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Volumn 89, Issue 2, 2014, Pages 242-247

Dasatinib, large granular lymphocytosis, and pleural effusion: Useful or adverse effect?

Author keywords

Chronic myeloid leukemia; Dasatinib; Immune regulation; Large granular lymphocytosis; Pleural effusion; Response

Indexed keywords

DASATINIB;

EID: 84892527099     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2013.10.005     Document Type: Review
Times cited : (35)

References (44)
  • 1
    • 70249141675 scopus 로고    scopus 로고
    • Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial
    • Apperley J.F., Cortes J.E., Kim D.W., et al. Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial. J Clin Oncol 2009, 27:3472-3479.
    • (2009) J Clin Oncol , vol.27 , pp. 3472-3479
    • Apperley, J.F.1    Cortes, J.E.2    Kim, D.W.3
  • 2
    • 34548097263 scopus 로고    scopus 로고
    • The Btk tyrosine kinase is a majör target of the Bcr-Abl inhibitör dasatinib
    • Hantschel O., Rix U., Schmidt U., et al. The Btk tyrosine kinase is a majör target of the Bcr-Abl inhibitör dasatinib. Proc Natl Acad Sci USA 2007, 104:13283-13288.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13283-13288
    • Hantschel, O.1    Rix, U.2    Schmidt, U.3
  • 3
    • 37049014938 scopus 로고    scopus 로고
    • Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets
    • Rix U., Hantschel O., Dürnberger G., et al. Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood 2007, 110:4055-4063.
    • (2007) Blood , vol.110 , pp. 4055-4063
    • Rix, U.1    Hantschel, O.2    Dürnberger, G.3
  • 4
    • 34948875686 scopus 로고    scopus 로고
    • Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    • Bantscheff M., Eberhard D., Abraham Y., et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol 2007, 25:1035-1044.
    • (2007) Nat Biotechnol , vol.25 , pp. 1035-1044
    • Bantscheff, M.1    Eberhard, D.2    Abraham, Y.3
  • 5
    • 84867399697 scopus 로고    scopus 로고
    • Killer-cell immunoglobulin-like receptor gene profile predicts good molecular response to dasatinib therapy in chronic myeloid leukemia
    • Kreutzman A., Jaatinen T., Greco D., et al. Killer-cell immunoglobulin-like receptor gene profile predicts good molecular response to dasatinib therapy in chronic myeloid leukemia. Exper Hematol 2012, 40:906-913.
    • (2012) Exper Hematol , vol.40 , pp. 906-913
    • Kreutzman, A.1    Jaatinen, T.2    Greco, D.3
  • 6
    • 34548798651 scopus 로고    scopus 로고
    • Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia
    • Savani B.N., Mielke S., Adams S., et al. Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia. Leukemia 2007, 21:21452152.
    • (2007) Leukemia , vol.21 , pp. 21452152
    • Savani, B.N.1    Mielke, S.2    Adams, S.3
  • 7
    • 58249105216 scopus 로고    scopus 로고
    • Does chemotherapy modify the immune surveillance of hematological malignancies
    • Barrett A.J., Savani B.N. Does chemotherapy modify the immune surveillance of hematological malignancies. Leukemia 2009, 23:53-58.
    • (2009) Leukemia , vol.23 , pp. 53-58
    • Barrett, A.J.1    Savani, B.N.2
  • 8
    • 45449102076 scopus 로고    scopus 로고
    • The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro
    • Blake S., Hughes T.P., Mayrhofer G., Lyons A.B. The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro. Clin Immunol 2008, 127:330-339.
    • (2008) Clin Immunol , vol.127 , pp. 330-339
    • Blake, S.1    Hughes, T.P.2    Mayrhofer, G.3    Lyons, A.B.4
  • 9
    • 52049085750 scopus 로고    scopus 로고
    • Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens
    • Fei F., Yu Y., Schmitt A., et al. Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens. Exp Hematol 2008, 36:1297-1308.
