메뉴 건너뛰기




Volumn 15, Issue 1, 2016, Pages

Essential role of miRNAs in orchestrating the biology of the tumor microenvironment

Author keywords

Cancer; Exosomes; MicroRNAs; Tumor microenvironment

Indexed keywords

MATRIX METALLOPROTEINASE; MICRORNA; MICRORNA 17; MICRORNA 18A; MICRORNA 19A; MICRORNA 19B; MICRORNA 20A; MICRORNA 92A; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84969802533     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-016-0525-3     Document Type: Review
Times cited : (56)

References (102)
  • 1
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373-83. doi: 10.1083/jcb.201211138. PubMed PMID: 23420871; PMCID: PMC3575529.
    • (2013) J Cell Biol , vol.200 , Issue.4 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 2
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: microRNAs can up-regulate translation
    • Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science. 2007;318(5858):1931-4. doi: 10.1126/science.1149460.
    • (2007) Science , vol.318 , Issue.5858 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 4
    • 33746782086 scopus 로고    scopus 로고
    • Intronic microRNA (miRNA)
    • Lin SL, Miller JD, Ying SY. Intronic microRNA (miRNA). J Biomed Biotechnol. 2006;2006(4):26818. doi: 10.1155/JBB/2006/26818. PubMed PMID: 17057362; PMCID: PMC1559912.
    • (2006) J Biomed Biotechnol , vol.2006 , Issue.4 , pp. 26818
    • Lin, S.L.1    Miller, J.D.2    Ying, S.Y.3
  • 5
    • 84887101163 scopus 로고    scopus 로고
    • MicroRNAs and other non-coding RNAs as targets for anticancer drug development
    • Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov. 2013;12(11):847-65. doi: 10.1038/nrd4140.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.11 , pp. 847-865
    • Ling, H.1    Fabbri, M.2    Calin, G.A.3
  • 6
    • 84955342359 scopus 로고    scopus 로고
    • Non-coding RNAs and cancer
    • New York: Springer
    • Fabbri M. Non-coding RNAs and cancer. New York: Springer; 2014.
    • (2014)
    • Fabbri, M.1
  • 7
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2013;32(22):2747-55. doi: 10.1038/onc.2012.295.
    • (2013) Oncogene , vol.32 , Issue.22 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.H.4
  • 9
    • 84907732356 scopus 로고    scopus 로고
    • Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1/5/8 signaling elicited by PML down-regulation in endothelial cells
    • Yamada N, Tsujimura N, Kumazaki M, Shinohara H, Taniguchi K, Nakagawa Y, Naoe T, Akao Y. Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1/5/8 signaling elicited by PML down-regulation in endothelial cells. Biochim Biophys Acta. 2014;1839(11):1256-72. doi: 10.1016/j.bbagrm.2014.09.002.
    • (2014) Biochim Biophys Acta , vol.1839 , Issue.11 , pp. 1256-1272
    • Yamada, N.1    Tsujimura, N.2    Kumazaki, M.3    Shinohara, H.4    Taniguchi, K.5    Nakagawa, Y.6    Naoe, T.7    Akao, Y.8
  • 10
    • 84931566041 scopus 로고    scopus 로고
    • Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer
    • Mao G, Liu Y, Fang X, Fang L, Lin L, Liu X, Wang N. Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer. Angiogenesis. 2015;18(3):373-82. doi: 10.1007/s10456-015-9474-5.
    • (2015) Angiogenesis , vol.18 , Issue.3 , pp. 373-382
    • Mao, G.1    Liu, Y.2    Fang, X.3    Fang, L.4    Lin, L.5    Liu, X.6    Wang, N.7
  • 11
    • 84919680938 scopus 로고    scopus 로고
    • Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
    • Umezu T, Tadokoro H, Azuma K, Yoshizawa S, Ohyashiki K, Ohyashiki JH. Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood. 2014;124(25):3748-57. doi: 10.1182/blood-2014-05-576116. PubMed PMID: 25320245; PMCID: PMC4263983.
