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Volumn 34, Issue 2-3, 1999, Pages 154-166

Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacl transgenic mice

Author keywords

Cyclophosphamide; lacl; Mutagenesis; Transgenic mice

Indexed keywords

CYCLOPHOSPHAMIDE;

EID: 0032698083     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1999)34:2/3<154::AID-EM15>3.0.CO;2-0     Document Type: Article
Times cited : (22)

References (67)
  • 1
    • 0027397165 scopus 로고
    • The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea
    • Aidoo A, Lyn-Cook LE, Mittelstaedt RA, Heflich RH, Casciano DA. 1993. The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea. Mutat Res 298:169-178.
    • (1993) Mutat Res , vol.298 , pp. 169-178
    • Aidoo, A.1    Lyn-Cook, L.E.2    Mittelstaedt, R.A.3    Heflich, R.H.4    Casciano, D.A.5
  • 2
    • 0029154091 scopus 로고
    • Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
    • Anderson D, Bishop JB, Garner RC, Ostrosky-Wegman P, Selby PB. 1995. Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res 330:115-181.
    • (1995) Mutat Res , vol.330 , pp. 115-181
    • Anderson, D.1    Bishop, J.B.2    Garner, R.C.3    Ostrosky-Wegman, P.4    Selby, P.B.5
  • 4
    • 0026498662 scopus 로고
    • 4 hot-spot of Salmonella typhimuirum hisD3052 carried on an M13 vector
    • 4 hot-spot of Salmonella typhimuirum hisD3052 carried on an M13 vector. J Biol Chem 267:22392-22400.
    • (1992) J Biol Chem , vol.267 , pp. 22392-22400
    • Benamira, M.1    Singh, U.2    Marnett, L.J.3
  • 5
    • 0026448886 scopus 로고
    • Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide
    • Boddy AV, Furtun Y, Sardas S, Sardas O, Idle JR. 1992. Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide. J Natl Cancer Inst 84:1744-1748.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1744-1748
    • Boddy, A.V.1    Furtun, Y.2    Sardas, S.3    Sardas, O.4    Idle, J.R.5
  • 6
    • 0029069484 scopus 로고
    • A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments
    • Butterworth BE, Conolly RB, Morgan KT. 1995. A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments. Cancer Lett 93:129-146.
    • (1995) Cancer Lett , vol.93 , pp. 129-146
    • Butterworth, B.E.1    Conolly, R.B.2    Morgan, K.T.3
  • 7
    • 0028625585 scopus 로고
    • Statistical tests of significance in transgenic assays: Considerations on the experimental unit
    • Carr GJ, Gorelick NJ. 1994. Statistical tests of significance in transgenic assays: considerations on the experimental unit. Environ Mol Mutagen 24:276-282.
    • (1994) Environ Mol Mutagen , vol.24 , pp. 276-282
    • Carr, G.J.1    Gorelick, N.J.2
  • 8
    • 0029038488 scopus 로고
    • Statistical design and analysis of mutation studies in transgenic mice
    • Carr GJ, Gorelick NJ. 1995. Statistical design and analysis of mutation studies in transgenic mice. Environ Mol Mutagen 25:246-255.
    • (1995) Environ Mol Mutagen , vol.25 , pp. 246-255
    • Carr, G.J.1    Gorelick, N.J.2
  • 9
    • 0030344622 scopus 로고    scopus 로고
    • Mutational spectra in transgenic animal research: Data analysis and study design based upon the mutant frequency
    • Carr GJ, Gorelick NJ. 1996. Mutational spectra in transgenic animal research: Data analysis and study design based upon the mutant frequency. Environ Mol Mutagen 28:405-413.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 405-413
    • Carr, G.J.1    Gorelick, N.J.2
  • 10
    • 0027081683 scopus 로고
    • Characterization of thymidine adducts fromed by acrolein and 2-bromoacrolein
    • Chenna A, Rieger RA, Iden CR. 1992. Characterization of thymidine adducts fromed by acrolein and 2-bromoacrolein. Carcinogenesis 13:2361-2365.
    • (1992) Carcinogenesis , vol.13 , pp. 2361-2365
    • Chenna, A.1    Rieger, R.A.2    Iden, C.R.3
  • 11
    • 0021319465 scopus 로고
    • 2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde
    • 2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde. Cancer Res 44:990-995.
