New approaches for cell-specific targeting: Identification of cell-selective peptides from combinatorial libraries

Current Opinion in Chemical Biology

Volumn 4, Issue 1, 2000, Pages 16-21

  Brown, Kathlynn C ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; BETA GALACTOSIDASE; CARBOHYDRATE ANTIGEN; CELL SURFACE MARKER; CELL SURFACE RECEPTOR; GELATINASE B; GREEN FLUORESCENT PROTEIN; INTEGRIN; LIGAND; MELANOCORTIN RECEPTOR; MEMBRANE PROTEIN; PEPTIDE; PEPTIDE LIBRARY; PROTEOGLYCAN;

BACTERIOPHAGE; BINDING AFFINITY; CELL SELECTION; CELL SPECIFICITY; CELL SURFACE; DRUG SCREENING; GENE LIBRARY; HUMAN; LIGAND BINDING; MOLECULAR PROBE; NEUTROPHIL; NONHUMAN; PHAGE DISPLAY; PROTEIN ANALYSIS; PROTEIN TARGETING; REVIEW; TARGET CELL; TARGET ORGAN;

ANIMALIA;

EID: 0033970095     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(99)00045-9     Document Type: Review

References (38)

1. Schally A.V., Nagy A. Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors. Eur J Endocrinol. 141:1999;1-14.
2. Pietersz G.A., McKenzie I.F.C. Antibody conjugates for the treatment of cancer. Immunol Rev. 129:1992;57-80.
3. Farah R.A., Clinchy B., Herrera L., Vitetta E.S. The development of monoclonal antibodies for the therapy of cancer. Crit Rev Eukaryot Gene Expr. 8:1998;321-356.
4. Smith G.P., Petrenko V.A. Phage display. Chem Rev. 97:1997;391-410.
5. Rodi D.J., Makowski L. Phage-display technology - finding a needle in a vast haystack. Curr Opin Biotechnol. 10:1999;87-93.
6. Lowman H.B. Bacteriphage display and discovery of peptide leads for drug development. Annu Rev Biophys Biomol Struct. 26:1997;401-424.
7. Still W.C. Discovery of sequence-selected peptide binding by synthetic receptors using encoded combinatorial libraries. Accounts Chem Res. 29:1996;155-163.
8. Ferry G., Boutin J.A., Atassi G., Fauchere J.L., Tucker G.C. Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries. Mol Divers. 2:1997;135-146.
9. Koivunen E., Arap W., Rajotte D., Lahdenranta J., Pasqualini R. Identification of receptor ligands with phage display peptide libraries. J Nucl Med. 40:1999;883-888.
10. Koivunen E., Wang B., Ruoslahti E. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins. Biotechnology. 13:1995;265-270.
11. Pasqualini R., Koivunen E., Ruoslahti E. αV Integrins as receptors for tumor targeting by circulating ligands. Nat Biotechnol. 15:1997;542-546.
12. Dmitriev I., Krasnykh V., Miller C.R., Wang M., Kashentseva E., Mikheeva G., Belousova N., Curiel D.T. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol. 72:1998;9706-9713.
13. Wickham T.J., Tzeng E., Shears L.L. II, Roelvink P.W., Li Y., Lee G.M., Brough D.E., Lizonova A., Kovesdi I. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins. J Virol. 71:1997;8221-8229.
14. Koivunen E., Arap W., Valtanen H., Rainisalo A., Medina O.P., Heikkila P., Kantor C., Gahmberg C.G., Salo T., Konttinen Y.T.et al. Tumor targeting with a selective gelantinase inhibitor. Nat Biotechnol. 17:1999;768-774. A peptide was isolated by phage display against purified MMP-9. This peptide was found to home to tumors that overexpress this cell-surface marker. This is an interesting example of how phage display on purified targets can translate to in vivo targeting reagents.
15. Burg M.A., Pasqualini R., Arap W., Ruislahti E., Stallcup W.B. NG2 proteoglycan-binding peptides target tumor vasculature. Cancer Res. 59:1999;2869-2874.
16. Gui J., Moyana T., Xiang J. Selection of a peptide with affinity for the tumor-associated TAG72 antigen from a phage-displayed library. Biochem Biophys Res Commun. 218:1996;414-419.
17. Gui J., Moyana T., Malcolm B., Xiang J. Identification of a decapeptide with the binding reactivity for tumor-associated TAG72 antigen from a phage displayed library. Proteins. 24:1996;352-358.