    • (2014) Blood , vol.124 , Issue.25 , pp. 3748-3757
    • Umezu, T.1    Tadokoro, H.2    Azuma, K.3    Yoshizawa, S.4    Ohyashiki, K.5    Ohyashiki, J.H.6
  • 12
    • 84866093563 scopus 로고    scopus 로고
    • Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
    • Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, Oeh J, Modrusan Z, Bais C, Sampath D, Ferrara N. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012;31(17):3513-23. doi: 10.1038/emboj.2012.183. PubMed PMID: 22773185; PMCID: PMC3433782.
    • (2012) EMBO J , vol.31 , Issue.17 , pp. 3513-3523
    • Zhuang, G.1    Wu, X.2    Jiang, Z.3    Kasman, I.4    Yao, J.5    Guan, Y.6    Oeh, J.7    Modrusan, Z.8    Bais, C.9    Sampath, D.10    Ferrara, N.11
  • 14
    • 80051752025 scopus 로고    scopus 로고
    • MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6
    • Saito K, Kondo E, Matsushita M. MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6. Nucleic Acids Res. 2011;39(14):6086-99. doi: 10.1093/nar/gkr194. PubMed PMID: 21486751; PMCID: PMC3152344.
    • (2011) Nucleic Acids Res , vol.39 , Issue.14 , pp. 6086-6099
    • Saito, K.1    Kondo, E.2    Matsushita, M.3
  • 15
    • 70449602451 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
    • Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One. 2009;4(10):e7629. doi: 10.1371/journal.pone.0007629. PubMed PMID: 19893619; PMCID: PMC2764090.
    • (2009) PLoS One , vol.4 , Issue.10 , pp. e7629
    • Lei, Z.1    Li, B.2    Yang, Z.3    Fang, H.4    Zhang, G.M.5    Feng, Z.H.6    Huang, B.7
  • 16
    • 84955438854 scopus 로고    scopus 로고
    • miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α
    • Wu Z, Cai X, Huang C, Xu J, Liu A. miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α. Oncol Rep. 2015. doi: 10.3892/or.2015.4529.
    • (2015) Oncol Rep.
    • Wu, Z.1    Cai, X.2    Huang, C.3    Xu, J.4    Liu, A.5
  • 17
    • 84945156918 scopus 로고    scopus 로고
    • MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1
    • Yan JJ, Zhang YN, Liao JZ, Ke KP, Chang Y, Li PY, Wang M, Lin JS, He XX. MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget. 2015;6(30):29527-42. doi: 10.18632/oncotarget.5012.
    • (2015) Oncotarget , vol.6 , Issue.30 , pp. 29527-29542
    • Yan, J.J.1    Zhang, Y.N.2    Liao, J.Z.3    Ke, K.P.4    Chang, Y.5    Li, P.Y.6    Wang, M.7    Lin, J.S.8    He, X.X.9
  • 18
    • 84924415559 scopus 로고    scopus 로고
    • microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma
    • Zhang Z, Zhang Y, Sun XX, Ma X, Chen ZN. microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma. Mol Cancer. 2015;14:5. doi: 10.1186/1476-4598-14-5. PubMed PMID: 25608619; PMCID: PMC4326400.
    • (2015) Mol Cancer , vol.14 , pp. 5
    • Zhang, Z.1    Zhang, Y.2    Sun, X.X.3    Ma, X.4    Chen, Z.N.5
  • 24
    • 84872790880 scopus 로고    scopus 로고
    • MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11
    • Siragam V, Rutnam ZJ, Yang W, Fang L, Luo L, Yang X, Li M, Deng Z, Qian J, Peng C, Yang BB. MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11. Oncotarget. 2012;3(11):1370-85. PubMed PMID: 23211491; PMCID: PMC3717799.
    • (2012) Oncotarget , vol.3 , Issue.11 , pp. 1370-1385
    • Siragam, V.1    Rutnam, Z.J.2    Yang, W.3    Fang, L.4    Luo, L.5    Yang, X.6    Li, M.7    Deng, Z.8    Qian, J.9    Peng, C.10    Yang, B.B.11
  • 25
    • 84947807456 scopus 로고    scopus 로고
    • MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA
    • Lu Z, Zhang W, Gao S, Jiang Q, Xiao Z, Ye L, Zhang X. MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA. Biochem Biophys Res Commun. 2015;468(1-2):8-13. doi: 10.1016/j.bbrc.2015.11.008.