    • (2008) Exp Hematol , vol.36 , pp. 1297-1308
    • Fei, F.1    Yu, Y.2    Schmitt, A.3
  • 10
    • 38949210227 scopus 로고    scopus 로고
    • A small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation
    • Schade A.E., Schieven G.L., Townsend R., et al. a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood 2008, 111:1366-1377.
    • (2008) Blood , vol.111 , pp. 1366-1377
    • Schade, A.E.1    Schieven, G.L.2    Townsend, R.3
  • 11
    • 77954536015 scopus 로고    scopus 로고
    • Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion
    • Nagata Y., Ohashi K., Fukuda S., Kamata N., Akiyama H., Sakamaki H. Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion. Int J Hematol 2010, 91:799-807.
    • (2010) Int J Hematol , vol.91 , pp. 799-807
    • Nagata, Y.1    Ohashi, K.2    Fukuda, S.3    Kamata, N.4    Akiyama, H.5    Sakamaki, H.6
  • 12
    • 79958724618 scopus 로고    scopus 로고
    • Protein tyrosine kinases in neutrophil activation and recruitment
    • Zarbock A., Ley K. Protein tyrosine kinases in neutrophil activation and recruitment. Arch Biochem Biophys 2011, 510:112-119.
    • (2011) Arch Biochem Biophys , vol.510 , pp. 112-119
    • Zarbock, A.1    Ley, K.2
  • 13
    • 84866994124 scopus 로고    scopus 로고
    • A sharp fluctuation in peripheral blood cells shortly after dasatinib administration
    • Imagawa J., Tanaka H., Matsumoto K., Morito K., Harada Y., Harada H. A sharp fluctuation in peripheral blood cells shortly after dasatinib administration. In J Hematol 2012, 96:194-199.
    • (2012) In J Hematol , vol.96 , pp. 194-199
    • Imagawa, J.1    Tanaka, H.2    Matsumoto, K.3    Morito, K.4    Harada, Y.5    Harada, H.6
  • 14
    • 43449091001 scopus 로고    scopus 로고
    • Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis
    • Lavallade H., Punnialingam S., Milojkovic D., et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol 2008, 141:734-747.
    • (2008) Br J Haematol , vol.141 , pp. 734-747
    • Lavallade, H.1    Punnialingam, S.2    Milojkovic, D.3
  • 15
    • 75649105405 scopus 로고    scopus 로고
    • Dasatinib 100mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukaemia in chronic phase and efficacy is uneffected in patients who develop pleural effusion
    • Porkka K., Khoury J., Paquette R.L., et al. Dasatinib 100mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukaemia in chronic phase and efficacy is uneffected in patients who develop pleural effusion. Cancer 2010, 116:377-386.
    • (2010) Cancer , vol.116 , pp. 377-386
    • Porkka, K.1    Khoury, J.2    Paquette, R.L.3
  • 16
    • 68749108104 scopus 로고    scopus 로고
    • Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy
    • Mustjoki S., Ekblom M., Arstila T.P., et al. Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia 2009, 23:1398-1405.
    • (2009) Leukemia , vol.23 , pp. 1398-1405
    • Mustjoki, S.1    Ekblom, M.2    Arstila, T.P.3
  • 17
    • 35349001079 scopus 로고    scopus 로고
    • Lung abnormalities after dasatinib treatment for chronic myeloid leukaemia
    • Bergeron A., Rea D., Levy V., et al. Lung abnormalities after dasatinib treatment for chronic myeloid leukaemia. Am J Resp Crit Care Med 2007, 176:814-818.
    • (2007) Am J Resp Crit Care Med , vol.176 , pp. 814-818
    • Bergeron, A.1    Rea, D.2    Levy, V.3
  • 18
    • 84867023568 scopus 로고    scopus 로고
    • Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myeloid leukaemia patients
    • Tanaka H., Nakashima S., Usuda M. Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myeloid leukaemia patients. In J Hematol 2012, 10.1007/s12185-012-1132-8.
