-
1
-
-
0035810145
-
Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441409
-
Goldman JM, Melo JV. Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344(14):1084-1086. (Pubitemid 32267980)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1084-1086
-
-
Goldman, J.M.1
Melo, J.V.2
-
3
-
-
0033614446
-
Chronic myeloid leukemia
-
DOI 10.1056/NEJM199904293401706
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340(17):1330- 1340. (Pubitemid 29196596)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.17
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
4
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
DOI 10.1056/NEJMoa022457
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348(11):994-1004. (Pubitemid 36302244)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.11
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
Gathmann, I.4
Baccarani, M.5
Cervantes, F.6
Cornelissen, J.J.7
Fischer, T.8
Hochhaus, A.9
Hughes, T.10
Lechner, K.11
Nielsen, J.L.12
Rousselot, P.13
Reiffers, J.14
Saglio, G.15
Shepherd, J.16
Simonsson, B.17
Gratwohl, A.18
Goldman, J.M.19
Kantarjian, H.20
Taylor, K.21
Verhoef, G.22
Bolton, A.E.23
Capdeville, R.24
Druker, B.J.25
more..
-
5
-
-
75349094716
-
Extended kinase profile and properties of the protein kinase inhibitor nilotinib
-
Manley PW, Drueckes P, Fendrich G, et al. Extended kinase profile and properties of the protein kinase inhibitor nilotinib. Biochim Biophys Acta. 2010;1804(3):445-453.
-
(2010)
Biochim Biophys Acta
, vol.1804
, Issue.3
, pp. 445-453
-
-
Manley, P.W.1
Drueckes, P.2
Fendrich, G.3
-
6
-
-
33745114173
-
AMN107 (nilotinib): A novel and selective inhibitor of BCR-ABL
-
DOI 10.1038/sj.bjc.6603170, PII 6603170
-
Weisberg E, Manley P, Mestan J, Cowan-Jacob S, Ray A, Griffin JD.AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. Br J Cancer. 2006;94(12):1765-1769. (Pubitemid 43882564)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.12
, pp. 1765-1769
-
-
Weisberg, E.1
Manley, P.2
Mestan, J.3
Cowan-Jacob, S.4
Ray, A.5
Griffin, J.D.6
-
7
-
-
36348968931
-
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
-
DOI 10.1182/blood-2007-03-080689
-
Kantarjian HM, Giles F, Gattermann N, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood. 2007;110(10):3540- 3546. (Pubitemid 350159618)
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3540-3546
-
-
Kantarjian, H.M.1
Giles, F.2
Gattermann, N.3
Bhalla, K.4
Alimena, G.5
Palandri, F.6
Ossenkoppele, G.J.7
Nicolini, F.-E.8
O'Brien, S.G.9
Litzow, M.10
Bhatia, R.11
Cervantes, F.12
Haque, A.13
Shou, Y.14
Resta, D.J.15
Weitzman, A.16
Hochhaus, A.17
Le, C.P.18
-
8
-
-
41349083969
-
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia
-
DOI 10.1182/blood-2007-04-083196
-
le Coutre P, Ottmann OG, Giles F, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia. Blood. 2008;111(4):1834-1839. (Pubitemid 351451490)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 1834-1839
-
-
Le, C.P.1
Ottmann, O.G.2
Giles, F.3
Kim, D.-W.4
Cortes, J.5
Gattermann, N.6
Apperley, J.F.7
Larson, R.A.8
Abruzzese, E.9
O'Brien, S.G.10
Kuliczkowski, K.11
Hochhaus, A.12
Mahon, F.-X.13
Saglio, G.14
Gobbi, M.15
Kwong, Y.-L.16
Baccarani, M.17
Hughes, T.18
Martinelli, G.19
Radich, J.P.20
Zheng, M.21
Shou, Y.22
Kantarjian, H.23
more..
-
9
-
-
77953691179
-
Nilotinib versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia
-
Saglio G, Kim DW, Issaragrisil S, et al. Nilotinib versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia. N Engl J Med. 2010;362(24):2251-2259.
-
(2010)
N Engl J Med
, vol.362
, Issue.24
, pp. 2251-2259
-
-
Saglio, G.1
Kim, D.W.2
Issaragrisil, S.3
-
10
-
-
75749119275
-
Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib
-
Tanaka C, Yin OQ, Sethuraman V, et al. Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib. Clin Pharmacol Ther. 2010;87(2):197-203.
-
(2010)
Clin Pharmacol Ther
, vol.87
, Issue.2
, pp. 197-203
-
-
Tanaka, C.1
Yin, O.Q.2
Sethuraman, V.3
-
11
-
-
84871774938
-
-
Version 3.0. Accessed April 14, 2011
-
The National Cancer Institute. Common Terminology Criteria for Adverse Events Version 3.0. http://ctep.cancer.gov/protocoldevelopment/ electronic-applications/docs/ctcaev3.pdf. Accessed April 14, 2011.
