European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia

Leukemia

Volumn 30, Issue 8, 2016, Pages 1648-1671

  Steegmann, J L ^a   Baccarani, M ^b   Breccia, M ^c   Casado, L F ^d   Garcia Gutierrez V ^e   Hochhaus, A ^f   Kim, D W ^g   Kim, T D ^h   Khoury, H J ⁱ   Le Coutre, P ^h   Mayer, J ^j   Milojkovic, D ^k   Porkka, K ^l,m   Rea, D ⁿ   Rosti, G ^b   Saussele, S ^o   Hehlmann, R ^o   Clark, R E ^p  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d HOSPITAL VIRGEN DE LA SALUD   (Spain)

^e HOSPITAL RAMÓN Y CAJAL   (Spain)

^f Universit tsklinikum Jena   (Germany)

^g The Catholic University of Korea   (South Korea)

^h CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

ⁱ EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^k HAMMERSMITH HOSPITAL   (United Kingdom)

^l HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^m UNIVERSITY OF HELSINKI   (Finland)

ⁿ SAINT LOUIS HOSPITAL   (France)

^o UNIVERSITY OF HEIDELBERG   (Germany)

^p UNIVERSITY OF LIVERPOOL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACENOCOUMAROL; BOSUTINIB; BRAIN NATRIURETIC PEPTIDE; DASATINIB; DIURETIC AGENT; IMATINIB; NILOTINIB; PONATINIB; PROTEIN TYROSINE KINASE INHIBITOR; STEROID; WARFARIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ABDOMINAL PAIN; ANKLE BRACHIAL INDEX; ARTERY OCCLUSION; ARTERY THROMBOSIS; BLEEDING; BLEEDING TENDENCY; BLURRED VISION; BONE DENSITOMETRY; BONE MARROW SUPPRESSION; CARDIOTOXICITY; CARDIOVASCULAR RISK; CHRONIC MYELOID LEUKEMIA; COMORBIDITY; CONJUNCTIVAL HEMORRHAGE; CONSTIPATION; CRANIAL NERVE PARALYSIS; CYTOPENIA; DIABETES MELLITUS; DISEASE SEVERITY; DISORDERS OF CARBOHYDRATE METABOLISM; DRUG MONITORING; DRUG SAFETY; DRY EYE; DUPLEX DOPPLER ULTRASONOGRAPHY; DYSPEPSIA; ELECTROCARDIOGRAPHY MONITORING; EPIPHORA; FEBRILE NEUTROPENIA; GASTROINTESTINAL HEMORRHAGE; GLUCOSE METABOLISM; HEADACHE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEMODIALYSIS; HEPATITIS B; HUMAN; HYPERBILIRUBINEMIA; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERPARATHYROIDISM; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOCALCEMIA; HYPOPHOSPHATEMIA; HYPOTHYROIDISM; INCIDENCE; ISCHEMIC HEART DISEASE; KETOACIDOSIS; KIDNEY FAILURE; LACRIMATION DISORDER; LIPID METABOLISM; LIVER FAILURE; LIVER TOXICITY; LONG QT SYNDROME; LUNG TUBERCULOSIS; LYMPHOCYTOSIS; MEMORY DISORDER; MENORRHAGIA; MENSTRUAL IRREGULARITY; MUSCLE CRAMP; MYALGIA; NAUSEA; NEUTROPENIA; OCULAR PRURITUS; OPTIC DISC EDEMA; OPTIC NEURITIS; PANCREATITIS; PERIORBITAL EDEMA; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHASE 3 CLINICAL TRIAL (TOPIC); PHOTOPHOBIA; PLEURA EFFUSION; PNEUMONIA; PRACTICE GUIDELINE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; QT PROLONGATION; QUALITY OF LIFE; RASH; REVIEW; STEM CELL TRANSPLANTATION; THORACOCENTESIS; THROMBOCYTOPENIA; VITAMIN DEFICIENCY; VOMITING; WEB BROWSER; ADVERSE DRUG REACTION; ANTAGONISTS AND INHIBITORS; COMPLICATION; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE;

DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES;

EID: 84973137731     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2016.104     Document Type: Review

References (276)