    • (2012) In J Hematol
    • Tanaka, H.1    Nakashima, S.2    Usuda, M.3
  • 19
    • 58149267985 scopus 로고    scopus 로고
    • Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia
    • Kim D.H., Kamel-Reid S., Chang H., et al. Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia. Haematologica 2009, 94:135-139.
    • (2009) Haematologica , vol.94 , pp. 135-139
    • Kim, D.H.1    Kamel-Reid, S.2    Chang, H.3
  • 20
    • 79953051767 scopus 로고    scopus 로고
    • Retrospective multicenter study on the development on the development of peripheral lymphocytosis following second-line dasatinib therapy for chronic myeloid leukaemia
    • Lee S.J., Jung C.W., Kim D.Y., et al. Retrospective multicenter study on the development on the development of peripheral lymphocytosis following second-line dasatinib therapy for chronic myeloid leukaemia. Am J Hematol 2011, 86:346-350.
    • (2011) Am J Hematol , vol.86 , pp. 346-350
    • Lee, S.J.1    Jung, C.W.2    Kim, D.Y.3
  • 21
    • 77956280601 scopus 로고    scopus 로고
    • Mono/oligoclonla T and NK cells are common in chronic myeloid leukaemia patients and expand during dasatinib therapy
    • Kreutzman A., Juvonen V., Kairisto V., et al. Mono/oligoclonla T and NK cells are common in chronic myeloid leukaemia patients and expand during dasatinib therapy. Blood 2010, 116:772-782.
    • (2010) Blood , vol.116 , pp. 772-782
    • Kreutzman, A.1    Juvonen, V.2    Kairisto, V.3
  • 22
    • 80054026109 scopus 로고    scopus 로고
    • Expansion of highly differentiated CD8+ T cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation
    • Kreutzman A., Ladell K., Koechel C., et al. Expansion of highly differentiated CD8+ T cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 2011, 25:1587-1597.
    • (2011) Leukemia , vol.25 , pp. 1587-1597
    • Kreutzman, A.1    Ladell, K.2    Koechel, C.3
  • 23
    • 78650171874 scopus 로고    scopus 로고
    • Prevalence of large granular lymphocytosis in patients with chronic myelogenous leukemia (CML)
    • Valent J.N., Schiffer C.A. Prevalence of large granular lymphocytosis in patients with chronic myelogenous leukemia (CML). Leuk Res 2011, 35:e1-e3.
    • (2011) Leuk Res , vol.35
    • Valent, J.N.1    Schiffer, C.A.2
  • 24
    • 77952302554 scopus 로고    scopus 로고
    • Clinical profiles of 7 patients with chronic myelogenous leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib
    • Hoshino T., Tahara K., Miyawaki K., et al. Clinical profiles of 7 patients with chronic myelogenous leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib. Rinsho Ketsueki. 2010, 51:181-188.
    • (2010) Rinsho Ketsueki. , vol.51 , pp. 181-188
    • Hoshino, T.1    Tahara, K.2    Miyawaki, K.3
  • 25
    • 0029984379 scopus 로고    scopus 로고
    • Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture
    • Cervantes F., Pierson B.A., McGlave P.B., Verfaillie C.M., Miller J.S. Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture. Blood 1996, 87:2476-2485.
    • (1996) Blood , vol.87 , pp. 2476-2485
    • Cervantes, F.1    Pierson, B.A.2    McGlave, P.B.3    Verfaillie, C.M.4    Miller, J.S.5
  • 26
    • 9344233330 scopus 로고    scopus 로고
    • Generation of activated natural killer (A-NK) cells in patients with chronic myelogenous leukemia and their role in the in vitro disappearance of BCR/ABL-positive targets
    • Silla L.M., Pincus S.M., Locker J.D., et al. Generation of activated natural killer (A-NK) cells in patients with chronic myelogenous leukemia and their role in the in vitro disappearance of BCR/ABL-positive targets. Br J Haematol 1996, 93:375-385.
    • (1996) Br J Haematol , vol.93 , pp. 375-385
    • Silla, L.M.1    Pincus, S.M.2    Locker, J.D.3
  • 27
    • 0036210733 scopus 로고    scopus 로고
    • A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors
    • Lowin-kropf B., Schneider P., Held W. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol 2002, 32:773-782.
