Genome-wide mutational signatures of aristolochic acid and its application as a screening tool

Science Translational Medicine

Volumn 5, Issue 197, 2013, Pages

  Poon, Song Ling ^a,b   Pang, See Tong ^c   McPherson, John R ^b   Yu, Willie ^a,b,d   Huang, Kie Kyon ^b,e   Guan, Peiyong ^d   Weng, Wen Hui ^f   Siew, Ee Yan ^a,b   Liu, Yujing ^b,d   Heng, Hong Lee ^a,b   Chong, Soo Ching ^a,b   Gan, Anna ^a,b   Tay, Su Ting ^a   Lim, Weng Khong ^a,b   Cutcutache, Ioana ^b   Huang, Dachuan ^a,b   Ler, Lian Dee ^a,b,d   Nairismägi, Maarja Liisa ^a,b   Lee, Ming Hui ^a   Chang, Ying Hsu ^c,m   Yu, Kai Jie ^c,m   Chan On, Waraporn ^a,b   Li, Bin Kui ^g   Yuan, Yun Fei ^g   Qian, Chao Nan ^g   Ng, Kwai Fong ^c,m   Wu, Ching Fang ^c,h   Hsu, Cheng Lung ^h   Bunte, Ralph M ^b   Stratton, Michael R ⁱ   Andrew Futreal, P ^j   Sung, Wing Kin ^d,k   Chuang, Cheng Keng ^c,m   Ong, Choon Kiat ^a,b   Rozen, Steven G ^b,l   Tan, Patrick ^a,b,e,k   Teh, Bin Tean ^a,b,e   more..

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY   (Taiwan)

^g SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^h CHANG GUNG UNIVERSITY   (Taiwan)

ⁱ WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^j UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^k GENOME INSTITUTE OF SINGAPORE   (Singapore)

^l DUKE UNIVERSITY MEDICAL CENTER   (United States)

^m CHANG GUNG UNIVERSITY   (Taiwan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARISTOLOCHIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN; CONTROLLED STUDY; EXOME; GENE; GENE MUTATION; GENETIC SCREENING; GENOME; HUMAN; HUMAN TISSUE; KDM6A GENE; KIDNEY DYSPLASIA; KIDNEY TUBULE CELL; LIVER CELL CARCINOMA; LUNG CANCER; MELANOMA; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA SEQUENCE; RNA SPLICING; SMOKING; SOMATIC MUTATION; TAIWAN; TRANSITIONAL CELL CARCINOMA; ULTRAVIOLET RADIATION; UPREGULATION;

ANIMALS; ARISTOLOCHIC ACIDS; CARCINOGENS; CELL LINE, TUMOR; GENOME, HUMAN; HUMANS; KIDNEY DISEASES; MICE; MICE, INBRED C57BL; MUTAGENS; MUTATION; NEOPLASMS; RNA SPLICING; UROLOGIC NEOPLASMS; UROTHELIUM;

EID: 84883872416     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006086     Document Type: Article

References (52)

