-
1
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker, BJ, Talpaz, M. Resta, DJ et al. (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med, 344, pp. 1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
2
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker, BJ, Tamura, S. Buchdunger, E. et al. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med, 2, pp. 561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
3
-
-
17044403497
-
Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib
-
Dewar, AL, Cambareri, AC Zannettino, AC et al. (2005) Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. Blood, 105, pp. 3127-3132.
-
(2005)
Blood
, vol.105
, pp. 3127-3132
-
-
Dewar, A.L.1
Cambareri, A.C.2
Zannettino, A.C.3
-
4
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien, SG, Guilhot, F. Larson, RA et al. (2003) Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med, 348, pp. 994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
5
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri, GD, von Mehren, M. Blanke, CD et al. (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med, 347, pp. 472-480.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
-
6
-
-
9144233483
-
Inhibitory effect of imatinib on normal progenitor cells in vitro
-
Bartolovic, K., Balabanov, S. Hartmann, U. et al. (2004) Inhibitory effect of imatinib on normal progenitor cells in vitro. Blood, 103, pp. 523-529.
-
(2004)
Blood
, vol.103
, pp. 523-529
-
-
Bartolovic, K.1
Balabanov, S.2
Hartmann, U.3
-
7
-
-
0037341414
-
Development of Varicella-Zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate
-
Mattiuzzi, GN, Cortes, JE Talpaz, M. et al. (2003) Development of Varicella-Zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate. Clin Cancer Res, 9, pp. 976-980.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 976-980
-
-
Mattiuzzi, G.N.1
Cortes, J.E.2
Talpaz, M.3
-
8
-
-
0345257260
-
EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate
-
Bekkenk, MW, Vermeer, MH Meijer, CJ et al. (2003) EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate. Blood, 102, p. 4243.
-
(2003)
Blood
, vol.102
, pp. 4243
-
-
Bekkenk, M.W.1
Vermeer, M.H.2
Meijer, C.J.3
-
9
-
-
0042388478
-
Treatment of rheumatoid arthritis with imatinib mesylate: Clinical improvement in three refractory cases
-
Eklund, KK and Joensuu, H. (2003) Treatment of rheumatoid arthritis with imatinib mesylate: Clinical improvement in three refractory cases. Ann Med, 35, pp. 362-367.
-
(2003)
Ann Med
, vol.35
, pp. 362-367
-
-
Eklund, K.K.1
Joensuu, H.2
-
10
-
-
0038454621
-
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
-
Bhatia, R., Holtz, M. Niu, N. et al. (2003) Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood, 101, pp. 4701-4707.
-
(2003)
Blood
, vol.101
, pp. 4701-4707
-
-
Bhatia, R.1
Holtz, M.2
Niu, N.3
-
11
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham, SM, Jorgensen, HG Allan, E. et al. (2002) Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood, 99, pp. 319-325.
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
12
-
-
33745081606
-
Circumventing resistance to kinase-inhibitor therapy
-
Druker, B. J. (2006) Circumventing resistance to kinase-inhibitor therapy. N Engl J Med, 354, pp. 2594-2596.
-
(2006)
N Engl J Med
, vol.354
, pp. 2594-2596
-
-
Druker, B.J.1
-
13
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker, BJ, Guilhot, F. O'Brien, SG et al. (2006) Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med, 355, pp. 2408-2417.
-
(2006)
N Engl J Med
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
14
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah, NP, Tran, C. Lee, FY et al. (2004) Overriding imatinib resistance with a novel ABL kinase inhibitor. Science, 305, pp. 399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
-
15
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
Talpaz, M., Shah, NP Kantarjian, H. et al. (2006) Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med, 354, pp. 2531-2541.
-
(2006)
N Engl J Med
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
16
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland, M., Hamilton, A. Elrick, LJ et al. (2006) Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood, 107, pp. 4532-4539.