    • (2002) Eur J Immunol , vol.32 , pp. 773-782
    • Lowin-kropf, B.1    Schneider, P.2    Held, W.3
  • 28
    • 22344436371 scopus 로고    scopus 로고
    • Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
    • Bloch-Queyrat C., Fondaneche M.C., Chen R., et al. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J Exp Med 2005, 202:181-192.
    • (2005) J Exp Med , vol.202 , pp. 181-192
    • Bloch-Queyrat, C.1    Fondaneche, M.C.2    Chen, R.3
  • 29
    • 0028828062 scopus 로고
    • Phosphorylation of src family tyrosine kinase following interleukin-12 activation of human natural killer cells
    • Pignata C., Prasad K.V., Hallek M., et al. Phosphorylation of src family tyrosine kinase following interleukin-12 activation of human natural killer cells. Cell Immunol 1995, 165:211-216.
    • (1995) Cell Immunol , vol.165 , pp. 211-216
    • Pignata, C.1    Prasad, K.V.2    Hallek, M.3
  • 30
    • 0029057410 scopus 로고
    • Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells
    • Ting T., Dick C.J., Schoon R., Karnitz L.M., Abraham R.T., Leibson P.J. Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells. J Biol Chem 1995, 270:16415-16421.
    • (1995) J Biol Chem , vol.270 , pp. 16415-16421
    • Ting, T.1    Dick, C.J.2    Schoon, R.3    Karnitz, L.M.4    Abraham, R.T.5    Leibson, P.J.6
  • 31
    • 0032723181 scopus 로고    scopus 로고
    • The Src family tyrosine kinase Fyn regulates natural killer T cell development
    • Gadue P., Morton N., Stein P.L. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 1999, 190:1189-1196.
    • (1999) J Exp Med , vol.190 , pp. 1189-1196
    • Gadue, P.1    Morton, N.2    Stein, P.L.3
  • 32
    • 42249088418 scopus 로고    scopus 로고
    • Profound inhibition of antigen- specific T-cell effector functions by dasatinib
    • Weichsel R., Dix C., Wooldridge L., et al. Profound inhibition of antigen- specific T-cell effector functions by dasatinib. Clin Cancer Res 2008, 14:2484-2491.
    • (2008) Clin Cancer Res , vol.14 , pp. 2484-2491
    • Weichsel, R.1    Dix, C.2    Wooldridge, L.3
  • 33
    • 77958553932 scopus 로고    scopus 로고
    • Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy
    • Rohon P., Porkka K., Mustjoki S. Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy. Eur J Haematol 2010, 85:387-398.
    • (2010) Eur J Haematol , vol.85 , pp. 387-398
    • Rohon, P.1    Porkka, K.2    Mustjoki, S.3
  • 34
    • 79953206281 scopus 로고    scopus 로고
    • A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors
    • Powers J.J., Dubovsky J.A., Epling-Burnette P.K., et al. A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors. Leuk Lymphoma 2011, 52:668-679.
    • (2011) Leuk Lymphoma , vol.52 , pp. 668-679
    • Powers, J.J.1    Dubovsky, J.A.2    Epling-Burnette, P.K.3
  • 35
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • Molldrem J.J., Lee P.P., Wang C., et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med 2000, 6:1018-1023.
    • (2000) Nat Med , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3
  • 36
    • 27744435829 scopus 로고    scopus 로고
    • The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target cell interactions
    • Sconocchia G., Lau M., Provenzano M., et al. The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target cell interactions. Blood 2005, 106:3666-3672.
    • (2005) Blood , vol.106 , pp. 3666-3672
    • Sconocchia, G.1    Lau, M.2    Provenzano, M.3
  • 37
    • 35349001079 scopus 로고    scopus 로고
    • Lung abnormalities after dasatinib treatment for chronic myeloid leukemia
    • Bergeron A., Rea D., Levy V., et al. Lung abnormalities after dasatinib treatment for chronic myeloid leukemia. Am J Crit Care Med 2007, 176:814-818.
