Substrate stiffness orchestrates epithelial cellular heterogeneity with controlled proliferative pattern via E-cadherin/β-catenin mechanotransduction

Acta Biomaterialia

Volumn 41, Issue , 2016, Pages 169-180

  Wang, Bingjie ^a,b   Qin, Peng ^c   Zhao, Hui ^a,b   Xia, Tie ^b   Wang, Jingyu ^b   Liu, Longwei ^a,b   Zhu, Lu ^b   Xu, Jing ^a,d   Huang, Chenyu ^a   Shi, Yan ^b   Du, Yanan ^b,e  

^a TSINGHUA UNIVERSITY   (China)

^b Tsinghua University   (China)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

^d FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^e China Orthopedic Regenerative Medicine Group   (China)

Author keywords

E cadherin catenin mechanotransduction; Epithelial cellular heterogeneity; Proliferative pattern; Substrate stiffness

Indexed keywords

CYTOLOGY; ELASTIC MODULI; GLYCOPROTEINS; STIFFNESS; STIFFNESS MATRIX; SUBSTRATES;

CELLULAR POPULATIONS; CELLULARS; E-CADHERIN/Β-CATENIN MECHANOTRANSDUCTION; E-CADHERINS; EPITHELIAL CELLULAR HETEROGENEITY; MECHANOTRANSDUCTION; PROLIFERATIVE PATTERN; SOFT SUBSTRATES; SUBSTRATE STIFFNESS; Β-CATENIN;

STEM CELLS;

BETA CATENIN; UVOMORULIN; CADHERIN; CDH1 PROTEIN, HUMAN; HYDROGEL; MACROGOL DERIVATIVE; POLY(ETHYLENE GLYCOL)DIACRYLATE;

ARTICLE; CELL EXPANSION; CELL FUNCTION; CELL HETEROGENEITY; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; HUMAN TISSUE; MECHANOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RIGIDITY; SINGLE CELL ANALYSIS; YOUNG MODULUS; BIOMECHANICS; CELL DIFFERENTIATION; CELL SHAPE; CRISPR CAS SYSTEM; CYTOLOGY; CYTOSKELETON; DRUG EFFECTS; FOCAL ADHESION; GENE INACTIVATION; HYDROGEL; LIVER; METABOLISM; PATHOLOGY; PHARMACOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BETA CATENIN; BIOMECHANICAL PHENOMENA; CADHERINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CRISPR-CAS SYSTEMS; CYTOSKELETON; ELASTIC MODULUS; EPITHELIAL CELLS; FOCAL ADHESIONS; GENE KNOCKOUT TECHNIQUES; HUMAN EMBRYONIC STEM CELLS; HUMANS; HYDROGELS; LIVER; MECHANOTRANSDUCTION, CELLULAR; POLYETHYLENE GLYCOLS; SIGNAL TRANSDUCTION;

EID: 84969941123     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2016.05.025     Document Type: Article

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