18. Peletskaya E.N., Glinsky G., Deutscher S.L., Quinn T.P. Identification of peptide sequences that bind the Thomsen-Friedenreich cancer-associated glyco-antigen from bacteriophage peptide display libraries. Mol Divers. 2:1996;13-18.
19. Goodson R.J., Doyle M.V., Kaufman S.E., Rosenberg S. High-affinity urokinase receptor antagonists identified with bacteriophage peptide display. Proc Natl Acad Sci USA. 91:1994;7129-7133.
20. Szardenings M., Tornroth S., Mutulis F., Muceniece R., Keinanen K., Kuusinen A., Wikberg J.E.S. Phage display selection on whole cells yields a peptide specific for melanocortin receptor 1. J Biol Chem. 272:1997;27943-27948.
21. Doorbar J., Winter G. Isolation of a peptide antagonist to the thrombin receptor using phage display. J Mol Biol. 244:1994;361-369.
22. Barry M.A., Dower W.J., Johnston S.A. Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nat Med. 2:1996;299-305.
23. Mazzucchelli L., Burrit J.B., Jesaitis A.J., Nusrat A., Liang T.W., Gewirtz A.T., Schnell F.J., Parkos C.A. Cell-specific peptide binding by human neutrophils. Blood. 93:1999;1738-1748.
24. Ivanenkov V.V., Felici F., Menon A.G. Targeted delivery of multivalent phage display vectors into mammalian cells. Biochim Biophys Acta. 1448:1999;463-472.
25. Ivanenkov V.V., Felici F., Menon A.G. Uptake and intracellular fate of phage display vectors in mammalian cells. Biochim Biophys Acta. 1448:1999;450-462.
26. Pasqualini R., Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature. 380:1996;364-366.
27. Rajotte D., Arap W., Hagerdorn M., Koivunen E., Pasqualini R., Ruoslahti E. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest. 102:1998;430-437.
28. Rajotte D., Ruoslahti E. Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display. J Biol Chem. 1999;11593-11598. This is the first example of the identification of a receptor for a peptide ligand that was isolated from a non-biased selection. As more and more targeting ligands are isolated from these types of phage-display screens, there will be an increasing need to identify the receptors for these ligands.
29. Arap W., Pasqualini R., Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 279:1998;377-380. The anti-cancer drug doxorubicin was delivered specifically to tumors by covalently attaching the drug to a tumor-homing peptide that had been identified by phage display. The efficacy and toxicity of the drug was reduced using this directed delivery strategy.
30. Ellerby H.M., Arap W., Ellerby L.M., Kain R., Andrusiak R., Del Rio G., Krajewski S., Lombardo C.R., Rao R., Ruoslahti E.et al. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med. 5:1999;1032-1038. A chimeric peptide construct consisting of a pro-apoptotic peptide and a targeting peptide was delivered to cancer cells and shown to have anti-cancer activity.
31. Larocca D., Kassner P.D., Witte A., Ladner R.C., Pierce G.F., Baird A. Gene transfer to mammalian cells using genetically targeted filamentous bacteriophage. FASEB J. 13:1999;727-734.
32. •], demonstrates that bacteriophage can be targeted to a cell surface receptor for the purpose of gene delivery.
33. •].
34. •].
35. Kassner P.D., Burg M.A., Baird A., Larocca D. Genetic selection of phage engineered for receptor-mediated gene transfer to mammalian cells. Biochem Biophys Res Commun. 264:1999;921-928.
36. Ballinger M.D., Shyamal S., Forrest L.D., Deuter-Reinhard M., Doyle L.V., Wang J., Panganiban-Lustan L., Stratton J.R., Apell G., Winter J.A.et al. Semirational design of a potent, artificial agonist of fibroblast growth factor receptors. Nat Biotechnol. 17:1999;1199-1204.
37. Herrmann A., Pieper M., Schrader J. Selection of cell specific peptides in a rat carotid injury model using a random peptide-presenting bacterial library. Biochim Biophys Acta. 1472:1999;529-536.
38. Szecsi P.B., Riise E., Roslund L.B., Engberg J., Turesson I., Buhl L., Schafer-Nielson C. Identification of patient-specific peptides for detection of M-proteins and myeloma cells. Brit J Haem. 107:1999;357-364.