1. O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994-1004
2. Saglio G, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Lobo C, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010; 362: 2251-2259
3. Larson RA, Hochhaus A, Hughes TP, Clark RE, Etienne G, Kim DW, et al. Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up. Leukemia 2012; 26: 2197-2203
4. Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010; 362: 2260-2270
5. Kantarjian HM, Shah NP, Cortes JE, Baccarani M, Agarwal MB, Undurraga MS, et al. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood 2012; 119: 1123-1129
6. Hehlmann R, Lauseker M, Jung-Munkwitz S, Leitner A, Muller MC, Pletsch N, et al. Tolerability-Adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-Alpha in newly diagnosed chronic myeloid leukemia. J Clin Oncol 2011; 29: 1634-1642
7. Kalmanti L, Saussele S, Lauseker M, Muller MC, Dietz CT, Heinrich L, et al. Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV. Leukemia 2015; 29: 1123-1132
8. Castagnetti F, Gugliotta G, Breccia M, Specchia G, Intermesoli T, Capucci A, et al. Frontline treatment with imatinib mesylate in chronic myeloid leukemia patients in early chronic phase: a very long-Term analysis by the GIMEMA CML Working Party. Blood 2013; 122: 258
9. Gambacorti-Passerini C, Antolini L, Mahon FX, Guilhot F, Deininger M, Fava C, et al. Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib. J Natl Cancer Inst 2011; 103: 553-561
10. Casado LF, Garcia-Gutierrez JV, Massague I, Giraldo P, Perez-Encinas M, de Paz R, et al. Switching to second-generation tyrosine kinase inhibitor improves the response and outcome of frontline imatinib-Treated patients with chronic myeloid leukemia with more than 10% of BCR-ABL/ABL ratio at 3 months. Cancer Med 2015; 4: 995-1002
11. Deininger M, O'Brien SG, Guilhot F, Goldman JM, Hochhaus A, Hughes TP, et al. International randomized study of interferon and STI571 (IRIS) 8-year follow-up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase treated with imatinib. Blood 2009; 114: 462
12. Giannoudis A, Wang L, Jorgensen AL, Xinarianos G, Davies A, Pushpakom S, et al. The hOCT1 SNPs, M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-Treated chronic myeloid leukemia. Blood 2013; 121: 628-637
13. Perneger T. The Council of Europe recommendation Rec(2006)7 on management of patient safety and prevention of adverse events in health care. Int J Qual Health Care 2008; 20: 305-307
14. Perneger T. The Council of Europe recommendation Rec(2006)7 on management of patient safety and prevention of adverse events in health care. Int J Qual Health Care 2008; 20: 305-307
15. Steegmann JL, Cervantes F, le Coutre P, Porkka K, Saglio G. Off-Target effects of BCR-ABL1 inhibitors and their potential long-Term implications in patients with chronic myeloid leukemia. Leuk Lymphoma 2012; 53: 2351-2361
16. Rosti G, Castagnetti F, Gugliotta G, Palandri F, Baccarani M. Physician's guide to the clinical management of adverse events on nilotinib therapy for the treatment of CML. Cancer Treat Rev 2012; 38: 241-248
17. Breccia M, Alimena G. Occurrence and current management of side effects in chronic myeloid leukemia patients treated frontline with tyrosine kinase inhibitors. Leuk Res 2013; 37: 713-720
18. Rea D. Management of adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukemia. Ann Hematol 2015; 94(Suppl 2): S149-S158
19. Shah NP, Guilhot F, Cortes JE, Schiffer CA, le Coutre P, Brummendorf TH, et al. Long-Term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of phase 3 study. Blood 2014; 123: 2317-2324
20. Giles FJ, le Coutre PD, Pinilla-Ibarz J, Larson RA, Gattermann N, Ottmann OG, et al. Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study. Leukemia 2013; 27: 107-112
21. Cortes JE, Kantarjian HM, Brummendorf TH, Kim DW, Turkina AG, Shen ZX, et al. Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood 2011; 118: 4567-4576
22. Cortes JE, Kim DW, Kantarjian HM, Brummendorf TH, Dyagil I, Griskevicius L, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol 2012; 30: 3486-3492
23. Cortes JE, Kim DW, Pinilla-Ibarz J, le Coutre P, Paquette R, Chuah C, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 2013; 369: 1783-1796
24. Valent P, Hadzijusufovic E, Schernthaner G, Wolf D, Rea D, le Coutre P. Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors. Blood 2014; 125: 901-906
25. Knickerbocker R, Dorer DJ, Haluska FG, Baccarani M, Cortes JE, Hochhaus A, et al. Impact of dose intensity of ponatinib on selected adverse events: multivariate analyses from a pooled population of clinical trial patients. Blood 2014; 124: 4546
26. Cortes JE, Kim D-W, Pinilla-Ibarz J, Le Coutre P, Paquette R, Chuah C, et al. Long-Term follow-up of ponatinib efficacy and safety in the phase 2 PACE trial. Blood 2014; 124: 3135
27. Mayer K, Gielen GH, Willinek W, Muller MC, Wolf D. Fatal progressive cerebral ischemia in CML under third-line treatment with ponatinib. Leukemia 2014; 28: 976-977
28. Cortes JE, Saglio G, Baccarani M, Kantarjian HM, Mayer J, Boqué C, et al. Final Study Results of the Phase 3 Dasatinib Versus Imatinib in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Trial (DASISION, CA180-056). Blood 2014; 124: 152
29. Gambacorti-Passerini C, Cortes JE, Lipton JH, Dmoszynska A, Wong RS, Rossiev V, et al. Safety of bosutinib versus imatinib in the phase 3 BELA trial in newly diagnosed chronic phase chronic myeloid leukemia. Am J Hematol 2014; 89: 947-953
30. Hochhaus A, O'Brien SG, Guilhot F, Druker BJ, Branford S, Foroni L, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23: 1054-1061
31. Lipton J, Chuah C, Guerci-Bresler A, Rosti G, Simpson D, Assouline S, et al. Epic: A phase 3 trial of ponatinib compared with imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CP-CML). Blood 2014; 124: 519
32. Giles FJ, Mauro MJ, Hong F, Ortmann CE, McNeill C, Woodman RC, et al. Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-Tyrosine kinase therapy: a retrospective cohort analysis. Leukemia 2013; 27: 1310-1315
33. Kim TD, Rea D, Schwarz M, Grille P, Nicolini FE, Rosti G, et al. Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinib. Leukemia 2013; 27: 1316-1321
34. Cortes J, Mauro M, Steegmann JL, Saglio G, Malhotra R, Ukropec JA, et al. Cardiovascular and pulmonary adverse events in patients treated with BCR-ABL inhibitors: data from the FDA adverse event reporting system. Am J Hematol 2015; 90: E66-E72
35. Cortes JE, Hochhaus A, Kim DW, Shah NP, Mayer J, Rowlings P, et al. Four-year (Yr) follow-up of patients (Pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) receiving dasatinib or imatinib: efficacy based on early response. Blood 2013; 122: 653
36. Hochhaus A, Rosti G, Cross NC, Steegmann JL, le Coutre P, Ossenkoppele G, et al. Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study. Leukemia 2016; 30: 57-64
37. Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, et al. Longterm benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial. Leukemia 2016; 30: 1044-1054
38. Tefferi A, Letendre L. Nilotinib treatment-Associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia. Am J Hematol 2011; 86: 610-611
39. Le Coutre P, Rea D, Abruzzese E, Dombret H, Trawinska MM, Herndlhofer S, et al. Severe peripheral arterial disease during nilotinib therapy. J Natl Cancer Inst 2011; 103: 1347-1348