1. Z. J. Zang, I. Cutcutache, S. L. Poon, S. L. Zhang, J. R. McPherson, J. Tao, V. Rajasegaran, H. L. Heng, N. Deng, A. Gan, K. H. Lim, C. K. Ong, D. Huang, S. Y. Chin, I. B. Tan, C. C. Ng, W. Yu, Y. Wu, M. Lee, J. Wu, D. Poh, W. K. Wan, S. Y. Rha, J. So, M. Salto-Tellez, K. G. Yeoh, W. K. Wong, Y. J. Zhu, P. A. Futreal, B. Pang, Y. Ruan, A. M. Hillmer, D. Bertrand, N. Nagarajan, S. Rozen, B. T. Teh, P. Tan, Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat. Genet. 44, 570-574 (2012).
2. C. K. Ong, C. Subimerb, C. Pairojkul, S. Wongkham, I. Cutcutache, W. Yu, J. R. McPherson, G. E. Allen, C. C. Ng, B. H. Wong, S. S. Myint, V. Rajasegaran, H. L. Heng, A. Gan, Z. J. Zang, Y. Wu, J. Wu, M.H. Lee, D. Huang, P. Ong, W. Chan-on, Y. Cao, C. N. Qian, K. H. Lim, A. Ooi, K. Dykema, K. Furge, V. Kukongviriyapan, B. Sripa, C. Wongkham, P. Yongvanit, P. A. Futreal, V. Bhudhisawasdi, S. Rozen, P. Tan, B. T. Teh, Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat. Genet. 44, 690-693 (2012).
3. M. Imielinski, A. H. Berger, P. S. Hammerman, B. Hernandez, T. J. Pugh, E. Hodis, J. Cho, J. Suh, M. Capelletti, A. Sivachenko, C. Sougnez, D. Auclair, M. S. Lawrence, P. Stojanov, K. Cibulskis, K. Choi, L. deWaal, T. Sharifnia, A. Brooks, H. Greulich, S. Banerji, T. Zander, D. Seidel, F. Leenders, S. Ansén, C. Ludwig, W. Engel-Riedel, E. Stoelben, J. Wolf, C. Goparju, K. Thompson, W. Winckler, D. Kwiatkowski, B. E. Johnson, P. A. Jänne, V. A. Miller, W. Pao, W. D. Travis, H. I. Pass, S. B. Gabriel, E. S. Lander, R. K. Thomas, L. A. Garraway, G. Getz, M. Meyerson, Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150, 1107-1120 (2012).
4. M. F. Berger, E. Hodis, T. P. Heffernan, Y. L. Deribe, M. S. Lawrence, A. Protopopov, E. Ivanova, I. R. Watson, E. Nickerson, P. Ghosh, H. Zhang, R. Zeid, X. Ren, K. Cibulskis, A. Y. Sivachenko, N. Wagle, A. Sucker, C. Sougnez, R. Onofrio, L. Ambrogio, D. Auclair, T. Fennell, S. L. Carter, Y. Drier, P. Stojanov, M. A. Singer, D. Voet, R. Jing, G. Saksena, J. Barretina, A. H. Ramos, T. J. Pugh, N. Stransky, M. Parkin, W. Winckler, S. Mahan, K. Ardlie, J. Baldwin, J. Wargo, D. Schadendorf, M. Meyerson, S. B. Gabriel, T. R. Golub, S. N. Wagner, E. S. Lander, G. Getz, L. Chin, L. A. Garraway, Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485, 502-506 (2012).
5. D. H. Kwak, J. H. Lee, T. Kim, H. S. Ahn, W. K. Cho, H. Ha, Y. H. Hwang, J. Y. Ma, Aristolochia manshuriensis Kom inhibits adipocyte differentiation by regulation of ERK1/2 and Akt pathway. PLoS One 7, e49530 (2012).
6. J. L. Vanherweghem, M. Depierreux, C. Tielemans, D. Abramowicz, M. Dratwa, M. Jadoul, C. Richard, D. Vandervelde, D. Verbeelen, R. Vanhaelen-Fastre, M. Vanhaelen, Rapidly progressive interstitial renal fibrosis in young women: Association with slimming regimen including Chinese herbs. Lancet 341, 387-391 (1993).
7. M. E. De Broe, On a nephrotoxic and carcinogenic slimming regimen. Am. J. Kidney Dis. 33, 1171-1173 (1999).
