-
1
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
DOI 10.1056/NEJMoa011573
-
Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002;346:645-652. (Pubitemid 34815868)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.9
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
Guilhot, F.4
Schiffer, C.5
Gambacorti-Passerini, C.6
Niederwieser, D.7
Resta, D.8
Capdeville, R.9
Zoellner, U.10
Talpaz, M.11
Druker, B.12
-
2
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
DOI 10.1056/NEJMoa022457
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348:994-1004. (Pubitemid 36302244)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.11
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
Gathmann, I.4
Baccarani, M.5
Cervantes, F.6
Cornelissen, J.J.7
Fischer, T.8
Hochhaus, A.9
Hughes, T.10
Lechner, K.11
Nielsen, J.L.12
Rousselot, P.13
Reiffers, J.14
Saglio, G.15
Shepherd, J.16
Simonsson, B.17
Gratwohl, A.18
Goldman, J.M.19
Kantarjian, H.20
Taylor, K.21
Verhoef, G.22
Bolton, A.E.23
Capdeville, R.24
Druker, B.J.25
more..
-
3
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science. 2000;289:1938-1942.
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
4
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
DOI 10.1182/blood.V101.2.690
-
Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood. 2003;101:690-698. (Pubitemid 36077594)
-
(2003)
Blood
, vol.101
, Issue.2
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
Gallick, G.4
Lin, H.5
Arlinghaus, R.6
Talpaz, M.7
-
5
-
-
9144234689
-
Imatinib Mesylate Resistance Through BCR-ABL Independence in Chronic Myelogenous Leukemia
-
DOI 10.1158/0008-5472.CAN-03-1484
-
Donato NJ, Wu JY, Stapley J, et al. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res. 2004;64:672-677. (Pubitemid 38120909)
-
(2004)
Cancer Research
, vol.64
, Issue.2
, pp. 672-677
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
Lin, H.4
Arlinghaus, R.5
Aggarwal, B.6
Shishodin, S.7
Albitar, M.8
Hayes, K.9
Kantarjian, H.10
Talpaz, M.11
-
6
-
-
4544343214
-
A Bcr/Abl-independent, lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
-
DOI 10.1074/jbc.M402290200
-
Dai Y, Rahmani M, Corey SJ, Dent P, Grant S. A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J Biol Chem. 2004;279:34227-34239. (Pubitemid 39318046)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.33
, pp. 34227-34239
-
-
Dai, Y.1
Rahmani, M.2
Corey, S.J.3
Dent, P.4
Grant, S.5
-
7
-
-
46849114097
-
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase
-
Wu J, Meng F, Kong LY, et al. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst. 2008;100:926-939.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 926-939
-
-
Wu, J.1
Meng, F.2
Kong, L.Y.3
-
8
-
-
19944428353
-
Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)- Piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
DOI 10.1021/jm049486a
-
Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-[2-hydroxyethyl]-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004;47:6658-6661. (Pubitemid 40053752)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.27
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
Castaneda, S.7
Cornelius, L.A.M.8
Das, J.9
Doweyko, A.M.10
Fairchild, C.11
Hunt, J.T.12
Inigo, I.13
Johnston, K.14
Kamath, A.15
Kan, D.16
Klei, H.17
Marathe, P.18
Pang, S.19
Peterson, R.20
Pitt, S.21
Schieven, G.L.22
Schmidt, R.J.23
Tokarski, J.24
Wen, M.-L.25
Wityak, J.26
Borzilleri, R.M.27
more..