-
(2006)
Blood
, vol.107
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
17
-
-
37049014938
-
Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets
-
Rix, U., Hantschel, O. Durnberger, G. et al. (2007) Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood, 110, pp. 4055-4063.
-
(2007)
Blood
, vol.110
, pp. 4055-4063
-
-
Rix, U.1
Hantschel, O.2
Durnberger, G.3
-
18
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
Wilhelm, S., Carter, C. Lynch, M. et al. (2006) Discovery and development of sorafenib: A multikinase inhibitor for treating cancer. Nat Rev Drug Discov, 5, pp. 835-844.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
-
19
-
-
0029080247
-
Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma
-
Oka, H., Chatani, Y. Hoshino, R. et al. (1995) Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res, 55, pp. 4182-4187.
-
(1995)
Cancer Res
, vol.55
, pp. 4182-4187
-
-
Oka, H.1
Chatani, Y.2
Hoshino, R.3
-
20
-
-
3142682595
-
T cell receptor signaling: Beyond complex complexes
-
Huang, Y. and Wange, R. L. (2004) T cell receptor signaling: Beyond complex complexes. J Biol Chem, 279, pp. 28827-28830.
-
(2004)
J Biol Chem
, vol.279
, pp. 28827-28830
-
-
Huang, Y.1
Wange, R.L.2
-
21
-
-
7944231534
-
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
-
Palacios, EH and Weiss, A. (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene, 23, pp. 7990-8000.
-
(2004)
Oncogene
, vol.23
, pp. 7990-8000
-
-
Palacios, E.H.1
Weiss, A.2
-
22
-
-
0030294283
-
Fyn can partially substitute for Lck in T lymphocyte development
-
Groves, T., Smiley, P. Cooke, MP et al. (1996) Fyn can partially substitute for Lck in T lymphocyte development. Immunity, 5, pp. 417-428.
-
(1996)
Immunity
, vol.5
, pp. 417-428
-
-
Groves, T.1
Smiley, P.2
Cooke, M.P.3
-
23
-
-
1342321661
-
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation
-
Gorska, MM, Stafford, SJ Cen, O. et al. (2004) Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med, 199, pp. 369-379.
-
(2004)
J Exp Med
, vol.199
, pp. 369-379
-
-
Gorska, M.M.1
Stafford, S.J.2
Cen, O.3
-
24
-
-
0030906543
-
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/ CD3 induction of interleukin-2
-
Raab, M., da Silva, AJ Findell, PR et al. (1997) Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity, 6, pp. 155-164.
-
(1997)
Immunity
, vol.6
, pp. 155-164
-
-
Raab, M.1
da Silva, A.J.2
Findell, P.R.3
-
25
-
-
0032498231
-
LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
Zhang, W., Sloan-Lancaster, J. Kitchen, J. et al. (1998) LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell, 92, pp. 83-92.
-
(1998)
Cell
, vol.92
, pp. 83-92
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
-
26
-
-
0000082758
-
Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
-
Wardenburg, JB, Fu, C. Jackman, JK et al. (1996) Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J Biol Chem, 271, pp. 19641-19644.
-
(1996)
J Biol Chem
, vol.271
, pp. 19641-19644
-
-
Wardenburg, J.B.1
Fu, C.2
Jackman, J.K.3
-
27
-
-
0028981212
-
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T-cell costimulation
-
Raab, M., Cai, YC Bunnell, SC et al. (1995) p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T-cell costimulation. Proc Natl Acad Sci USA, 92, pp. 8891-8895.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8891-8895
-
-
Raab, M.1
Cai, Y.C.2
Bunnell, S.C.3
-
28
-
-
0347505003
-
CD28-mediated co-stimulation: A quantitative support for TCR signalling
-
Acuto, O. and Michel, F. (2003) CD28-mediated co-stimulation: A quantitative support for TCR signalling. Nat Rev Immunol, 3, pp. 939-951.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 939-951
-
-
Acuto, O.1
Michel, F.2
-
29
-
-
0037564560
-
Molecular modifiers of T cell antigen receptor triggering threshold: The mechanism of CD28 costimulatory receptor
-
Acuto, O., Mise-Omata, S. Mangino, G. et al. (2003) Molecular modifiers of T cell antigen receptor triggering threshold: The mechanism of CD28 costimulatory receptor. Immunol Rev, 192, pp. 21-31.
