Modulation of integrin and E-cadherin-mediated adhesions to spatially control heterogeneity in human pluripotent stem cell differentiation

Biomaterials

Volumn 50, Issue 1, 2015, Pages 87-97

  Toh, Yi Chin ^a,e   Xing, Jiangwa ^a,b   Yu, Hanry ^a,b,c,d,f,g  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^g Massachusetts Institute of Technology   (United States)

Author keywords

Cell fate heterogeneity; Human pluripotent stem cells; Mechanical forces; Micropatterning

Indexed keywords

CELL ADHESION; GLYCOPROTEINS; POLARIZATION;

CELL FATES; CELL MICROPATTERNING; CELL-MATRIX ADHESION; LOCALIZATION PATTERNS; MECHANICAL FORCE; MICRO PATTERNING; PLURIPOTENT STEM CELLS; SPATIAL POLARIZATION;

STEM CELLS;

INTEGRIN; MYOSIN II; RHO FACTOR; UVOMORULIN; CADHERIN; CDH1 PROTEIN, HUMAN; COLLAGEN; DRUG COMBINATION; LAMININ; MATRIGEL; MYOSIN ADENOSINE TRIPHOSPHATASE; PROTEOGLYCAN; RHO KINASE;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL FATE; CELL JUNCTION; CELL POPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDODERM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MESODERM; PLURIPOTENT STEM CELL; POLARIZATION; PRIORITY JOURNAL; CELL LINEAGE; CELL POLARITY; CYTOLOGY; DRUG COMBINATION; DRUG EFFECTS; EMBRYONIC STEM CELL; METABOLISM; SIGNAL TRANSDUCTION;

PYRONIA TITHONUS;

ACTOMYOSIN; CADHERINS; CELL ADHESION; CELL DIFFERENTIATION; CELL LINEAGE; CELL POLARITY; COLLAGEN; DRUG COMBINATIONS; EMBRYONIC STEM CELLS; ENDODERM; HUMANS; INTEGRINS; LAMININ; MESODERM; MYOSIN TYPE II; PLURIPOTENT STEM CELLS; PROTEOGLYCANS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 84929151746     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.01.019     Document Type: Article

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