Mimicking natural evolution in metallo-β-lactamases through second-shell ligand mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 39, 2005, Pages 13761-13766

  Tomatis, Pablo E ^a   Rasia, Rodolfo M ^a   Segovia, Lorenzo ^b   Vila, Alejandro J ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Antibiotic resistance; Co(II) substitution; Directed evolution; Zinc enzymes

Indexed keywords

4 (2 PYRIDYLAZO)RESORCINOL; AMPICILLIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOGLYCIN; CEFALORIDINE; CEFOTAXIME; CEFRADINE; CEFTAZIDIME; CEPHALOSPORIN; CHLORAMPHENICOL; IMIPENEM; KANAMYCIN; LIGAND; NITROCEFIN; PENICILLIN G; RESORCINOL DERIVATIVE; TETRACYCLINE; UNCLASSIFIED DRUG; ZINC ION;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS CEREUS; BINDING AFFINITY; ENERGY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; EVOLUTION; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BACILLUS CEREUS; BETA-LACTAMASES; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; COBALT; DIRECTED MOLECULAR EVOLUTION; EVOLUTION, MOLECULAR; GENE LIBRARY; HYDROPHOBICITY; LIGANDS; METALLOPROTEINS; MUTATION; SUBSTRATE SPECIFICITY;

BACILLUS CEREUS;

EID: 25644459220     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0503495102     Document Type: Article

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