-
(2003)
Immunol Rev
, vol.192
, pp. 21-31
-
-
Acuto, O.1
Mise-Omata, S.2
Mangino, G.3
-
30
-
-
0033083788
-
Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases
-
Chuang, E., Lee, KM Robbins, MD et al. (1999) Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol, 162, pp. 1270-1277.
-
(1999)
J Immunol
, vol.162
, pp. 1270-1277
-
-
Chuang, E.1
Lee, K.M.2
Robbins, M.D.3
-
31
-
-
0032545452
-
Molecular basis of T cell inactivation by CTLA-4
-
Lee, KM, Chuang, E. Griffin, M. et al. (1998) Molecular basis of T cell inactivation by CTLA-4. Science, 282, pp. 2263-2266.
-
(1998)
Science
, vol.282
, pp. 2263-2266
-
-
Lee, K.M.1
Chuang, E.2
Griffin, M.3
-
32
-
-
3342956520
-
Requirement for Abl kinases in T cell receptor signaling
-
Zipfel, PA, Zhang, W. Quiroz, M. et al. (2004) Requirement for Abl kinases in T cell receptor signaling. Curr Biol, 14, pp. 1222-1231.
-
(2004)
Curr Biol
, vol.14
, pp. 1222-1231
-
-
Zipfel, P.A.1
Zhang, W.2
Quiroz, M.3
-
33
-
-
0037049772
-
Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML
-
Druker, B. J. (2002) Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML. Oncogene, 21, pp. 8541-8546.
-
(2002)
Oncogene
, vol.21
, pp. 8541-8546
-
-
Druker, B.J.1
-
34
-
-
2342475200
-
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
-
Roose, JP, Diehn, M. Tomlinson, MG et al. (2003) T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol, 1, p. E53.
-
(2003)
PLoS Biol
, vol.1
-
-
Roose, J.P.1
Diehn, M.2
Tomlinson, M.G.3
-
35
-
-
0025923088
-
Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations
-
Schwartzberg, PL, Stall, AM Hardin, JD et al. (1991) Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell, 65, pp. 1165-1175.
-
(1991)
Cell
, vol.65
, pp. 1165-1175
-
-
Schwartzberg, P.L.1
Stall, A.M.2
Hardin, J.D.3
-
36
-
-
0025780879
-
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
-
Tybulewicz, VL, Crawford, CE Jackson, PK et al. (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell, 65, pp. 1153-1163.
-
(1991)
Cell
, vol.65
, pp. 1153-1163
-
-
Tybulewicz, V.L.1
Crawford, C.E.2
Jackson, P.K.3
-
37
-
-
15244351682
-
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
-
Seggewiss, R., Lore, K. Greiner, E. et al. (2005) Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood, 105, pp. 2473-2479.
-
(2005)
Blood
, vol.105
, pp. 2473-2479
-
-
Seggewiss, R.1
Lore, K.2
Greiner, E.3
-
38
-
-
3843119865
-
Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
-
Dietz, AB, Souan, L. Knutson, GJ et al. (2004) Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood, 104, pp. 1094-1099.
-
(2004)
Blood
, vol.104
, pp. 1094-1099
-
-
Dietz, A.B.1
Souan, L.2
Knutson, G.J.3
-
39
-
-
4344597828
-
Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro
-
Cwynarski, K., Laylor, R. Macchiarulo, E. et al. (2004) Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro. Leukemia, 18, pp. 1332-1339.