-
Common Terminology Criteria for Adverse Events
-
-
-
12
-
-
79251546724
-
Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase following imatinib resistance or intolerance: 24-month follow-up results
-
Kantarjian HM, Giles FJ, Bhalla KN, et al. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase following imatinib resistance or intolerance: 24-month follow-up results. Blood. 2011;117(4):1141-1145.
-
(2011)
Blood
, vol.117
, Issue.4
, pp. 1141-1145
-
-
Kantarjian, H.M.1
Giles, F.J.2
Bhalla, K.N.3
-
13
-
-
74849136196
-
Nilotinib in chronic myeloid leukemia patients in accelerated phase (CML-AP) with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study
-
abstract Abstract 631
-
Hochhaus AH, Giles F, Apperley J, et al. Nilotinib in chronic myeloid leukemia patients in accelerated phase (CML-AP) with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study [abstract]. Haematologica. 2009; 94(suppl 2):256. Abstract 631.
-
(2009)
Haematologica
, vol.94
, Issue.SUPPL. 2
, pp. 256
-
-
Hochhaus, A.H.1
Giles, F.2
Apperley, J.3
-
14
-
-
44949149150
-
Hypersensitivity reactions to cephalosporins
-
DOI 10.1517/14740338.7.3.295
-
Moreno E, Macias E, Davila I, Laffond E, Ruiz A, Lorente F. Hypersensitivity reactions to cephalosporins. Expert Opin Drug Saf. 2008;7(3):295-304. (Pubitemid 351802829)
-
(2008)
Expert Opinion on Drug Safety
, vol.7
, Issue.3
, pp. 295-304
-
-
Moreno, E.1
Macias, E.2
Davila, I.3
Laffond, E.4
Ruiz, A.5
Lorente, F.6
-
15
-
-
36549088120
-
Part II: Management of resistance to imatinib in chronic myeloid leukaemia
-
DOI 10.1016/S1470-2045(07)70379-0, PII S1470204507703790
-
Apperley JF. Part II: management of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007;8(12):1116-1128. (Pubitemid 350182968)
-
(2007)
Lancet Oncology
, vol.8
, Issue.12
, pp. 1116-1128
-
-
Apperley, J.F.1
-
16
-
-
42049123098
-
Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib
-
DOI 10.1080/10428190801896103, PII 791364886
-
Hantschel O, Rix U, Superti-Furga G. Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk Lymphoma. 2008;49(4):615-619. (Pubitemid 351517198)
-
(2008)
Leukemia and Lymphoma
, vol.49
, Issue.4
, pp. 615-619
-
-
Hantschel, O.1
Rix, U.2
Superti-Furga, G.3
-
17
-
-
34047127376
-
PDGF receptors as targets in tumor treatment
-
Ostman A, Heldin CH. PDGF receptors as targets in tumor treatment. Adv Cancer Res. 2007;97:247-274.
-
(2007)
Adv Cancer Res
, vol.97
, pp. 247-274
-
-
Ostman, A.1
Heldin, C.H.2
-
18
-
-
2942670180
-
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
-
DOI 10.1016/j.cytogfr.2004.03.002, PII S1359610104000127
-
Ostman A. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev. 2004;15(4):275-286. (Pubitemid 38781051)
-
(2004)
Cytokine and Growth Factor Reviews
, vol.15
, Issue.4
, pp. 275-286
-
-
Ostman, A.1
-
19
-
-
0035297541
-
Ihibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K, Ostman A, Sjoquist M, et al. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 2001;61(7):2929-2934. (Pubitemid 32691937)
-
(2001)
Cancer Research
, vol.61
, Issue.7
, pp. 2929-2934
-
-
Pietras, K.1
Ostman, A.2
Sjoquist, M.3
Buchdunger, E.4
Reed, R.K.5
Heldin, C.-H.6
Rubin, K.7
-
20
-
-
10744230175
-
The Significance of Myelosuppression during Therapy with Imatinib Mesylate in Patients with Chronic Myelogenous Leukemia in Chronic Phase
-
DOI 10.1002/cncr.11863
-
Sneed TB, Kantarjian HM, Talpaz M, et al. The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase. Cancer. 2004;100(1):116-121. (Pubitemid 37553546)
-
(2004)
Cancer
, vol.100
, Issue.1
, pp. 116-121
-
-
Sneed, T.B.1
Kantarjian, H.M.2
Talpaz, M.3
O'Brien, S.4
Rios, M.B.5
Bekele, B.N.6
Zhou, X.7
Resta, D.8
Wierda, W.9
Faderl, S.10
Giles, F.11
Cortes, J.E.12
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