8. A. P. Grollman, S. Shibutani, M. Moriya, F. Miller, L. Wu, U. Moll, N. Suzuki, A. Fernandes, T. Rosenquist, Z. Medverec, K. Jakovina, B. Brdar, N. Slade, R. J. Turesky, A. K. Goodenough, R. Rieger, M. Vukelic, B. Jelakovic, Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. U.S.A. 104, 12129-12134 (2007).
9. F. D. Debelle, J. L. Vanherweghem, J. L. Nortier, Aristolochic acid nephropathy: A worldwide problem. Kidney Int. 74, 158-169 (2008).
10. J. L. Nortier, M. C. Martinez, H. H. Schmeiser, V. M. Arlt, C. A. Bieler, M. Petein, M. F. Depierreux, L. De Pauw, D. Abramowicz, P. Vereerstraeten, J. L. Vanherweghem, Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N. Engl. J. Med. 342, 1686-1692 (2000).
11. H. H. Schmeiser, K. B. Schoepe, M. Wiessler, DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis 9, 297-303 (1988).
12. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Pharmaceuticals. Volume 100 A. A review of human carcinogens. IARC Monogr. Eval. Carcinog. Risks Hum. 100, 1-401 (2012).
13. C. H. Chen, K. G. Dickman, M. Moriya, J. Zavadil, V. S. Sidorenko, K. L. Edwards, D. V. Gnatenko, L. Wu, R. J. Turesky, X. R. Wu, Y. S. Pu, A. P. Grollman, Aristolochic acid-associated urothelial cancer in Taiwan. Proc. Natl. Acad. Sci. U.S.A. 109, 8241-8246 (2012).
14. M. H. Yang, K. K. Chen, C. C. Yen, W. S. Wang, Y. H. Chang, W. J. Huang, F. S. Fan, T. J. Chiou, J. H. Liu, P. M. Chen, Unusually high incidence of upper urinary tract urothelial carcinoma in Taiwan. Urology 59, 681-687 (2002).
15. M. Moriya, N. Slade, B. Brdar, Z. Medverec, K. Tomic, B. Jelakovic, L. Wu, S. Truong, A. Fernandes, A. P. Grollman, TP53 Mutational signature for aristolochic acid: An environmental carcinogen. Int. J. Cancer 129, 1532-1536 (2011).
16. C. H. Chen, K. G. Dickman, C. Y. Huang, M. Moriya, C. T. Shun, H. C. Tai, K. H. Huang, S.M. Wang, Y. J. Lee, A. P. Grollman, Y. S. Pu, Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: Clinical characteristics and outcomes. Int. J. Cancer 133, 14-20 (2013).
17. M. Hollstein, M. Moriya, A. P. Grollman, M. Olivier, Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid. Mutat. Res. 10.1016/j.mrrev.2013.02.003 (2013).
18. C. F. Wu, S. T. Pang, J. J. Shee, P. L. Chang, C. K. Chuang, C. S. Chen, S. K. Liao, W. H. Weng, Identification of genetic alterations in upper urinary tract urothelial carcinoma in end-stage renal disease patients. Genes Chromosomes Cancer 49, 928-934 (2010).
19. C. F. Wu, K. F. Ng, C. S. Chen, P. L. Chang, C. K. Chuang, W. H. Weng, S. K. Liao, S. T. Pang, Expression of parvin-b is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract. Br. J. Cancer 103, 852-860 (2010).
20. S. I. Nikolaev, D. Rimoldi, C. Iseli, A. Valsesia, D. Robyr, C. Gehrig, K. Harshman, M. Guipponi, O. Bukach, V. Zoete, O. Michielin, K. Muehlethaler, D. Speiser, J. S. Beckmann, I. Xenarios, T. D. Halazonetis, C. V. Jongeneel, B. J. Stevenson, S. E. Antonarakis, Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat. Genet. 44, 133-139 (2012).