40. Quintas-Cardama A, Kantarjian H, Cortes J. Nilotinib-Associated vascular events. Clin Lymphoma Myeloma Leuk 2012; 12: 337-340
41. Labussière-Wallet H, Guillermin Y, Etienne M, Barale A-C, Serrier C, Tigaud I, et al. Analysis of clinical arterial and metabolic parameters in chronic phase CML patients on nilotinib in a single center cohort. Blood 2012; 120: 3756
42. Levato L, Cantaffa R, Kropp MG, Magro D, Piro E, Molica S. Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in chronic myeloid leukemia: a single institution study. Eur J Haematol 2013; 90: 531-532
43. Giles F, Baccarani M, Brümmendorf TH, Hellmann A, Mahon F-X, Rosti G, et al. Deep molecular responses in patients with newly diagnosed chronic myeloid leukemia receiving nilotinib as assessed within the EUTOS laboratory network in the ENEST1st study. Blood 2013; 122: 4030
44. Jeon YW, Lee SE, Choi S-Y, Kim S-H, Park J-E, Jeon H-R, et al. Peripheral arterial occlusive disease (PAOD) in chronic phase chronic myeloid leukemia patients treated with nilotinib. Blood 2013; 122: 4018
45. le Coutre PD, Hughes TP, Mahon F-X, Kim D-W, Steegmann JL, Shah NP, et al. Peripheral arterial occlusive disease (PAOD) in patients (Pts) receiving dasatinib: experience across multiple clinical trials. Blood 2013; 122: 1489
46. Larson RA, Kim DW, Issaragrilsil S, le Coutre P, Dorlhiac Llacer PE, Etienne G, et al. Efficacy and safety of nilotinib (NIL) vs imatinib (IM) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): long-Term follow-up (f/u) of ENESTnd. Blood 2014; 124: 4541
47. Gugliotta G, Castagnetti F, Breccia M. Five-year outcome of 215 newly diagnosed chronic myeloid leukemia patients treated frontline with nilotinib-based regimens: a gimema cml working party analysis. Blood 2014; 124: 3141
48. Hadzijusufovic E, Albrecht-Schgoer K, Huber K, Grebien F, Eisenwort G, Schgoer W, et al. Further evaluation of pro-Atherogenic and anti-Angiogenic effects of nilotinib in mice and in patients with Ph-Chromosome+ CML. Blood 2014; 124: 1800
49. Fossard G, Blond E, Giraudier S, Morisset S, Ruby J, Escoffre-Barbe M, et al. Hyperhomocysteinemia and high doses of nilotinib favour cardio-vascular events in chronic phase chronic myelogenous leukemia (CML) patients. Blood 2014; 124: 3136
50. Gilbert J, Deplano S, Szydlo R, Palanicawandar R, Gerrard G, Foroni L, et al. Incidence of vascular thrombotic events in 183 consecutive patients treated with nilotinib: a single centre experience. Blood 2014; 124: 3147
51. Rea D, Mirault T, Raffoux E, Boissel N, Andreoli AL, Rousselot P, et al. Usefulness of the 2012 European CVD risk assessment model to identify patients at high risk of cardiovascular events during nilotinib therapy in chronic myeloid leukemia. Leukemia 2015; 29: 1206-1209
52. Cortes JE, Saglio G, Baccarani M, Kantarjian HM, Mayer J, Boqué C, et al. Final study results of the phase 3 dasatinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) trial (DASISION, CA180-056). Blood 2014; 124: 152
53. Aichberger KJ, Herndlhofer S, Schernthaner GH, Schillinger M, Mitterbauer-Hohendanner G, Sillaber C, et al. Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML. Am J Hematol 2011; 86: 533-539
54. Gora-Tybor J, Medras E, Calbecka M, Kolkowska-Lesniak A, Ponikowska-Szyba E, Robak T, et al. Real-life comparison of severe vascular events and other nonhematological complications in chronic myeloid leukemia patients undergoing second line nilotinib or dasatinib treatment. Leuk Lymphoma 2015; 7: 1-19
55. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012; 33: 1635-1701
56. Rooke TW, Hirsch AT, Misra S, Sidawy AN, Beckman JA, Findeiss L, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013; 61: 1555-1570
57. Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg 1997; 26: 517-538
58. Mirault T, Rea D, Azarine A, Messas E. Rapid onset of peripheral artery disease in a chronic myeloid leukemia patient without prior arterial disorder: direct relationship with nilotinib exposure and clinical outcome. Eur J Haematol 2015; 94: 363-367
59. Kerkela R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 2006; 12: 908-916
60. Rosti G, Martinelli G, Baccarani M. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007; 13: 15
61. Atallah E, Kantarjian H, Cortes J. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007; 13: 14
62. Hatfield A, Owen S, Pilot PR. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007; 13: 13
63. Gambacorti-Passerini C, Tornaghi L, Franceschino A, Piazza R, Corneo G, Pogliani E. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007; 13: 13-14
64. Estabragh ZR, Knight K, Watmough SJ, Lane S, Vinjamuri S, Hart G, et al. A prospective evaluation of cardiac function in patients with chronic myeloid leukaemia treated with imatinib. Leuk Res 2011; 35: 49-51
65. Ribeiro AL, Marcolino MS, Bittencourt HN, Barbosa MM, Nunes Mdo C, Xavier VF, et al. An evaluation of the cardiotoxicity of imatinib mesylate. Leuk Res 2008; 32: 1809-1814
66. Marcolino MS, Ribeiro AL, Clementino NC, Nunes Mdo C, Barbosa MM, Silva MH, et al. The use of imatinib mesylate has no adverse effects on the heart function. Results of a pilot study in patients with chronic myeloid leukemia. Leuk Res 2011; 35: 317-322
67. Atallah E, Durand JB, Kantarjian H, Cortes J. Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood 2007; 110: 1233-1237
68. Marcolino MS, Boersma E, Clementino NC, Nunes Mdo C, Barbosa MM, Silva MH, et al. The duration of the use of imatinib mesylate is only weakly related to elevated BNP levels in chronic myeloid leukaemia patients. Hematol Oncol 2011; 29: 124-130
69. Jabbour E, Kantarjian HM, Saglio G, Steegmann JL, Shah NP, Boque C, et al. Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION). Blood 2014; 123: 494-500
70. Shah DR, Shah RR, Morganroth J. Tyrosine kinase inhibitors: their on-Target toxicities as potential indicators of efficacy. Drug Safety 2013; 36: 413-426
71. Kloth JS, Pagani A, Verboom MC, Malovini A, Napolitano C, Kruit WH, et al. Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors. Br J Cancer 2015; 112: 1011-1016
72. Sonnichsen D, Dorer DJ, Cortes J, Talpaz M, Deininger MW, Shah NP, et al. Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies. Cancer Chemother Pharmacol 2013; 71: 1599-1607
73. Abbas R, Hug BA, Leister C, Gaaloul ME, Chalon S, Sonnichsen D. A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects. Cancer Chemother Pharmacol 2012; 69: 221-227
74. Brummendorf TH, Cortes JE, de Souza CA, Guilhot F, Duvillie L, Pavlov D, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukaemia: results from the 24-month follow-up of the BELA trial. Br J Haematol 2015; 1: 69-81
75. Sonnichsen D, Dorer DJ, Cortes J, Talpaz M, Deininger MW, Shah NP, et al. Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies. Cancer Chemother Pharmacol 2013; 71: 1599-1607
76. Johnson FM, Agrawal S, Burris H, Rosen L, Dhillon N, Hong D, et al. Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors. Cancer 2010; 116: 1582-1591
77. Orphanos GS, Ioannidis GN, Ardavanis AG. Cardiotoxicity induced by tyrosine kinase inhibitors. Acta Oncol 2009; 48: 964-970
78. Quintas-Cardama A, Kantarjian H, O'Brien S, Borthakur G, Bruzzi J, Munden R, et al. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007; 25: 3908-3914
79. de Lavallade H, Punnialingam S, Milojkovic D, Bua M, Khorashad JS, Gabriel IH, et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol 2008; 141: 745-747