    • (1984) Cancer Res , vol.44 , pp. 990-995
    • Chung, F.-L.1    Young, R.2    Hecht, S.3
  • 12
    • 0028026138 scopus 로고
    • Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice
    • Cochrane JE, Skopek TR. 1994. Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice. Carcinogenesis 15:719-723.
    • (1994) Carcinogenesis , vol.15 , pp. 719-723
    • Cochrane, J.E.1    Skopek, T.R.2
  • 13
    • 0344067678 scopus 로고
    • Micronucleus test with rodent peripheral blood reticulocytes by acridine orange supravital staining
    • Collaborative Study Group for the Micronucleus Test (CSGMT) of the Mammalian Mutagenesis Study subgroup of the Environmental Mutagen Society of Japan (JEMS-MMS). 1992. Micronucleus test with rodent peripheral blood reticulocytes by acridine orange supravital staining. Mutat Res 278:2/3.
    • (1992) Mutat Res , vol.278 , pp. 2-3
  • 14
    • 2342531228 scopus 로고    scopus 로고
    • Organ variation in the mutagenicity of ethylnitrosourea in Muta™Mouse: Results of the collaborative study on the transgenic mutation assay by IEMS/MMS
    • CSGTM (Collaborative Study Group on the Transgenic Mutation Assay). 1996. Organ variation in the mutagenicity of ethylnitrosourea in Muta™Mouse: Results of the collaborative study on the transgenic mutation assay by IEMS/MMS. Environ Mol Mutagen 28:363-375.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 363-375
  • 17
    • 0030599151 scopus 로고    scopus 로고
    • In vivo mutagenicity and DNA adduct levels of heterocyclic amines in MutaMice and c-myc/lacZ double transgenic mice
    • Davis CD, Dacquel EJ, Schut HAJ, Thorgeirsson SS, Snyderwine EG. 1996. In vivo mutagenicity and DNA adduct levels of heterocyclic amines in MutaMice and c-myc/lacZ double transgenic mice. Mutat Res 356:287-296.
    • (1996) Mutat Res , vol.356 , pp. 287-296
    • Davis, C.D.1    Dacquel, E.J.2    Schut, H.A.J.3    Thorgeirsson, S.S.4    Snyderwine, E.G.5
  • 18
    • 0030329708 scopus 로고    scopus 로고
    • Spectrum of mutations in kidney, stomach and liver from lad transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate
    • de Boer JG, Mirsalis JC, Provost GS, Tindall KR, Glickman, BW. 1996. Spectrum of mutations in kidney, stomach and liver from lad transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate. Environ Mol Mutagen 28:418-423.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 418-423
    • De Boer, J.G.1    Mirsalis, J.C.2    Provost, G.S.3    Tindall, K.R.4    Glickman, B.W.5
  • 21
    • 0030337742 scopus 로고    scopus 로고
    • Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice
    • Douglas GR, Jiao J, Gingerich JD, Soper LM, Gossen JA. 1996. Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ Mol Mutagen 28:317-324.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 317-324
    • Douglas, G.R.1    Jiao, J.2    Gingerich, J.D.3    Soper, L.M.4    Gossen, J.A.5
  • 23
    • 0018138536 scopus 로고
    • Sequence of the lacl gene
    • Farabaugh PJ. 1978. Sequence of the lacl gene. Nature 274:765-769.
    • (1978) Nature , vol.274 , pp. 765-769
    • Farabaugh, P.J.1
  • 24
    • 0029061266 scopus 로고
    • Overview of mutation assays in transgenic mice for routine testing
    • Gorelick NJ. 1995. Overview of mutation assays in transgenic mice for routine testing. Environ Mol Mutagen 25:218-230.
    • (1995) Environ Mol Mutagen , vol.25 , pp. 218-230
    • Gorelick, N.J.1
  • 25
    • 0030344623 scopus 로고    scopus 로고
    • A strategy for the application of transgenic mutagenesis assays
    • Gorelick NJ, Mirsalis JC. 1996. A strategy for the application of transgenic mutagenesis assays. Environ Mol Mutagen 28:434-442.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 434-442
    • Gorelick, N.J.1    Mirsalis, J.C.2
  • 26
    • 0028971022 scopus 로고
    • Mutational spectra in the lacI gene in skin from 7,12-dimethylbenz[a]anthracene-treated and untreated transgenic mice
    • Gorelick NJ, Andrews JL, Gu M, Glickman BW. 1995. Mutational spectra in the lacI gene in skin from 7,12-dimethylbenz[a]anthracene-treated and untreated transgenic mice. Mol Carcinog 14:53-62.