21. R. Govindan, L. Ding, M. Griffith, J. Subramanian, N. D. Dees, K. L. Kanchi, C. A. Maher, R. Fulton, L. Fulton, J. Wallis, K. Chen, J. Walker, S. McDonald, R. Bose, D. Ornitz, D. Xiong, M. You, D. J. Dooling, M. Watson, E. R. Mardis, R. K. Wilson, Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150, 1121-1134 (2012).
22. M. Stiborová, E. Frei, B. Sopko, K. Sopková, V. Marková, M. Lanková, T. Kumstýrová, M. Wiessler, H. H. Schmeiser, Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: Evidence for reductive activation by human NAD(P)H:quinone oxidoreductase. Carcinogenesis 24, 1695-1703 (2003).
23. L. Chen, N. Mei, L. Yao, T. Chen, Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats. Toxicol. Lett. 165, 250-256 (2006).
24. Y. Gui, G. Guo, Y. Huang, X. Hu, A. Tang, S. Gao, R. Wu, C. Chen, X. Li, L. Zhou, M. He, Z. Li, X. Sun, W. Jia, J. Chen, S. Yang, F. Zhou, X. Zhao, S. Wan, R. Ye, C. Liang, Z. Liu, P. Huang, C. Liu, H. Jiang, Y. Wang, H. Zheng, L. Sun, X. Liu, Z. Jiang, D. Feng, J. Chen, S. Wu, J. Zou, Z. Zhang, R. Yang, J. Zhao, C. Xu, W. Yin, Z. Guan, J. Ye, H. Zhang, J. Li, K. Kristiansen, M. L. Nickerson, D. Theodorescu, Y. Li, X. Zhang, S. Li, J. Wang, H. Yang, J. Wang, Z. Cai, Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat. Genet. 43, 875-878 (2011).
25. G. van Haaften, G. L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S. O'Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P. J. Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C. Y. Kok, C. Leroy, M. L. Lin, D. J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P. S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V. P. Collins, K. Ichimura, S. Law, J. Wong, S. T. Yuen, S. Y. Leung, G. Tonon, R. A. DePinho, Y. T. Tai, K. C. Anderson, R. J. Kahnoski, A. Massie, S. K. Khoo, B. T. Teh, M. R. Stratton, P. A. Futreal, Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet. 41, 521-523 (2009).
26. K. Yoshida, M. Sanada, Y. Shiraishi, D. Nowak, Y. Nagata, R. Yamamoto, Y. Sato, A. Sato-Otsubo, A. Kon, M. Nagasaki, G. Chalkidis, Y. Suzuki, M. Shiosaka, R. Kawahata, T. Yamaguchi, M. Otsu, N. Obara, M. Sakata-Yanagimoto, K. Ishiyama, H. Mori, F. Nolte, W. K. Hofmann, S. Miyawaki, S. Sugano, C. Haferlach, H. P. Koeffler, L. Y. Shih, T. Haferlach, S. Chiba, H. Nakauchi, S. Miyano, S. Ogawa, Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478, 64-69 (2011).
27. E. D. Pleasance, P. J. Stephens, S. O'Meara, D. J. McBride, A. Meynert, D. Jones, M. L. Lin, D. Beare, K. W. Lau, C. Greenman, I. Varela, S. Nik-Zainal, H. R. Davies, G. R. Ordoñez, L. J. Mudie, C. Latimer, S. Edkins, L. Stebbings, L. Chen, M. Jia, C. Leroy, J. Marshall, A. Menzies, A. Butler, J. W. Teague, J. Mangion, Y. A. Sun, S. F. McLaughlin, H. E. Peckham, E. F. Tsung, G. L. Costa, C. C. Lee, J. D. Minna, A. Gazdar, E. Birney, M. D. Rhodes, K. J. McKernan, M. R. Stratton, P. A. Futreal, P. J. Campbell, A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463, 184-190 (2010).