-
(2004)
Leukemia
, vol.18
, pp. 1332-1339
-
-
Cwynarski, K.1
Laylor, R.2
Macchiarulo, E.3
-
40
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian, MA, Biggs, WH 3rd Treiber, DK et al. (2005) A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol, 23, pp. 329-336.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs III, W.H.2
Treiber, D.K.3
-
41
-
-
42249088418
-
Profound inhibition of antigen-specific T-cell effector functions by dasatinib
-
Weichsel, R., Dix, C. Wooldridge, L. et al. (2008) Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin Cancer Res, 14, pp. 2484-2491.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2484-2491
-
-
Weichsel, R.1
Dix, C.2
Wooldridge, L.3
-
42
-
-
38949210227
-
Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation
-
Schade, AE, Schieven, GL Townsend, R. et al. (2008) Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood, 111, pp. 1366-1377.
-
(2008)
Blood
, vol.111
, pp. 1366-1377
-
-
Schade, A.E.1
Schieven, G.L.2
Townsend, R.3
-
43
-
-
45449102076
-
The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro
-
Blake, S., Hughes, TP Mayrhofer, G. et al. (2008) The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro. Clin Immunol, 127:3, pp. 330-339.
-
(2008)
Clin Immunol
, vol.127
, Issue.3
, pp. 330-339
-
-
Blake, S.1
Hughes, T.P.2
Mayrhofer, G.3
-
44
-
-
53749086585
-
Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signaling
-
Chen, J., Schmitt, A. Chen, B. et al. (2008) Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signaling. J Cell Mol Med
-
(2008)
J Cell Mol Med
-
-
Chen, J.1
Schmitt, A.2
Chen, B.3
-
45
-
-
0037217978
-
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia
-
Burchert, A., Wolfl, S. Schmidt, M. et al. (2003) Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. Blood, 101, pp. 259-264.
-
(2003)
Blood
, vol.101
, pp. 259-264
-
-
Burchert, A.1
Wolfl, S.2
Schmidt, M.3
-
46
-
-
34347271941
-
BCR-ABL activity is critical for the immunogenicity of chronic myelogenous leukemia cells
-
Brauer, KM, Werth, D. von Schwarzenberg, K. et al. (2007) BCR-ABL activity is critical for the immunogenicity of chronic myelogenous leukemia cells. Cancer Res, 67, pp. 5489-5497.
-
(2007)
Cancer Res
, vol.67
, pp. 5489-5497
-
-
Brauer, K.M.1
Werth, D.2
von Schwarzenberg, K.3
-
47
-
-
12844265929
-
Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance
-
Wang, H., Cheng, F. Cuenca, A. et al. (2005) Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood, 105, pp. 1135-1143.
-
(2005)
Blood
, vol.105
, pp. 1135-1143
-
-
Wang, H.1
Cheng, F.2
Cuenca, A.3
-
48
-
-
33644978035
-
Imatinib does not impair specific antitumor T-cell immunity in patients with chronic myeloid leukemia
-
Bocchia, M., Abruzzese, E. Forconi, F. et al. (2006) Imatinib does not impair specific antitumor T-cell immunity in patients with chronic myeloid leukemia. Leukemia, 20, pp. 142-143.
-
(2006)
Leukemia
, vol.20
, pp. 142-143
-
-
Bocchia, M.1
Abruzzese, E.2
Forconi, F.3
-
49
-
-
0041381363
-
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
-
Seder, RA and Ahmed, R. (2003) Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol, 4, pp. 835-842.
-
(2003)
Nat Immunol
, vol.4
, pp. 835-842
-
-
Seder, R.A.1
Ahmed, R.2
-
50
-
-
0036721320
-
Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia
-
Kantarjian, HM, O'Brien, S. Cortes, JE et al. (2002) Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia. Blood, 100, pp. 1590-1595.
