메뉴 건너뛰기




Volumn 116, Issue 6, 2010, Pages 1582-1591

Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors

Author keywords

Cardiac; Dasatinib; Pharmacokinetics; Phase 1; Src

Indexed keywords

DASATINIB; KETOCONAZOLE;

EID: 77949369418     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.24927     Document Type: Article
Times cited : (106)

References (26)
  • 1
    • 36949032298 scopus 로고    scopus 로고
    • SRC family nonreceptor tyrosine kinases as molecular targets for cancer therapy
    • Johnson FM, Gallick GE. SRC family nonreceptor tyrosine kinases as molecular targets for cancer therapy. Anticancer Agents Med Chem. 2007;7:651-659.
    • (2007) Anticancer Agents Med Chem , vol.7 , pp. 651-659
    • Johnson, F.M.1    Gallick, G.E.2
  • 2
    • 0027469402 scopus 로고
    • Increase in activity and level of pp60c-Src in progressive stages of human colorectal cancer
    • Talamonti MS, Roh MS, Curley SA, Gallick GE. Increase in activity and level of pp60c-Src in progressive stages of human colorectal cancer. J Clin Invest. 1993;91:53-60.
    • (1993) J Clin Invest , vol.91 , pp. 53-60
    • Talamonti, M.S.1    Roh, M.S.2    Curley, S.A.3    Gallick, G.E.4
  • 3
    • 0033572412 scopus 로고    scopus 로고
    • Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest
    • Moasser MM, Srethapakdi M, Sachar KS, Kraker AJ, Rosen N. Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest. Cancer Res. 1999;59:6145-6152.
    • (1999) Cancer Res , vol.59 , pp. 6145-6152
    • Moasser, M.M.1    Srethapakdi, M.2    Sachar, K.S.3    Kraker, A.J.4    Rosen, N.5
  • 4
    • 9744242077 scopus 로고    scopus 로고
    • Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice
    • Yezhelyev MV, Koehl G, Guba M, et al. Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin Cancer Res. 2004;10:8028-8036.
    • (2004) Clin Cancer Res , vol.10 , pp. 8028-8036
    • Yezhelyev, M.V.1    Koehl, G.2    Guba, M.3
  • 5
    • 33644647192 scopus 로고    scopus 로고
    • Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model
    • Trevino JG, Summy JM, Lesslie DP, et al. Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am J Pathol. 2006;168:962-972.
    • (2006) Am J Pathol , vol.168 , pp. 962-972
    • Trevino, J.G.1    Summy, J.M.2    Lesslie, D.P.3
  • 6
    • 26444468152 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells
    • Johnson FM, Saigal B, Talpaz M, Donato NJ. Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin Cancer Res. 2005;11(19 pt 1):6924-6932.
    • (2005) Clin Cancer Res , vol.11 , Issue.19 PART 1 , pp. 6924-6932
    • Johnson, F.M.1    Saigal, B.2    Talpaz, M.3    Donato, N.J.4
  • 7
    • 57749172257 scopus 로고    scopus 로고
    • Src family kinases as mediators of endothelial permeability: Effects on inflammation and metastasis
    • Kim MP, Park SI, Kopetz S, Gallick GE. Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. Cell Tissue Res. 2009;335:249-259.
    • (2009) Cell Tissue Res , vol.335 , pp. 249-259
    • Kim, M.P.1    Park, S.I.2    Kopetz, S.3    Gallick, G.E.4
  • 8
    • 44849134528 scopus 로고    scopus 로고
    • Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model
    • Park SI, Zhang J, Phillips KA, et al. Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res. 2008;68:3323-3333.
    • (2008) Cancer Res , vol.68 , pp. 3323-3333
    • Park, S.I.1    Zhang, J.2    Phillips, K.A.3
  • 9
    • 34447316429 scopus 로고    scopus 로고
    • Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion
    • Tsao AS, He D, Saigal B, et al. Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion. Mol Cancer Ther. 2007;6:1962-1972.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1962-1972
    • Tsao, A.S.1    He, D.2    Saigal, B.3
  • 10
    • 33846241683 scopus 로고    scopus 로고
    • Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib
    • Serrels A, Macpherson IR, Evans TR, et al. Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther. 2006;5:3014-3022.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3014-3022
    • Serrels, A.1    Macpherson, I.R.2    Evans, T.R.3
  • 11
    • 56449100212 scopus 로고    scopus 로고
    • Inhibition of SRC family kinases with dasatinib blocks migration and invasion of human melanoma cells
    • Buettner R, Mesa T, Vultur A, Lee F, Jove R. Inhibition of SRC family kinases with dasatinib blocks migration and invasion of human melanoma cells. Mol Cancer Res. 2008;6:1766-1774.
    • (2008) Mol Cancer Res , vol.6 , pp. 1766-1774
    • Buettner, R.1    Mesa, T.2    Vultur, A.3    Lee, F.4    Jove, R.5
  • 12
    • 37249048453 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): A potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL
    • Kamath AV, Wang J, Lee FY, Marathe PH. Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL. Cancer Chemother Pharmacol. 2008;61:365-376.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 365-376
    • Kamath, A.V.1    Wang, J.2    Lee, F.Y.3    Marathe, P.H.4
  • 13
    • 49249121723 scopus 로고    scopus 로고
    • Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and - intolerant chronic-phase chronic myeloid leukemia
    • Shah NP, Kantarjian HM, Kim DW, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and - intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol. 2008;26:3204-32122.
    • (2008) J Clin Oncol , vol.26 , pp. 3204-32122
    • Shah, N.P.1    Kantarjian, H.M.2    Kim, D.W.3
  • 14
    • 0032757213 scopus 로고    scopus 로고
    • Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: Review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group
    • Young H, Baum R, Cremerius U, et al. Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. Eur J Cancer. 1999;35:1773-1782.
    • (1999) Eur J Cancer , vol.35 , pp. 1773-1782
    • Young, H.1    Baum, R.2    Cremerius, U.3
  • 15
    • 33646654192 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation [serial online]
    • Piotrovsky V. Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation [serial online]. AAPS J. 2005;7:E609-E624.
    • (2005) AAPS J , vol.7
    • Piotrovsky, V.1
  • 16
    • 34548523623 scopus 로고    scopus 로고
    • Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure
    • Quintas-Cardama A, Kantarjian H, O'Brien S, et al. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol. 2007;25:3908-3914.
    • (2007) J Clin Oncol , vol.25 , pp. 3908-3914
    • Quintas-Cardama, A.1    Kantarjian, H.2    O'Brien, S.3
  • 17
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • Cortes J, Rousselot P, Kim DW, et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood. 2007;109:3207-3213.
    • (2007) Blood , vol.109 , pp. 3207-3213
    • Cortes, J.1    Rousselot, P.2    Kim, D.W.3
  • 18
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 19
    • 33745914717 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors [abstract]
    • Abstract 3034
    • Evans TR, Morgan JA, van den Abbeele AD, et al. Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors [abstract]. J Clin Oncol. 2005;23(16S). Abstract 3034.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S
    • Evans, T.R.1    Morgan, J.A.2    van den Abbeele, A.D.3
  • 20
    • 43449091001 scopus 로고    scopus 로고
    • Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis
    • de Lavallade H, Punnialingam S, Milojkovic D, et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol. 2008;141:745-747.
    • (2008) Br J Haematol , vol.141 , pp. 745-747
    • de Lavallade, H.1    Punnialingam, S.2    Milojkovic, D.3
  • 21
    • 35349001079 scopus 로고    scopus 로고
    • Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: A case series
    • Bergeron A, Rea D, Levy V, et al. Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am J Respir Crit Care Med. 2007;176:814-818.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 814-818
    • Bergeron, A.1    Rea, D.2    Levy, V.3
  • 23
    • 56149095226 scopus 로고    scopus 로고
    • A phase I study of dasatinib, a Src multi-kinase inhibitor, in patients with GIST and other solid tumors [abstract]
    • Abstract 383
    • Morgan JA, Demetri G, Wang D, et al. A phase I study of dasatinib, a Src multi-kinase inhibitor, in patients with GIST and other solid tumors [abstract]. Eur J Cancer. 2006;12(suppl 4):118. Abstract 383.
    • (2006) Eur J Cancer , vol.12 , Issue.SUPPL. 4 , pp. 118
    • Morgan, J.A.1    Demetri, G.2    Wang, D.3
  • 24
    • 77949416487 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Company, Princeton, NJ: Bristol-Myers Squibb Company;
    • Bristol-Myers Squibb Company. SPRYCEL prescribing information. Princeton, NJ: Bristol-Myers Squibb Company; 2008.
    • (2008) SPRYCEL prescribing information
  • 25
    • 54349127397 scopus 로고    scopus 로고
    • Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells
    • Will Y, Dykens JA, Nadanaciva S, et al. Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells. Toxicol Sci. 2008;106: 153-161.
    • (2008) Toxicol Sci , vol.106 , pp. 153-161
    • Will, Y.1    Dykens, J.A.2    Nadanaciva, S.3
  • 26
    • 0346399929 scopus 로고    scopus 로고
    • QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles
    • Hamlin RL, Kijtawornrat A, Keene BW, Hamlin DM. QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles. Toxicol Sci. 2003;76:437-442.
    • (2003) Toxicol Sci , vol.76 , pp. 437-442
    • Hamlin, R.L.1    Kijtawornrat, A.2    Keene, B.W.3    Hamlin, D.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.