    • (2015) Biochem Biophys Res Commun , vol.468 , Issue.1-2 , pp. 8-13
    • Lu, Z.1    Zhang, W.2    Gao, S.3    Jiang, Q.4    Xiao, Z.5    Ye, L.6    Zhang, X.7
  • 26
    • 84855813448 scopus 로고    scopus 로고
    • A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    • Png KJ, Halberg N, Yoshida M, Tavazoie SF. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature. 2012;481(7380):190-4. doi: 10.1038/nature10661.
    • (2012) Nature , vol.481 , Issue.7380 , pp. 190-194
    • Png, K.J.1    Halberg, N.2    Yoshida, M.3    Tavazoie, S.F.4
  • 27
    • 84866653610 scopus 로고    scopus 로고
    • let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer
    • Jusufović E, Rijavec M, Keser D, Korošec P, Sodja E, Iljazović E, Radojević Z, Košnik M. let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer. PLoS One. 2012;7(9):e45577. doi: 10.1371/journal.pone.0045577. PubMed PMID: 23029111; PMCID: PMC3454421.
    • (2012) PLoS One , vol.7 , Issue.9 , pp. e45577
    • Jusufović, E.1    Rijavec, M.2    Keser, D.3    Korošec, P.4    Sodja, E.5    Iljazović, E.6    Radojević, Z.7    Košnik, M.8
  • 28
    • 84895923770 scopus 로고    scopus 로고
    • MicroRNA-542-3p inhibits tumour angiogenesis by targeting angiopoietin-2
    • He T, Qi F, Jia L, Wang S, Song N, Guo L, Fu Y, Luo Y. MicroRNA-542-3p inhibits tumour angiogenesis by targeting angiopoietin-2. J Pathol. 2014;232(5):499-508. doi: 10.1002/path.4324.
    • (2014) J Pathol , vol.232 , Issue.5 , pp. 499-508
    • He, T.1    Qi, F.2    Jia, L.3    Wang, S.4    Song, N.5    Guo, L.6    Fu, Y.7    Luo, Y.8
  • 29
    • 84858592019 scopus 로고    scopus 로고
    • The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis
    • Vong S, Kalluri R. The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. Genes Cancer. 2011;2(12):1139-45. doi: 10.1177/1947601911423940. PubMed PMID: 22866205; PMCID: PMC3411128.
    • (2011) Genes Cancer , vol.2 , Issue.12 , pp. 1139-1145
    • Vong, S.1    Kalluri, R.2
  • 30
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6(5):392-401. doi: 10.1038/nrc1877.
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 31
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420-8. doi: 10.1172/JCI39104. PubMed PMID: 19487818; PMCID: PMC2689101.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 32
    • 84871528926 scopus 로고    scopus 로고
    • MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer
    • Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, Lengyel E. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012;2(12):1100-8. doi: 10.1158/2159-8290.CD-12-0206. PubMed PMID: 23171795; PMCID: PMC3685866.
    • (2012) Cancer Discov , vol.2 , Issue.12 , pp. 1100-1108
    • Mitra, A.K.1    Zillhardt, M.2    Hua, Y.3    Tiwari, P.4    Murmann, A.E.5    Peter, M.E.6    Lengyel, E.7
  • 35
    • 84866640259 scopus 로고    scopus 로고
    • Autocrine CCL5 signaling promotes invasion and migration of CD133+ ovarian cancer stem-like cells via NF-ΚB-mediated MMP-9 upregulation
    • Long H, Xie R, Xiang T, Zhao Z, Lin S, Liang Z, Chen Z, Zhu B. Autocrine CCL5 signaling promotes invasion and migration of CD133+ ovarian cancer stem-like cells via NF-ΚB-mediated MMP-9 upregulation. Stem Cells. 2012;30(10):2309-19. doi: 10.1002/stem.1194.
