Microengineered in vitro model of cardiac fibrosis through modulating myofibroblast mechanotransduction

Biofabrication

Volumn 6, Issue 4, 2014, Pages

  Zhao, Hui ^a,b   Li, Xiaokang ^b   Zhao, Shan ^b   Zeng, Yang ^b   Zhao, Long ^a   Ding, Haiyan ^b   Sun, Wei ^a,d   Du, Yanan ^b,c  

^a TSINGHUA UNIVERSITY   (China)

^b Tsinghua University   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d Drexel University   (United States)

Author keywords

cardiac fibrosis; drug testing; fibroblast mechanotransduction; in vitro model; micro fabrication

Indexed keywords

BIOMIMETICS; BLOOD VESSELS; CELL CULTURE; FIBROBLASTS; GRAFTING (CHEMICAL); IMPLANTS (SURGICAL);

CARDIAC FIBROSIS; CARDIAC INFARCTION; CORONARY ARTERIES; DRUG TESTING; IN-VITRO MODELS; MECHANICAL HETEROGENEITY; MECHANOTRANSDUCTION; PATHWAY INHIBITORS;

HEART;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMIDE; CARDIOVASCULAR AGENT; PYRIDINE DERIVATIVE;

3T3 CELL LINE; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL PROLIFERATION; DRUG DEVELOPMENT; DRUG EFFECTS; FIBROSIS; HEART DISEASE; MALE; MECHANOTRANSDUCTION; MOUSE; MYOFIBROBLAST; PATHOPHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT;

AMIDES; ANIMALS; CARDIOVASCULAR AGENTS; CELL PROLIFERATION; CELLS, CULTURED; DRUG DISCOVERY; FIBROSIS; HEART DISEASES; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MODELS, CARDIOVASCULAR; MYOFIBROBLASTS; NIH 3T3 CELLS; PYRIDINES; RATS, SPRAGUE-DAWLEY;

EID: 84914669552     PISSN: 17585082     EISSN: 17585090     Source Type: Journal    
DOI: 10.1088/1758-5082/6/4/045009     Document Type: Article

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