28. D. J. Burgess, Transcriptomics: Sense and antisense ability. Nat. Rev. Genet. 12, 519 (2011).
29. L. B. Gardner, Nonsense-mediated RNA decay regulation by cellular stress: Implications for tumorigenesis. Mol. Cancer Res. 8, 295-308 (2010).
30. D. Chen, Z. Tang, C. Luo, H. Chen, Z. Liu, Clinical and pathological spectrums of aristolochic acid nephropathy. Clin. Nephrol. 78, 54-60 (2012).
31. W. K. Sung, H. Zheng, S. Li, R. Chen, X. Liu, Y. Li, N. P. Lee, W. H. Lee, P. N. Ariyaratne, C. Tennakoon, F. H. Mulawadi, K. F. Wong, A. M. Liu, R. T. Poon, S. T. Fan, K. L. Chan, Z. Gong, Y. Hu, Z. Lin, G. Wang, Q. Zhang, T. D. Barber, W. C. Chou, A. Aggarwal, K. Hao, W. Zhou, C. Zhang, J. Hardwick, C. Buser, J. Xu, Z. Kan, H. Dai, M. Mao, C. Reinhard, J. Wang, J. M. Luk, Genomewide survey of recurrent HBV integration in hepatocellular carcinoma. Nat. Genet. 44, 765-769 (2012).
32. N. Nagarajan, D. Bertrand, A. M. Hillmer, Z. J. Zang, F. Yao, P. E. Jacques, A. S. Teo, I. Cutcutache, Z. Zhang, W. H. Lee, Y. Y. Sia, S. Gao, P. N. Ariyaratne, A. Ho, X. Y. Woo, L. Veeravali, C. K. Ong, N. Deng, K. V. Desai, C. C. Khor, M. L. Hibberd, A. Shahab, J. Rao, M. Wu, M. Teh, F. Zhu, S. Y. Chin, B. Pang, J. B. So, G. Bourque, R. Soong, W. K. Sung, B. Tean Teh, S. Rozen, X. Ruan, K. G. Yeoh, P. B. Tan, Y. Ruan, Whole-genome reconstruction and mutational signatures in gastric cancer. Genome Biol. 13, R115 (2012).
33. B. Vogelstein, N. Papadopoulos, V. E. Velculescu, S. Zhou, L. A. Diaz Jr., K. W. Kinzler, Cancer genome landscapes. Science 339, 1546-1558 (2013).
34. C. Palles, J. B. Cazier, K.M. Howarth, E. Domingo, A. M. Jones, P. Broderick, Z. Kemp, S. L. Spain, E. Guarino Almeida, I. Salguero, A. Sherborne, D. Chubb, L. G. Carvajal-Carmona, Y. Ma, K. Kaur, S. Dobbins, E. Barclay, M. Gorman, L. Martin, M. B. Kovac, S. Humphray, A. Lucassen, C. C. Holmes, D. Bentley, P. Donnelly, J. Taylor, C. Petridis, R. Roylance, E. J. Sawyer, D. J. Kerr, S. Clark, J. Grimes, S. E. Kearsey, H. J. Thomas, G. McVean, R. S. Houlston, I. Tomlinson, Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat. Genet. 45, 136-144 (2013).
35. J. S. You, P. A. Jones, Cancer genetics and epigenetics: Two sides of the same coin? Cancer Cell 22, 9-20 (2012).
36. M. W. Germann, C. N. Johnson, A. M. Spring, Recognition of damaged DNA: Structure and dynamic markers. Med. Res. Rev. 32, 659-683 (2012).
37. E. Compe, J. M. Egly, TFIIH: When transcription met DNA repair. Nat. Rev. Mol. Cell Biol. 13, 343-354 (2012).
38. M. Lukin, T. Zaliznyak, F. Johnson, C. de los Santos, Structure and stability of DNA containing an aristolactam II-dA lesion: Implications for the NER recognition of bulky adducts. Nucleic Acids Res. 40, 2759-2770 (2012).
39. B. Jelakovic, S. Karanovic, I. Vukovic-Lela, F. Miller, K. L. Edwards, J. Nikolic, K. Tomic, N. Slade, B. Brdar, R. J. Turesky, Z. Stipancic, D. Dittrich, A. P. Grollman, K. G. Dickman, Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid. Kidney Int. 81, 559-567 (2012).