    • (2012) Stem Cells , vol.30 , Issue.10 , pp. 2309-2319
    • Long, H.1    Xie, R.2    Xiang, T.3    Zhao, Z.4    Lin, S.5    Liang, Z.6    Chen, Z.7    Zhu, B.8
  • 36
    • 84874646861 scopus 로고    scopus 로고
    • A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells
    • Zhang Y, Lv D, Kim HJ, Kurt RA, Bu W, Li Y, Ma X. A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells. Cell Res. 2013;23(3):394-408. doi: 10.1038/cr.2012.178. PubMed PMID: 23266888; PMCID: PMC3587709.
    • (2013) Cell Res , vol.23 , Issue.3 , pp. 394-408
    • Zhang, Y.1    Lv, D.2    Kim, H.J.3    Kurt, R.A.4    Bu, W.5    Li, Y.6    Ma, X.7
  • 38
    • 84945542006 scopus 로고    scopus 로고
    • Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation
    • Doldi V, Callari M, Giannoni E, D'Aiuto F, Maffezzini M, Valdagni R, Chiarugi P, Gandellini P, Zaffaroni N. Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation. Oncotarget. 2015;6(31):31441-60. doi: 10.18632/oncotarget.5056.
    • (2015) Oncotarget , vol.6 , Issue.31 , pp. 31441-31460
    • Doldi, V.1    Callari, M.2    Giannoni, E.3    D'Aiuto, F.4    Maffezzini, M.5    Valdagni, R.6    Chiarugi, P.7    Gandellini, P.8    Zaffaroni, N.9
  • 41
    • 84915755909 scopus 로고    scopus 로고
    • miR-200-containing extracellular vesicles promote breast cancer cell metastasis
    • Le MT, Hamar P, Guo C, Basar E, Perdigão-Henriques R, Balaj L, Lieberman J. miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest. 2014;124(12):5109-28. doi: 10.1172/JCI75695. PubMed PMID: 25401471; PMCID: PMC4348969.
    • (2014) J Clin Invest , vol.124 , Issue.12 , pp. 5109-5128
    • Le, M.T.1    Hamar, P.2    Guo, C.3    Basar, E.4    Perdigão-Henriques, R.5    Balaj, L.6    Lieberman, J.7
  • 42
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblasts in cancer initiation and progression. Nature. 2004;432(7015):332-7. doi: 10.1038/nature03096. PubMed PMID: 15549095; PMCID: PMC3050735.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 48
    • 70349145414 scopus 로고    scopus 로고
    • MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
    • Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 2009;23(18):2152-65. doi: 10.1101/gad.1820109. PubMed PMID: 19759263; PMCID: PMC2751988.
    • (2009) Genes Dev , vol.23 , Issue.18 , pp. 2152-2165
    • Olson, P.1    Lu, J.2    Zhang, H.3    Shai, A.4    Chun, M.G.5    Wang, Y.6    Libutti, S.K.7    Nakakura, E.K.8    Golub, T.R.9    Hanahan, D.10
  • 49
    • 84883818845 scopus 로고    scopus 로고
    • Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma
    • Nouraee N, Van Roosbroeck K, Vasei M, Semnani S, Samaei NM, Naghshvar F, Omidi AA, Calin GA, Mowla SJ. Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma. PLoS One. 2013;8(9):e73009. doi: 10.1371/journal.pone.0073009. PubMed PMID: 24039846; PMCID: PMC3769386.
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e73009
    • Nouraee, N.1    Roosbroeck, K.2    Vasei, M.3    Semnani, S.4    Samaei, N.M.5    Naghshvar, F.6    Omidi, A.A.7    Calin, G.A.8    Mowla, S.J.9
  • 50
    • 84940884425 scopus 로고    scopus 로고
    • miR-101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down-regulating CXCL12
    • Zhang J, Liu J, Liu Y, Wu W, Li X, Wu Y, Chen H, Zhang K, Gu L. miR-101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down-regulating CXCL12. Biomed Pharmacother. 2015;74:215-21. doi: 10.1016/j.biopha.2015.08.013.
    • (2015) Biomed Pharmacother , vol.74 , pp. 215-221
    • Zhang, J.1    Liu, J.2    Liu, Y.3    Wu, W.4    Li, X.5    Wu, Y.6    Chen, H.7    Zhang, K.8    Gu, L.9
  • 53
    • 84949657146 scopus 로고    scopus 로고
    • CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p
    • Farahani M, Rubbi C, Liu L, Slupsky JR, Kalakonda N. CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p. PLoS One. 2015;10(10):e0141429. doi: 10.1371/journal.pone.0141429. PubMed PMID: 26509439; PMCID: PMC4625016.
