimerization hub essential in diverse protein networks Biochemistry 47 2008 503 508 (Pubitemid 351195422)
2. K. Dohner, C.H. Nagel, and B. Sodeik Viral stop-and-go along microtubules: taking a ride with dynein and kinesins Trends Microbiol. 13 2005 320 327 (Pubitemid 40884467)
3. S. Futaki, W. Ohashi, T. Suzuki, M. Niwa, S. Tanaka, K. Ueda, H. Harashima, and Y. Sugiura Stearylated arginine-rich peptides: a new class of transfection systems Bioconjug. Chem. 12 2001 1005 1011 (Pubitemid 33136872)
4. P. Giannakakou, D.L. Sackett, Y. Ward, K.R. Webster, M.V. Blagosklonny, and T. Fojo p53 is associated with cellular microtubules and is transported to the nucleus by dynein Nat. Cell Biol. 2 2000 709 717
5. L. Huo, D. Li, L. Sun, M. Liu, X. Shi, X. Sun, J. Li, B. Dong, X. Dong, and J. Zhou Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes J. Pathol. 223 2011 28 36
6. G.W. Moseley, D.L. Leyton, D.J. Glover, R.P. Filmer, and D.A. Jans Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules J. Biotechnol. 145 2010 222 225
7. G.W. Moseley, D.M. Roth, M.A. DeJesus, D.L. Leyton, R.P. Filmer, C.W. Pouton, and D.A. Jans Dynein light chain association sequences can facilitate nuclear protein import Mol. Biol. Cell 18 2007 3204 3213 (Pubitemid 47235323)
8. C.W. Pouton, K.M. Wagstaff, D.M. Roth, G.W. Moseley, and D.A. Jans Targeted delivery to the nucleus Adv Drug Deliv Rev 59 2007 698 717 (Pubitemid 47320817)
9. K. Rathinasamy, and D. Panda Kinetic stabilization of microtubule dynamic instability by benomyl increases the nuclear transport of p53 Biochem. Pharmacol. 76 2008 1669 1680
10. D.M. Roth, G.W. Moseley, D. Glover, C.W. Pouton, and D.A. Jans A microtubule-facilitated nuclear import pathway for cancer regulatory proteins Traffic 8 2007 673 686 (Pubitemid 46785150)
11. K. Tanaka, T. Kanazawa, T. Ogawa, S. Yumiko, Y. Takashima, T. Fukuda, and H. Okada A novel, bio-reducible gene vector containing arginine and histidine enhances gene transfection and expression of plasmid DNA Chem. Pharm. Bull. 59 2010 202 220
12. Z. Yang, G. Sahay, S. Sriadibhatla, and A.V. Kabanov Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA Bioconjug. Chem. 19 2008 1987 1994