80. Breccia M, D'Elia GM, D'Andrea M, Latagliata R, Alimena G. Pleural-pericardic effusion as uncommon complication in CML patients treated with Imatinib. Eur J Haematol 2005; 74: 89-90
81. Brave M, Goodman V, Kaminskas E, Farrell A, Timmer W, Pope S, et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res 2008; 14: 352-359
82. Pavlu J, Marin D. Dasatinib and chronic myeloid leukemia: two-year follow-up in eight clinical trials. Clin Lymphoma Myeloma 2009; 9: 417-424
83. Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronicphase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007; 109: 2303-2309
84. Kantarjian H, Pasquini R, Hamerschlak N, Rousselot P, Holowiecki J, Jootar S, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood 2007; 109: 5143-5150
85. Apperley JF, Cortes JE, Kim DW, Roy L, Roboz GJ, Rosti G, et al. Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial. J Clin Oncol 2009; 27: 3472-3479
86. Saglio G, Hochhaus A, Goh YT, Masszi T, Pasquini R, Maloisel F, et al. Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily. Cancer 2010; 116: 3852-3861
87. Shah NP, Kantarjian HM, Kim DW, Rea D, Dorlhiac-Llacer PE, Milone JH, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and-intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol 2008; 26: 3204-3212
88. Porkka K, Baccarani M, Cortes J, Hochhaus A, Kantarjian H, Shah N, et al. Pleural effusion in patients with chronic-phase chronic myeloid leukemia (CMLCP) who received first-line dasatinib in the DASISION trial patient characteristics, management, and outcomes. 16th Congress of the EHA. Haematologica 2011; 692
89. Porkka K, Khoury HJ, Paquette RL, Matloub Y, Sinha R, Cortes JE. Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion. Cancer 2010; 116: 377-386
90. Latagliata R, Breccia M, Fava C, Stagno F, Tiribelli M, Luciano L, et al. Incidence, risk factors and management of pleural effusions during dasatinib treatment in unselected elderly patients with chronic myelogenous leukaemia. Hematol Oncol 2013; 31: 363-369
91. Kim D, Goh HG, Kim SH, Cho BS, Kim DW. Long-Term pattern of pleural effusion from chronic myeloid leukemia patients in second-line dasatinib therapy. Int J Hematol 2011; 94: 361-371
92. Breccia M, Latagliata R, Stagno F, Luciano L, Gozzini A, Castagnetti F, et al. Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib. Haematologica 2011; 96: 1457-1461
93. La Rosee P, Martiat P, Leitner A, Klag T, Muller MC, Erben P, et al. Improved tolerability by a modified intermittent treatment schedule of dasatinib for patients with chronic myeloid leukemia resistant or intolerant to imatinib. Ann Hematol 2013; 92: 1345-1350
94. Rasheed W, Flaim B, Seymour JF. Reversible severe pulmonary hypertension secondary to dasatinib in a patient with chronic myeloid leukemia. Leuk Res 2009; 33: 861-864
95. Mattei D, Feola M, Orzan F, Mordini N, Rapezzi D, Gallamini A. Reversible dasatinib-induced pulmonary arterial hypertension and right ventricle failure in a previously allografted CML patient. Bone Marrow Transplant 2009; 43: 967-968
96. Dumitrescu D, Seck C, ten Freyhaus H, Gerhardt F, Erdmann E, Rosenkranz S. Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia. Eur Respir J 2011; 38: 218-220
97. Montani D, Bergot E, Gunther S, Savale L, Bergeron A, Bourdin A, et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation 2012; 125: 2128-2137
98. Bergeron A, Bergot E, Vilela G, Ades L, Devergie A, Esperou H, et al. Hypersensitivity pneumonitis related to imatinib mesylate. J Clin Oncol 2002; 20: 4271-4272
99. Ma CX, Hobday TJ, Jett JR. Imatinib mesylate-induced interstitial pneumonitis. Mayo Clin Proc 2003; 78: 1578-1579
100. Rajda J, Phatak PD. Reversible drug-induced interstitial pneumonitis following imatinib mesylate therapy. Am J Hematol 2005; 79: 80-81
101. Go SW, Kim BK, Lee SH, Kim TJ, Huh JY, Lee JM, et al. Successful rechallenge with imatinib in a patient with chronic myeloid leukemia who previously experienced imatinib mesylate induced pneumonitis. Tuberc Respir Dis 2013; 75: 256-259
102. Tamura M, Saraya T, Fujiwara M, Hiraoka S, Yokoyama T, Yano K, et al. High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist 2013; 18: 454-459
103. Bergeron A, Rea D, Levy V, Picard C, Meignin V, Tamburini J, et al. Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am J Respir Crit Care Med 2007; 176: 814-818
104. Teo YL, Ho HK, Chan A. Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: a meta-Analysis. Cancer Treat Rev 2013; 39: 199-206
105. Kantarjian HM, Giles FJ, Bhalla KN, Pinilla-Ibarz J, Larson RA, Gattermann N, et al. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results. Blood 2011; 117: 1141-1145
106. Shah NP, Kim DW, Kantarjian H, Rousselot P, Llacer PE, Enrico A, et al. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib. Haematologica 2010; 95: 232-240
107. Khoury HJ, Cortes JE, Kantarjian HM, Gambacorti-Passerini C, Baccarani M, Kim DW, et al. Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure. Blood 2012; 119: 3403-3412
108. Shah RR, Morganroth J, Shah DR. Hepatotoxicity of tyrosine kinase inhibitors: clinical and regulatory perspectives. Drug Safety 2013; 36: 491-503
109. Spataro V. Nilotinib in a patient with postnecrotic liver cirrhosis related to imatinib. J Clin Oncol 2011; 29: e50-e52
110. Tonyali O, Coskun U, Yildiz R, Karakan T, Demirci U, Akyurek N, et al. Imatinib mesylate-induced acute liver failure in a patient with gastrointestinal stromal tumors. Med Oncol 2010; 27: 768-773
111. Lin NU, Sarantopoulos S, Stone JR, Galinsky I, Stone RM, Deangelo DJ, et al. Fatal hepatic necrosis following imatinib mesylate therapy. Blood 2003; 102: 3455-3456
112. Kikuchi S, Muroi K, Takahashi S, Kawano-Yamamoto C, Takatoku M, Miyazato A, et al. Severe hepatitis and complete molecular response caused by imatinib mesylate: possible association of its serum concentration with clinical outcomes. Leuk Lymphoma 2004; 45: 2349-2351
113. Cross TJ, Bagot C, Portmann B, Wendon J, Gillett D. Imatinib mesylate as a cause of acute liver failure. Am J Hematol 2006; 81: 189-192
114. James C, Trouette H, Marit G, Cony-Makhoul P, Mahon FX. Histological features of acute hepatitis after imatinib mesylate treatment. Leukemia 2003; 17: 978-979
115. Ohyashiki K, Kuriyama Y, Nakajima A, Tauchi T, Ito Y, Miyazawa H, et al. Imatinib mesylate-induced hepato-Toxicity in chronic myeloid leukemia demonstrated focal necrosis resembling acute viral hepatitis. Leukemia 2002; 16: 2160-2161
116. Singer JB, Shou Y, Giles F, Kantarjian HM, Hsu Y, Robeva AS, et al. UGT1A1 promoter polymorphism increases risk of nilotinib-induced hyperbilirubinemia. Leukemia 2007; 21: 2311-2315
117. Ayoub WS, Geller SA, Tran T, Martin P, Vierling JM, Poordad FF. Imatinib (Gleevec)-induced hepatotoxicity. J Clin Gastroenterol 2005; 39: 75-77
118. Ridruejo E, Cacchione R, Villamil AG, Marciano S, Gadano AC, Mando OG. Imatinib-induced fatal acute liver failure. World J Gastroenterol 2007; 13: 6608-6111
119. Ferrero D, Pogliani EM, Rege-Cambrin G, Fava C, Mattioli G, Dellacasa C, et al. Corticosteroids can reverse severe imatinib-induced hepatotoxicity. Haematologica 2006; 91 (6 Suppl): ECR27
120. Perini GF, Santos FP, Funke V, Ruiz J, Neto BH, Hamerschlak N. Nilotinib post-liver transplantation for acute hepatic failure related to imatinib. Leuk Res 2009; 33: e234-e235