-
(2002)
Blood
, vol.100
, pp. 1590-1595
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.E.3
-
51
-
-
33644877460
-
Allogeneic haematopoietic cell transplantation for chronic myelogenous leukaemia in the era of imatinib: A retrospective multicentre study
-
Bornhauser, M., Kroger, N. Schwerdtfeger, R. et al. (2006) Allogeneic haematopoietic cell transplantation for chronic myelogenous leukaemia in the era of imatinib: A retrospective multicentre study. Eur J Haematol, 76, pp. 9-17.
-
(2006)
Eur J Haematol
, vol.76
, pp. 9-17
-
-
Bornhauser, M.1
Kroger, N.2
Schwerdtfeger, R.3
-
52
-
-
0344089318
-
Imatinib mesylate (STI571) in preparation for allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusions in patients with Philadelphia-positive acute leukemias
-
Shimoni, A., Kroger, N. Zander, AR et al. (2003) Imatinib mesylate (STI571) in preparation for allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusions in patients with Philadelphia-positive acute leukemias. Leukemia, 17, pp. 290-297.
-
(2003)
Leukemia
, vol.17
, pp. 290-297
-
-
Shimoni, A.1
Kroger, N.2
Zander, A.R.3
-
53
-
-
33746957383
-
Imatinib preceding allogeneic stem cell transplantation in chronic myeloid leukemia
-
Perz, JB, Khorashad, JS Marin, D. et al. (2006) Imatinib preceding allogeneic stem cell transplantation in chronic myeloid leukemia. Haematologica, 91, pp. 1145-1146.
-
(2006)
Haematologica
, vol.91
, pp. 1145-1146
-
-
Perz, J.B.1
Khorashad, J.S.2
Marin, D.3
-
54
-
-
33846925617
-
The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia
-
Oehler, VG, Gooley, T. Snyder, DS et al. (2007) The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia. Blood, 109, pp. 1782-1789.
-
(2007)
Blood
, vol.109
, pp. 1782-1789
-
-
Oehler, V.G.1
Gooley, T.2
Snyder, D.S.3
-
55
-
-
33744503915
-
A comparison of donor lymphocyte infusions or imatinib mesylate for patients with chronic myelogenous leukemia who have relapsed after allogeneic stem cell transplantation
-
Weisser, M., Tischer, J. Schnittger, S. et al. (2006) A comparison of donor lymphocyte infusions or imatinib mesylate for patients with chronic myelogenous leukemia who have relapsed after allogeneic stem cell transplantation. Haematologica, 91, pp. 663-666.
-
(2006)
Haematologica
, vol.91
, pp. 663-666
-
-
Weisser, M.1
Tischer, J.2
Schnittger, S.3
-
56
-
-
28544440836
-
Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation
-
Savani, BN, Montero, A. Kurlander, R. et al. (2005) Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation. Bone Marrow Transplant, 36, pp. 1009-1015.
-
(2005)
Bone Marrow Transplant
, vol.36
, pp. 1009-1015
-
-
Savani, B.N.1
Montero, A.2
Kurlander, R.3
-
57
-
-
34547178987
-
Novel tyrosine kinase inhibitor therapy before allogeneic stem cell transplantation in patients with chronic myeloid leukemia: No evidence for increased transplant-related toxicity
-
Jabbour, E., Cortes, J. Kantarjian, H. et al. (2007) Novel tyrosine kinase inhibitor therapy before allogeneic stem cell transplantation in patients with chronic myeloid leukemia: No evidence for increased transplant-related toxicity. Cancer, 110, pp. 340-344.
-
(2007)
Cancer
, vol.110
, pp. 340-344
-
-
Jabbour, E.1
Cortes, J.2
Kantarjian, H.3
-
58
-
-
24344507209
-
Imatinib: The narrow line between immune tolerance and activation
-
Mohty, M., Blaise, D. Olive, D. et al. (2005) Imatinib: The narrow line between immune tolerance and activation. Trends Mol Med, 11, pp. 397-402.