    • (2015) PLoS One , vol.10 , Issue.10 , pp. e0141429
    • Farahani, M.1    Rubbi, C.2    Liu, L.3    Slupsky, J.R.4    Kalakonda, N.5
  • 54
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010;141(1):52-67. doi: 10.1016/j.cell.2010.03.015. PubMed PMID: 20371345; PMCID: PMC2862057.
    • (2010) Cell , vol.141 , Issue.1 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 55
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 2007;133(2):647-58. doi: 10.1053/j.gastro.2007.05.022.
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 56
    • 84876276223 scopus 로고    scopus 로고
    • Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9
    • Wang Q, Tang H, Yin S, Dong C. Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9. Oncol Rep. 2013;29(5):2046-52. doi: 10.3892/or.2013.2304.
    • (2013) Oncol Rep , vol.29 , Issue.5 , pp. 2046-2052
    • Wang, Q.1    Tang, H.2    Yin, S.3    Dong, C.4
  • 57
    • 84873364088 scopus 로고    scopus 로고
    • GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
    • Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013;15(2):201-13. doi: 10.1038/ncb2672. PubMed PMID: 23354167; PMCID: PMC3660859.
    • (2013) Nat Cell Biol , vol.15 , Issue.2 , pp. 201-213
    • Chou, J.1    Lin, J.H.2    Brenot, A.3    Kim, J.W.4    Provot, S.5    Werb, Z.6
  • 58
    • 84942242855 scopus 로고    scopus 로고
    • Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7
    • Song N, Liu H, Ma X, Zhang S. Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7. Cell Physiol Biochem. 2015;37(3):1104-12. doi: 10.1159/000430235.
    • (2015) Cell Physiol Biochem , vol.37 , Issue.3 , pp. 1104-1112
    • Song, N.1    Liu, H.2    Ma, X.3    Zhang, S.4
  • 60
    • 50249173450 scopus 로고    scopus 로고
    • MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    • Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008;28(17):5369-80. doi: 10.1128/MCB.00479-08. PubMed PMID: 18591254; PMCID: PMC2519720.
    • (2008) Mol Cell Biol , vol.28 , Issue.17 , pp. 5369-5380
    • Gabriely, G.1    Wurdinger, T.2    Kesari, S.3    Esau, C.C.4    Burchard, J.5    Linsley, P.S.6    Krichevsky, A.M.7
  • 62
    • 78650864750 scopus 로고    scopus 로고
    • MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1
    • Hunt S, Jones AV, Hinsley EE, Whawell SA, Lambert DW. MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1. FEBS Lett. 2011;585(1):187-92. doi: 10.1016/j.febslet.2010.11.038.
    • (2011) FEBS Lett , vol.585 , Issue.1 , pp. 187-192
    • Hunt, S.1    Jones, A.V.2    Hinsley, E.E.3    Whawell, S.A.4    Lambert, D.W.5
  • 63
    • 77949321139 scopus 로고    scopus 로고
    • Targeting of integrin beta1 and kinesin 2alpha by microRNA 183
    • Li G, Luna C, Qiu J, Epstein DL, Gonzalez P. Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. J Biol Chem. 2010;285(8):5461-71. doi: 10.1074/jbc.M109.037127. PubMed PMID: 19940135; PMCID: PMC2820774.
    • (2010) J Biol Chem , vol.285 , Issue.8 , pp. 5461-5471
    • Li, G.1    Luna, C.2    Qiu, J.3    Epstein, D.L.4    Gonzalez, P.5
  • 65
    • 77951623294 scopus 로고    scopus 로고
    • Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma
    • Ji J, Zhao L, Budhu A, Forgues M, Jia HL, Qin LX, Ye QH, Yu J, Shi X, Tang ZY, Wang XW. Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. J Hepatol. 2010;52(5):690-7. doi: 10.1016/j.jhep.2009.12.025. PubMed PMID: 20338660; PMCID: PMC2862772.
