A comprehensive survey of the mutagenic impact of common cancer cytotoxics

Genome Biology

Volumn 17, Issue 1, 2016, Pages 1-16

  Szikriszt, Bernadett ^a   PotiAdam ^a   Pipek, Orsolya ^b   Krzystanek, Marcin ^c   Kanu, Nnennaya ^d   Molnár, János ^a   Ribli, Dezso ^b   Szeltner, Zoltán ^a   Tusnády, Gábor E ^a   Csabai, István ^b   Szallasi, Zoltan ^c,e,f,h   Swanton, Charles ^d,g   Szüts, Dávid ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^h SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

BRCA2; Cancer chemotherapy; Chemotherapy resistance; Cisplatin; Cyclophosphamide; Cytotoxics; DT40; Etoposide; Mutagenesis; Spontaneous mutagenesis; Whole genome sequencing

Indexed keywords

BRCA2 PROTEIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; HYDROXYUREA; PACLITAXEL; ANTINEOPLASTIC AGENT; CYTOTOXIN; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; CROSS LINKING; DNA REPAIR; GENE MUTATION; IN VITRO STUDY; INDEL MUTATION; MUTATION RATE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; REVERTANT; SEQUENCE ANALYSIS; ANIMAL; CHICKEN; DRUG SCREENING; GENOME; PROCEDURES; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHICKENS; CISPLATIN; CYTOTOXINS; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, BRCA2; GENOME; MUTAGENS; MUTATION RATE;

EID: 84973401146     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-0963-7     Document Type: Article

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