121. Cortes JE, Hochhaus A, le Coutre PD, Rosti G, Pinilla-Ibarz J, Jabbour E, et al. Minimal cross-intolerance with nilotinib in patients with chronic myeloid leukemia in chronic or accelerated phase who are intolerant to imatinib. Blood 2011; 117: 5600-5606
122. Harbaum L, Marx A, Goekkurt E, Schafhausen P, Atanackovic D. Treatment with dasatinib for chronic myeloid leukemia following imatinib-induced hepatotoxicity. Int J Hematol 2014; 99: 91-94
123. Breccia M, Muscaritoli M, Gentilini F, Latagliata R, Carmosino I, Rossi Fanelli F, et al. Impaired fasting glucose level as metabolic side effect of nilotinib in nondiabetic chronic myeloid leukemia patients resistant to imatinib. Leuk Res 2007; 31: 1770-1772
124. Nicolini FE, Turkina A, Shen ZX, Gallagher N, Jootar S, Powell BL, et al. Expanding nilotinib access in clinical trials (ENACT): an open-label, multicenter study of oral nilotinib in adult patients with imatinib-resistant or imatinib-intolerant Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. Cancer 2012; 118: 118-126
125. le Coutre P, Giles FJ, Hochhaus A, Martinelli G, Wang J, Passos V, et al. Analysis of glucose profiles in imatinib-resistant or intolerant chronic myelogenous leukemia (CML) patients (pts) treated with nilotinib: lack of correlation between glucose levels and nilotinib efficacy. Blood 2007; 110: 4588
126. Saglio G, Larson RA, Hughes TP, Issaragrisil S, Turkina AG, Marin D, et al. Efficacy and safety of nilotinib in chronic phase (CP) chronic myeloid leukemia (CML) patients (Pts) with type 2 diabetes in the ENESTnd trial. Blood 2010; 116: 3430
127. Rea D, Gautier JF, Breccia M, Saglio G, Hughes TP, Kantarjian HM, et al. Incidence of Hyperglycemia by 3 Years in Patients (Pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Treated with Nilotinib (NIL) or Imatinib (IM) in ENESTnd. Blood 2012; 120: 1686
128. Breccia M, Muscaritoli M, Cannella L, Stefanizzi C, Frustaci A, Alimena G. Fasting glucose improvement under dasatinib treatment in an accelerated phase chronic myeloid leukemia patient unresponsive to imatinib and nilotinib. Leuk Res 2008; 32: 1626-1628
129. Agostino NM, Chinchilli VM, Lynch CJ, Koszyk-Szewczyk A, Gingrich R, Sivik J, et al. Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practice. J Oncol Pharm Pract 2011; 17: 197-202
130. Larson R, le Coutre P, Reiffers J, Hughes TP, Saglio G, Edrich P, et al. Comparison of nilotinib and imatinib in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd beyond one year. ASCO Meeting Abstracts 2008; 26(15-suppl): 6501
131. Gottardi M, Manzato E, Gherlinzoni F. Imatinib and hyperlipidemia. N Engl J Med 2005; 353: 2722-2723
132. Franceschino A, Tornaghi L, Benemacher V, Assouline S, Gambacorti-Passerini C. Alterations in creatine kinase, phosphate and lipid values in patients with chronic myeloid leukemia during treatment with imatinib. Haematologica 2008; 93: 317-318
133. Gologan R, Constantinescu G, Georgescu D, Ostroveanu D, Vasilache D, Dobrea C, et al. Hypolipemiant besides antileukemic effect of imatinib mesylate. Leuk Res 2009; 33: 1285-1287
134. Rea D, Mirault T, Cluzeau T, Gautier JF, Guilhot F, Dombret H, et al. Early onset hypercholesterolemia induced by the second generation tyrosine kinase inhibitor nilotinib in patients with chronic phase-chronic myeloid leukemia. Haematologica 2014; 99: 1197-1203
135. Cortes JE, Kantarjian H, Shah NP, Bixby D, Mauro MJ, Flinn I, et al. Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med 2012; 367: 2075-2088
136. Hiwase DK, Yeung DT, Carne L. Hypercholesterolemia in imatinib intolerant/resistant CML-CP patients treated with nilotinib: a retrospective analysis. Blood 2013; 122: 1503
137. Berman E, Nicolaides M, Maki RG, Fleisher M, Chanel S, Scheu K, et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006; 354: 2006-2013
138. Osorio S, Noblejas AG, Duran A, Steegmann JL. Imatinib mesylate induces hypophosphatemia in patients with chronic myeloid leukemia in late chronic phase, and this effect is associated with response. Am J Hematol 2007; 82: 394-395
139. Berman E, Girotra M, Cheng C, Chanel S, Maki R, Shelat M, et al. Effect of long term imatinib on bone in adults with chronic myelogenous leukemia and gastrointestinal stromal tumors. Leuk Res 2013; 37: 790-794
140. Kim TD, Schwarz M, Nogai H, Grille P, Westermann J, Plockinger U, et al. Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia. Thyroid 2010; 20: 1209-1214
141. Gambacorti-Passerini C, Tornaghi L, Cavagnini F, Rossi P, Pecori-Giraldi F, Mariani L, et al. Gynaecomastia in men with chronic myeloid leukaemia after imatinib. Lancet 2003; 361: 1954-1956
142. Caocci G, Atzeni S, Orru N, Azzena L, Martorana L, Littera R, et al. Gynecomastia in a male after dasatinib treatment for chronic myeloid leukemia. Leukemia 2008; 22: 2127-2128
143. Sneed TB, Kantarjian HM, Talpaz M, O'Brien S, Rios MB, Bekele BN, et al. The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase. Cancer 2004; 100: 116-121
144. Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia. Blood 2013; 122: 872-884
145. NCCN. Chronic Myelogenous leukemia. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) version 3.2013. Available at http://www.nccn.org/professionals/physician-gls/pdf/cml.pdf
146. Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006; 108: 1809-1820
147. Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J, et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009; 27: 6041-6051
148. Kantarjian H, Talpaz M, O'Brien S, Garcia-Manero G, Verstovsek S, Giles F, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 2004; 103: 2873-2878
149. Kantarjian HM, Giles F, Gattermann N, Bhalla K, Alimena G, Palandri F, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007; 110: 3540-3546
150. Hochhaus A, Baccarani M, Deininger M, Apperley JF, Lipton JH, Goldberg SL, et al. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia 2008; 22: 1200-1206
151. Cortes JE, Kantarjian HM, Goldberg SL, Powell BL, Giles FJ, Wetzler M, et al. High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responses. J Clin Oncol 2009; 27: 4754-4759
152. Cortes JE, Jones D, O'Brien S, Jabbour E, Konopleva M, Ferrajoli A, et al. Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase. J Clin Oncol 2010; 28: 392-397
153. Rosti G, Palandri F, Castagnetti F, Breccia M, Levato L, Gugliotta G, et al. Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia. Blood 2009; 114: 4933-4938
154. Castagnetti F, Palandri F, Amabile M, Testoni N, Luatti S, Soverini S, et al. Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: a phase 2 trial of the GIMEMA CML Working Party. Blood 2009; 113: 3428-3434
155. Preudhomme C, Guilhot J, Nicolini FE, Guerci-Bresler A, Rigal-Huguet F, Maloisel F, et al. Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med 2010; 363: 2511-2521
156. Radich JP, Kopecky KJ, Appelbaum FR, Kamel-Reid S, Stock W, Malnassy G, et al. A randomized trial of dasatinib 100 mg vs imatinib 400 mg in newly diagnosed chronic phase chromic myeloid leukemia. Blood 2012; 120: 3898-3905
157. Baccarani M, Druker BJ, Branford S, Kim DW, Pane F, Mongay L, et al. Long-Term response to imatinib is not affected by the initial dose in patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: final update from the Tyrosine Kinase Inhibitor Optimization and Selectivity (TOPS) study. Int J Hematol 2014; 99: 616-624