-
(2005)
Trends Mol Med
, vol.11
, pp. 397-402
-
-
Mohty, M.1
Blaise, D.2
Olive, D.3
-
59
-
-
25444525158
-
Effects of imatinib on normal hematopoiesis and immune activation
-
Appel, S., Balabanov, S. Brummendorf, TH et al. (2005) Effects of imatinib on normal hematopoiesis and immune activation. Stem Cells, 23, pp. 1082-1088.
-
(2005)
Stem Cells
, vol.23
, pp. 1082-1088
-
-
Appel, S.1
Balabanov, S.2
Brummendorf, T.H.3
-
60
-
-
34247847932
-
The kinase inhibitor imatinib: An immunosuppressive drug?
-
Wolf, D., Tilg, H. Rumpold, H. et al. (2007) The kinase inhibitor imatinib: An immunosuppressive drug?. Curr Cancer Drug Targets, 7, pp. 251-258.
-
(2007)
Curr Cancer Drug Targets
, vol.7
, pp. 251-258
-
-
Wolf, D.1
Tilg, H.2
Rumpold, H.3
-
61
-
-
34250696993
-
Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions
-
Appel, S. and Brossart, P. (2007) Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. Endocr Metab Immune Disord Drug Targets, 7, pp. 93-97.
-
(2007)
Endocr Metab Immune Disord Drug Targets
, vol.7
, pp. 93-97
-
-
Appel, S.1
Brossart, P.2
-
62
-
-
33751167425
-
Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections
-
Mumprecht, S., Matter, M. Pavelic, V. et al. (2006) Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections. Blood, 108, pp. 3406-3413.
-
(2006)
Blood
, vol.108
, pp. 3406-3413
-
-
Mumprecht, S.1
Matter, M.2
Pavelic, V.3
-
63
-
-
0034041033
-
Immunobiology of dendritic cells
-
Banchereau, J., Briere, F. Caux, C. et al. (2000) Immunobiology of dendritic cells. Annu Rev Immunol, 18, pp. 767-811.
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 767-811
-
-
Banchereau, J.1
Briere, F.2
Caux, C.3
-
64
-
-
0033168696
-
Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis
-
Dittel, BN, Visintin, I. Merchant, RM et al. (1999) Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis. J Immunol, 163, pp. 32-39.
-
(1999)
J Immunol
, vol.163
, pp. 32-39
-
-
Dittel, B.N.1
Visintin, I.2
Merchant, R.M.3
-
65
-
-
0032547818
-
Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue
-
Ludewig, B., Odermatt, B. Landmann, S. et al. (1998) Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med, 188, pp. 1493-1501.
-
(1998)
J Exp Med
, vol.188
, pp. 1493-1501
-
-
Ludewig, B.1
Odermatt, B.2
Landmann, S.3
-
66
-
-
2442494120
-
Autoimmunity through cytokine-induced dendritic cell activation
-
Banchereau, J., Pascual, V. and Palucka, A. K. (2004) Autoimmunity through cytokine-induced dendritic cell activation. Immunity, 20, pp. 539-550.
-
(2004)
Immunity
, vol.20
, pp. 539-550
-
-
Banchereau, J.1
Pascual, V.2
Palucka, A.K.3
-
67
-
-
33644502594
-
Dendritic cell apoptosis in the maintenance of immune tolerance
-
Chen, M., Wang, YH Wang, Y. et al. (2006) Dendritic cell apoptosis in the maintenance of immune tolerance. Science, 311, pp. 1160-1164.
-
(2006)
Science
, vol.311
, pp. 1160-1164
-
-
Chen, M.1
Wang, Y.H.2
Wang, Y.3
-
68
-
-
2442658900
-
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
-
Merad, M., Hoffmann, P. Ranheim, E. et al. (2004) Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med, 10, pp. 510-517.