    • (2010) J Hepatol , vol.52 , Issue.5 , pp. 690-697
    • Ji, J.1    Zhao, L.2    Budhu, A.3    Forgues, M.4    Jia, H.L.5    Qin, L.X.6    Ye, Q.H.7    Yu, J.8    Shi, X.9    Tang, Z.Y.10    Wang, X.W.11
  • 66
    • 84907385669 scopus 로고    scopus 로고
    • Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7
    • Su B, Zhao W, Shi B, Zhang Z, Yu X, Xie F, Guo Z, Zhang X, Liu J, Shen Q, Wang J, Li X, Zhou L. Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7. Mol Cancer. 2014;13:206. doi: 10.1186/1476-4598-13-206. PubMed PMID: 25193015; PMCID: PMC4168121.
    • (2014) Mol Cancer , vol.13 , pp. 206
    • Su, B.1    Zhao, W.2    Shi, B.3    Zhang, Z.4    Yu, X.5    Xie, F.6    Guo, Z.7    Zhang, X.8    Liu, J.9    Shen, Q.10    Wang, J.11    Li, X.12    Zhou, L.13
  • 69
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 71
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
    • Zhang QW, Liu L, Gong CY, Shi HS, Zeng YH, Wang XZ, Zhao YW, Wei YQ. Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One. 2012;7(12), e50946. doi: 10.1371/journal.pone.0050946. PubMed PMID: 23284651; PMCID: PMC3532403.
    • (2012) PLoS One , vol.7 , Issue.12
    • Zhang, Q.W.1    Liu, L.2    Gong, C.Y.3    Shi, H.S.4    Zeng, Y.H.5    Wang, X.Z.6    Zhao, Y.W.7    Wei, Y.Q.8
  • 72
    • 84921916858 scopus 로고    scopus 로고
    • Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside
    • Jinushi M, Komohara Y. Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside. Biochim Biophys Acta. 2015;1855(2):123-30. doi: 10.1016/j.bbcan.2015.01.002.
    • (2015) Biochim Biophys Acta , vol.1855 , Issue.2 , pp. 123-130
    • Jinushi, M.1    Komohara, Y.2
  • 73
    • 84904654557 scopus 로고    scopus 로고
    • Tumor-associated macrophages contribute to tumor progression in ovarian cancer
    • Colvin EK. Tumor-associated macrophages contribute to tumor progression in ovarian cancer. Front Oncol. 2014;4:137. doi: 10.3389/fonc.2014.00137. PubMed PMID: 24936477; PMCID: PMC4047518.
    • (2014) Front Oncol , vol.4 , pp. 137
    • Colvin, E.K.1
  • 74
    • 85008952417 scopus 로고    scopus 로고
    • Tumor-associated macrophages, multi-tasking cells in the cancer landscape
    • Marelli G, Allavena P, Erreni M. Tumor-associated macrophages, multi-tasking cells in the cancer landscape. Cancer Res Frontiers. 2015;1(2):149-61.
    • (2015) Cancer Res Frontiers , vol.1 , Issue.2 , pp. 149-161
    • Marelli, G.1    Allavena, P.2    Erreni, M.3
  • 78
    • 84896736752 scopus 로고    scopus 로고
    • High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome
    • Stenvold H, Donnem T, Andersen S, Al-Saad S, Valkov A, Pedersen MI, Busund LT, Bremnes RM. High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome. BMC Clin Pathol. 2014;14(1):9. doi: 10.1186/1472-6890-14-9. PubMed PMID: 24524655; PMCID: PMC3931486.
    • (2014) BMC Clin Pathol , vol.14 , Issue.1 , pp. 9
    • Stenvold, H.1    Donnem, T.2    Andersen, S.3    Al-Saad, S.4    Valkov, A.5    Pedersen, M.I.6    Busund, L.T.7    Bremnes, R.M.8
  • 79
    • 84901641136 scopus 로고    scopus 로고
    • Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA
    • Gao J, Zhang Q, Xu J, Guo L, Li X. Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA. Chin J Cancer Res. 2013;25(6):743-8. doi: 10.3978/j.issn.1000-9604.2013.12.04. PubMed PMID: 24385703; PMCID: PMC3872537.