158. Cortes JE, Jones D, O'Brien S, Jabbour E, Ravandi F, Koller C, et al. Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia. J Clin Oncol 2010; 28: 398-404
159. Wang J, Shen ZX, Saglio G, Jin J, Huang H, Hu Y, et al. Phase 3 study of nilotinib vs imatinib in Chinese patients with newly diagnosed chronic myeloid leukemia in chronic phase: ENESTchina. Blood 2015; 125: 2771-2778
160. Guilhot F, Hughes TP, Cortes J, Druker BJ, Baccarani M, Gathmann I, et al. Plasma exposure of imatinib and its correlation with clinical response in the Tyrosine Kinase Inhibitor Optimization and Selectivity Trial. Haematologica 2012; 97: 731-738
161. Proetel U, Pletsch N, Lauseker M, Muller MC, Hanfstein B, Krause SW, et al. Older patients with chronic myeloid leukemia (X65 years) profit more from higher imatinib doses than younger patients: a subanalysis of the randomized CML-Study IV. Ann Hematol 2014; 93: 1167-1176
162. Cortes J, Hochhaus A, Kim DW, Shah NP, Mayer J, Rowlings P, et al. Four-year (Yr) follow-up of patients (Pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) receiving dasatinib or imatinib: efficacy based on early response. Blood 2013; 122: 653
163. Futosi K, Nemeth T, Pick R, Vantus T, Walzog B, Mocsai A. Dasatinib inhibits proinflammatory functions of mature human neutrophils. Blood 2012; 119: 4981-4991
164. Quintas-Cardama A, Kantarjian H, Ravandi F, O'Brien S, Thomas D, Vidal-Senmache G, et al. Bleeding diathesis in patients with chronic myelogenous leukemia receiving dasatinib therapy. Cancer 2009; 115: 2482-2490
165. Nazha A, Romo CG, Kantarjian H, Cortes J. The clinical impact of ponatinib on the risk of bleeding in patients with chronic myeloid leukemia. Haematologica 2013; 98: e131
166. Gratacap MP, Martin V, Valera MC, Allart S, Garcia C, Sie P, et al. The new tyrosinekinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo. Blood 2009; 114: 1884-1892
167. Quintas-Cardama A, Han X, Kantarjian H, Cortes J. Tyrosine kinase inhibitorinduced platelet dysfunction in patients with chronic myeloid leukemia. Blood 2009; 114: 261-263
168. Neelakantan P, Marin D, Laffan M, Goldman J, Apperley J, Milojkovic D. Platelet dysfunction associated with ponatinib, a new pan BCR-ABL inhibitor with efficacy for chronic myeloid leukemia resistant to multiple tyrosine kinase inhibitor therapy. Haematologica 2012; 97: 1444
169. Marin D, Marktel S, Bua M, Szydlo RM, Franceschino A, Nathan I, et al. Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa. Leukemia 2003; 17: 1448-1453
170. Cortes J, O'Brien S, Quintas A, Giles F, Shan J, Rios MB, et al. Erythropoietin is effective in improving the anemia induced by imatinib mesylate therapy in patients with chronic myeloid leukemia in chronic phase. Cancer 2004; 100: 2396-2402
171. Gallipoli P, Pellicano F, Morrison H, Laidlaw K, Allan EK, Bhatia R, et al. Autocrine TNF-Alpha production supports CML stem and progenitor cell survival and enhances their proliferation. Blood 2013; 122: 3335-3339
172. Jorgensen HG, Copland M, Holyoake TL. Granulocyte-colony-stimulating factor (Filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase myelogenous leukemia. Cancer 2005; 103: 210-211
173. Khoury HJ, Goldberg SL, Mauro MJ. Dasatinib lack of cross intolerance to imatinib in patients (pts) with chronic myelogenous leukemia chronic phase (CML-CP) intolerant to imatinib: a retrospective analysis of safety. ASCO Meeting Abstracts 2008; 26(15-suppl): 7015
174. Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355: 2408-2417
175. Deininger MW, Kopecky KJ, Radich JP, Kamel-Reid S, Stock W, Paietta E, et al. Imatinib 800 mg daily induces deeper molecular responses than imatinib 400 mg daily: results of SWOG S0325, an intergroup randomized PHASE II trial in newly diagnosed chronic phase chronic myeloid leukaemia. Br J Haematol 2014; 164: 223-232
176. Efficace F, Baccarani M, Breccia M, Alimena G, Rosti G, Cottone F, et al. Health-related quality of life in chronic myeloid leukemia patients receiving long-Term therapy with imatinib compared with the general population. Blood 2011; 118: 4554-4560
177. Joensuu H, Trent JC, Reichardt P. Practical management of tyrosine kinase inhibitor-Associated side effects in GIST. Cancer Treat Rev 2011; 37: 75-88
178. Kantarjian H, Shah NP, Hochhaus A, Cortes JE, Shah S, Ayala M, et al. Dasatinib compared to imatinib (IM) in patients (pts) with newly diagnosed chronic-phase chronic myelogenous leukemia in chronic phase (CML-CP): Twelve-month efficacy and safety from the phase III DASISION study. ASCO Meeting Abstracts 2010; 28(18-suppl): 6500
179. Palandri F, Castagnetti F, Soverini S, Poerio A, Gugliotta G, Luatti S, et al. Pancreatic enzyme elevation in chronic myeloid leukemia patients treated with nilotinib after imatinib failure. Haematologica 2009; 94: 1758-1761
180. Nicolini FE, Masszi T, Shen Z, Gallagher NJ, Jootar S, Powell BL, et al. Expanding Nilotinib Access in Clinical Trials (ENACT), an open-label multicenter study of oral nilotinib in adult patients with imatinib-resistant or-intolerant chronic myeloid leukemia in accelerated phase or blast crisis. Leuk Lymphoma 2012; 53: 907-914
181. Brazzelli V, Grasso V, Borroni G. Imatinib, dasatinib and nilotinib: a review of adverse cutaneous reactions with emphasis on our clinical experience. J Eur Acad Dermatol Venereol 2013; 27: 1471-1480
182. Cortes JE, Baccarani M, Guilhot F, Druker BJ, Branford S, Kim DW, et al. Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimization and selectivity study. J Clin Oncol 2010; 28: 424-430
183. Valeyrie L, Bastuji-Garin S, Revuz J, Bachot N, Wechsler J, Berthaud P, et al. Adverse cutaneous reactions to imatinib (STI571) in Philadelphia chromosomepositive leukemias: a prospective study of 54 patients. J Am Acad Dermatol 2003; 48: 201-206
184. Drummond A, Micallef-Eynaud P, Douglas WS, Hay I, Holyoake TL, Drummond MW. A spectrum of skin reactions caused by the tyrosine kinase inhibitor imatinib mesylate (STI 571, Glivec). Br J Haematol 2003; 120: 911-913
185. Amitay-Laish I, Stemmer SM, Lacouture ME. Adverse cutaneous reactions secondary to tyrosine kinase inhibitors including imatinib mesylate, nilotinib, and dasatinib. Dermatol Ther 2011; 24: 386-395
186. Scheinfeld N. Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. J Drugs Dermatol 2006; 5: 228-231
187. Hensley ML, Ford JM. Imatinib treatment: specific issues related to safety, fertility, and pregnancy. Semin Hematol 2003; 40 (2 Suppl 2): 21-25
188. Breccia M, Carmosino I, Russo E, Morano SG, Latagliata R, Alimena G. Early and tardive skin adverse events in chronic myeloid leukaemia patients treated with imatinib. Eur J Haematol 2005; 74: 121-123
189. Leong KW, Lee TC, Goh AS. Imatinib mesylate causes hypopigmentation in the skin. Cancer 2004; 100: 2486-2487, author reply 2487-2488
190. Llamas-Velasco M, Fraga J, Kutzner H, Steegmann JL, Garcia-Diez A, Requena L. Hypopigmented macules secondary to imatinib for the treatment of chronic myeloid leukemia: a histopathologic and immunohistochemical study. J Cutan Pathol 2014; 41: 417-426
191. Brazzelli V, Prestinari F, Barbagallo T, Rona C, Orlandi E, Passamonti F, et al. A long-Term time course of colorimetric assessment of the effects of imatinib mesylate on skin pigmentation: a study of five patients. J Eur Acad Dermatol Venereol 2007; 21: 384-387