    • (1995) Mol Carcinog , vol.14 , pp. 53-62
    • Gorelick, N.J.1    Andrews, J.L.2    Gu, M.3    Glickman, B.W.4
  • 28
    • 0025203206 scopus 로고
    • The micronucleus assay with mouse perpheral blood reticulocytes by acridine orange-coated slides
    • Hayashi M, Morita T, Kodama Y, Sofuni T, Ishidate M Jr. 1990. The micronucleus assay with mouse perpheral blood reticulocytes by acridine orange-coated slides. Mutat Res 245:245-249.
    • (1990) Mutat Res , vol.245 , pp. 245-249
    • Hayashi, M.1    Morita, T.2    Kodama, Y.3    Sofuni, T.4    Ishidate M., Jr.5
  • 29
    • 0028786875 scopus 로고
    • Differential in vivo mutagenicity of the carcinogen/non-carcinogen pairs 2,4-and 2,6-diaminotoluene
    • Hayward JJ, Shane BS, Tindall KR, Cunningham ML. 1995. Differential in vivo mutagenicity of the carcinogen/non-carcinogen pairs 2,4-and 2,6-diaminotoluene. Carcinogenesis 16:2429-2433.
    • (1995) Carcinogenesis , vol.16 , pp. 2429-2433
    • Hayward, J.J.1    Shane, B.S.2    Tindall, K.R.3    Cunningham, M.L.4
  • 30
    • 0025825613 scopus 로고
    • Enzymatic detoxification of phosphoramide mustard by soluble fractions from rat organ tissues
    • Hong PS, Chan KK. 1991. Enzymatic detoxification of phosphoramide mustard by soluble fractions from rat organ tissues. Drug Metab Dispos 19:568-573.
    • (1991) Drug Metab Dispos , vol.19 , pp. 568-573
    • Hong, P.S.1    Chan, K.K.2
  • 32
    • 0031784732 scopus 로고    scopus 로고
    • Mutation studies in lacI transgenic mice after exposure to radiation or cyclophosphamide
    • Hoyes KP, Wadeson PJ, Sharma HL, Hendry JH. Morris ID. 1998. Mutation studies in lacI transgenic mice after exposure to radiation or cyclophosphamide. Mutagenesis 13:607-612.
    • (1998) Mutagenesis , vol.13 , pp. 607-612
    • Hoyes, Kp.1    Wadeson, P.J.2    Sharma, H.L.3    Hendry, J.H.4    Morris, I.D.5
  • 34
    • 0026665818 scopus 로고
    • Pharmacokinetics, metabolic activation, and lung toxicity of cyclophosphamide in C57/B16 and ICR mice
    • Kanekal S, Fraiser L. Kehrer JP. 1992. Pharmacokinetics, metabolic activation, and lung toxicity of cyclophosphamide in C57/B16 and ICR mice. Toxicol Appl Pharmacol 114:1-8.
    • (1992) Toxicol Appl Pharmacol , vol.114 , pp. 1-8
    • Kanekal, S.1    Fraiser, L.2    Kehrer, J.P.3
  • 35
    • 0014788551 scopus 로고
    • Tables for determining the statistical significance of mutation frequencies
    • Kastenbaum MA, Bowman KO. 1970. Tables for determining the statistical significance of mutation frequencies. Mutat Res 9:527-549.
    • (1970) Mutat Res , vol.9 , pp. 527-549
    • Kastenbaum, M.A.1    Bowman, K.O.2
  • 38
    • 0030585739 scopus 로고    scopus 로고
    • Human γ-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization and tissue expression
    • Lin SW, Chen JC, Hsu LC, Hsieh C-L, Yoshida A. 1996. Human γ-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization and tissue expression. Genomics 34:376-380.
    • (1996) Genomics , vol.34 , pp. 376-380
    • Lin, S.W.1    Chen, J.C.2    Hsu, L.C.3    Hsieh, C.-L.4    Yoshida, A.5
  • 39
    • 0031878243 scopus 로고    scopus 로고
    • Species comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats
    • Meng Q, Recio L, Reilly AA, Wong B, Bauer M, Walker VE. 1998. Species comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats. Carcinogenesis 19:1019-1027.