    • (2013) Chin J Cancer Res , vol.25 , Issue.6 , pp. 743-748
    • Gao, J.1    Zhang, Q.2    Xu, J.3    Guo, L.4    Li, X.5
  • 80
    • 84923651749 scopus 로고    scopus 로고
    • Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese females
    • Wang G, Wang L, Sun S, Wu J, Wang Q. Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese females. Ann Lab Med. 2015;35(2):226-32. doi: 10.3343/alm.2015.35.2.226. PubMed PMID: 25729725; PMCID: PMC4330173.
    • (2015) Ann Lab Med , vol.35 , Issue.2 , pp. 226-232
    • Wang, G.1    Wang, L.2    Sun, S.3    Wu, J.4    Wang, Q.5
  • 82
    • 80053175966 scopus 로고    scopus 로고
    • Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
    • Yang M, Chen J, Su F, Yu B, Lin L, Liu Y, Huang JD, Song E. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer. 2011;10:117. doi: 10.1186/1476-4598-10-117. PubMed PMID: 21939504; PMCID: PMC3190352.
    • (2011) Mol Cancer , vol.10 , pp. 117
    • Yang, M.1    Chen, J.2    Su, F.3    Yu, B.4    Lin, L.5    Liu, Y.6    Huang, J.D.7    Song, E.8
  • 83
    • 84940204789 scopus 로고    scopus 로고
    • CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis
    • Lin X, Chen L, Yao Y, Zhao R, Cui X, Chen J, Hou K, Zhang M, Su F, Song E. CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis. Oncotarget. 2015;6(24):20485-99. doi: 10.18632/oncotarget.4107. PubMed PMID: 26244871; PMCID: PMC4653020.
    • (2015) Oncotarget , vol.6 , Issue.24 , pp. 20485-20499
    • Lin, X.1    Chen, L.2    Yao, Y.3    Zhao, R.4    Cui, X.5    Chen, J.6    Hou, K.7    Zhang, M.8    Su, F.9    Song, E.10
  • 84
    • 84860370107 scopus 로고    scopus 로고
    • Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration
    • Nilsson S, Möller C, Jirström K, Lee A, Busch S, Lamb R, Landberg G. Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. PLoS One. 2012;7(4), e36051. doi: 10.1371/journal.pone.0036051. PubMed PMID: 22563438; PMCID: PMC3338574.
    • (2012) PLoS One , vol.7 , Issue.4
    • Nilsson, S.1    Möller, C.2    Jirström, K.3    Lee, A.4    Busch, S.5    Lamb, R.6    Landberg, G.7
  • 86
    • 84886031527 scopus 로고    scopus 로고
    • MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α
    • Xu Z, Zhao L, Zhu LY, He M, Zheng L, Wu Y. MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α. PLoS One. 2013;8(10), e77890. doi: 10.1371/journal.pone.0077890. PubMed PMID: 24194900; PMCID: PMC3806827.
    • (2013) PLoS One , vol.8 , Issue.10
    • Xu, Z.1    Zhao, L.2    Zhu, L.Y.3    He, M.4    Zheng, L.5    Wu, Y.6
  • 87
    • 84951310499 scopus 로고    scopus 로고
    • Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer
    • Li Y, Zhao L, Shi B, Ma S, Xu Z, Ge Y, Liu Y, Zheng D, Shi J. Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer. Sci Rep. 2015;5:18648. doi: 10.1038/srep18648. PubMed PMID: 26689540; PMCID: PMC4686897.
    • (2015) Sci Rep , vol.5 , pp. 18648
    • Li, Y.1    Zhao, L.2    Shi, B.3    Ma, S.4    Xu, Z.5    Ge, Y.6    Liu, Y.7    Zheng, D.8    Shi, J.9
  • 89
    • 84971646937 scopus 로고    scopus 로고
    • A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression
    • Ma S, Liu M, Xu Z, Li Y, Guo H, Ge Y, Liu Y, Zheng D, Shi J. A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression. Oncotarget. 2015. doi: 10.18632/oncotarget.6284
    • (2015) Oncotarget
    • Ma, S.1    Liu, M.2    Xu, Z.3    Li, Y.4    Guo, H.5    Ge, Y.6    Liu, Y.7    Zheng, D.8    Shi, J.9
  • 92
    • 84926675081 scopus 로고    scopus 로고
    • miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression
    • Sun X, Zhang J, Hou Z, Han Q, Zhang C, Tian Z. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. Cell Cycle. 2015;14(2):243-52. doi: 10.4161/15384101.2014.977112. PubMed PMID: 25607648; PMCID: PMC4352959.