192. Etienne G, Cony-Makhoul P, Mahon FX. Imatinib mesylate and gray hair. N Engl J Med 2002; 347: 446
193. Mariani S, Abruzzese E, Basciani S, Fiore D, Persichetti A, Watanabe M, et al. Reversible hair depigmentation in a patient treated with imatinib. Leuk Res 2011; 35: e64-e66
194. Gambacorti-Passerini C, Piazza R. Choosing the right TKI for chronic myeloid leukemia: when the truth lies in long-Term safety and efficacy. Am J Hematol 2011; 86: 531-532
195. Llamas-Velasco M, Fraga J, Solano-Lopez GE, Steegmann JL, Garcia Diez A, Requena L. Multiple eruptive dermatofibromas related to imatinib treatment. J Eur Acad Dermatol Venereol 2014; 28: 979-981
196. Breccia M, Latagliata R, Carmosino I, Mandelli F, Alimena G. Reactivation of porphyria cutanea tarda as a possible side effect of Imatinib at high dosage in chronic myeloid leukemia. Leukemia 2004; 18: 182
197. Kantarjian HM, Hochhaus A, Saglio G, De Souza C, Flinn IW, Stenke L, et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011; 12: 841-851
198. Drucker AM, Wu S, Busam KJ, Berman E, Amitay-Laish I, Lacouture ME. Rash with the multitargeted kinase inhibitors nilotinib and dasatinib: meta-Analysis and clinical characterization. Eur J Haematol 2013; 90: 142-150
199. Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354: 2542-2551
200. Kaune KM, Baumgart M, Gesk S, Mitteldorf C, Baesecke J, Glass B, et al. Bullous sweet syndrome in a patient with t(9; 22)(q34; q11)-positive chronic myeloid leukemia treated with the tyrosine kinase inhibitor nilotinib: interphase cytogenetic detection of BCR-ABL-positive lesional cells. Arch Dermatol 2008; 144: 361-364
201. Ogura M, Nakamae H, Fujisawa S, Ishizawa K, Taniwaki M, Utsunomiya A, et al. Dasatinib compared with imatinib in newly diagnosed chronic myelogenous leukemia in chronic phase (CML-CP): results of Japanese Subset Analysis In DASISION Trial. ASH Annual Meeting Abstracts 2010; 116: 4484
202. Saglio G, Hochhaus A, Cortes JE, Kantarjian H, Baccarani M, Bradley-Garelik MB, et al. Safety and efficacy of dasatinib versus imatinib by baseline cardiovascular comorbidity in patients with chronic myeloid leukemia in chronic phase (CML-CP): analysis of the DASISION Trial. ASH Annual Meeting Abstracts 2010; 116: 2286
203. Breccia M, Alimena G. Activity and safety of dasatinib as second-line treatment or in newly diagnosed chronic phase chronic myeloid leukemia patients. Bio-Drugs 2011; 25: 147-157
204. Deininger MW, O'Brien SG, Ford JM, Druker BJ. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 2003; 21: 1637-1647
205. Rule SA, O'Brien SG, Crossman LC. Managing cutaneous reactions to imatinib therapy. Blood 2002; 100: 3434-3435
206. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331: 1272-1285
207. Khoury HJ, Guilhot F, Hughes TP, Kim DW, Cortes JE. Dasatinib treatment for Philadelphia chromosome-positive leukemias: practical considerations. Cancer 2009; 115: 1381-1394
208. Seggewiss R, Price DA, Purbhoo MA. Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update. Cytotherapy 2008; 10: 633-641
209. Salih J, Hilpert J, Placke T, Grunebach F, Steinle A, Salih HR, et al. The BCR/ABLinhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivity. Int J Cancer 2010; 127: 2119-2128
210. Breccia M, Girmenia C, Latagliata R, Loglisci G, Santopietro M, Federico V, et al. Low incidence rate of opportunistic and viral infections during imatinib treatment in chronic myeloid leukemia patients in early and late chronic phase. Mediterr J Hematol Infect Dis 2011; 3: e2011021
211. Mattiuzzi GN, Cortes JE, Talpaz M, Reuben J, Rios MB, Shan J, et al. Development of Varicella-Zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate. Clin Cancer Res 2003; 9: 976-980
212. Lakhani S, Davidson L, Priebat DA, Sherker AH. Reactivation of chronic hepatitis B infection related to imatinib mesylate therapy. Hepatol Int 2008; 2: 498-499
213. Daniels JM, Vonk-Noordegraaf A, Janssen JJ, Postmus PE, van Altena R. Tuberculosis complicating imatinib treatment for chronic myeloid leukaemia. Eur Respir J 2009; 33: 670-672
214. Agaimy A, Brueckl V, Schmidt D, Krieg S, Ullrich E, Meidenbauer N. Tuberculous and non-Tuberculous granulomatous lymphadenitis in patients receiving imatinib mesylate (glivec) for metastatic gastrointestinal stromal tumor. Case Rep Oncol 2013; 6: 134-142
215. Sanchez-Guijo FM, Duran S, Galende J, Boque C, Nieto JB, Balanzat J, et al. Evaluation of tolerability and efficacy of imatinib mesylate in elderly patients with chronic phase CML: ELDERGLI study. Leuk Res 2011; 35: 1184-1187
216. Koren-Michowitz M, le Coutre P, Duyster J, Scheid C, Panayiotidis P, Prejzner W, et al. Activity and tolerability of nilotinib: a retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerant. Cancer 2010; 116: 4564-4572
217. Hazarika M, Jiang X, Liu Q, Lee SL, Ramchandani R, Garnett C, et al. Tasigna for chronic and accelerated phase Philadelphia chromosome-positive chronic myelogenous leukemia resistant to or intolerant of imatinib. Clin Cancer Res 2008; 14: 5325-5331
218. Rodriguez GH, Ahmed SI, Al-Akhrass F, Rallapalli V, Safdar A. Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complications. Leuk Lymphoma 2012; 53: 1530-1535
219. Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, Bohm A, et al. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest 2009; 39: 1098-1109
220. Kantarjian H, Shah NP, Cortes JE, Baccarani M, Bradley-Garelik MB, Zhu C, et al. Dasatinib or imatinib (IM) in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): two-year follow-up from DASISION. ASCO Meeting Abstracts 2011; 29(15-suppl): 6510
221. de Lavallade H, Khoder A, Hart M, Sarvaria A, Sekine T, Alsuliman A, et al. Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-Target inhibition of kinases important for cell signaling. Blood 2013; 122: 227-238
222. Kim S-H, Kim HJ, Kwak J-Y, Kim JS, Mun Y-C, Park JS, et al. Hepatitis B virus reactivation in chronic myeloid leukemia treated with various tyrosine kinase inhibitors: multicenter, retrospective study. Blood 2012; 120: 3738
223. Kreutzman A, Ladell K, Koechel C, Gostick E, Ekblom M, Stenke L, et al. Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 2011; 25: 1587-1597
224. Tanaka H, Nakashima S, Usuda M. Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myelogenous leukemia patients. Int J Hematol 2012; 96: 308-319
225. Mustjoki S, Ekblom M, Arstila TP, Dybedal I, Epling-Burnette PK, Guilhot F, et al. Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia 2009; 23: 1398-1405
226. Sunami Y, Sato E, Ichikawa K, Yasuda H, Komatsu N. Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase. Rinsho Ketsueki 2011; 52: 282-286
227. Kim DH, Kamel-Reid S, Chang H, Sutherland R, Jung CW, Kim HJ, et al. Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia. Haematologica 2009; 94: 135-139
228. Lee SJ, Jung CW, Kim DY, Lee KH, Sohn SK, Kwak JY, et al. Retrospective multicenter study on the development of peripheral lymphocytosis following secondline dasatinib therapy for chronic myeloid leukemia. Am J Hematol 2011; 86: 346-350
229. Mustjoki S, Auvinen K, Kreutzman A, Rousselot P, Hernesniemi S, Melo T, et al. Rapid mobilization of cytotoxic lymphocytes induced by dasatinib therapy. Leukemia 2013; 27: 914-924