    • (1998) Carcinogenesis , vol.19 , pp. 1019-1027
    • Meng, Q.1    Recio, L.2    Reilly, A.A.3    Wong, B.4    Bauer, M.5    Walker, V.E.6
  • 40
    • 0032841055 scopus 로고    scopus 로고
    • Comparisons of the mutations in hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposures by inhalation to 1,3-butadiene or 1,2:3.4-diepoxybutane
    • Meng Q, Singh NK, Heflich RH, Walker VE. 1999. Comparisons of the mutations in hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposures by inhalation to 1,3-butadiene or 1,2:3.4-diepoxybutane. Mutat Res 429:107-125.
    • (1999) Mutat Res , vol.429 , pp. 107-125
    • Meng, Q.1    Singh, N.K.2    Heflich, R.H.3    Walker, V.E.4
  • 41
    • 0026779664 scopus 로고
    • Identification of cyclophosphamide - DNA adducts in rat embryos exposed in vitro to 4-hydroperoxycyclophosphamide
    • Mirkes PE. Brown NA, Kajbaf M, Lamb JH, Farmer PB, Naylor S. 1992. Identification of cyclophosphamide - DNA adducts in rat embryos exposed in vitro to 4-hydroperoxycyclophosphamide. Chem Res Toxicol 5:382-385.
    • (1992) Chem Res Toxicol , vol.5 , pp. 382-385
    • Mirkes, P.E.1    Brown, N.A.2    Kajbaf, M.3    Lamb, J.H.4    Farmer, P.B.5    Naylor, S.6
  • 42
    • 0027963635 scopus 로고
    • Transgenic animal models for measuring mutations in vivo
    • Mirsalis JC, Monforte JA, Winegar RA. 1994. Transgenic animal models for measuring mutations in vivo. Crit Rev Toxicol 24: 255-280.
    • (1994) Crit Rev Toxicol , vol.24 , pp. 255-280
    • Mirsalis, J.C.1    Monforte, J.A.2    Winegar, R.A.3
  • 43
    • 0027973376 scopus 로고
    • Mutagenic potency of exocyclic DNA adducts: Marked differences between Escherichia coli and simian kidney cells
    • Moriya M, Zhang W, Johnson F, Grollman AP. 1994. Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells. Proc Natl Acad Sci U S A 91:11899-11903.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11899-11903
    • Moriya, M.1    Zhang, W.2    Johnson, F.3    Grollman, A.P.4
  • 44
    • 0025748131 scopus 로고
    • Validation studies with Muta™ Mouse: A transgenic mouse model for detecting mutations in vivo
    • Myhr BC. 1991. Validation studies with Muta™ Mouse: A transgenic mouse model for detecting mutations in vivo. Environ Mol Mutagen 18:308-315.
    • (1991) Environ Mol Mutagen , vol.18 , pp. 308-315
    • Myhr, B.C.1
  • 45
    • 0030345885 scopus 로고    scopus 로고
    • Mutation frequencies but not mutant frequencies in Big Blue® mice fit a poisson distribution
    • Nishino H, Schaid DJ, Buettner VL, Haavik J, Sommer SS. 1996. Mutation frequencies but not mutant frequencies in Big Blue® mice fit a poisson distribution. Environ Mol Mutagen 28:414-417.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 414-417
    • Nishino, H.1    Schaid, D.J.2    Buettner, V.L.3    Haavik, J.4    Sommer, S.S.5
  • 46
    • 0025336340 scopus 로고
    • Metabolism and pulmonary toxicity of cyclophosphamide
    • Patel JM. 1990. Metabolism and pulmonary toxicity of cyclophosphamide. Pharmacol Ther 47:137-146.
    • (1990) Pharmacol Ther , vol.47 , pp. 137-146
    • Patel, J.M.1
  • 47
    • 0028227149 scopus 로고
    • Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice
    • Provost GS, Short JM. 1994. Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc Natl Acad Sci U S A 91:6564-6568.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6564-6568
    • Provost, G.S.1    Short, J.M.2
  • 48
    • 0030329356 scopus 로고    scopus 로고
    • Mutagenic response to benzene and tris(2,3-dibromopropyl)-phosphate in the lamdba lacl transgenic mouse mutation assay: A standardized approach to in vivo mutation analysis
    • Provost GS, Mirsalis JC, Rogers BJ, Short JM. 1996. Mutagenic response to benzene and tris(2,3-dibromopropyl)-phosphate in the lamdba lacl transgenic mouse mutation assay: A standardized approach to in vivo mutation analysis. Environ Mol Mutagen 28:342-347.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 342-347
    • Provost, G.S.1    Mirsalis, J.C.2    Rogers, B.J.3    Short, J.M.4
  • 49
    • 0027526525 scopus 로고
    • Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals
    • Shelby MD, Erexson GL, Hook GJ, Tice RR. 1993. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen 21:160-179.