    • (2007) Am J Crit Care Med , vol.176 , pp. 814-818
    • Bergeron, A.1    Rea, D.2    Levy, V.3
  • 38
    • 63449094749 scopus 로고    scopus 로고
    • Dasatinib treatment for Philadelphia chromosome positive leukemias
    • Khoury H.J., Guilhot F., Hughes T.P., Kim D.W., Cortes J.E. Dasatinib treatment for Philadelphia chromosome positive leukemias. Cancer 2009, 115:1381-1394.
    • (2009) Cancer , vol.115 , pp. 1381-1394
    • Khoury, H.J.1    Guilhot, F.2    Hughes, T.P.3    Kim, D.W.4    Cortes, J.E.5
  • 39
    • 49249121723 scopus 로고    scopus 로고
    • Dasatinib 50mg or 70mg BID compared to 100mg or 140mg QD in patients with CML in chronic phase (CP) who are resistant or intolerant to imatinib: one-year results of CA180034 (abs)
    • Shah N.P., Kim D.W., Kantarjian H.M., et al. Dasatinib 50mg or 70mg BID compared to 100mg or 140mg QD in patients with CML in chronic phase (CP) who are resistant or intolerant to imatinib: one-year results of CA180034 (abs). J Clin Oncol 2008, 26:3204-3212.
    • (2008) J Clin Oncol , vol.26 , pp. 3204-3212
    • Shah, N.P.1    Kim, D.W.2    Kantarjian, H.M.3
  • 40
    • 34548523623 scopus 로고    scopus 로고
    • Pleural effusion in patients with chronic myeloid leukemia treated ith dasatinib after imatinib failure
    • Quintâs-Cardama A., Kantarjian H., O'brien S., et al. Pleural effusion in patients with chronic myeloid leukemia treated ith dasatinib after imatinib failure. J Clin Oncol 2007, 25:3908-3914.
    • (2007) J Clin Oncol , vol.25 , pp. 3908-3914
    • Quintâs-Cardama, A.1    Kantarjian, H.2    O'brien, S.3
  • 41
    • 43449091001 scopus 로고    scopus 로고
    • Pleural effusions in patients with chronic myeloid leukemia treated with dasatinib may have an immun-mediated pathogenesis
    • de Lavallade H., Punnialingam S., Milojkovic D., et al. Pleural effusions in patients with chronic myeloid leukemia treated with dasatinib may have an immun-mediated pathogenesis. Br J Haematol 2008, 141:745-747.
    • (2008) Br J Haematol , vol.141 , pp. 745-747
    • de Lavallade, H.1    Punnialingam, S.2    Milojkovic, D.3
  • 42
    • 0038518619 scopus 로고    scopus 로고
    • Practical management of patients with chronic myeloid leukemia receiving imatinib
    • Deininger M.W., O'Brien S.G., Ford J.M., Druker B.J. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 2003, 21:1637-1647.
    • (2003) J Clin Oncol , vol.21 , pp. 1637-1647
    • Deininger, M.W.1    O'Brien, S.G.2    Ford, J.M.3    Druker, B.J.4
  • 43
    • 33746918759 scopus 로고    scopus 로고
    • B cell receptor signaling in human systemic lupus erythematosus
    • Pugh-Bernard A.E., Cambier J.C. B cell receptor signaling in human systemic lupus erythematosus. Curr Opin Rheumatol 2006, 18:451-455.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 451-455
    • Pugh-Bernard, A.E.1    Cambier, J.C.2
  • 44
    • 0037653244 scopus 로고    scopus 로고
    • Increased ubiquination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus
    • Jury E.C., Kabouridis P.S., Abba A., Mageed R.A., Isenberg D.A. Increased ubiquination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 2003, 48:1343-1354.
    • (2003) Arthritis Rheum , vol.48 , pp. 1343-1354
    • Jury, E.C.1    Kabouridis, P.S.2    Abba, A.3    Mageed, R.A.4    Isenberg, D.A.5


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