230. Cortes J, Saglio G, le Coutre PD, Porkka K, Mustjoki S, Mohamed H, et al. The association of dasatinib-induced lymphocytosis with treatment outcome in patients with chronic myeloid leukemia (CML). Blood 2013; 122: 2741
231. Nagata Y, Ohashi K, Fukuda S, Kamata N, Akiyama H, Sakamaki H. Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion. Int J Hematol 2010; 91: 799-807
232. Paydas S. Dasatinib, large granular lymphocytosis, and pleural effusion: useful or adverse effect? Crit Rev Oncol Hematol 2014; 89: 242-247
233. Schiffer C, Cortes J, Saglio G, le Coutre P, Guilhot F, Chen A, et al. Lymphocytosis following first-line treatment for cml in chronic phase with dasatinib is associated with improved responses: a comparison with imatinib. Blood 2010; 116: 358
234. Efficace F, Breccia M, Saussele S, Kossak-Roth U, Cardoni A, Caocci G, et al. Which health-related quality of life aspects are important to patients with chronic myeloid leukemia receiving targeted therapies and to health care professionals? GIMEMA and EORTC Quality of Life Group. Ann Hematol 2012; 91: 1371-1381
235. Zekri JM, Robinson MH, Woll PJ. Relative hypocalcaemia and muscle cramps in patients receiving imatinib for gastrointestinal stromal tumour. Sarcoma 2006; 2006: 48948
236. Dogan SS, Esmaeli B. Ocular side effects associated with imatinib mesylate and perifosine for gastrointestinal stromal tumor. Hematol Oncol Clin North Am 2009; 23: 109-114, ix
237. Ho WL, Wong H, Yau T. The ophthalmological complications of targeted agents in cancer therapy: what do we need to know as ophthalmologists? Acta Ophthalmol 2013; 91: 604-609
238. Esmaeli B, Diba R, Ahmadi MA, Saadati HG, Faustina MM, Shepler TR, et al. Periorbital oedema and epiphora as ocular side effects of imatinib mesylate (Gleevec). Eye 2004; 18: 760-762
239. Radaelli F, Vener C, Ripamonti F, Iurlo A, Colombi M, Artoni A, et al. Conjunctival hemorrhagic events associated with imatinib mesylate. Int J Hematol 2007; 86: 390-393
240. Kwon SI, Lee DH, Kim YJ. Optic disc edema as a possible complication of Imatinib mesylate (Gleevec). Jpn J Ophthalmol 2008; 52: 331-333
241. Govind Babu K, Attili VS, Bapsy PP, Anupama G. Imatinib-induced optic neuritis in a patient of chronic myeloid leukemia. Int Ophthalmol 2007; 27: 43-44
242. eMC TeMC. Tasigna SPC. Datapharm Communications Limited 2015. Available at http//www.medicines.org.uk/emc/medicine/24089
243. eMC TeMC. Sprycel SPC. Datapharm Communications Limited 2015. Available at http//www.medicines.org.uk/emc/medicine/26080
244. eMC TeMC. Bosulif. SPC. Datapharm Communivations Limited 2015. Available at http//www.medicines.org.uk/emc/print-document'documentId = 27795
245. eMC TeMC. Iclusig. SPC. Datapharm Communications limited 2015. Available at http//www.medicines.org.uk/emc/medicine/28145
246. McClelland CM, Harocopos GJ, Custer PL. Periorbital edema secondary to imatinib mesylate. Clin Ophthalmol 2010; 4: 427-431
247. eMC TeMC. Glivec SPC. Datapharm Communications Limited 2015. Available at http//www.medicines.org.uk/emc/medicine/15014
248. Milojkovic D, Apperley JF. How I treat leukemia during pregnancy. Blood 2014; 123: 974-984
249. EMEA Glivec: EPAR Product Information EMEA: London, UK, 2015
250. EMEA. Tasigna: EPAR product Information EMEA: London, UK, 2015
251. EMEA. Sprycel. Product Information EMEA: London, UK, 2015
252. EMEA. Bosulif. EPAR Product Information EMEA: London, UK, 2015
253. EMEA. Iclusig: EPAR Product Information EMEA: London, UK, 2015
254. Ross DM. Peripheral neuropathy on imatinib treatment for chronic myeloid leukaemia: suspected adverse drug interaction with amlodipine. Intern Med J 2009; 39: 708
255. Chakupurakal G, Etti RJ, Murray JA. Peripheral neuropathy as an adverse effect of imatinib therapy. J Clin Pathol 2011; 64: 456
256. Ebnoether M, Stentoft J, Ford J, Buhl L, Gratwohl A. Cerebral oedema as a possible complication of treatment with imatinib. Lancet 2002; 359: 1751-1752
257. Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001; 344: 1038-1042
258. Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-1037
259. Marcolino MS, Boersma E, Clementino NC, Macedo AV, Marx-Neto AD, Silva MH, et al. Imatinib treatment duration is related to decreased estimated glomerular filtration rate in chronic myeloid leukemia patients. Ann Oncol 2011; 22: 2073-2079
260. Kitiyakara C, Atichartakarn V. Renal failure associated with a specific inhibitor of BCR-ABL tyrosine kinase, STI 571. Nephrol Dial Transplant 2002; 17: 685-687
261. Gafter-Gvili A, Ram R, Gafter U, Shpilberg O, Raanani P. Renal failure associated with tyrosine kinase inhibitors-case report and review of the literature. Leuk Res 2010; 34: 123-127
262. Pou M, Saval N, Vera M, Saurina A, Sole M, Cervantes F, et al. Acute renal failure secondary to imatinib mesylate treatment in chronic myeloid leukemia. Leuk Lymphoma 2003; 44: 1239-1241
263. Al Aly Z, Philoctete Ashley JM, Gellens ME, Gonzalez EA. Thrombotic thrombocytopenic purpura in a patient treated with imatinib mesylate: true association or mere coincidence? Am J Kidney Dis 2005; 45: 762-768
264. Foringer JR, Verani RR, Tjia VM, Finkel KW, Samuels JA, Guntupalli JS. Acute renal failure secondary to imatinib mesylate treatment in prostate cancer. Ann Pharmacother 2005; 39: 2136-2138
265. Francois H, Coppo P, Hayman JP, Fouqueray B, Mougenot B, Ronco P. Partial fanconi syndrome induced by imatinib therapy: a novel cause of urinary phosphate loss. Am J Kidney Dis 2008; 51: 298-301
266. Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354: 2531-2541
267. Guilhot F, Apperley J, Kim DW, Bullorsky EO, Baccarani M, Roboz GJ, et al. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in accelerated phase. Blood 2007; 109: 4143-4150
268. Holstein SA, Stokes JB, Hohl RJ. Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia. Leuk Res 2009; 33: 344-347
269. Kaiafa G, Kakaletsis N, Savopoulos C, Perifanis V, Giannouli A, Papadopoulos N, et al. Simultaneous manifestation of pleural effusion and acute renal failure associated with dasatinib: a case report. J Clin Pharm Ther 2014; 39: 102-105
270. Ozkurt S, Temiz G, Acikalin MF, Soydan M. Acute renal failure under dasatinib therapy. Ren Fail 2010; 32: 147-149
271. Martino S, Daguindau E, Ferrand C, Bamoulid J, Hayette S, Nicolini FE, et al. A successful renal transplantation for renal failure after dasatinib-induced thrombotic thrombocytopenic purpura in a patient with imatinib-resistant chronic myelogenous leukaemia on nilotinib. Leuk Res Rep 2013; 2: 29-31
272. Sonmez M, Ovali E, Omay SB. Tumor lysis syndrome during treatment with AMN107 (Nilotinib) in a patient with chronic myelogenous leukemia accelerated phase. J Clin Pharm Ther 2008; 33: 91-92
273. Iyoda M, Shibata T, Hirai Y, Kuno Y, Akizawa T. Nilotinib attenuates renal injury and prolongs survival in chronic kidney disease. J Am Soc Nephrol 2011; 22: 1486-1496
274. Sonmez M, Cobanoglu U, Ovali E, Omay SB. Use of dasatinib in the patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia with resistance to imatinib and renal failure. J Clin Pharm Ther 2008; 33: 329-330
275. Onaka T, Takahashi N, Miura M, Yonezawa A, Imada K, Sawada K. Pharmacokinetics of nilotinib in imatinib-resistant/intolerant chronic myeloid leukemia patients on hemodialysis for chronic renal failure. Am J Hematol 2012; 87: 451
276. Efficace F, Breccia M, Francesco LC. Patient-reported outcomes in acute leukemia: a roadmap for future research. Eur J Haematol 2014; 93: 86-87