-
(2004)
Nat Med
, vol.10
, pp. 510-517
-
-
Merad, M.1
Hoffmann, P.2
Ranheim, E.3
-
69
-
-
16244421996
-
In vitro depletion of tissue-derived dendritic cells by CMRF-44 antibody and alemtuzumab: Implications for the control of graft-versus-host disease
-
Collin, MP, Munster, D. Clark, G. et al. (2005) In vitro depletion of tissue-derived dendritic cells by CMRF-44 antibody and alemtuzumab: implications for the control of graft-versus-host disease. Transplantation, 79, pp. 722-725.
-
(2005)
Transplantation
, vol.79
, pp. 722-725
-
-
Collin, M.P.1
Munster, D.2
Clark, G.3
-
70
-
-
0141685067
-
Persistence of host dendritic cells after transplantation is associated with graft-versus-host disease
-
Chan, GW, Gorgun, G. Miller, KB et al. (2003) Persistence of host dendritic cells after transplantation is associated with graft-versus-host disease. Biol Blood Marrow Transplant, 9, pp. 170-176.
-
(2003)
Biol Blood Marrow Transplant
, vol.9
, pp. 170-176
-
-
Chan, G.W.1
Gorgun, G.2
Miller, K.B.3
-
71
-
-
0036530011
-
Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution
-
Klangsinsirikul, P., Carter, GI Byrne, JL et al. (2002) Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution. Blood, 99, pp. 2586-2591.
-
(2002)
Blood
, vol.99
, pp. 2586-2591
-
-
Klangsinsirikul, P.1
Carter, G.I.2
Byrne, J.L.3
-
72
-
-
34248397181
-
Alemtuzumab depletes dendritic cells more effectively in blood than in skin: A pilot study in patients with chronic lymphocytic leukemia
-
Auffermann-Gretzinger, S., Eger, L. Schetelig, J. et al. (2007) Alemtuzumab depletes dendritic cells more effectively in blood than in skin: A pilot study in patients with chronic lymphocytic leukemia. Transplantation, 83, pp. 1268-1272.
-
(2007)
Transplantation
, vol.83
, pp. 1268-1272
-
-
Auffermann-Gretzinger, S.1
Eger, L.2
Schetelig, J.3
-
73
-
-
23844518326
-
The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation
-
Chu, CL and Lowell, C. A. (2005) The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol, 175, pp. 2880-2889.
-
(2005)
J Immunol
, vol.175
, pp. 2880-2889
-
-
Chu, C.L.1
Lowell, C.A.2
-
74
-
-
0242335086
-
Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation
-
Napolitani, G., Bortoletto, N. Racioppi, L. et al. (2003) Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. Eur J Immunol, 33, pp. 2832-2841.
-
(2003)
Eur J Immunol
, vol.33
, pp. 2832-2841
-
-
Napolitani, G.1
Bortoletto, N.2
Racioppi, L.3
-
75
-
-
3042802079
-
Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells
-
Appel, S., Boehmler, AM Grunebach, F. et al. (2004) Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells. Blood, 103, pp. 538-544.
-
(2004)
Blood
, vol.103
, pp. 538-544
-
-
Appel, S.1
Boehmler, A.M.2
Grunebach, F.3
-
76
-
-
16344368251
-
Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-kappaB and Akt signaling pathways
-
Appel, S., Rupf, A. Weck, MM et al. (2005) Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-kappaB and Akt signaling pathways. Clin Cancer Res, 11, pp. 1928-1940.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1928-1940
-
-
Appel, S.1
Rupf, A.2
Weck, M.M.3
-
77
-
-
1442331705
-
Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo
-
Taieb, J., Maruyama, K. Borg, C. et al. (2004) Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo. Blood, 103, pp. 1966-1967.
