Sequence-function-stability relationships in proteins from datasets of functionally annotated variants: The case of TEM β-lactamases

FEBS Letters

Volumn 586, Issue 19, 2012, Pages 3330-3335

  Abriata, Luciano A ^a,c   M Salverda, Merijn L ^b   Tomatis, Pablo E ^a,d  

^a Instituto de Biologia Molecular y Celular de Rosario   (Argentina)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c EPFL   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Antibiotic resistance; Function stability tradeoff; Lactamase; Protein evolution; Structure function relationship; TEM

Indexed keywords

AMINO ACID; BETA LACTAMASE; BETA LACTAMASE TEM; CEFOTAXIME; CLAVULANIC ACID; ENZYME VARIANT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BIOACCUMULATION; DATA BASE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE; MOLECULAR MODEL; MUTATION; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY;

AMINO ACID SUBSTITUTION; BETA-LACTAMASES; DATABASES, PROTEIN; ENZYME STABILITY; EVOLUTION, MOLECULAR; GENETIC VARIATION; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION;

EID: 84866602137     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.07.010     Document Type: Article

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