    • (1993) Environ Mol Mutagen , vol.21 , pp. 160-179
    • Shelby, M.D.1    Erexson, G.L.2    Hook, G.J.3    Tice, R.R.4
  • 50
    • 0028786356 scopus 로고
    • Of mice and men: Target size and sensitivity
    • Skopek TR. 1995. Of mice and men: target size and sensitivity. Mutat Res 331:225-228.
    • (1995) Mutat Res , vol.331 , pp. 225-228
    • Skopek, T.R.1
  • 51
    • 0026629905 scopus 로고
    • Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea
    • Skopek TR, Walker VE, Cochrane JE, Craft TR, Cariello NF. 1992. Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea. Proc Natl Acad Sci U S A 89:7866-7870.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 7866-7870
    • Skopek, T.R.1    Walker, V.E.2    Cochrane, J.E.3    Craft, T.R.4    Cariello, N.F.5
  • 52
    • 0024470905 scopus 로고
    • Identification of 3,N4-propanodeoxycytidine 5′-monophosphate formed by reaction of acrolein with deoxycytidine-5′-monophosphate
    • Smith RA, Williamson DS, Cohen SM. 1989. Identification of 3,N4-propanodeoxycytidine 5′-monophosphate formed by reaction of acrolein with deoxycytidine-5′-monophosphate. Chem Res Toxicol 2:267-271.
    • (1989) Chem Res Toxicol , vol.2 , pp. 267-271
    • Smith, R.A.1    Williamson, D.S.2    Cohen, S.M.3
  • 53
    • 0025195081 scopus 로고
    • Detection of 1,N6-propanodeoxyadenosine in acrolein-modified polydeoxyadenylic acid and DNA by 32P-postlabeling
    • Smith RA, Williamson DS, Cerny RL, Cohen SM. 1990. Detection of 1,N6-propanodeoxyadenosine in acrolein-modified polydeoxyadenylic acid and DNA by 32P-postlabeling. Cancer Res 50:3005-3012.
    • (1990) Cancer Res , vol.50 , pp. 3005-3012
    • Smith, R.A.1    Williamson, D.S.2    Cerny, R.L.3    Cohen, S.M.4
  • 54
    • 0026017740 scopus 로고
    • Cooxidation of cyclophosphamide as an alternative pathway for its bioactivation and lung toxicity
    • Smith RD, Kehrer JP. 1991. Cooxidation of cyclophosphamide as an alternative pathway for its bioactivation and lung toxicity. Cancer Res 51:542-548.
    • (1991) Cancer Res , vol.51 , pp. 542-548
    • Smith, R.D.1    Kehrer, J.P.2
  • 55
    • 0023695007 scopus 로고
    • Reaction of acrolein with cytosine and adenine derivatives
    • Sodum RS, Shapiro R. 1988. Reaction of acrolein with cytosine and adenine derivatives. Bioorg Chem 16:272-282.
    • (1988) Bioorg Chem , vol.16 , pp. 272-282
    • Sodum, R.S.1    Shapiro, R.2
  • 58
    • 0027421332 scopus 로고
    • Comparison of somatic mutation in a transgenic versus host locus
    • Tao KS, Urlando C, Heddle JA. 1993. Comparison of somatic mutation in a transgenic versus host locus. Proc Natl Acad Sci U S A 90:10681-10685.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10681-10685
    • Tao, K.S.1    Urlando, C.2    Heddle, J.A.3
  • 59
    • 0003672085 scopus 로고    scopus 로고
    • EPA/600/P-92/003C. Washington: US Environmental Protection Agency
    • U.S. Environmental Protection Agency (US EPA). 1996. Proposed guidelines for carcinogen risk assessment. EPA/600/P-92/003C. Washington: US Environmental Protection Agency.