    • (2015) Cell Cycle , vol.14 , Issue.2 , pp. 243-252
    • Sun, X.1    Zhang, J.2    Hou, Z.3    Han, Q.4    Zhang, C.5    Tian, Z.6
  • 93
    • 84918517100 scopus 로고    scopus 로고
    • Activation of glioma cells generates immune tolerant NKT cells
    • Tang B, Wu W, Wei X, Li Y, Ren G, Fan W. Activation of glioma cells generates immune tolerant NKT cells. J Biol Chem. 2014;289(50):34595-600. doi: 10.1074/jbc.M114.614503. PubMed PMID: 25342742; PMCID: PMC4263866.
    • (2014) J Biol Chem , vol.289 , Issue.50 , pp. 34595-34600
    • Tang, B.1    Wu, W.2    Wei, X.3    Li, Y.4    Ren, G.5    Fan, W.6
  • 94
    • 84948845576 scopus 로고    scopus 로고
    • miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function
    • Noman MZ, Janji B, Berchem G, Chouaib S. miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function. Cancer Lett. 2015. doi: 10.1016/j.canlet.2015.10.026.
    • (2015) Cancer Lett.
    • Noman, M.Z.1    Janji, B.2    Berchem, G.3    Chouaib, S.4
  • 98
    • 84906851359 scopus 로고    scopus 로고
    • Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression
    • Xie J, Liu M, Li Y, Nie Y, Mi Q, Zhao S. Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression. Cell Mol Immunol. 2014;11(5):495-502. doi: 10.1038/cmi.2014.30. PubMed PMID: 24813230; PMCID: PMC4197204.
    • (2014) Cell Mol Immunol , vol.11 , Issue.5 , pp. 495-502
    • Xie, J.1    Liu, M.2    Li, Y.3    Nie, Y.4    Mi, Q.5    Zhao, S.6
  • 100
    • 84964313996 scopus 로고    scopus 로고
    • Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2
    • Jiang H, Wang P, Li X, Wang Q, Deng ZB, Zhuang X, Mu J, Zhang L, Wang B, Yan J, Miller D, Zhang HG. Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2. Cancer Immunol Res. 2014;2(8):789-99. doi: 10.1158/2326-6066.CIR-13-0162. PubMed PMID: 24801835; PMCID: PMC4396632.
    • (2014) Cancer Immunol Res , vol.2 , Issue.8 , pp. 789-799
    • Jiang, H.1    Wang, P.2    Li, X.3    Wang, Q.4    Deng, Z.B.5    Zhuang, X.6    Mu, J.7    Zhang, L.8    Wang, B.9    Yan, J.10    Miller, D.11    Zhang, H.G.12
  • 101
    • 68049117231 scopus 로고    scopus 로고
    • MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors
    • Xu H, Cheung IY, Guo HF, Cheung NK. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. Cancer Res. 2009;69(15):6275-81. doi: 10.1158/0008-5472.CAN-08-4517. PubMed PMID: 19584290; PMCID: PMC2719680.
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6275-6281
    • Xu, H.1    Cheung, I.Y.2    Guo, H.F.3    Cheung, N.K.4
  • 102
    • 84855906694 scopus 로고    scopus 로고
    • Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D
    • Heinemann A, Zhao F, Pechlivanis S, Eberle J, Steinle A, Diederichs S, Schadendorf D, Paschen A. Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res. 2012;72(2):460-71. doi: 10.1158/0008-5472.CAN-11-1977.
    • (2012) Cancer Res , vol.72 , Issue.2 , pp. 460-471
    • Heinemann, A.1    Zhao, F.2    Pechlivanis, S.3    Eberle, J.4    Steinle, A.5    Diederichs, S.6    Schadendorf, D.7    Paschen, A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.