-
(2004)
Blood
, vol.103
, pp. 1966-1967
-
-
Taieb, J.1
Maruyama, K.2
Borg, C.3
-
78
-
-
0141836920
-
Imatinib inhibits the in vitro development of the monocyte/macrophage lineage from normal human bone marrow progenitors
-
Dewar, AL, Domaschenz, RM Doherty, KV et al. (2003) Imatinib inhibits the in vitro development of the monocyte/macrophage lineage from normal human bone marrow progenitors. Leukemia, 17, pp. 1713-1721.
-
(2003)
Leukemia
, vol.17
, pp. 1713-1721
-
-
Dewar, A.L.1
Domaschenz, R.M.2
Doherty, K.V.3
-
79
-
-
10744232318
-
The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia
-
Sato, N., Narita, M. Takahashi, M. et al. (2003) The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia. Hematol Oncol, 21, pp. 67-75.
-
(2003)
Hematol Oncol
, vol.21
, pp. 67-75
-
-
Sato, N.1
Narita, M.2
Takahashi, M.3
-
80
-
-
30444443121
-
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3
-
Kawakami, Y., Inagaki, N. Salek-Ardakani, S. et al. (2006) Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3. Proc Natl Acad Sci USA, 103, pp. 153-158.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 153-158
-
-
Kawakami, Y.1
Inagaki, N.2
Salek-Ardakani, S.3
-
81
-
-
0038723629
-
Bruton's tyrosine kinase defect in dendritic cells from X-linked agammaglobulinaemia patients does not influence their differentiation, maturation and antigen-presenting cell function
-
Gagliardi, MC, Finocchi, A. Orlandi, P. et al. (2003) Bruton's tyrosine kinase defect in dendritic cells from X-linked agammaglobulinaemia patients does not influence their differentiation, maturation and antigen-presenting cell function. Clin Exp Immunol, 133, pp. 115-122.
-
(2003)
Clin Exp Immunol
, vol.133
, pp. 115-122
-
-
Gagliardi, M.C.1
Finocchi, A.2
Orlandi, P.3
-
82
-
-
47049127786
-
Sorafenib but not sunitinib affects function of dendritic cells and induction of primary immune responses
-
Hipp, MM, Hilf, N. Walter, S. et al. (2008) Sorafenib but not sunitinib affects function of dendritic cells and induction of primary immune responses. Blood, 111:12, pp. 5610-5620.
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5610-5620
-
-
Hipp, M.M.1
Hilf, N.2
Walter, S.3
-
83
-
-
32244445715
-
A novel dendritic cell subset involved in tumor immunosurveillance
-
Taieb, J., Chaput, N. Menard, C. et al. (2006) A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med, 12, pp. 214-219.
-
(2006)
Nat Med
, vol.12
, pp. 214-219
-
-
Taieb, J.1
Chaput, N.2
Menard, C.3
-
84
-
-
32244448339
-
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
-
Chan, CW, Crafton, E. Fan, HN et al. (2006) Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med, 12, pp. 207-213.
-
(2006)
Nat Med
, vol.12
, pp. 207-213
-
-
Chan, C.W.1
Crafton, E.2
Fan, H.N.3
-
85
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger, M., Buchdunger, E. and Druker, B. J. (2005) The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood, 105, pp. 2640-2653.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
86
-
-
33746418579
-
Imatinib mesylate minimally affects bcr-abl+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation
-
Boissel, N., Rousselot, P. Raffoux, E. et al. (2006) Imatinib mesylate minimally affects bcr-abl+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation. J Leukoc Biol, 79, pp. 747-756.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 747-756
-
-
Boissel, N.1
Rousselot, P.2
Raffoux, E.3
-
87
-
-
22544470270
-
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
-
Reeves, PM, Bommarius, B. Lebeis, S. et al. (2005) Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases. Nat Med, 11, pp. 731-739.
-
(2005)
Nat Med
, vol.11
, pp. 731-739
-
-
Reeves, P.M.1
Bommarius, B.2
Lebeis, S.3
|