-
9
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
DOI 10.1126/science.1099480
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004;305:399-401. (Pubitemid 38938156)
-
(2004)
Science
, vol.305
, Issue.5682
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
10
-
-
54949154484
-
Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C)
-
abstract. Abstract 7009
-
Mauro M, Baccarani M, Cervantes F, et al. Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C) [abstract]. Proc Am Soc Clin Oncol. 2008;26:374s. Abstract 7009.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Mauro, M.1
Baccarani, M.2
Cervantes, F.3
-
11
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
DOI 10.1056/NEJMoa055229
-
Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531-2541. (Pubitemid 43882349)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.-T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
12
-
-
33947356135
-
Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
-
DOI 10.1182/blood-2006-09-046888
-
Cortes J, Rousselot P, Kim DW, et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood. 2007;109:3207-3213. (Pubitemid 46572505)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3207-3213
-
-
Cortes, J.1
Rousselot, P.2
Kim, D.-W.3
Ritchie, E.4
Hamerschlak, N.5
Coutre, S.6
Hochhaus, A.7
Guilhot, F.8
Saglio, G.9
Apperley, J.10
Ottmann, O.11
Shah, N.12
Erben, P.13
Branford, S.14
Agarwal, P.15
Gollerkeri, A.16
Baccarani, M.17
-
13
-
-
65249125980
-
Clonal large granular lymphocyte (LGL) expansion associated with dasatinib therapy
-
abstract. Abstract 2938
-
Mustjoki S, Laurinolli T, Ekblom M, et al. Clonal large granular lymphocyte (LGL) expansion associated with dasatinib therapy [abstract]. Blood. 2007;110:863a. Abstract 2938.
-
(2007)
Blood
, vol.110
-
-
Mustjoki, S.1
Laurinolli, T.2
Ekblom, M.3
-
14
-
-
49249121723
-
Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and - intolerant chronic-phase chronic myeloid leukemia
-
Shah NP, Kantarjian HM, Kim DW, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and - intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol. 2008;26:3204-3212.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3204-3212
-
-
Shah, N.P.1
Kantarjian, H.M.2
Kim, D.W.3
-
15
-
-
66649134315
-
-
Available at: Accessed on November 17, 2007
-
Sprycel Scientific Discussion. Available at: http://209.85.165.104/ search?q=cache:KW1gSD1bwJQJ:www.emea.eu.int/humandocs/PDFs/EPAR/sprycel/ H-709-en6.pdf+dasatinib+and+bleeding&hl=en&gl=us&ct=clnk&cd=1. Accessed on November 17, 2007.
-
Sprycel Scientific Discussion
-
-
-
18
-
-
33645821453
-
Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib)
-
Chen Z, Lee FY, Bhalla KN, Wu J. Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib). Mol Pharmacol. 2006;69:1527-1533.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1527-1533
-
-
Chen, Z.1
Lee, F.Y.2
Bhalla, K.N.3
Wu, J.4
-
19
-
-
0032768156
-
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
-
Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999;126:3047-3055. (Pubitemid 29378170)
-
(1999)
Development
, vol.126
, Issue.14
, pp. 3047-3055
-
-
Hellstrom, M.1
Kalen, M.2
Lindahl, P.3
Abramsson, A.4
Betsholtz, C.5
-
20
-
-
0030756325
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
-
DOI 10.1126/science.277.5323.242
-
Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997;277:242-245. (Pubitemid 27446080)
-
(1997)
Science
, vol.277
, Issue.5323
, pp. 242-245
-
-
Lindahl, P.1
Johansson, B.R.2
Leveen, P.3
Betsholtz, C.4
-
21
-
-
0035312964
-
Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF β-receptor null mice
-
DOI 10.1182/blood.V97.7.1990
-
Kaminski WE, Lindahl P, Lin NL, et al. Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Blood. 2001;97:1990-1998. (Pubitemid 32239078)
-
(2001)
Blood
, vol.97
, Issue.7
, pp. 1990-1998
-
-
Kaminski, W.E.1
Lindahl, P.2
Lin, N.L.3
Broudy, V.C.4
Crosby, J.R.5
Hellstrom, M.6
Swolin, B.7
Bowen-Pope, D.F.8
Martin, P.J.9
Ross, R.10
Betsholtz, C.11
Raines, E.W.12
-
22
-
-
46449088111
-
Metabolism and disposition of dasatinib after oral administration to humans
-
Christopher LJ, Cui D, Wu C, et al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008;36:1357-1364.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1357-1364
-
-
Christopher, L.J.1
Cui, D.2
Wu, C.3
|