    • (1996) Proposed Guidelines for Carcinogen Risk Assessment
  • 61
    • 0019769657 scopus 로고
    • Identification of three alkylated nucleotide adducts from the reaction of guanosine-5′-monophosphate with phosphoramide mustard
    • Vu TV, Fenselau C, Colvin OM. 1981. Identification of three alkylated nucleotide adducts from the reaction of guanosine-5′-monophosphate with phosphoramide mustard. J Am Chem Soc 103:7362-7364.
    • (1981) J Am Chem Soc , vol.103 , pp. 7362-7364
    • Vu, T.V.1    Fenselau, C.2    Colvin, O.M.3
  • 62
    • 0027198881 scopus 로고
    • A mouse model for the study of in vivo mutational spectra: Sequence specificity of ethylene oxide at the hprt locus
    • Walker VE, Skopek TR. 1993. A mouse model for the study of in vivo mutational spectra: Sequence specificity of ethylene oxide at the hprt locus. Mutat Res 288:151-162.
    • (1993) Mutat Res , vol.288 , pp. 151-162
    • Walker, V.E.1    Skopek, T.R.2
  • 63
    • 0029821901 scopus 로고    scopus 로고
    • Frequency and spectrum of ethylnitrosourea induced mutation at the hprt and lacl loci in splenic T-cells of exposed lacl transgenic mice
    • Walker VE, Gorelick NJ, Andrews JL, Craft TR, de Boer JG, Glickman BW, Skopek TR. 1996. Frequency and spectrum of ethylnitrosourea induced mutation at the hprt and lacl loci in splenic T-cells of exposed lacl transgenic mice. Cancer Res 56:4654-4661.
    • (1996) Cancer Res , vol.56 , pp. 4654-4661
    • Walker, V.E.1    Gorelick, N.J.2    Andrews, J.L.3    Craft, T.R.4    De Boer, J.G.5    Glickman, B.W.6    Skopek, T.R.7
  • 64
    • 0032699143 scopus 로고    scopus 로고
    • Detection of cyclophosphamide-induced mutations at the hprt but not the lacI locus in splenic T-cells of exposed transgenic mice
    • Walker VE, Andrews JL, Upton PB, de Boer JG, Gorelick NJ. 1999. Detection of cyclophosphamide-induced mutations at the hprt but not the lacI locus in splenic T-cells of exposed transgenic mice. Environ Mol Mutagen 34:167-181.
    • (1999) Environ Mol Mutagen , vol.34 , pp. 167-181
    • Walker, V.E.1    Andrews, J.L.2    Upton, P.B.3    De Boer, J.G.4    Gorelick, N.J.5
  • 65
    • 0004786419 scopus 로고    scopus 로고
    • Spectra of mutations in HPRT exon 3 of T-cells from F344 rats and lad transgenic and nontransgenic B6C3F1 mice exposed by inhalation to ethylene oxide
    • Walker VE, Meng Q, Clement CL. 1997. Spectra of mutations in HPRT exon 3 of T-cells from F344 rats and lad transgenic and nontransgenic B6C3F1 mice exposed by inhalation to ethylene oxide. Environ Mol Mutagen 29(Suppl. 28):54.
    • (1997) Environ Mol Mutagen , vol.29 , Issue.SUPPL. 28 , pp. 54
    • Walker, V.E.1    Meng, Q.2    Clement, C.L.3
  • 66
    • 0028336644 scopus 로고
    • Radiation-induced point mutations, deletions and micronuclei in lacl transgenic mice
    • Winegar RA, Lutze LH, Hamer JD, O'Loughlin KG, Mirsalis JC. 1994. Radiation-induced point mutations, deletions and micronuclei in lacl transgenic mice. Mutat Res 307:479-487.
    • (1994) Mutat Res , vol.307 , pp. 479-487
    • Winegar, R.A.1    Lutze, L.H.2    Hamer, J.D.3    O'Loughlin, K.G.4    Mirsalis, J.C.5
  • 67
    • 0027054015 scopus 로고
    • Tissue-specific expression, induction and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily
    • Yamada H, Kaneko H, Takeuchi K, Oguri K, Yoshimura H. 1992. Tissue-specific expression, induction and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily. Arch Biochem Biophys 299: 248-254.
    • (1992) Arch Biochem Biophys , vol.299 , pp. 248-254
    • Yamada, H.1    Kaneko, H.2    Takeuchi, K.3    Oguri, K.4    Yoshimura, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.