40. V. S. Sidorenko, J. E. Yeo, R. R. Bonala, F. Johnson, O. D. Schärer, A. P. Grollman, Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts. Nucleic Acids Res. 40, 2494-2505 (2012).
41. M. Stiborová, E. Frei, H. H. Schmeiser, Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid. Kidney Int. 73, 1209-1211 (2008).
42. K. Wang, J. Kan, S. T. Yuen, S. T. Shi, K. M. Chu, S. Law, T. L. Chan, Z. Kan, A. S. Chan, W. Y. Tsui, S. P. Lee, S. L. Ho, A. K. Chan, G. H. Cheng, P. C. Roberts, P. A. Rejto, N. W. Gibson, D. J. Pocalyko, M. Mao, J. Xu, S. Y. Leung, Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat. Genet. 43, 1219-1223 (2011).
43. M. R. Gökmen, J. P. Cosyns, V. M. Arlt, M. Stiborová, D. H. Phillips, H. H. Schmeiser, M. S. Simmonds, H. T. Cook, J. L. Vanherweghem, J. L. Nortier, G. M. Lord, The epidemiology, diagnosis, and management of aristolochic acid nephropathy: A narrative review. Ann. Intern. Med. 158, 469-477 (2013).
44. D. H. Phillips, V. M. Arlt, The 32P-postlabeling assay for DNA adducts. Nat. Protoc. 2, 2772-2781 (2007).
45. W. Chan, Y. Zheng, Z. Cai, Liquid chromatography-tandem mass spectrometry analysis of the DNA adducts of aristolochic acids. J. Am. Soc. Mass Spectrom. 18, 642-650 (2007).
46. M. Mosihuzzaman, Herbal medicine in healthcare-An overview. Nat. Prod. Commun. 7, 807-812 (2012).
47. W. Chau, R. Ross, J. Y. Li, T. Y. Yong, S. Klebe, J. A. Barbara, Nephropathy associated with use of a Chinese herbal product containing aristolochic acid. Med. J. Aust. 194, 367-368 (2011).
48. J.-P. Rojas, "Judge calls for regulation over 'cancer' pills," The Independent, 18 February 2010; http://www.independent.co.uk/life-style/ health-and-families/health-news/judge-callsfor-regulation-over-cancer-pills- 1903247.html.
49. G. Gluhovschi, F. Margineanu, S. Velciov, C. Gluhovschi, F. Bob, L. Petrica, G. Bozdog, V. Trandafirescu, M. Modalca, Fifty years of Balkan endemic nephropathy in Romania: Some aspects of the endemic focus in the Mehedinti county. Clin. Nephrol. 75, 34-48 (2011).
50. National Toxicology Program, NTP 12th Report on Carcinogens. Rep. Carcinog. 12, iii-499 (2011).
51. M. L. Hoang, C.-H. Chen, V. S. Sidorenko, J. He, K. G. Dickman, B. H. Yun, M. Moriya, N. Niknafs, C. Douville, R. Karchin, R. J. Turesky, Y.-S. Pu, B. Vogelstein, N. Papadopoulos, A. P. Grollman, K. W. Kinzler, T. A. Rosenquist, Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing. Sci. Transl. Med. 5, 197ra102 (2013).
52. S. L. Poon, S.-T. Pang, J. R. McPherson, W. Yu, K. K. Huang, P. Guan, W.-H. Weng, E. Y. Siew, Y. Liu, H. L. Heng, S. C. Chong, A. Gan, S. T. Tay, W. K. Lim, I. Cutcutache, D. Huang, L. D. Ler, M.-L. Nairismägi, M. H. Lee, Y.-H. Chang, K.-J. Yu, W. Chan-on, B.-K. Li, Y.-F. Yuan, C.-N. Qian, K.-F. Ng, C.-F. Wu, C.-L. Hsu, R. M. Bunte, M. R. Stratton, P. A. Futreal, W.-K. Sung, C.-K. Chuang, C. K. Ong, S. G. Rozen, P. Tan, B. T. Teh, Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. Sci. Transl. Med. 5, 197ra101 (2013).